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Frank Sicheri grad student 2006 University of Toronto
 (Catalytic switching and substrate recognition mechanisms of the RNA dependent protein kinase PKR)
Kevan Michael Shokat post-doc 2006-2011 UCSF
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Publications

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Mendez AS, Alfaro J, Morales-Soto MA, et al. (2015) Endoplasmic reticulum stress-independent activation of unfolded protein response kinases by a small molecule ATP-mimic. Elife. 4
Zhang C, Lopez MS, Dar AC, et al. (2013) Structure-guided inhibitor design expands the scope of analog-sensitive kinase technology. Acs Chemical Biology. 8: 1931-8
Dar AC, Das TK, Shokat KM, et al. (2012) Chemical genetic discovery of targets and anti-targets for cancer polypharmacology. Nature. 486: 80-4
Dar AC, Shokat KM. (2011) The evolution of protein kinase inhibitors from antagonists to agonists of cellular signaling. Annual Review of Biochemistry. 80: 769-95
Brennan DF, Dar AC, Hertz NT, et al. (2011) A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK. Nature. 472: 366-9
Hertz NT, Wang BT, Allen JJ, et al. (2010) Chemical genetic approach for kinase-substrate mapping by covalent capture of thiophosphopeptides and analysis by mass spectrometry. Current Protocols in Chemical Biology. 2: 15-36
Seo EJ, Liu F, Kawagishi-Kobayashi M, et al. (2008) Protein kinase PKR mutants resistant to the poxvirus pseudosubstrate K3L protein. Proceedings of the National Academy of Sciences of the United States of America. 105: 16894-9
Dar AC, Lopez MS, Shokat KM. (2008) Small molecule recognition of c-Src via the Imatinib-binding conformation. Chemistry & Biology. 15: 1015-22
Dey M, Cao C, Dar AC, et al. (2005) Mechanistic link between PKR dimerization, autophosphorylation, and eIF2alpha substrate recognition. Cell. 122: 901-13
Dar AC, Dever TE, Sicheri F. (2005) Higher-order substrate recognition of eIF2alpha by the RNA-dependent protein kinase PKR. Cell. 122: 887-900
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