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Astrid M. Kral, Ph.D.

Affiliations: 
2000 University of Pennsylvania, Philadelphia, PA, United States 
Area:
Biochemistry
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"Astrid Kral"
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Charles A. Omer grad student 2000 Penn
 (Structure-function studies of farnesyl:proteintransferase.)

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Publications

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Kopinja J, Sevilla RS, Levitan D, et al. (2017) A Brain Penetrant Mutant IDH1 Inhibitor Provides In Vivo Survival Benefit. Scientific Reports. 7: 13853
O'Neil J, Benita Y, Feldman I, et al. (2016) An unbiased oncology compound screen to identify novel combination strategies. Molecular Cancer Therapeutics
Methot JL, Hoffman DM, Witter DJ, et al. (2014) Delayed and Prolonged Histone Hyperacetylation with a Selective HDAC1/HDAC2 Inhibitor. Acs Medicinal Chemistry Letters. 5: 340-5
Kral AM, Ozerova N, Close J, et al. (2014) Divergent kinetics differentiate the mechanism of action of two HDAC inhibitors. Biochemistry. 53: 725-34
Newbold A, Matthews GM, Bots M, et al. (2013) Molecular and biologic analysis of histone deacetylase inhibitors with diverse specificities. Molecular Cancer Therapeutics. 12: 2709-21
Methot JL, Chenard M, Joshua C, et al. (2010) Abstract 5433: Prolonged histone hyperacetylation with a novel class of HDAC1/2 selective inhibitors Cancer Research. 70: 5433-5433
Heidebrecht RW, Chenard M, Close J, et al. (2009) Exploring the pharmacokinetic properties of phosphorus-containing selective HDAC 1 and 2 inhibitors (SHI-1:2). Bioorganic & Medicinal Chemistry Letters. 19: 2053-8
Kattar SD, Surdi LM, Zabierek A, et al. (2009) Parallel medicinal chemistry approaches to selective HDAC1/HDAC2 inhibitor (SHI-1:2) optimization. Bioorganic & Medicinal Chemistry Letters. 19: 1168-72
Lee AY, Paweletz CP, Pollock RM, et al. (2008) Quantitative analysis of histone deacetylase-1 selective histone modifications by differential mass spectrometry. Journal of Proteome Research. 7: 5177-86
Methot JL, Hamblett CL, Mampreian DM, et al. (2008) SAR profiles of spirocyclic nicotinamide derived selective HDAC1/HDAC2 inhibitors (SHI-1:2). Bioorganic & Medicinal Chemistry Letters. 18: 6104-9
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