Ta-Yuan Chang
Affiliations: | Biochemistry | Dartmouth College, Hanover, NH, United States |
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| Harned TC, Stan RV, Cao Z, et al. (2023) Acute ACAT1/SOAT1 Blockade Increases MAM Cholesterol and Strengthens ER-Mitochondria Connectivity. International Journal of Molecular Sciences. 24 |
| Rogers MA, Chang CCY, Maue RA, et al. (2022) knockout extends the mutant mouse lifespan and ameliorates functional deficiencies in multiple organelles of mutant cells. Proceedings of the National Academy of Sciences of the United States of America. 119: e2201646119 |
| Chang TY, Chang CCY, Harned TC, et al. (2022) Blocking cholesterol storage to treat Alzheimer's disease. Exploration of Neuroprotective Therapy. 1: 173-184 |
| Neumann B, Chao K, Chang CCY, et al. (2020) Nanodisc scaffold peptide (NSP) replaces detergent by reconstituting acyl-CoA:cholesterol acyltransferase 1 into peptidiscs. Archives of Biochemistry and Biophysics. 108518 |
| Guan C, Niu Y, Chen SC, et al. (2020) Structural insights into the inhibition mechanism of human sterol O-acyltransferase 1 by a competitive inhibitor. Nature Communications. 11: 2478 |
| Melton EM, Li H, Benson J, et al. (2019) Myeloid Acat1/Soat1 KO attenuates pro-inflammatory responses in macrophages and protects against atherosclerosis in a model of advanced lesions. The Journal of Biological Chemistry |
| Neumann B, Chang CCY, Chang TY. (2019) Triton X-100 or octyl glucoside inactivates acyl-CoA:cholesterol acyltransferase 1 by dissociating it from a two-fold dimer to a two-fold monomer. Archives of Biochemistry and Biophysics |
| Huang LH, Melton EM, Li H, et al. (2018) Myeloid-specific Acat1 ablation attenuates inflammatory responses in macrophages, improves insulin sensitivity, and suppresses diet-induced obesity. American Journal of Physiology. Endocrinology and Metabolism |
| Wang YJ, Bian Y, Luo J, et al. (2017) Corrigendum: Cholesterol and fatty acids regulate cysteine ubiquitylation of ACAT2 through competitive oxidation. Nature Cell Biology. 19: 1441 |
| Wang YJ, Bian Y, Luo J, et al. (2017) Cholesterol and fatty acids regulate cysteine ubiquitylation of ACAT2 through competitive oxidation. Nature Cell Biology |