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Xu Ran

Affiliations: 
University of Michigan, Ann Arbor, Ann Arbor, MI 
Area:
Drug Discovery
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"Xu Ran"
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Shaomeng Wang grad student 2010-2014 University of Michigan

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Nadel CM, Ran X, Gestwicki JE. (2020) Luminescence Complementation Assay for Measurement of Binding to Protein C-Termini in Live Cells. Analytical Biochemistry. 113947
Zhao Y, Zhou B, Bai L, et al. (2018) Structure-Based Discovery of CF53 as a Potent and Orally Bioavailable Bromodomain and Extra-Terminal (BET) Bromodomain Inhibitor. Journal of Medicinal Chemistry
Ran X, Gestwicki JE. (2018) Inhibitors of protein-protein interactions (PPIs): an analysis of scaffold choices and buried surface area. Current Opinion in Chemical Biology. 44: 75-86
Ran X, Burchfiel ET, Dong B, et al. (2018) Rational design and screening of peptide-based inhibitors of heat shock factor 1 (HSF1). Bioorganic & Medicinal Chemistry
Taylor IR, Dunyak BM, Komiyama T, et al. (2018) High Throughput Screen for Inhibitors of Protein-Protein Interactions in a Reconstituted Heat Shock Protein 70 (Hsp70) Complex. The Journal of Biological Chemistry
Karatas H, Li Y, Liu L, et al. (2017) Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)-Mixed Lineage Leukemia (MLL) Protein-Protein Interaction. Journal of Medicinal Chemistry
Zhao Y, Bai L, Liu L, et al. (2017) Structure-Based Discovery of 4-(6-Methoxy-2-methyl-4-(quinolin-4-yl)-9H-pyrimido[4,5-b]indol-7-yl)-3,5-dimethylisoxazole (CD161) as a Potent and Orally Bioavailable BET Bromodomain Inhibitor. Journal of Medicinal Chemistry
Ran X, Liu L, Yang C, et al. (2015) Design of High-affinity Stapled Peptides to Target the Repressor Activator Protein 1 (RAP1)/Telomeric Repeat-binding Factor 2 (TRF2) Protein-Protein Interaction in the Shelterin Complex. Journal of Medicinal Chemistry
Ran X, Zhao Y, Liu L, et al. (2015) Structure-Based Design of γ-Carboline Analogues as Potent and Specific BET Bromodomain Inhibitors. Journal of Medicinal Chemistry. 58: 4927-39
Kurokawa M, Kim J, Geradts J, et al. (2013) A network of substrates of the E3 ubiquitin ligases MDM2 and HUWE1 control apoptosis independently of p53. Science Signaling. 6: ra32
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