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Haley E Melikian, Ph.D. - Publications

Affiliations: 
1991-1995 Neuroscience Emory University, Atlanta, GA 
 1997-2000 Neurobiology Harvard Medical School, Boston, MA, United States 
 2001- Brudnick Neuropsychiatric Research Institute University of Massachussetts Medical School, Worcester, MA, United States 
 2017- Neurbiology University of Massachussetts Medical School, Worcester, MA, United States 
Area:
Dopamine Transporters, psychostimulant addiction
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31/35 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Kearney PJ, Zhang Y, Liang M, Tan Y, Kahuno E, Conklin TL, Fagan RR, Pavchinskiy RG, Shaffer SA, Yue Z, Melikian HE. Silencing Parkinson's risk allele Rit2 sex-specifically compromises motor function and dopamine neuron viability. Npj Parkinson's Disease. 10: 41. PMID 38395968 DOI: 10.1038/s41531-024-00648-8  0.411
2023 Kearney P, Zhang Y, Tan Y, Kahuno E, Conklin T, Fagan R, Pavchinskiy R, Shaffer S, Yue Z, Melikian H. Rit2 silencing in dopamine neurons drives a progressive Parkinsonian phenotype. Research Square. PMID 37293098 DOI: 10.21203/rs.3.rs-2944614/v1  0.802
2023 Kearney PJ, Zhang Y, Tan Y, Kahuno E, Conklin TL, Fagan RR, Pavchinskiy RG, Shafer SA, Yue Z, Melikian HE. Rit2 silencing in dopamine neurons drives a progressive Parkinsonian phenotype. Biorxiv : the Preprint Server For Biology. PMID 37162843 DOI: 10.1101/2023.04.26.538430  0.802
2023 Kearney PJ, Bolden NC, Kahuno E, Conklin TL, Martin GE, Lubec G, Melikian HE. Presynaptic Gq-coupled receptors drive biphasic dopamine transporter trafficking that modulates dopamine clearance and motor function. The Journal of Biological Chemistry. 102900. PMID 36640864 DOI: 10.1016/j.jbc.2023.102900  0.821
2021 Fagan RR, Kearney PJ, Luethi D, Bolden NC, Sitte HH, Emery P, Melikian HE. Dopaminergic Ric GTPase activity impacts amphetamine sensitivity and sleep quality in a dopamine transporter-dependent manner in Drosophila melanogaster. Molecular Psychiatry. PMID 34471250 DOI: 10.1038/s41380-021-01275-y  0.807
2020 Fagan RR, Kearney PJ, Melikian HE. In Situ Regulated Dopamine Transporter Trafficking: There's No Place Like Home. Neurochemical Research. PMID 32146647 DOI: 10.1007/S11064-020-03001-6  0.84
2020 Fagan RR, Kearney PJ, Sweeney CG, Luethi D, Schoot Uiterkamp FE, Schicker K, Alejandro BS, O'Connor LC, Sitte HH, Melikian HE. Dopamine transporter trafficking and Rit2 GTPase: Mechanism of action and in vivo impact. The Journal of Biological Chemistry. PMID 32132171 DOI: 10.1074/Jbc.Ra120.012628  0.818
2019 Sweeney CG, Kearney PJ, Fagan RR, Smith LA, Bolden NC, Zhao-Shea R, Rivera IV, Kolpakova J, Xie J, Gao G, Tapper AR, Martin GE, Melikian HE. Conditional, inducible gene silencing in dopamine neurons reveals a sex-specific role for Rit2 GTPase in acute cocaine response and striatal function. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 31277075 DOI: 10.1038/S41386-019-0457-X  0.739
2017 Wu S, Fagan RR, Uttamapinant C, Lifshitz LM, Fogarty KE, Ting AY, Melikian HE. The Dopamine Transporter Recycles Via A Retromer-Dependent Post-Endocytic Mechanism: Tracking Studies Using A Novel Fluorophore-Coupling Approach. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28847807 DOI: 10.1523/Jneurosci.3885-16.2017  0.847
2016 Sweeney CG, Tremblay BP, Stockner T, Sitte HH, Melikian HE. Dopamine Transporter Amino- and Carboxy-Termini Synergistically Contribute to Substrate and Inhibitor Affinities. The Journal of Biological Chemistry. PMID 27986813 DOI: 10.1074/Jbc.M116.762872  0.821
2015 Wu S, Bellve KD, Fogarty KE, Melikian HE. Ack1 is a dopamine transporter endocytic brake that rescues a trafficking-dysregulated ADHD coding variant. Proceedings of the National Academy of Sciences of the United States of America. PMID 26621748 DOI: 10.1073/Pnas.1512957112  0.751
2014 Gabriel LR, Wu S, Melikian HE. Brain slice biotinylation: an ex vivo approach to measure region-specific plasma membrane protein trafficking in adult neurons. Journal of Visualized Experiments : Jove. PMID 24747337 DOI: 10.3791/51240  0.784
2013 Gabriel LR, Wu S, Kearney P, Bellvé KD, Standley C, Fogarty KE, Melikian HE. Dopamine transporter endocytic trafficking in striatal dopaminergic neurons: differential dependence on dynamin and the actin cytoskeleton. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 17836-46. PMID 24198373 DOI: 10.1523/Jneurosci.3284-13.2013  0.822
2012 Gabriel L, Lvov A, Orthodoxou D, Rittenhouse AR, Kobertz WR, Melikian HE. The acid-sensitive, anesthetic-activated potassium leak channel, KCNK3, is regulated by 14-3-3β-dependent, protein kinase C (PKC)-mediated endocytic trafficking. The Journal of Biological Chemistry. 287: 32354-66. PMID 22846993 DOI: 10.1074/Jbc.M112.391458  0.794
2011 Navaroli DM, Stevens ZH, Uzelac Z, Gabriel L, King MJ, Lifshitz LM, Sitte HH, Melikian HE. The plasma membrane-associated GTPase Rin interacts with the dopamine transporter and is required for protein kinase C-regulated dopamine transporter trafficking. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 13758-70. PMID 21957239 DOI: 10.1523/Jneurosci.2649-11.2011  0.849
2011 Lvov A, Gabriel LR, Rittenhouse AR, Melikian HE, Kobertz WR. KCNK3 (Task-1) Potassium Leak Channels Internalize in a PKC- and 14-3-3beta-Dependent Manner Biophysical Journal. 100: 99a. DOI: 10.1016/J.Bpj.2010.12.746  0.767
2010 Navaroli DM, Melikian HE. Insertion of tetracysteine motifs into dopamine transporter extracellular domains. Plos One. 5: e9113. PMID 20161733 DOI: 10.1371/Journal.Pone.0009113  0.593
2009 Gabriel L, Stevens Z, Melikian H. Measuring plasma membrane protein endocytic rates by reversible biotinylation. Journal of Visualized Experiments : Jove. PMID 20032927 DOI: 10.3791/1669  0.787
2008 Boudanova E, Navaroli DM, Stevens Z, Melikian HE. Dopamine transporter endocytic determinants: carboxy terminal residues critical for basal and PKC-stimulated internalization. Molecular and Cellular Neurosciences. 39: 211-7. PMID 18638559 DOI: 10.1016/J.Mcn.2008.06.011  0.848
2008 Boudanova E, Navaroli DM, Melikian HE. Amphetamine-induced decreases in dopamine transporter surface expression are protein kinase C-independent. Neuropharmacology. 54: 605-12. PMID 18164041 DOI: 10.1016/J.Neuropharm.2007.11.007  0.856
2005 Holton KL, Loder MK, Melikian HE. Nonclassical, distinct endocytic signals dictate constitutive and PKC-regulated neurotransmitter transporter internalization. Nature Neuroscience. 8: 881-8. PMID 15924135 DOI: 10.1038/Nn1478  0.824
2004 Melikian HE. Neurotransmitter transporter trafficking: endocytosis, recycling, and regulation. Pharmacology & Therapeutics. 104: 17-27. PMID 15500906 DOI: 10.1016/J.Pharmthera.2004.07.006  0.479
2003 Loder MK, Melikian HE. The dopamine transporter constitutively internalizes and recycles in a protein kinase C-regulated manner in stably transfected PC12 cell lines. The Journal of Biological Chemistry. 278: 22168-74. PMID 12682063 DOI: 10.1074/Jbc.M301845200  0.853
2000 Buckley KM, Melikian HE, Provoda CJ, Waring MT. Regulation of neuronal function by protein trafficking: a role for the endosomal pathway. The Journal of Physiology. 525: 11-9. PMID 10811720 DOI: 10.1111/J.1469-7793.2000.T01-2-00011.X  0.666
1999 Paradee W, Melikian HE, Rasmussen DL, Kenneson A, Conn PJ, Warren ST. Fragile X mouse: strain effects of knockout phenotype and evidence suggesting deficient amygdala function. Neuroscience. 94: 185-92. PMID 10613508 DOI: 10.1016/S0306-4522(99)00285-7  0.529
1999 Melikian HE, Buckley KM. Membrane trafficking regulates the activity of the human dopamine transporter. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 7699-710. PMID 10479674 DOI: 10.1523/Jneurosci.19-18-07699.1999  0.757
1998 Ramamoorthy S, Melikian HE, Qian Y, Blakely RD. Biosynthesis, N-glycosylation, and surface trafficking of biogenic amine transporter proteins. Methods in Enzymology. 296: 347-70. PMID 9779460 DOI: 10.1016/S0076-6879(98)96026-8  0.731
1996 Melikian HE, Ramamoorthy S, Tate CG, Blakely RD. Inability to N-glycosylate the human norepinephrine transporter reduces protein stability, surface trafficking, and transport activity but not ligand recognition. Molecular Pharmacology. 50: 266-76. PMID 8700133  0.541
1995 Qian Y, Melikian HE, Rye DB, Levey AI, Blakely RD. Identification and characterization of antidepressant-sensitive serotonin transporter proteins using site-specific antibodies. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 15: 1261-74. PMID 7869097 DOI: 10.1523/Jneurosci.15-02-01261.1995  0.653
1994 Melikian HE, McDonald JK, Gu H, Rudnick G, Moore KR, Blakely RD. Human norepinephrine transporter. Biosynthetic studies using a site-directed polyclonal antibody. The Journal of Biological Chemistry. 269: 12290-7. PMID 8163533  0.51
1993 Ramamoorthy S, Cool DR, Mahesh VB, Leibach FH, Melikian HE, Blakely RD, Ganapathy V. Regulation of the human serotonin transporter. Cholera toxin-induced stimulation of serotonin uptake in human placental choriocarcinoma cells is accompanied by increased serotonin transporter mRNA levels and serotonin transporter-specific ligand binding. The Journal of Biological Chemistry. 268: 21626-31. PMID 8408014  0.546
Low-probability matches (unlikely to be authored by this person)
1985 Melikian HE. Treatment of ligneous conjunctivitis. Annals of Ophthalmology. 17: 763-5. PMID 2936292  0.11
1985 Ferry AP, Safir A, Melikian HE. Ocular abnormalities in patients with gout. Annals of Ophthalmology. 17: 632-5. PMID 4073719  0.041
1971 Melikian HE, Lieberman TW, Leopold IH. Ocular pigmentation and pressure and outflow responses to pilocarpine and epinephrine. American Journal of Ophthalmology. 72: 70-3. PMID 5571213  0.027
1971 Melikian HE, Nowakowski J, Boyle GL, Leopold IH. Use of subconjunctival hyaluronidase. American Journal of Ophthalmology. 71: 1313-6. PMID 5091130  0.01
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