John C. Spurlino

Affiliations: 
Johnson and Johnson, New Brunswick, NJ, United States 
Area:
Structure based drug design, Crystallography, FBDD
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"John Spurlino"
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SNBCP
Cross-listing: Computational Biology Tree

Parents

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Florante A. Quiocho grad student 1982-1990 Baylor College of Medicine and Rice University
 (Graduate student & HHMI postdoc)
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Publications

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Xu G, Liu Z, Wang X, et al. (2022) Discovery of Potent and Orally Bioavailable Pyridine N-Oxide-Based Factor XIa Inhibitors through Exploiting Nonclassical Interactions. Journal of Medicinal Chemistry
Barbay JK, Cummings MD, Abad M, et al. (2017) 6-Substituted quinolines as RORγt inverse agonists. Bioorganic & Medicinal Chemistry Letters
Kervinen J, Abad M, Crysler C, et al. (2008) Structural basis for elastolytic substrate specificity in rodent α-chymases Journal of Biological Chemistry. 283: 427-436
Abad MC, Askari H, O'Neill J, et al. (2008) Structural determination of estrogen-related receptor gamma in the presence of phenol derivative compounds. The Journal of Steroid Biochemistry and Molecular Biology. 108: 44-54
Schubert C, Schalk-Hihi C, Struble GT, et al. (2007) Crystal structure of the tyrosine kinase domain of colony-stimulating factor-1 receptor (cFMS) in complex with two inhibitors Journal of Biological Chemistry. 282: 4094-4101
Lu T, Markotan T, Coppo F, et al. (2004) Oxyguanidines. Part 2: Discovery of a novel orally active thrombin inhibitor through structure-based drug design and parallel synthesis Bioorganic and Medicinal Chemistry Letters. 14: 3727-3731
Subasinghe NL, Ali F, Illig CR, et al. (2004) A novel series of potent and selective small molecule inhibitors of the complement component C1s Bioorganic and Medicinal Chemistry Letters. 14: 3043-3047
Tomczuk B, Lu T, Soll RM, et al. (2003) Oxyguanidines: Application to non-peptidic phenyl-based thrombin inhibitors Bioorganic and Medicinal Chemistry Letters. 13: 1495-1498
Rudolph MJ, Illig CR, Subasinghe NL, et al. (2002) Design and Synthesis of 4,5-disubstituted-thiophene-2-amidines as potent urokinase inhibitors Bioorganic and Medicinal Chemistry Letters. 12: 491-495
Subasinghe NL, Illig C, Hoffman J, et al. (2001) Structure-Based design, synthesis and SAR of a novel series of thiopheneamidine urokinase plasminogen activator inhibitors Bioorganic and Medicinal Chemistry Letters. 11: 1379-1382
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