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Robert Scism, Ph.D.

Alexion Pharmaceuticals 
 2003-2010 Chemistry Vanderbilt University, Nashville, TN 
"Robert Scism"
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Brian O. Bachmann grad student 2003-2010 Vanderbilt
 (Directed evolution and pathway engineering for nucleotide analogue biosynthesis.)
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Hemachandra LP, Patel H, Chandrasena RE, et al. (2014) SERMs attenuate estrogen-induced malignant transformation of human mammary epithelial cells by upregulating detoxification of oxidative metabolites. Cancer Prevention Research (Philadelphia, Pa.). 7: 505-15
Schiefer IT, Tapadar S, Litosh V, et al. (2013) Design, synthesis, and optimization of novel epoxide incorporating peptidomimetics as selective calpain inhibitors. Journal of Medicinal Chemistry. 56: 6054-68
Hemachandra LP, Madhubhani P, Chandrasena R, et al. (2012) Hops (Humulus lupulus) inhibits oxidative estrogen metabolism and estrogen-induced malignant transformation in human mammary epithelial cells (MCF-10A). Cancer Prevention Research (Philadelphia, Pa.). 5: 73-81
Nannemann DP, Birmingham WR, Scism RA, et al. (2011) Assessing directed evolution methods for the generation of biosynthetic enzymes with potential in drug biosynthesis. Future Medicinal Chemistry. 3: 809-19
Scism RA, Bachmann BO. (2010) Five-component cascade synthesis of nucleotide analogues in an engineered self-immobilized enzyme aggregate. Chembiochem : a European Journal of Chemical Biology. 11: 67-70
Scism RA, Stec DF, Bachmann BO. (2007) Synthesis of nucleotide analogues by a promiscuous phosphoribosyltransferase. Organic Letters. 9: 4179-82
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