☰ Chemistry Tree

Paul R. Gardner, Ph.D.

Affiliations:

Miami Valley Biotech

Area:

free radicals/ nitric oxide dioxygenase/ hemoglobin evolution

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"Paul R. Gardner"

Mean distance: 8.81

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Parents

David H. Ives	research assistant	1982-1984	Ohio State
(barley nucleoside phosphotransferase affinity isolation and mechanism)
Irwin Fridovich	grad student	1984-1990	Duke
(sensitive targets of superoxide (e.g., aconitase) and superoxide dismutase regulation in E. coli)
Joe Milton McCord	post-doc	1992-1993	CU Boulder
(oxidative stress in mitochondria and neurodegeneration (e.g., Down's syndrome))

Children

Collaborators

Anne M. Gardner	collaborator	1998-2006	Cincinnati Children's Hospital
John S. Olson	collaborator	1999-2006	Rice University

BETA: Related publications

Publications

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Gardner AM, Gardner PR. (2023) Dioxygen and glucose force motion of the electron-transfer switch in the iron(III) flavohemoglobin-type nitric oxide dioxygenase. Journal of Inorganic Biochemistry. 245: 112257
Gardner PR. (2022) Ordered Motions in the Nitric-Oxide Dioxygenase Mechanism of Flavohemoglobin and Assorted Globins with Tightly Coupled Reductases. Advances in Experimental Medicine and Biology
Gardner AM, Gardner PR. (2021) Correction: Allostery in the nitric oxide dioxygenase mechanism of flavohemoglobin. The Journal of Biological Chemistry. 296: 100542
Gardner AM, Gardner PR. (2020) Allostery in the nitric-oxide dioxygenase mechanism of flavohemoglobin. The Journal of Biological Chemistry
Gardner PR, Gardner DP, Gardner AP. (2015) Globins Scavenge Sulfur Trioxide Anion Radical. The Journal of Biological Chemistry. 290: 27204-14
Gardner AM, Cook MR, Gardner PR. (2010) Nitric-oxide dioxygenase function of human cytoglobin with cellular reductants and in rat hepatocytes. The Journal of Biological Chemistry. 285: 23850-7
Gardner PR, Gardner AM. (2008) Nitric oxide dioxygenase. an ancient enzymic function of hemoglobin The Smallest Biomolecules: Diatomics and Their Interactions With Heme Proteins. 290-326
Gardner PR, Gardner AM, Brashear WT, et al. (2006) Hemoglobins dioxygenate nitric oxide with high fidelity. Journal of Inorganic Biochemistry. 100: 542-50
Helmick RA, Fletcher AE, Gardner AM, et al. (2005) Imidazole antibiotics inhibit the nitric oxide dioxygenase function of microbial flavohemoglobin. Antimicrobial Agents and Chemotherapy. 49: 1837-43
Gardner PR. (2005) Nitric oxide dioxygenase function and mechanism of flavohemoglobin, hemoglobin, myoglobin and their associated reductases. Journal of Inorganic Biochemistry. 99: 247-66

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