Christian Speck
Affiliations: | Cold Spring Harbor Laboratory, Cold Spring Harbor, NY | ||
| Imperial College, London, London, England, United Kingdom |
Website:
http://www.imperial.ac.uk/people/chris.speckGoogle:
"Christian Speck"Mean distance: (not calculated yet)
Parents
Sign in to add mentor| Walter Messer | grad student | 1997-2000 | Max-Planck Institute for Molecular Genetics |
| Bruce W. Stillman | post-doc | CSHL |
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Publications
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| Wells JN, Edwardes LV, Leber V, et al. (2025) Reconstitution of human DNA licensing and the structural and functional analysis of key intermediates. Nature Communications. 16: 478 |
| Faull SV, Barbon M, Mossler A, et al. (2025) MCM2-7 ring closure involves the Mcm5 C-terminus and triggers Mcm4 ATP hydrolysis. Nature Communications. 16: 14 |
| Reuter LM, Khadayate SP, Mossler A, et al. (2024) MCM2-7 loading-dependent ORC release ensures genome-wide origin licensing. Nature Communications. 15: 7306 |
| Saleh A, Noguchi Y, Aramayo R, et al. (2022) The structural basis of Cdc7-Dbf4 kinase dependent targeting and phosphorylation of the MCM2-7 double hexamer. Nature Communications. 13: 2915 |
| Feng X, Noguchi Y, Barbon M, et al. (2021) The structure of ORC-Cdc6 on an origin DNA reveals the mechanism of ORC activation by the replication initiator Cdc6. Nature Communications. 12: 3883 |
| Yuan Z, Schneider S, Dodd T, et al. (2020) Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6. Proceedings of the National Academy of Sciences of the United States of America |
| Roman-Trufero M, Ito CM, Pedebos C, et al. (2020) Evolution of an amniote-specific mechanism for modulating ubiquitin signalling via phosphoregulation of the E2 enzyme UBE2D3. Molecular Biology and Evolution |
| Noguchi Y, Yuan Z, Bai L, et al. (2017) Cryo-EM structure of Mcm2-7 double hexamer on DNA suggests a lagging-strand DNA extrusion model. Proceedings of the National Academy of Sciences of the United States of America |
| Riera A, Barbon M, Noguchi Y, et al. (2017) From structure to mechanism-understanding initiation of DNA replication. Genes & Development. 31: 1073-1088 |
| Yuan Z, Riera A, Bai L, et al. (2017) Structural basis of Mcm2-7 replicative helicase loading by ORC-Cdc6 and Cdt1. Nature Structural & Molecular Biology |