Haiying Sun, Ph.D
Affiliations: | 1997-2000 | SIOC,CAS | |
| 2014- | China Pharmaceutical University |
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Publications
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| Sun H, Fu Y, Yuan Y, et al. (2024) Development of Small Molecular Hyper-activators of Human Caseinolytic Peptidase P (hClpP) with a [1,8]-Naphthyridinone Scaffold as Novel Anti-cancer Agents. Chemmedchem. e202400528 |
| Zhang Y, Jiang J, Ding H, et al. (2024) Development of novel imipridone derivatives with potent anti-cancer activities as human caseinolytic peptidase P (hClpP) activators. Bioorganic Chemistry. 153: 107765 |
| Jiang J, Xie G, Li T, et al. (2024) Discovery of Dehydrogenated Imipridone Derivatives as Activators of Human Caseinolytic Protease P. Journal of Medicinal Chemistry |
| Yuan Y, Du L, Tan R, et al. (2022) Design, Synthesis, and Biological Evaluations of DOT1L Peptide Mimetics Targeting the Protein-Protein Interactions between DOT1L and MLL-AF9/MLL-ENL. Journal of Medicinal Chemistry. 65: 7770-7785 |
| Ma Z, Gao G, Fang K, et al. (2019) Development of Novel Anticancer Agents with a Scaffold of Tetrahydropyrido[4,3-]pyrimidine-2,4-dione. Acs Medicinal Chemistry Letters. 10: 191-195 |
| Sun H, Lu J, Liu L, et al. (2014) Potent and selective small-molecule inhibitors of cIAP1/2 proteins reveal that the binding of Smac mimetics to XIAP BIR3 is not required for their effective induction of cell death in tumor cells. Acs Chemical Biology. 9: 994-1002 |
| Sheng R, Sun H, Liu L, et al. (2013) A potent bivalent Smac mimetic (SM-1200) achieving rapid, complete, and durable tumor regression in mice. Journal of Medicinal Chemistry. 56: 3969-79 |
| Wang S, Bai L, Lu J, et al. (2012) Targeting inhibitors of apoptosis proteins (IAPs) for new breast cancer therapeutics. Journal of Mammary Gland Biology and Neoplasia. 17: 217-28 |
| Bai L, McEachern D, Yang CY, et al. (2012) LRIG1 modulates cancer cell sensitivity to Smac mimetics by regulating TNFα expression and receptor tyrosine kinase signaling. Cancer Research. 72: 1229-38 |
| Peng Y, Sun H, Lu J, et al. (2012) Bivalent Smac mimetics with a diazabicyclic core as highly potent antagonists of XIAP and cIAP1/2 and novel anticancer agents. Journal of Medicinal Chemistry. 55: 106-14 |