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Javier Suarez, Ph.D. - Publications

Affiliations: 
2009 Biochemistry City University of New York, New York, NY, United States 
Area:
Biochemistry
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14 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Zoi I, Suarez J, Antoniou D, Cameron SA, Schramm VL, Schwartz SD. Modulating enzyme catalysis through mutations designed to alter rapid protein dynamics. Journal of the American Chemical Society. PMID 26927977 DOI: 10.1021/Jacs.5B12551  0.438
2015 Suarez J, Schramm VL. Isotope-specific and amino acid-specific heavy atom substitutions alter barrier crossing in human purine nucleoside phosphorylase. Proceedings of the National Academy of Sciences of the United States of America. 112: 11247-51. PMID 26305965 DOI: 10.1073/Pnas.1513956112  0.383
2015 Evans GB, Cameron SA, Luxenburger A, Guan R, Suarez J, Thomas K, Schramm VL, Tyler PC. Tight binding enantiomers of pre-clinical drug candidates. Bioorganic & Medicinal Chemistry. 23: 5326-33. PMID 26260335 DOI: 10.1016/J.Bmc.2015.07.059  0.377
2013 Suarez J, Haapalainen AM, Cahill SM, Ho MC, Yan F, Almo SC, Schramm VL. Catalytic site conformations in human PNP by 19F-NMR and crystallography. Chemistry & Biology. 20: 212-22. PMID 23438750 DOI: 10.1016/J.Chembiol.2013.01.009  0.404
2012 Zhao X, Khajo A, Jarrett S, Suarez J, Levitsky Y, Burger RM, Jarzecki AA, Magliozzo RS. Specific function of the Met-Tyr-Trp adduct radical and residues Arg-418 and Asp-137 in the atypical catalase reaction of catalase-peroxidase KatG. The Journal of Biological Chemistry. 287: 37057-65. PMID 22918833 DOI: 10.1074/Jbc.M112.401208  0.715
2011 Martínez A, Suárez J, Shand T, Magliozzo RS, Sánchez-Delgado RA. Interactions of arene-Ru(II)-chloroquine complexes of known antimalarial and antitumor activity with human serum albumin (HSA) and transferrin. Journal of Inorganic Biochemistry. 105: 39-45. PMID 21113330 DOI: 10.1016/J.Jinorgbio.2010.09.005  0.595
2011 Spealman P, Khajo A, Suarez J, Ovalle R, Magliozzo R. Analysis of structure and function of the Aspergillus nidulans PpoC enzyme F1000research. 2. DOI: 10.7490/F1000Research.1611.1  0.7
2010 Zhao X, Suarez J, Khajo A, Yu S, Metlitsky L, Magliozzo RS. A radical on the Met-Tyr-Trp modification required for catalase activity in catalase-peroxidase is established by isotopic labeling and site-directed mutagenesis. Journal of the American Chemical Society. 132: 8268-9. PMID 20507091 DOI: 10.1021/Ja103311E  0.712
2009 Suarez J, Ranguelova K, Schelvis JP, Magliozzo RS. Antibiotic resistance in Mycobacterium tuberculosis: peroxidase intermediate bypass causes poor isoniazid activation by the S315G mutant of M. tuberculosis catalase-peroxidase (KatG). The Journal of Biological Chemistry. 284: 16146-55. PMID 19363028 DOI: 10.1074/Jbc.M109.005546  0.748
2009 Suarez J, Ranguelova K, Jarzecki AA, Manzerova J, Krymov V, Zhao X, Yu S, Metlitsky L, Gerfen GJ, Magliozzo RS. An oxyferrous heme/protein-based radical intermediate is catalytically competent in the catalase reaction of Mycobacterium tuberculosis catalase-peroxidase (KatG). The Journal of Biological Chemistry. 284: 7017-29. PMID 19139099 DOI: 10.1074/Jbc.M808106200  0.772
2009 Zhao X, Yu S, Ranguelova K, Suarez J, Metlitsky L, Schelvis JP, Magliozzo RS. Role of the oxyferrous heme intermediate and distal side adduct radical in the catalase activity of Mycobacterium tuberculosis KatG revealed by the W107F mutant. The Journal of Biological Chemistry. 284: 7030-7. PMID 19139098 DOI: 10.1074/Jbc.M808107200  0.791
2008 Ranguelova K, Suarez J, Metlitsky L, Yu S, Brejt SZ, Brejt SZ, Zhao L, Schelvis JP, Magliozzo RS. Impact of distal side water and residue 315 on ligand binding to ferric Mycobacterium tuberculosis catalase-peroxidase (KatG). Biochemistry. 47: 12583-92. PMID 18956888 DOI: 10.1021/Bi801511U  0.704
2008 Ranguelova K, Suarez J, Magliozzo RS, Mason RP. Spin trapping investigation of peroxide- and isoniazid-induced radicals in Mycobacterium tuberculosis catalase-peroxidase. Biochemistry. 47: 11377-85. PMID 18831539 DOI: 10.1021/Bi800952B  0.704
2007 Ranguelova K, Girotto S, Gerfen GJ, Yu S, Suarez J, Metlitsky L, Magliozzo RS. Radical sites in Mycobacterium tuberculosis KatG identified using electron paramagnetic resonance spectroscopy, the three-dimensional crystal structure, and electron transfer couplings. The Journal of Biological Chemistry. 282: 6255-64. PMID 17204474 DOI: 10.1074/Jbc.M607309200  0.782
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