Parents

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Jan Drenth grad student 1971 RUG
 ( The three-dimensional structure of subtilisin Novo)

Children

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Piet Gros grad student 1990 RUG
Andrea Mattevi grad student 1992 RUG (StructuralBiologyTree)
Titia K. Sixma grad student 1992 RUG
Bradley E. Bernstein grad student 1997 University of Washington - Seattle/ NIH (Cell Biology Tree)
Focco van den Akker grad student 1997 University of Washington
Arthur M. Baca grad student 2000 University of Washington (Microtree)
David M. Chudzik grad student 2000 University of Washington (Microtree)
Bianca T. Hovey grad student 2000 University of Washington (Microtree)
Jungwoo Choe grad student 2003 University of Washington (Microtree)
Jason C. Pickens grad student 2003 University of Washington
Paulene M. Quigley grad student 2003 University of Washington (Microtree)
Claire J. O'Neal grad student 2005 University of Washington
Goragot Wisedchaisri grad student 2005 University of Washington
Marissa E. Yanez grad student 2007 University of Washington
Anita Y. Lam grad student 2008 University of Washington
Ximena Barros-Álvarez grad student 2013-2018 University of Washington
Gert Vriend post-doc 1989 RUG (Computational Biology Tree)
Catherine L Lawson post-doc 1987-1990 RUG (StructuralBiologyTree)
Christophe L.M.J. Verlinde post-doc 1989-1992 RUG
Shekhar C. Mande post-doc 1991-1992 RUG
Matthew R. Redinbo post-doc 1999 University of Washington
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Publications

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Devine WG, Díaz González R, Ceballos-Perez G, et al. (2017) From cells, to mice, to target: Characterization of NEU-1053 (SB-443342) and its analogs for treatment of human African trypanosomiasis. Acs Infectious Diseases
Huang W, Zhang Z, Barros-Álvarez X, et al. (2016) Structure-guided design of novel Trypanosoma brucei Methionyl-tRNA synthetase inhibitors. European Journal of Medicinal Chemistry. 124: 1081-1092
Zhang Z, Koh CY, Ranade RM, et al. (2016) 5-Fluoroimidazo[4,5-b]pyridine Is a Privileged Fragment That Conveys Bioavailability to Potent Trypanosomal Methionyl-tRNA Synthetase Inhibitors. Acs Infectious Diseases. 2: 399-404
Ranade RM, Zhang Z, Gillespie JR, et al. (2015) Inhibitors of methionyl-tRNA synthetase have potent activity against Giardia intestinalis trophozoites. Antimicrobial Agents and Chemotherapy. 59: 7128-31
Koh CY, Siddaramaiah LK, Ranade RM, et al. (2015) A binding hotspot in Trypanosoma cruzi histidyl-tRNA synthetase revealed by fragment-based crystallographic cocktail screens. Acta Crystallographica. Section D, Biological Crystallography. 71: 1684-98
Pedró-Rosa L, Buckner FS, Ranade RM, et al. (2015) Identification of potent inhibitors of the Trypanosoma brucei methionyl-tRNA synthetase via high-throughput orthogonal screening. Journal of Biomolecular Screening. 20: 122-30
Koh CY, Kim JE, Wetzel AB, et al. (2014) Structures of Trypanosoma brucei methionyl-tRNA synthetase with urea-based inhibitors provide guidance for drug design against sleeping sickness. Plos Neglected Tropical Diseases. 8: e2775
Zhang Z, Ojo KK, Vidadala R, et al. (2014) Potent and selective inhibitors of CDPK1 from T. gondii and C. parvum based on a 5-aminopyrazole-4-carboxamide scaffold. Acs Medicinal Chemistry Letters. 5: 40-44
Gadwal S, Korotkov KV, Delarosa JR, et al. (2014) Functional and structural characterization of Vibrio cholerae extracellular serine protease B, VesB. The Journal of Biological Chemistry. 289: 8288-98
Koh CY, Nguyen J, Shibata S, et al. (2014) Structure-based drug design against Trypanosoma brucei methionyl-tRNA synthetase Acta Crystallographica Section a Foundations and Advances. 70: C708-C708
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