Javier Suarez, Ph.D.
Affiliations: | 2009 | Biochemistry | City University of New York, New York, NY, United States |
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"Javier Suarez"Mean distance: (not calculated yet)
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Sign in to add mentor| Richard S. Magliozzo | grad student | 2009 | CUNY | |
| (The catalytic mechanisms of Mycobacterium tuberculosis catalase-peroxidase (KatG) and the origin of antibiotic resistance in the KatG[S315G] mutant.) | ||||
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| Zoi I, Suarez J, Antoniou D, et al. (2016) Modulating enzyme catalysis through mutations designed to alter rapid protein dynamics. Journal of the American Chemical Society |
| Suarez J, Schramm VL. (2015) Isotope-specific and amino acid-specific heavy atom substitutions alter barrier crossing in human purine nucleoside phosphorylase. Proceedings of the National Academy of Sciences of the United States of America. 112: 11247-51 |
| Evans GB, Cameron SA, Luxenburger A, et al. (2015) Tight binding enantiomers of pre-clinical drug candidates. Bioorganic & Medicinal Chemistry. 23: 5326-33 |
| Suarez J, Haapalainen AM, Cahill SM, et al. (2013) Catalytic site conformations in human PNP by 19F-NMR and crystallography. Chemistry & Biology. 20: 212-22 |
| Zhao X, Khajo A, Jarrett S, et al. (2012) Specific function of the Met-Tyr-Trp adduct radical and residues Arg-418 and Asp-137 in the atypical catalase reaction of catalase-peroxidase KatG. The Journal of Biological Chemistry. 287: 37057-65 |
| Martínez A, Suárez J, Shand T, et al. (2011) Interactions of arene-Ru(II)-chloroquine complexes of known antimalarial and antitumor activity with human serum albumin (HSA) and transferrin. Journal of Inorganic Biochemistry. 105: 39-45 |
| Spealman P, Khajo A, Suarez J, et al. (2011) Analysis of structure and function of the Aspergillus nidulans PpoC enzyme F1000research. 2 |
| Zhao X, Suarez J, Khajo A, et al. (2010) A radical on the Met-Tyr-Trp modification required for catalase activity in catalase-peroxidase is established by isotopic labeling and site-directed mutagenesis. Journal of the American Chemical Society. 132: 8268-9 |
| Suarez J, Ranguelova K, Schelvis JP, et al. (2009) Antibiotic resistance in Mycobacterium tuberculosis: peroxidase intermediate bypass causes poor isoniazid activation by the S315G mutant of M. tuberculosis catalase-peroxidase (KatG). The Journal of Biological Chemistry. 284: 16146-55 |
| Suarez J, Ranguelova K, Jarzecki AA, et al. (2009) An oxyferrous heme/protein-based radical intermediate is catalytically competent in the catalase reaction of Mycobacterium tuberculosis catalase-peroxidase (KatG). The Journal of Biological Chemistry. 284: 7017-29 |