Angela K. Goodenough, Ph.D.

2005 Vanderbilt University, Nashville, TN 
Organic Chemistry, Toxicology
"Angela Goodenough"
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Carmelo Rizzo grad student 2005 Vanderbilt
 (DNA adducts of bis-electrophiles.)
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Huang A, Jayaraman L, Fura A, et al. (2016) Discovery of the Selective CYP17A1 Lyase Inhibitor BMS-351 for the Treatment of Prostate Cancer. Acs Medicinal Chemistry Letters. 7: 40-5
Bessette EE, Spivack SD, Goodenough AK, et al. (2010) Identification of carcinogen DNA adducts in human saliva by linear quadrupole ion trap/multistage tandem mass spectrometry. Chemical Research in Toxicology. 23: 1234-44
Dimitri A, Goodenough AK, Guengerich FP, et al. (2008) Transcription processing at 1,N2-ethenoguanine by human RNA polymerase II and bacteriophage T7 RNA polymerase. Journal of Molecular Biology. 375: 353-66
Shanmugam G, Goodenough AK, Kozekov ID, et al. (2007) Structure of the 1,N2-etheno-2'-deoxyguanosine adduct in duplex DNA at pH 8.6. Chemical Research in Toxicology. 20: 1601-11
Choi JY, Zang H, Angel KC, et al. (2006) Translesion synthesis across 1,N2-ethenoguanine by human DNA polymerases. Chemical Research in Toxicology. 19: 879-86
Goodenough AK, Kozekov ID, Zang H, et al. (2005) Site specific synthesis and polymerase bypass of oligonucleotides containing a 6-hydroxy-3,5,6,7-tetrahydro-9H-imidazo[1,2-a]purin-9-one base, an intermediate in the formation of 1,N2-etheno-2'-deoxyguanosine. Chemical Research in Toxicology. 18: 1701-14
Zang H, Goodenough AK, Choi JY, et al. (2005) DNA adduct bypass polymerization by Sulfolobus solfataricus DNA polymerase Dpo4: analysis and crystal structures of multiple base pair substitution and frameshift products with the adduct 1,N2-ethenoguanine. The Journal of Biological Chemistry. 280: 29750-64
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