Melissa Howard, Ph.D.

Affiliations: 
2011 Pharmaceutical Sciences University of Kentucky, Lexington, KY 
Area:
Pharmacy, Chemical Engineering, Physical Chemistry
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Michael Jay grad student 2011 University of Kentucky
 (Evaluation of the physicochemical properties and stability of solid lipid nanoparticles designed for the delivery of dexamethasone to tumors.)
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Publications

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Howard MD, Hood ED, Greineder CF, et al. (2014) Targeting to endothelial cells augments the protective effect of novel dual bioactive antioxidant/anti-inflammatory nanoparticles. Molecular Pharmaceutics. 11: 2262-70
Howard M, Zern BJ, Anselmo AC, et al. (2014) Vascular targeting of nanocarriers: perplexing aspects of the seemingly straightforward paradigm. Acs Nano. 8: 4100-32
Howard MD, Greineder CF, Hood ED, et al. (2014) Endothelial targeting of liposomes encapsulating SOD/catalase mimetic EUK-134 alleviates acute pulmonary inflammation. Journal of Controlled Release : Official Journal of the Controlled Release Society. 177: 34-41
Howard MD, Hood ED, Zern B, et al. (2014) Nanocarriers for vascular delivery of anti-inflammatory agents. Annual Review of Pharmacology and Toxicology. 54: 205-26
Greineder CF, Howard MD, Carnemolla R, et al. (2013) Advanced drug delivery systems for antithrombotic agents. Blood. 122: 1565-75
Howard MD, Lu X, Rinehart JJ, et al. (2012) Carboxylesterase-triggered hydrolysis of nanoparticle PEGylating agents. Langmuir : the Acs Journal of Surfaces and Colloids. 28: 12030-7
Howard MD, Lu X, Jay M, et al. (2012) Optimization of the lyophilization process for long-term stability of solid-lipid nanoparticles. Drug Development and Industrial Pharmacy. 38: 1270-9
Howard MD, Ponta A, Eckman A, et al. (2011) Polymer micelles with hydrazone-ester dual linkers for tunable release of dexamethasone. Pharmaceutical Research. 28: 2435-46
Howard MD, Lu X, Rinehart JJ, et al. (2011) Physicochemical characterization of nanotemplate engineered solid lipid nanoparticles. Langmuir : the Acs Journal of Surfaces and Colloids. 27: 1964-71
Kim JK, Howard MD, Dziubla TD, et al. (2011) Uniformity of drug payload and its effect on stability of solid lipid nanoparticles containing an ester prodrug. Acs Nano. 5: 209-16
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