Sabyasachi Bhattacharya, Ph.D.

Affiliations: 
2008 Temple University, Philadelphia, PA, United States 
Area:
Molecular Biology, Genetics
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"Sabyasachi Bhattacharya"

Parents

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Dale Haines grad student 2008 Temple University
 (Structural and functional studies of ubiquitin ligase Rsp5p and its substrates Spt23p and Mga2p.)
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Publications

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Ortiz A, Gui J, Zahedi F, et al. (2019) An Interferon-Driven Oxysterol-Based Defense against Tumor-Derived Extracellular Vesicles. Cancer Cell. 35: 33-45.e6
Zhao B, Bhattacharya S, Yu Q, et al. (2017) Expression of the IFNAR1 chain of type 1 interferon receptor in benign cells protects against progression of acute leukemia. Leukemia & Lymphoma. 1-7
Katlinski KV, Gui J, Katlinskaya YV, et al. (2017) Inactivation of Interferon Receptor Promotes the Establishment of Immune Privileged Tumor Microenvironment. Cancer Cell. 31: 194-207
Bhattacharya S, Katlinski KV, Reichert M, et al. (2014) Triggering ubiquitination of IFNAR1 protects tissues from inflammatory injury. Embo Molecular Medicine. 6: 384-97
Zheng H, Gupta V, Patterson-Fortin J, et al. (2013) A BRISC-SHMT complex deubiquitinates IFNAR1 and regulates interferon responses. Cell Reports. 5: 180-93
Katlinski KV, Bhattacharya S, Fuchs SY. (2013) 139: Tumors selectively eliminate cancer cells incapable of downregulating type I interferon receptor Cytokine. 63: 275
Carbone CJ, Zheng H, Bhattacharya S, et al. (2012) Protein tyrosine phosphatase 1B is a key regulator of IFNAR1 endocytosis and a target for antiviral therapies. Proceedings of the National Academy of Sciences of the United States of America. 109: 19226-31
Bhattacharya S, Zheng H, Tzimas C, et al. (2011) Bcr-abl signals to desensitize chronic myeloid leukemia cells to IFNα via accelerating the degradation of its receptor. Blood. 118: 4179-87
Bhattacharya S, Qian J, Tzimas C, et al. (2011) Role of p38 protein kinase in the ligand-independent ubiquitination and down-regulation of the IFNAR1 chain of type I interferon receptor. The Journal of Biological Chemistry. 286: 22069-76
Bhattacharya S, HuangFu WC, Liu J, et al. (2010) Inducible priming phosphorylation promotes ligand-independent degradation of the IFNAR1 chain of type I interferon receptor. The Journal of Biological Chemistry. 285: 2318-25
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