Christopher Ott

Affiliations: 
Massachusetts General Hospital, Boston, MA 
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"Christopher Ott"
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Takahashi M, Chong HB, Zhang S, et al. (2023) DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Biorxiv : the Preprint Server For Biology
Zhang Y, Remillard D, Onubogu U, et al. (2023) Collateral lethality between HDAC1 and HDAC2 exploits cancer-specific NuRD complex vulnerabilities. Nature Structural & Molecular Biology
Isozaki H, Sakhtemani R, Abbasi A, et al. (2023) Therapy-induced APOBEC3A drives evolution of persistent cancer cells. Nature
de Matos Simoes R, Shirasaki R, Downey-Kopyscinski SL, et al. (2023) Genome-scale functional genomics identify genes preferentially essential for multiple myeloma cells compared to other neoplasias. Nature Cancer. 4: 754-773
Bishop TR, Subramanian C, Bilotta EM, et al. (2023) Acetyl-CoA biosynthesis drives resistance to histone acetyltransferase inhibition. Nature Chemical Biology
Gill T, Wang H, Bandaru R, et al. (2021) Selective targeting of MYC mRNA by stabilized antisense oligonucleotides. Oncogene
Kong W, Dimitri A, Wang W, et al. (2021) BET bromodomain protein inhibition reverses chimeric antigen receptor extinction and reinvigorates exhausted T cells in chronic lymphocytic leukemia. The Journal of Clinical Investigation. 131
Lazarian G, Yin S, Ten Hacken E, et al. (2021) A hotspot mutation in transcription factor IKZF3 drives B cell neoplasia via transcriptional dysregulation. Cancer Cell. 39: 380-393.e8
Koduri V, Duplaquet L, Lampson BL, et al. (2021) Targeting oncoproteins with a positive selection assay for protein degraders. Science Advances. 7
Shirasaki R, Matthews GM, Gandolfi S, et al. (2021) Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins. Cell Reports. 34: 108532
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