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Richard D. Dyer, Ph. D.

Affiliations: 
Inflammation Biology Pfizer Global Research & Development 
Website:
https://www.biospace.com/article/releases/former-pfizer-inc-director-of-inflammation-molecular-sciences-to-spearhead-velcura-therapeutics-inc-inflammatory-disease-initiatives-/
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"Richard Dennis Dyer"
Bio:

https://books.google.com/books?id=fPJsAAAAMAAJ

Mean distance: 9.39
 
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Parents

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Antonio E. Colás grad student 1978 UW Madison
 (High-affinity binding of progesterone by the human uterus: properties and functional significance.)

Children

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Adam R. Johnson post-doc 1996-1999 Pfizer Global Research & Development

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Publications

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Schnute ME, O'Brien PM, Nahra J, et al. (2010) Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis. Bioorganic & Medicinal Chemistry Letters. 20: 576-80
Li JJ, Nahra J, Johnson AR, et al. (2008) Quinazolinones and pyrido[3,4-d]pyrimidin-4-ones as orally active and specific matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis. Journal of Medicinal Chemistry. 51: 835-41
Johnson AR, Pavlovsky AG, Ortwine DF, et al. (2007) Discovery and characterization of a novel inhibitor of matrix metalloprotease-13 that reduces cartilage damage in vivo without joint fibroplasia side effects. The Journal of Biological Chemistry. 282: 27781-91
Johnson AR, Marletta MA, Dyer RD. (2001) Slow-binding inhibition of human prostaglandin endoperoxide synthase-2 with darbufelone, an isoform-selective antiinflammatory di-tert-butyl phenol. Biochemistry. 40: 7736-45
O'Brien PM, Ortwine DF, Pavlovsky AG, et al. (2000) Structure-activity relationships and pharmacokinetic analysis for a series of potent, systemically available biphenylsulfonamide matrix metalloproteinase inhibitors Journal of Medicinal Chemistry. 43: 156-166
Wang Y, Johnson AR, Ye QZ, et al. (1999) Catalytic activities and substrate specificity of the human membrane type 4 matrix metalloproteinase catalytic domain. The Journal of Biological Chemistry. 274: 33043-9
Song Y, Connor DT, Sercel AD, et al. (1999) Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 2. 1,3,4- and 1,2,4-thiadiazole series. Journal of Medicinal Chemistry. 42: 1161-9
Song Y, Connor DT, Doubleday R, et al. (1999) Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 1. Thiazolone and oxazolone series. Journal of Medicinal Chemistry. 42: 1151-60
Lesch CA, Gilbertsen RB, Song Y, et al. (1998) Effects of novel anti-inflammatory compounds on healing of acetic acid- induced gastric ulcer in rats Journal of Pharmacology and Experimental Therapeutics. 287: 301-306
Song Y, Connor DT, Sorenson RJ, et al. (1997) 2,6-di-tert-butylphenols: a new class of potent and selective PGHS-2 inhibitor. Inflammation Research : Official Journal of the European Histamine Research Society ... [Et Al.]. 46: S141-2
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