Philip F. Hughes, Ph.D.

Pharmacology & Cancer Biology Duke University, Durham, NC 
Drug Discovery
"Philip Hughes"
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Slayton A. Evans research assistant 1975-1976 UNC Chapel Hill
 (Undergraduate research)
Jon C. Clardy grad student 1979-1983 Cornell
Timothy Arthur James Haystead research scientist Duke
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Mansfield CR, Quan B, Chirgwin ME, et al. (2024) Selective targeting of Plasmodium falciparum Hsp90 disrupts the 26S proteasome. Cell Chemical Biology
Haystead T, Lee E, Cho K, et al. (2023) Investigation of SARS-CoV-2 individual proteins reveals the in vitro and in vivo immunogenicity of membrane protein. Scientific Reports. 13: 22873
Freeze R, Yang KW, Haystead T, et al. (2023) Delineation of the distinct inflammatory signaling roles of TAK1 and JAK1/3 in the CIA model of rheumatoid arthritis. Pharmacology Research & Perspectives. 11: e01124
Bale S, Verma P, Yalavarthi B, et al. (2023) Pharmacological inhibition of TAK1 prevents and induces regression of experimental organ fibrosis. Jci Insight
Kaneko K, Nagata H, Yang XY, et al. (2022) A Non-Invasive Deep Photoablation Technique to Inhibit DCIS Progression and Induce Antitumor Immunity. Cancers. 14
Scarneo S, Hughes P, Freeze R, et al. (2022) Development and Efficacy of an Orally Bioavailable Selective TAK1 Inhibitor for the Treatment of Inflammatory Arthritis. Acs Chemical Biology
Wang Y, Scarneo SA, Kim SH, et al. (2021) Expression of ectopic heat shock protein 90 in male and female primary afferent nociceptors regulates inflammatory pain. Pain
Goswami R, Russell VS, Tu JJ, et al. (2021) Oral Hsp90 inhibitor SNX-5422 attenuates SARS-CoV-2 replication and dampens inflammation in airway cells. Iscience. 103412
Osada T, Crosby EJ, Kaneko K, et al. (2021) HSP90-specific nIR probe identifies aggressive prostate cancers: translation from preclinical models to a human phase I study. Molecular Cancer Therapeutics
Wang R, Alvarez DA, Crouch BT, et al. (2021) Understanding the sources of errors in Hsp90 molecular imaging for rapid-on-site breast cancer diagnosis. Biomedical Optics Express. 12: 2299-2311
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