John R Lakanen
Affiliations: | 1988-1994 | Chemistry | University of Michigan, Ann Arbor, Ann Arbor, MI |
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| Lakanen JR, Pegg AE, Coward JK. (1995) Synthesis and biochemical evaluation of adenosylspermidine, a nucleoside-polyamine adduct inhibitor of spermidine synthase. Journal of Medicinal Chemistry. 38: 2714-27 |
| Byers TL, Lakanen JR, Coward JK, et al. (1994) The role of hypusine depletion in cytostasis induced by S-adenosyl-L-methionine decarboxylase inhibition: new evidence provided by 1-methylspermidine and 1,12-dimethylspermine. The Biochemical Journal. 303: 363-8 |
| Poulin R, Coward JK, Lakanen JR, et al. (1993) Enhancement of the spermidine uptake system and lethal effects of spermidine overaccumulation in ornithine decarboxylase-overproducing L1210 cells under hyposmotic stress. The Journal of Biological Chemistry. 268: 4690-8 |
| Lakanen JR, Coward JK, Pegg AE. (1992) alpha-Methyl polyamines: metabolically stable spermidine and spermine mimics capable of supporting growth in cells depleted of polyamines. Journal of Medicinal Chemistry. 35: 724-34 |