Geoff P. Horsman, Ph.D.

2011- Chemistry & Biochemistry Wilfrid Laurier University (Canada) 
Enzymology, Natural products biosynthesis, biocatalysis
"Geoff Horsman"
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Hao T, Xie Z, Wang M, et al. (2019) An anaerobic bacterium host system for heterologous expression of natural product biosynthetic gene clusters. Nature Communications. 10: 3665
Liu L, Hao T, Xie Z, et al. (2016) Genome mining unveils widespread natural product biosynthetic capacity in human oral microbe Streptococcus mutans. Scientific Reports. 6: 37479
Yan Y, Ma YT, Yang J, et al. (2016) Tropolone Ring Construction in the Biosynthesis of Rubrolone B, a Cationic Tropolone Alkaloid from Endophytic Streptomyces. Organic Letters
Horsman GP, Lechner A, Ohnishi Y, et al. (2013) Predictive model for epoxide hydrolase-generated stereochemistry in the biosynthesis of nine-membered enediyne antitumor antibiotics. Biochemistry. 52: 5217-24
Lohman JR, Huang SX, Horsman GP, et al. (2013) Cloning and sequencing of the kedarcidin biosynthetic gene cluster from Streptoalloteichus sp. ATCC 53650 revealing new insights into biosynthesis of the enediyne family of antitumor antibiotics. Molecular Biosystems. 9: 478-91
Ruzzini AC, Horsman GP, Eltis LD. (2012) The catalytic serine of meta-cleavage product hydrolases is activated differently for C-O bond cleavage than for C-C bond cleavage. Biochemistry. 51: 5831-40
Lin S, Huang T, Horsman GP, et al. (2012) Specificity of the ester bond forming condensation enzyme SgcC5 in C-1027 biosynthesis. Organic Letters. 14: 2300-3
Ruzzini AC, Ghosh S, Horsman GP, et al. (2012) Identification of an acyl-enzyme intermediate in a meta-cleavage product hydrolase reveals the versatility of the catalytic triad. Journal of the American Chemical Society. 134: 4615-24
Chen Y, Yin M, Horsman GP, et al. (2011) Improvement of the enediyne antitumor antibiotic C-1027 production by manipulating its biosynthetic pathway regulation in Streptomyces globisporus. Journal of Natural Products. 74: 420-4
Ling J, Horsman GP, Huang SX, et al. (2010) Enediyne antitumor antibiotic maduropeptin biosynthesis featuring a C-methyltransferase that acts on a CoA-tethered aromatic substrate. Journal of the American Chemical Society. 132: 12534-6
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