Howard S. Tager

Affiliations: 
Biochemistry & Molecular Biology University of Chicago, Chicago, IL 
Area:
diabetes
Website:
http://chronicle.uchicago.edu/940929/tager.shtml
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"Howard S. Tager"
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Parents

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Halvor N. Christensen grad student 1971 University of Michigan
 (2-Aminonorbornane-2-carboxylic acid: Physical, chemical and biochemical properties of the four isomers)
Donald F. Steiner post-doc 1973 Chicago
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Publications

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Nakagawa SH, Tager HS, Steiner DF. (2000) Mutational analysis of invariant valine B12 in insulin: implications for receptor binding. Biochemistry. 39: 15826-35
Pittman I, Nakagawa SH, Tager HS, et al. (1997) Maintenance of the B-chain beta-turn in [GlyB24] insulin mutants: a steady-state fluorescence anisotropy study. Biochemistry. 36: 3430-7
Pittman I, Tager HS. (1995) A spectroscopic investigation of the conformational dynamics of insulin in solution. Biochemistry. 34: 10578-90
Polonsky KS, Gumbiner B, Ostrega D, et al. (1994) Alterations in immunoreactive proinsulin and insulin clearance induced by weight loss in NIDDM Diabetes. 43: 871-877
Schäffer L, Kjeldsen T, Andersen AS, et al. (1993) Interactions of a hybrid insulin/insulin-like growth factor-I analog with chimeric insulin/type I insulin-like growth factor receptors. The Journal of Biological Chemistry. 268: 3044-7
Post SR, Rubinstein PG, Tager HS. (1993) Mechanism of action of des-His1-[Glu9]glucagon amide, a peptide antagonist of the glucagon receptor system. Proceedings of the National Academy of Sciences of the United States of America. 90: 1662-6
Nakagawa SH, Tager HS. (1993) Importance of main-chain flexibility and the insulin fold in insulin-receptor interactions. Biochemistry. 32: 7237-43
Nakagawa SH, Johansen NL, Madsen K, et al. (1993) Implications of replacing peptide bonds in the COOH-terminal B chain domain of insulin by the psi (CH2-NH) linker. International Journal of Peptide and Protein Research. 42: 578-84
Zhong P, Cara JF, Tager HS. (1993) Importance of receptor occupancy, concentration differences, and ligand exchange in the insulin-like growth factor I receptor system. Proceedings of the National Academy of Sciences of the United States of America. 90: 11451-5
Nakagawa SH, Tager HS. (1992) Importance of aliphatic side-chain structure at positions 2 and 3 of the insulin A chain in insulin-receptor interactions. Biochemistry. 31: 3204-14
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