Alireza Ghanbarpour, Ph.D.

Affiliations: 
2014-2019 Chemistry Michigan State University, East Lansing, MI 
 2019-2021 Cell Biology Yale School of Medicine/Yale University 
 2021-2024 Biology Massachusetts Institute of Technology, Cambridge, MA, United States 
 2024- Biochemistry and Molecular Biophysics Washington University School of Medicine, St. Louis, MO, United States 
Area:
protein degradation, biochemistry, structural biology
Website:
https://sites.wustl.edu/ghanbarpour/
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Parents

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James H. Geiger grad student 2014-2019 Michigan State
Joseph H Davis post-doc 2021- MIT
Robert T. Sauer post-doc 2021- MIT
Karin M. Reinisch post-doc 2019-2021 Yale University Medical School (Physics Tree)
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Publications

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Ghanbarpour A, Sauer RT, Davis JH. (2024) A proteolytic AAA+ machine poised to unfold protein substrates. Nature Communications. 15: 9681
Ghanbarpour A, Telusma B, Powell BM, et al. (2024) An asymmetric nautilus-like HflK/C assembly controls FtsH proteolysis of membrane proteins. Biorxiv : the Preprint Server For Biology
Santos EM, Chandra I, Assar Z, et al. (2024) Regulation of Absorption and Emission in a Protein/Fluorophore Complex. Acs Chemical Biology
Ghanbarpour A, Sauer RT, Davis JH. (2023) A proteolytic AAA+ machine poised to unfold a protein substrate. Biorxiv : the Preprint Server For Biology
Ghanbarpour A, Cohen SE, Fei X, et al. (2023) A closed translocation channel in the substrate-free AAA+ ClpXP protease diminishes rogue degradation. Nature Communications. 14: 7281
Ghanbarpour A, Fei X, Baker TA, et al. (2023) The SspB adaptor drives structural changes in the AAA+ ClpXP protease during ssrA-tagged substrate delivery. Proceedings of the National Academy of Sciences of the United States of America. 120: e2219044120
Gavgani HN, Fawaz R, Ehyaei N, et al. (2021) A structural explanation for the mechanism and specificity of plant branching enzymes I and IIb. The Journal of Biological Chemistry. 101395
Santos EM, Sheng W, Esmatpour Salmani R, et al. (2021) Design of Large Stokes Shift Fluorescent Proteins Based on Excited State Proton Transfer of an Engineered Photobase. Journal of the American Chemical Society
Huang D, Xu B, Liu L, et al. (2021) TMEM41B acts as an ER scramblase required for lipoprotein biogenesis and lipid homeostasis. Cell Metabolism
Ghanbarpour A, Valverde DP, Melia TJ, et al. (2021) A model for a partnership of lipid transfer proteins and scramblases in membrane expansion and organelle biogenesis. Proceedings of the National Academy of Sciences of the United States of America. 118
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