Siddhant Jain
Affiliations: | 2013-2020 | University of Wisconsin, Madison, Madison, WI |
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| Jain SU, Khazaei S, Marchione DM, et al. (2020) Histone H3.3 G34 mutations promote aberrant PRC2 activity and drive tumor progression. Proceedings of the National Academy of Sciences of the United States of America |
| Jain SU, Rashoff AQ, Krabbenhoft SD, et al. (2020) H3 K27M and EZHIP Impede H3K27-Methylation Spreading by Inhibiting Allosterically Stimulated PRC2. Molecular Cell |
| Khazaei S, De Jay N, Deshmukh S, et al. (2020) H3.3G34W promotes growth and impedes differentiation of osteoblast-like mesenchymal progenitors in Giant Cell Tumour of Bone. Cancer Discovery |
| Jain SU, Do TJ, Lund PJ, et al. (2019) PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism. Nature Communications. 10: 2146 |
| Jani KS, Jain SU, Ge EJ, et al. (2019) Histone H3 tail binds a unique sensing pocket in EZH2 to activate the PRC2 methyltransferase. Proceedings of the National Academy of Sciences of the United States of America |
| Harutyunyan AS, Krug B, Chen H, et al. (2019) H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis. Nature Communications. 10: 1262 |
| McDaniel SL, Gibson TJ, Schulz KN, et al. (2019) Continued Activity of the Pioneer Factor Zelda Is Required to Drive Zygotic Genome Activation. Molecular Cell |
| Lu C, Jain S, Hoelper D, et al. (2018) Abstract PR12: Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape Clinical Cancer Research. 24 |
| Venneti S, Bayliss J, Mukherjee P, et al. (2017) Abstract 3863: A subset of poorly prognostic pediatric posterior fossa ependymomas exhibit lowered H3K27me3 and DNA hypomethylation and show epigenetic similarities with H3K27M mutant diffuse intrinsic pontine gliomas Cancer Research. 77: 3863-3863 |
| Venneti S, Bayliss J, Mukherjee P, et al. (2017) EPND-08. EPIGENETIC H3K27ME3 DEREGULATION IN PEDIATRIC POSTERIOR FOSSA EPENDYMOMAS Neuro-Oncology. 19: iv16-iv17 |