Joshua Boger, Ph.D.

Affiliations: 
1989-2009 CEO Vertex Pharmaceuticals, Boston, MA, United States 
 2012- Alkeus Pharmaceuticals 
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"Joshua Boger"
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Parents

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Max Tishler research assistant 1969-1973 Wesleyan
Jeremy R. Knowles grad student 1973-1979 Harvard
Jean-Marie Lehn post-doc 1974-1978 Université de Strasbourg
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Publications

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Rupprecht KM, Baker RK, Boger J, et al. (1998) Synthetic studies on the immunosuppressive agent FK-506: Construction of the polycarbonyl region Tetrahedron Letters. 39: 233-236
Baker RK, Rupprecht KM, Armistead DM, et al. (1998) Synthetic studies on the immunosuppressive agent FK-506: Enantioselective synthesis of a C22-C34 fragment Tetrahedron Letters. 39: 229-232
Germann UA, Shlyakhter D, Mason VS, et al. (1997) Cellular and biochemical characterization of VX-710 as a chemosensitizer: reversal of P-glycoprotein-mediated multidrug resistance in vitro. Anti-Cancer Drugs. 8: 125-40
Suguna K, Padlan EA, Bott R, et al. (1992) Structures of complexes of rhizopuspepsin with pepstatin and other statine-containing inhibitors. Proteins. 13: 195-205
Durette PL, Kopka IE, Lanza TJ, et al. (1992) The inhibition of C5a receptor binding by analogs of L-156,602, a cyclic hexadepsipeptide antibiotic Bioorganic and Medicinal Chemistry Letters. 2: 1033-1038
Gooley PR, Durette PL, Boger J, et al. (1991) Conformation of MeAla6-cyclosporin A by NMR. Relationship of sidechain orientation of the MeBmt-1, MeLeu-9, and MeLeu-10 residues to immunosuppressive activity. International Journal of Peptide and Protein Research. 37: 351-63
Rosborough SL, Fleming M, Nelson PA, et al. (1991) Identification of FKBP-related proteins with antibodies of predetermined specificity and isolation by FK 506 affinity chromatography. Transplantation Proceedings. 23: 2890-3
Rupprecht KM, Boger J, Hoogsteen K, et al. (1991) Controlling the stereochemistry of the ring junction in hexahydrodibenzofurans Journal of Organic Chemistry. 56: 6180-6188
Jupp RA, Dunn BM, Jacobs JW, et al. (1990) The selectivity of statine-based inhibitors against various human aspartic proteinases. The Biochemical Journal. 265: 871-8
T. Goulet M, Boger J. (1990) Degradative studies on the tricarbonyl containing macrolide rapamycin Tetrahedron Letters. 31: 4845-4848
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