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Frederick S. Gimble

Affiliations: 
Biochemistry Purdue University, West Lafayette, IN, United States 
Area:
Biochemistry, General Biophysics
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"Frederick Gimble"
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Rakesh Joshi grad student 2011 Purdue

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Nawimanage R, Yuan Z, Casares M, et al. (2022) Structure-function studies of two yeast homing endonucleases that evolved to cleave identical targets with dissimilar rates and specificities. Journal of Molecular Biology. 167550
Lee KZ, Mechikoff MA, Kikla A, et al. (2021) NgAgo possesses guided DNA nicking activity. Nucleic Acids Research
Katz SS, Gimble FS, Storici F. (2014) To nick or not to nick: comparison of I-SceI single- and double-strand break-induced recombination in yeast and human cells. Plos One. 9: e88840
Joshi R, Gimble FS. (2014) A bacterial one-hybrid system to isolate homing endonuclease variants with altered DNA target specificities. Methods in Molecular Biology (Clifton, N.J.). 1114: 221-36
Joshi R, Ho KK, Tenney K, et al. (2011) Evolution of I-SceI homing endonucleases with increased DNA recognition site specificity. Journal of Molecular Biology. 405: 185-200
Niu Y, Tenney K, Li H, et al. (2008) Engineering variants of the I-SceI homing endonuclease with strand-specific and site-specific DNA-nicking activity. Journal of Molecular Biology. 382: 188-202
Moure CM, Gimble FS, Quiocho FA. (2008) Crystal structures of I-SceI complexed to nicked DNA substrates: snapshots of intermediates along the DNA cleavage reaction pathway. Nucleic Acids Research. 36: 3287-96
Gimble FS. (2007) Engineering homing endonucleases to modify complex genomes Gene Therapy and Regulation. 3: 33-50
Gimble FS. (2006) Broken symmetry in homing endonucleases. Structure (London, England : 1993). 14: 804-6
Posey KL, Koufopanou V, Burt A, et al. (2004) Evolution of divergent DNA recognition specificities in VDE homing endonucleases from two yeast species. Nucleic Acids Research. 32: 3947-56
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