David B. Williams

Affiliations: 
University of Toronto University of Toronto, Toronto, ON, Canada 
Area:
Protein chaperones in the ER, MHC processing, calnexin
Website:
http://biochem17.med.utoronto.ca/~david_williams/lab/Home.html
Google:
"David Williams"
Bio:

I was born and raised in Winnipeg and, from an
early age, had an interest in chemistry. In fact I
was the only one of my elementary school friends
to own and actually use (for what purposes I can’t
quite recall now) a chemistry set. Those were the
days when it was considered character-building to
leave 10-year olds alone with a collection of toxic
chemicals. Somehow I survived to adulthood and
my undergrad training was an indecisive mix of
engineering, chemical engineering and ultimately
chemistry at the Universities of Saskatchewan and
Manitoba.

Mean distance: 10.11
 
BETA: Related publications

Publications

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Rapp CL, Li J, Badior KE, et al. (2018) Role of N-glycosylation in the expression of human SLC26A2 and A3 anion transport membrane glycoproteins. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire
Lum R, Ahmad S, Hong SJ, et al. (2016) Contributions of the lectin and polypeptide-binding sites of calreticulin to its chaperone functions in vitro and in cells. The Journal of Biological Chemistry
Stocki P, Sawicki M, Mays CE, et al. (2016) Inhibition of the FKBP family of peptidyl prolyl isomerases induces abortive translocation and degradation of the cellular prion protein. Molecular Biology of the Cell
Chapman DC, Stocki P, Williams DB. (2015) Cyclophilin C Participates in the US2-Mediated Degradation of Major Histocompatibility Complex Class I Molecules. Plos One. 10: e0145458
Gold L, Williams D, Groenendyk J, et al. (2015) Unfolding the complexities of ER chaperones in health and disease: report on the 11th international calreticulin workshop. Cell Stress & Chaperones. 20: 875-83
Stocki P, Chapman DC, Beach LA, et al. (2014) Depletion of cyclophilins B and C leads to dysregulation of endoplasmic reticulum redox homeostasis. The Journal of Biological Chemistry. 289: 23086-96
Rutkevich LA, Williams DB. (2012) Vitamin K epoxide reductase contributes to protein disulfide formation and redox homeostasis within the endoplasmic reticulum. Molecular Biology of the Cell. 23: 2017-27
Rutkevich LA, Williams DB. (2011) Participation of lectin chaperones and thiol oxidoreductases in protein folding within the endoplasmic reticulum. Current Opinion in Cell Biology. 23: 157-66
Rutkevich LA, Cohen-Doyle MF, Brockmeier U, et al. (2010) Functional relationship between protein disulfide isomerase family members during the oxidative folding of human secretory proteins. Molecular Biology of the Cell. 21: 3093-105
Chapman DC, Williams DB. (2010) ER quality control in the biogenesis of MHC class I molecules. Seminars in Cell & Developmental Biology. 21: 512-9
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