Parents

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Jan Drenth grad student 1971 RUG
 ( The three-dimensional structure of subtilisin Novo)

Children

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Piet Gros grad student 1990 RUG
Andrea Mattevi grad student 1992 RUG (StructuralBiologyTree)
Titia K. Sixma grad student 1992 RUG
Bradley E. Bernstein grad student 1997 University of Washington - Seattle/ NIH (Cell Biology Tree)
Focco van den Akker grad student 1997 University of Washington
Arthur M. Baca grad student 2000 University of Washington (Microtree)
David M. Chudzik grad student 2000 University of Washington (Microtree)
Bianca T. Hovey grad student 2000 University of Washington (Microtree)
Jungwoo Choe grad student 2003 University of Washington (Microtree)
Jason C. Pickens grad student 2003 University of Washington
Paulene M. Quigley grad student 2003 University of Washington (Microtree)
Claire J. O'Neal grad student 2005 University of Washington
Goragot Wisedchaisri grad student 2005 University of Washington
Marissa E. Yanez grad student 2007 University of Washington
Anita Y. Lam grad student 2008 University of Washington
Gert Vriend post-doc 1989 RUG (Computational Biology Tree)
Catherine L Lawson post-doc 1987-1990 RUG (StructuralBiologyTree)
Christophe L.M.J. Verlinde post-doc 1989-1992 RUG
Matthew R. Redinbo post-doc 1999 University of Washington
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Publications

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Buckner FS, Ranade RM, Gillespie JR, et al. (2019) Optimization of methionyl tRNA-synthetase inhibitors for treatment of infection. Antimicrobial Agents and Chemotherapy
Barros-Álvarez X, Turley S, Ranade RM, et al. (2018) The crystal structure of the drug target Mycobacterium tuberculosis methionyl-tRNA synthetase in complex with a catalytic intermediate. Acta Crystallographica. Section F, Structural Biology Communications. 74: 245-254
Vu H, Pedro L, Mak T, et al. (2018) Fragment-Based Screening of a Natural Product Library against 62 Potential Malaria Drug Targets Employing Native Mass Spectrometry. Acs Infectious Diseases
Faghih O, Zhang Z, Ranade RM, et al. (2017) Development of methionyl-tRNA synthetase inhibitors as antibiotics for Gram-positive bacterial infections. Antimicrobial Agents and Chemotherapy
Huang W, Zhang Z, Ranade RM, et al. (2017) Optimization of a binding fragment targeting the "enlarged methionine pocket" leads to potent Trypanosoma brucei methionyl-tRNA synthetase inhibitors. Bioorganic & Medicinal Chemistry Letters
Barros-Álvarez X, Kerchner KM, Koh CY, et al. (2017) Leishmania donovani tyrosyl-tRNA synthetase structure in complex with a tyrosyl adenylate analog and comparisons with human and protozoan counterparts. Biochimie
Devine WG, Díaz González R, Ceballos-Perez G, et al. (2017) From cells, to mice, to target: Characterization of NEU-1053 (SB-443342) and its analogs for treatment of human African trypanosomiasis. Acs Infectious Diseases
Huang W, Zhang Z, Barros-Álvarez X, et al. (2016) Structure-guided design of novel Trypanosoma brucei Methionyl-tRNA synthetase inhibitors. European Journal of Medicinal Chemistry. 124: 1081-1092
Zhang Z, Koh CY, Ranade RM, et al. (2016) 5-Fluoroimidazo[4,5-b]pyridine Is a Privileged Fragment That Conveys Bioavailability to Potent Trypanosomal Methionyl-tRNA Synthetase Inhibitors. Acs Infectious Diseases. 2: 399-404
Vidadala RS, Rivas KL, Ojo KK, et al. (2016) Development of an Orally Available and Central Nervous System (CNS) Penetrant Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitor with Minimal Human Ether-a-go-go-Related Gene (hERG) Activity for the Treatment of Toxoplasmosis. Journal of Medicinal Chemistry. 59: 6531-46
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