Michael A. Parniak
Affiliations: | 1986-2001 | McGill University, Montreal, QC, Canada | |
| 2001-2015 | Microbiology and Molecular Genetics | University of Pittsburgh, Pittsburgh, PA, United States |
Area:
antiretroviral therapeuticsWebsite:
http://www.mmg.pitt.edu/news-events/remembrance-dr-michael-parniakGoogle:
"Michael A. Parniak"Bio:
https://www.researchgate.net/profile/Michael_Parniak/3
DOI: 10.1016/0005-2744(79)90085-8
DOI: 10.1139/o77-090
https://www.researchgate.net/profile/Gary_Murray/publication/23115786_Effect_of_metabolites_on_e_N_hydroxylysine_formation_in_cell_free_extracts_of_Aerobacter_aerogenes_62_1/links/00463529e572fa5685000000.pdf
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Parents
Sign in to add mentor| Thammaiah Viswanatha | grad student | 1973-1978 | University of Waterloo | |
| (N-hydroxy amino acids: biosynthesis and nucleophilicity.) | ||||
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Publications
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| Cilento ME, Wen X, Reeve AB, et al. (2023) HIV-1 Resistance to Islatravir/Tenofovir Combination Therapy in Wild-Type or NRTI-Resistant Strains of Diverse HIV-1 Subtypes. Viruses. 15 |
| Slack RL, Ilina TV, Xi Z, et al. (2019) Conformational Changes in HIV-1 Reverse Transcriptase that Facilitate Its Maturation. Structure (London, England : 1993) |
| Gong T, Patel SK, Parniak MA, et al. (2019) Nanocrystal Formulation Improves Vaginal Delivery of CSIC for HIV Prevention. Aaps Pharmscitech. 20: 286 |
| Tang J, Do HT, Huber AD, et al. (2019) Pharmacophore-based design of novel 3-hydroxypyrimidine-2,4-dione subtypes as inhibitors of HIV reverse transcriptase-associated RNase H: Tolerance of a nonflexible linker. European Journal of Medicinal Chemistry. 166: 390-399 |
| Wang L, Tang J, Huber AD, et al. (2018) 6-Biphenylmethyl-3-hydroxypyrimidine-2,4-diones potently and selectively inhibited HIV reverse transcriptase-associated RNase H. European Journal of Medicinal Chemistry. 156: 680-691 |
| Wang L, Tang J, Huber AD, et al. (2018) 6-Arylthio-3-hydroxypyrimidine-2,4-diones potently inhibited HIV reverse transcriptase-associated RNase H with antiviral activity. European Journal of Medicinal Chemistry. 156: 652-665 |
| Ilina TV, Slack RL, Elder JH, et al. (2018) Effect of tRNA on the Maturation of HIV-Reverse Transcriptase. Journal of Molecular Biology |
| Gong T, Zhang W, Parniak MA, et al. (2017) Preformulation and Vaginal Film Formulation Development of Microbicide Drug Candidate CSIC for HIV prevention. Journal of Pharmaceutical Innovation. 12: 142-154 |
| Kirby KA, Myshakina NA, Christen MT, et al. (2017) A 2-hydroxyisoquinoline-1,3-dione active site RNase H inhibitor binds in multiple modes to HIV-1 reverse transcriptase. Antimicrobial Agents and Chemotherapy |
| Vernekar SKV, Tang J, Wu B, et al. (2017) Double-winged 3-Hydroxypyrimidine-2,4-diones: Potent and Selective Inhibition against HIV-1 RNase H with Significant Antiviral Activity. Journal of Medicinal Chemistry |