Rikkert K. Wierenga

Biochemistry University of Oulu, Oulu, Finland 
Structural Enzymology
"Rikkert K. Wierenga"


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Jan Drenth grad student 1978 RUG
 (Crystal structure of p-hydroxybenzoate hydroxylase)
Michael G. Rossmann post-doc 1978-1980 Purdue
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Sridhar S, Schmitz W, Hiltunen JK, et al. (2020) Crystallographic binding studies of rat peroxisomal multifunctional enzyme type 1 with 3-ketodecanoyl-CoA: capturing active and inactive states of its hydratase and dehydrogenase catalytic sites. Acta Crystallographica. Section D, Structural Biology. 76: 1256-1269
Abdelkreem E, Harijan RK, Yamaguchi S, et al. (2019) Mutation update on ACAT1 variants associated with mitochondrial acetoacetyl-CoA thiolase (T2) deficiency. Human Mutation
Millerioux Y, Mazet M, Bouyssou G, et al. (2018) De novo biosynthesis of sterols and fatty acids in the Trypanosoma brucei procyclic form: Carbon source preferences and metabolic flux redistributions. Plos Pathogens. 14: e1007116
Kasaragod P, Midekessa GB, Sridhar S, et al. (2017) Structural enzymology comparisons of multifunctional enzyme, type-1 (MFE1): the flexibility of its dehydrogenase part. Febs Open Bio. 7: 1830-1842
Harijan RK, Kiema TR, Syed SM, et al. (2017) Crystallographic substrate binding studies of Leishmania mexicana SCP2-thiolase (type-2): unique features of oxyanion hole-1. Protein Engineering, Design & Selection : Peds. 30: 225-233
Krause M, Kiema TR, Neubauer P, et al. (2016) Crystal structures of two monomeric triosephosphate isomerase variants identified via a directed-evolution protocol selecting for L-arabinose isomerase activity. Acta Crystallographica. Section F, Structural Biology Communications. 72: 490-9
Richard JP, Amyes TL, Malabanan MM, et al. (2016) Structure-Function Studies on Hydrophobic Residues that Clamp a Basic Glutamate Side-Chain During Catalysis by Triosephosphate Isomerase. Biochemistry
Harijan RK, Mazet M, Kiema TR, et al. (2016) The SCP2-thiolase-like protein (SLP) of Trypanosoma brucei is an enzyme involved in lipid metabolism. Proteins
Meriläinen G, Koski MK, Wierenga RK. (2016) The extended structure of the periplasmic region of CdsD, a structural protein of the type III secretion system of Chlamydia trachomatis Protein Science. 25: 987-998
Janardan N, Harijan RK, Kiema TR, et al. (2015) Structural characterization of a mitochondrial 3-ketoacyl-CoA (T1)-like thiolase from Mycobacterium smegmatis. Acta Crystallographica. Section D, Biological Crystallography. 71: 2479-93
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