Daryl E. Klein, Ph.D.

Affiliations: 
2008 University of Pennsylvania, Philadelphia, PA, United States 
Area:
Medical Biophysics, Molecular Biology, Biochemistry
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Parents

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Mark A. Lemmon grad student 2008 Penn
 (Biochemical and structural studies of a secreted antagonist of the epidermal growth factor receptor.)
Stephen C. Harrison post-doc 2009-2016 Harvard Medical School
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Publications

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Li T, Stayrook SE, Tsutsui Y, et al. (2021) Structural basis for ligand reception by anaplastic lymphoma kinase. Nature. 600: 148-152
Kiyatkin A, van Alderwerelt van Rosenburgh IK, Klein DE, et al. (2020) Kinetics of receptor tyrosine kinase activation define ERK signaling dynamics. Science Signaling. 13
Klein DE. (2017) A ligand divided: antagonist, agonist and analog control. The Biochemical Journal. 474: 3087-3088
Kim AR, Ulirsch JC, Wilmes S, et al. (2017) Functional Selectivity in Cytokine Signaling Revealed Through a Pathogenic EPO Mutation. Cell. 168: 1053-1064.e15
Kim AR, Ulirsch JC, Wilmes S, et al. (2016) Discovery of the First Pathogenic Human EPO Mutation Provides Mechanistic Insight into Cytokine Signaling Blood. 128: 331-331
Jenni S, Goyal Y, von Grotthuss M, et al. (2015) Structural Basis of Neurohormone Perception by the Receptor Tyrosine Kinase Torso. Molecular Cell. 60: 941-52
Chao LH, Klein DE, Schmidt AG, et al. (2015) Correction: Sequential conformational rearrangements in flavivirus membrane fusion. Elife. 4
Chao LH, Klein DE, Schmidt AG, et al. (2014) Sequential conformational rearrangements in flavivirus membrane fusion. Elife. 3: e04389
Chao LH, Klein DE, Schmidt AG, et al. (2014) Author response: Sequential conformational rearrangements in flavivirus membrane fusion Elife
Klein DE, Choi JL, Harrison SC. (2013) Structure of a dengue virus envelope protein late-stage fusion intermediate. Journal of Virology. 87: 2287-93
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