Philip F. Hughes, Ph.D.
Affiliations: | Pharmacology & Cancer Biology | Duke University, Durham, NC |
Area:
Drug DiscoveryWebsite:
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"Philip Hughes"Mean distance: 8.71 | S | N | B | C | P |
Parents
Sign in to add mentor| Slayton A. Evans | research assistant | 1975-1976 | UNC Chapel Hill | |
| (Undergraduate research) | ||||
| Jon C. Clardy | grad student | 1979-1983 | Cornell | |
| Timothy Arthur James Haystead | research scientist | Duke | ||
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Publications
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| Freeze R, Hughes P, Haystead T, et al. (2024) Transforming Growth Factor-β-Activated Kinase 1 (TAK1) Alleviates Inflammatory Joint Pain in Osteoarthritis and Gouty Arthritis Preclinical Models. Journal of Pain Research. 17: 2287-2298 |
| Damhofer H, Tatar T, Southgate B, et al. (2024) TAK1 inhibition leads to RIPK1-dependent apoptosis in immune-activated cancers. Cell Death & Disease. 15: 273 |
| Mansfield CR, Quan B, Chirgwin ME, et al. (2024) Selective targeting of Plasmodium falciparum Hsp90 disrupts the 26S proteasome. Cell Chemical Biology |
| Haystead T, Lee E, Cho K, et al. (2023) Investigation of SARS-CoV-2 individual proteins reveals the in vitro and in vivo immunogenicity of membrane protein. Scientific Reports. 13: 22873 |
| Freeze R, Yang KW, Haystead T, et al. (2023) Delineation of the distinct inflammatory signaling roles of TAK1 and JAK1/3 in the CIA model of rheumatoid arthritis. Pharmacology Research & Perspectives. 11: e01124 |
| Bale S, Verma P, Yalavarthi B, et al. (2023) Pharmacological inhibition of TAK1 prevents and induces regression of experimental organ fibrosis. Jci Insight |
| Kaneko K, Nagata H, Yang XY, et al. (2022) A Non-Invasive Deep Photoablation Technique to Inhibit DCIS Progression and Induce Antitumor Immunity. Cancers. 14 |
| Scarneo S, Hughes P, Freeze R, et al. (2022) Development and Efficacy of an Orally Bioavailable Selective TAK1 Inhibitor for the Treatment of Inflammatory Arthritis. Acs Chemical Biology |
| Wang Y, Scarneo SA, Kim SH, et al. (2021) Expression of ectopic heat shock protein 90 in male and female primary afferent nociceptors regulates inflammatory pain. Pain |
| Goswami R, Russell VS, Tu JJ, et al. (2021) Oral Hsp90 inhibitor SNX-5422 attenuates SARS-CoV-2 replication and dampens inflammation in airway cells. Iscience. 103412 |