Rikkert K. Wierenga

Biochemistry University of Oulu, Oulu, Finland 
Structural Enzymology
"Rikkert K. Wierenga"


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Jan Drenth grad student 1978 RUG
 (Crystal structure of p-hydroxybenzoate hydroxylase)
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Onwukwe GU, Koski MK, Pihko P, et al. (2015) Structures of yeast peroxisomal Δ(3),Δ(2)-enoyl-CoA isomerase complexed with acyl-CoA substrate analogues: the importance of hydrogen-bond networks for the reactivity of the catalytic base and the oxyanion hole. Acta Crystallographica. Section D, Biological Crystallography. 71: 2178-91
Daniel E, Onwukwe GU, Wierenga RK, et al. (2015) ATGme: Open-source web application for rare codon identification and custom DNA sequence optimization. Bmc Bioinformatics. 16: 303
Krause M, Neubauer P, Wierenga RK. (2015) Structure-based directed evolution of a monomeric triosephosphate isomerase: toward a pentose sugar isomerase. Protein Engineering, Design & Selection : Peds. 28: 187-97
Onwukwe GU, Kursula P, Koski MK, et al. (2015) Human Δ³,Δ²-enoyl-CoA isomerase, type 2: a structural enzymology study on the catalytic role of its ACBP domain and helix-10. The Febs Journal. 282: 746-68
Kiema TR, Harijan RK, Strozyk M, et al. (2014) The crystal structure of human mitochondrial 3-ketoacyl-CoA thiolase (T1): insight into the reaction mechanism of its thiolase and thioesterase activities. Acta Crystallographica. Section D, Biological Crystallography. 70: 3212-25
Meriläinen G, Wierenga RK. (2014) Crystallization and preliminary X-ray diffraction studies of the C-terminal domain of Chlamydia trachomatis CdsD. Acta Crystallographica. Section F, Structural Biology Communications. 70: 1431-3
Fukao T, Akiba K, Goto M, et al. (2014) The first case in Asia of 2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency (HSD10 disease) with atypical presentation. Journal of Human Genetics. 59: 609-14
Venkatesan R, Sah-Teli SK, Awoniyi LO, et al. (2014) Insights into mitochondrial fatty acid synthesis from the structure of heterotetrameric 3-ketoacyl-ACP reductase/3R-hydroxyacyl-CoA dehydrogenase. Nature Communications. 5: 4805
Anbazhagan P, Harijan RK, Kiema TR, et al. (2014) Phylogenetic relationships and classification of thiolases and thiolase-like proteins of Mycobacterium tuberculosis and Mycobacterium smegmatis. Tuberculosis (Edinburgh, Scotland). 94: 405-12
Peterhoff D, Beer B, Rajendran C, et al. (2014) A comprehensive analysis of the geranylgeranylglyceryl phosphate synthase enzyme family identifies novel members and reveals mechanisms of substrate specificity and quaternary structure organization. Molecular Microbiology. 92: 885-99
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