Emmanuel S. Akinboye, Ph.D.

Affiliations: 
2012 Chemistry Howard University 
Area:
Biochemistry, Organic Chemistry, Pharmaceutical Chemistry, Oncology
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"Emmanuel Akinboye"
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Oladapo Bakare grad student 2012 Howard University
 (Synthesis and Biological Evaluation of N-2' Derived Emetine Analogs and pH-Activatable Prodrugs as Potential Chemotherapy for Prostate Cancer.)
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Publications

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Akinboye ES, Rosen MD, Bakare O, et al. (2017) Anticancer activities of emetine prodrugs that are proteolytically activated by the prostate specific antigen (PSA) and evaluation of in vivo toxicity of emetine derivatives. Bioorganic & Medicinal Chemistry
Akinboye ES, Brennen WN, Rosen DM, et al. (2016) Iterative design of emetine-based prodrug targeting fibroblast activation protein (FAP) and dipeptidyl peptidase IV DPPIV using a tandem enzymatic activation strategy. The Prostate
Akinboye ES, Brennen WN, Rosen DM, et al. (2016) Iterative design of emetine-based prodrug targeting fibroblast activation protein (FAP) and dipeptidyl peptidase IV DPPIV using a tandem enzymatic activation strategy Prostate
Bamji ZD, Washington KN, Akinboye E, et al. (2015) Apoptotic Effects of Novel Dithiocarbamate Analogs of Emetine in Prostate Cancer Cell Lines. Anticancer Research. 35: 4723-32
Akinboye ES, Bamji ZD, Kwabi-Addo B, et al. (2015) Design, synthesis and cytotoxicity studies of dithiocarbamate ester derivatives of emetine in prostate cancer cell lines. Bioorganic & Medicinal Chemistry. 23: 5839-45
Brandy Y, Brandy N, Akinboye E, et al. (2013) Synthesis and characterization of novel unsymmetrical and symmetrical 3-halo- or 3-methoxy-substituted 2-dibenzoylamino-1,4-naphthoquinone derivatives. Molecules (Basel, Switzerland). 18: 1973-84
Akinboye ES, Rosen MD, Denmeade SR, et al. (2012) Design, synthesis, and evaluation of pH-dependent hydrolyzable emetine analogues as treatment for prostate cancer. Journal of Medicinal Chemistry. 55: 7450-9
Khraiwesh MH, Lee CM, Brandy Y, et al. (2012) Antitrypanosomal activities and cytotoxicity of some novel imido-substituted 1,4-naphthoquinone derivatives. Archives of Pharmacal Research. 35: 27-33
Akinboye ES, Bakare O. (2011) Biological activities of emetine Open Natural Products Journal. 4: 8-15
Akinboye ES, Butcher RJ, Wright DA, et al. (2009) N-(3-Bromo-1,4-dioxo-1,4-dihydro-2-naphth-yl)-4-fluoro-N-(4-fluoro-benzo-yl)benzamide. Acta Crystallographica. Section E, Structure Reports Online. 65: o277
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