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Leonid Dzantiev, Ph.D.

Affiliations: 
2001 Wayne State University, Detroit, MI, United States 
Area:
Biochemistry, Toxicology
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Parents

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Louis James Romano grad student 2001 Wayne State
 (Enzymatic DNA synthesis and its inhibition by carcinogenic DNA adducts.)

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Collaborators

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Ravi R. Iyer collaborator 2001- Duke University School of Medicine
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Publications

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Pluciennik A, Dzantiev L, Iyer RR, et al. (2010) PCNA function in the activation and strand direction of MutLα endonuclease in mismatch repair. Proceedings of the National Academy of Sciences of the United States of America. 107: 16066-71
Iyer RR, Pohlhaus TJ, Chen S, et al. (2008) The MutSalpha-proliferating cell nuclear antigen interaction in human DNA mismatch repair. The Journal of Biological Chemistry. 283: 13310-9
Kadyrov FA, Dzantiev L, Constantin N, et al. (2006) Endonucleolytic function of MutLalpha in human mismatch repair. Cell. 126: 297-308
Constantin N, Dzantiev L, Kadyrov FA, et al. (2005) Human mismatch repair: reconstitution of a nick-directed bidirectional reaction. The Journal of Biological Chemistry. 280: 39752-61
Dutta S, Li Y, Johnson D, et al. (2004) Crystal structures of 2-acetylaminofluorene and 2-aminofluorene in complex with T7 DNA polymerase reveal mechanisms of mutagenesis. Proceedings of the National Academy of Sciences of the United States of America. 101: 16186-91
Dzantiev L, Constantin N, Genschel J, et al. (2004) A defined human system that supports bidirectional mismatch-provoked excision. Molecular Cell. 15: 31-41
Alekseyev YO, Dzantiev L, Romano LJ. (2001) Effects of benzo[a]pyrene DNA adducts on Escherichia coli DNA polymerase I (Klenow fragment) primer-template interactions: evidence for inhibition of the catalytically active ternary complex formation. Biochemistry. 40: 2282-90
Dzantiev L, Alekseyev YO, Morales JC, et al. (2001) Significance of nucleobase shape complementarity and hydrogen bonding in the formation and stability of the closed polymerase - DNA complex Biochemistry. 40: 3215-3221
Dzantiev L, Romano LJ. (2000) Differential effects of N-acetyl-2-aminofluorene and N-2-aminofluorene adducts on the conformational change in the structure of DNA polymerase I (Klenow fragment). Biochemistry. 39: 5139-45
Dzantiev L, Romano LJ. (2000) A conformational change in E. coli DNA polymerase I (Klenow fragment) is induced in the presence of a dNTP complementary to the template base in the active site. Biochemistry. 39: 356-61
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