Brandon J Turunen

GSK, Rixensart, Wallonie, Belgium 
Medicinal Chemistry, Chemical biology and ImmunoOncology
"Brandon Turunen"
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Lobera M, Madauss KP, Pohlhaus DT, et al. (2013) Selective class IIa histone deacetylase inhibition via a nonchelating zinc-binding group. Nature Chemical Biology. 9: 319-25
Bee WT, Xie W, Truong M, et al. (2012) The development of a high-content screening binding assay for the smoothened receptor. Journal of Biomolecular Screening. 17: 900-11
Niphakis MJ, Turunen BJ, Georg GI. (2010) Synthesis of 6- and 7-membered cyclic enaminones: scope and mechanism. The Journal of Organic Chemistry. 75: 6793-805
Ward TR, Turunen BJ, Haack T, et al. (2009) Synthesis of a quinolone library from ynones. Tetrahedron Letters. 50: 6494-9497
Rominger CM, Bee WL, Copeland RA, et al. (2009) Evidence for allosteric interactions of antagonist binding to the smoothened receptor. The Journal of Pharmacology and Experimental Therapeutics. 329: 995-1005
Turunen BJ, Ge H, Oyetunji J, et al. (2008) Paclitaxel succinate analogs: Anionic and amide introduction as a strategy to impart blood-brain barrier permeability. Bioorganic & Medicinal Chemistry Letters. 18: 5971-4
Kimball FS, Turunen BJ, Ellis KC, et al. (2008) Enantiospecific synthesis and cytotoxicity of 7-(4-methoxyphenyl)-6-phenyl-2,3,8,8a-tetrahydroindolizin-5(1H)-one enantiomers. Bioorganic & Medicinal Chemistry. 16: 4367-77
Wang X, Turunen BJ, Leighty MW, et al. (2007) Microwave-assisted Suzuki-Miyaura couplings on α-iodoenaminones. Tetrahedron Letters. 48: 8811-8814
Turunen BJ, Georg GI. (2006) Amino acid-derived enaminones: a study in ring formation providing valuable asymmetric synthons. Journal of the American Chemical Society. 128: 8702-3
Spletstoser JT, Turunen BJ, Desino K, et al. (2006) Single-site chemical modification at C10 of the baccatin III core of paclitaxel and Taxol C reduces P-glycoprotein interactions in bovine brain microvessel endothelial cells. Bioorganic & Medicinal Chemistry Letters. 16: 495-8
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