Leon van Haandel, Ph.D.

Affiliations: 
2010 Pharmaceutical Chemistry University of Kansas, Lawrence, KS, United States 
Area:
Pharmacy, Biochemistry
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John F. Stobaugh grad student 2010 University of Kansas
 (Bioanalysis of Pteroyl Derivatives in Various Aspects of Human Health.)
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Publications

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Stancil SL, van Haandel L, Abdel-Rahman S, et al. (2018) Development of a UPLC-MS/MS method for quantitation of metronidazole and 2-hydroxy metronidazole in human plasma and its application to a pharmacokinetic study. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 1092: 272-278
van Haandel L, Stobaugh JF. (2013) Folate determination in human health: UPLC-MS/MS is the emerging methodology of choice. Bioanalysis. 5: 3023-31
van Haandel L, Becker ML, Williams TD, et al. (2012) Comprehensive quantitative measurement of folate polyglutamates in human erythrocytes by ion pairing ultra-performance liquid chromatography/tandem mass spectrometry. Rapid Communications in Mass Spectrometry : Rcm. 26: 1617-30
Becker ML, van Haandel L, Gaedigk R, et al. (2012) Red blood cell folate concentrations and polyglutamate distribution in juvenile arthritis: predictors of folate variability. Pharmacogenetics and Genomics. 22: 236-46
van Haandel L, Becker ML, Williams TD, et al. (2011) Measurement of methotrexate polyglutamates in human erythrocytes by ion-pair UPLC-MS/MS. Bioanalysis. 3: 2783-2796
Heemskerk AA, van Haandel L, Woods JM, et al. (2011) LC-MS/MS method for the determination of carbamathione in human plasma. Journal of Pharmaceutical and Biomedical Analysis. 54: 799-806
Becker ML, Gaedigk R, van Haandel L, et al. (2011) The effect of genotype on methotrexate polyglutamate variability in juvenile idiopathic arthritis and association with drug response. Arthritis and Rheumatism. 63: 276-85
van Haandel L, Stobaugh JF. (2010) Bioanalytical method development for a generation 5 polyamidoamine folic acid methotrexate conjugated nanoparticle. Analytical and Bioanalytical Chemistry. 397: 1841-52
Becker ML, van Haandel L, Gaedigk R, et al. (2010) Analysis of intracellular methotrexate polyglutamates in patients with juvenile idiopathic arthritis: effect of route of administration on variability in intracellular methotrexate polyglutamate concentrations. Arthritis and Rheumatism. 62: 1803-12
van Haandel L, Becker ML, Leeder JS, et al. (2009) A novel high-performance liquid chromatography/mass spectrometry method for improved selective and sensitive measurement of methotrexate polyglutamation status in human red blood cells. Rapid Communications in Mass Spectrometry : Rcm. 23: 3693-702
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