Elena Y. Bryleva, Ph.D.
Affiliations: | 2008 | Biochemistry | Dartmouth College, Hanover, NH, United States |
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Cell BiologyGoogle:
"Elena Bryleva"Mean distance: (not calculated yet)
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Sign in to add mentor| Ta-Yuan Chang | grad student | 2008 | Dartmouth | |
| (Genetic inactivation of ACAT1 ameliorates the amyloid pathology and cognitive deficits in a mouse model of Alzheimer's disease.) | ||||
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| Shibuya Y, Niu Z, Bryleva EY, et al. (2015) Acyl-coenzyme A:cholesterol acyltransferase 1 blockage enhances autophagy in the neurons of triple transgenic Alzheimer's disease mouse and reduces human P301L-tau content at the presymptomatic stage. Neurobiology of Aging. 36: 2248-59 |
| Shibuya Y, Chang CC, Huang LH, et al. (2014) Inhibiting ACAT1/SOAT1 in microglia stimulates autophagy-mediated lysosomal proteolysis and increases Aβ1-42 clearance. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 14484-501 |
| Murphy SR, Chang CC, Dogbevia G, et al. (2013) Acat1 knockdown gene therapy decreases amyloid-β in a mouse model of Alzheimer's disease. Molecular Therapy : the Journal of the American Society of Gene Therapy. 21: 1497-506 |
| Rogers MA, Liu J, Kushnir MM, et al. (2012) Cellular pregnenolone esterification by acyl-CoA:cholesterol acyltransferase. The Journal of Biological Chemistry. 287: 17483-92 |
| Bryleva EY, Rogers MA, Chang CC, et al. (2010) ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD. Proceedings of the National Academy of Sciences of the United States of America. 107: 3081-6 |
| Chang TY, Chang CC, Bryleva E, et al. (2010) Neuronal cholesterol esterification by ACAT1 in Alzheimer's disease. Iubmb Life. 62: 261-7 |
| Rogers M, Bryleva E, Chang C, et al. (2010) P3-285: ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in Alzheimer mice Alzheimer's & Dementia. 6: S535-S535 |