☰ Chemistry Tree

Lewis E. Kay

Affiliations:

Biochemistry

University of Toronto, Toronto, ON, Canada

Area:

Development and Application of NMR Methods for The Study of Protein Structure and Dynamics

Website:

http://biochemistry.utoronto.ca/person/lewis-e-kay/

Google:

Bio:

http://proquest.umi.com/pqdlink?did=747046351&Fmt=7&clientId =79356&RQT=309&VName=PQD

Mean distance: 9.15

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Parents

Brian D. Sykes	research assistant	1983	University of Alberta
(BSc)
James H. Prestegard	grad student	1988	Yale
(A quantitative study of structural and motional properties of macromolecules using NMR)
Ad Bax	post-doc	1988-1992	NIH

Children

Natalie K. Goto	grad student	2001	University of Toronto
Anthony K. Mittermaier	grad student	2004	University of Toronto
Rui Huang	post-doc		University of Toronto
Frans A.A. Mulder	post-doc		University of Toronto
Michael K. Rosen	post-doc		University of Toronto
Kevin H. Gardner	post-doc	1995-1998	University of Toronto
Nikolai R. Skrynnikov	post-doc	1999-2002	University of Toronto
Michael Parker Latham	post-doc	2008-2014	University of Toronto

Collaborators

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Publications

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Ahmed R, Liang M, Hudson RP, et al. (2024) Atomic resolution map of the solvent interactions driving SOD1 unfolding in CAPRIN1 condensates. Proceedings of the National Academy of Sciences of the United States of America. 121: e2408554121
Rangadurai AK, Ruetz L, Ahmed R, et al. (2024) Phase Separation Modulates the Thermodynamics and Kinetics of RNA Hybridization. Journal of the American Chemical Society
Harkness RW, Zhao H, Toyama Y, et al. (2024) Exploring Host-Guest Interactions within a 600 kDa DegP Protease Cage Complex Using Hydrodynamics Measurements and Methyl-TROSY NMR. Journal of the American Chemical Society. 146: 8242-8259
Nosella ML, Kim TH, Huang SK, et al. (2024) Poly(ADP-ribosyl)ation enhances nucleosome dynamics and organizes DNA damage repair components within biomolecular condensates. Molecular Cell
Rennella E, Sahtoe DD, Baker D, et al. (2023) Exploiting conformational dynamics to modulate the function of designed proteins. Proceedings of the National Academy of Sciences of the United States of America. 120: e2303149120
Toyama Y, Rangadurai AK, Forman-Kay JD, et al. (2022) Surface electrostatics dictate RNA-binding protein CAPRIN1 condensate concentration and hydrodynamic properties. The Journal of Biological Chemistry. 102776
Toyama Y, Rangadurai AK, Forman-Kay JD, et al. (2022) Mapping the per-residue surface electrostatic potential of CAPRIN1 along its phase-separation trajectory. Proceedings of the National Academy of Sciences of the United States of America. 119: e2210492119
Toyama Y, Rangadurai AK, Kay LE. (2022) Measurement of H transverse relaxation rates in proteins: application to solvent PREs. Journal of Biomolecular Nmr
Tiwari VP, Toyama Y, De D, et al. (2021) The A39G FF domain folds on a volcano-shaped free energy surface via separate pathways. Proceedings of the National Academy of Sciences of the United States of America. 118
Kim TH, Payliss BJ, Nosella ML, et al. (2021) Interaction hot spots for phase separation revealed by NMR studies of a CAPRIN1 condensed phase. Proceedings of the National Academy of Sciences of the United States of America. 118

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