Charles A. Boswell, Ph.D. - Publications

2004 Washington University, Saint Louis, St. Louis, MO 
PET agents for cancer imaging

53 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Deng R, Bumbaca D, Pastuskovas CV, Boswell CA, West D, Cowan KJ, Chiu H, McBride J, Johnson C, Xin Y, Koeppen H, Leabman M, Iyer S. Preclinical pharmacokinetics, pharmacodynamics, tissue distribution, and tumor penetration of anti-PD-L1 monoclonal antibody, an immune checkpoint inhibitor. Mabs. 1-11. PMID 26918260 DOI: 10.1080/19420862.2015.1136043  0.52
2015 Bien-Ly N, Boswell CA, Jeet S, Beach TG, Hoyte K, Luk W, Shihadeh V, Ulufatu S, Foreman O, Lu Y, DeVoss J, van der Brug M, Watts RJ. Lack of Widespread BBB Disruption in Alzheimer's Disease Models: Focus on Therapeutic Antibodies. Neuron. 88: 289-97. PMID 26494278 DOI: 10.1016/j.neuron.2015.09.036  0.52
2015 Bumbaca Yadav D, Sharma VK, Boswell CA, Hotzel I, Tesar D, Shang Y, Ying Y, Fischer SK, Grogan JL, Chiang EY, Urban K, Ulufatu S, Khawli LA, Prabhu S, Joseph S, et al. Evaluating the use of antibody variable region (Fv) charge as a risk assessment tool for predicting typical cynomolgus monkey pharmacokinetics. The Journal of Biological Chemistry. PMID 26491012 DOI: 10.1074/jbc.M115.692434  0.52
2014 Li B, Tesar D, Boswell CA, Cahaya HS, Wong A, Zhang J, Meng YG, Eigenbrot C, Pantua H, Diao J, Kapadia SB, Deng R, Kelley RF. Framework selection can influence pharmacokinetics of a humanized therapeutic antibody through differences in molecule charge. Mabs. 6: 1255-64. PMID 25517310 DOI: 10.4161/mabs.29809  0.52
2014 Kamath AV, Yip V, Gupta P, Boswell CA, Bumbaca D, Haughney P, Castro J, Tsai SP, Pacheco G, Ross S, Yan M, Damico-Beyer LA, Khawli L, Shen BQ. Dose dependent pharmacokinetics, tissue distribution, and anti-tumor efficacy of a humanized monoclonal antibody against DLL4 in mice. Mabs. 6: 1631-7. PMID 25484068 DOI: 10.4161/mabs.36107  0.52
2014 Boswell CA, Mundo EE, Ulufatu S, Bumbaca D, Cahaya HS, Majidy N, Van Hoy M, Schweiger MG, Fielder PJ, Prabhu S, Khawli LA. Comparative physiology of mice and rats: radiometric measurement of vascular parameters in rodent tissues. Molecular Pharmaceutics. 11: 1591-8. PMID 24702191 DOI: 10.1021/mp400748t  0.52
2014 Yip V, Palma E, Tesar DB, Mundo EE, Bumbaca D, Torres EK, Reyes NA, Shen BQ, Fielder PJ, Prabhu S, Khawli LA, Boswell CA. Quantitative cumulative biodistribution of antibodies in mice: effect of modulating binding affinity to the neonatal Fc receptor. Mabs. 6: 689-96. PMID 24572100 DOI: 10.4161/mabs.28254  0.52
2014 Bien-Ly N, Yu YJ, Bumbaca D, Elstrott J, Boswell CA, Zhang Y, Luk W, Lu Y, Dennis MS, Weimer RM, Chung I, Watts RJ. Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants. The Journal of Experimental Medicine. 211: 233-44. PMID 24470444 DOI: 10.1084/jem.20131660  0.52
2013 Boswell CA, Marik J, Elowson MJ, Reyes NA, Ulufatu S, Bumbaca D, Yip V, Mundo EE, Majidy N, Van Hoy M, Goriparthi SN, Trias A, Gill HS, Williams SP, Junutula JR, et al. Enhanced tumor retention of a radiohalogen label for site-specific modification of antibodies. Journal of Medicinal Chemistry. 56: 9418-26. PMID 24131491 DOI: 10.1021/jm401365h  0.52
2013 Boswell CA, Mundo EE, Johnstone B, Ulufatu S, Schweiger MG, Bumbaca D, Fielder PJ, Prabhu S, Khawli LA. Vascular physiology and protein disposition in a preclinical model of neurodegeneration. Molecular Pharmaceutics. 10: 1514-21. PMID 23383983 DOI: 10.1021/mp3004786  0.52
2013 Boswell CA, Mundo EE, Firestein R, Zhang C, Mao W, Gill H, Young C, Ljumanovic N, Stainton S, Ulufatu S, Fourie A, Kozak KR, Fuji R, Polakis P, Khawli LA, et al. An integrated approach to identify normal tissue expression of targets for antibody-drug conjugates: case study of TENB2. British Journal of Pharmacology. 168: 445-57. PMID 22889168 DOI: 10.1111/j.1476-5381.2012.02138.x  0.52
2012 Boswell CA, Mundo EE, Zhang C, Stainton SL, Yu SF, Lacap JA, Mao W, Kozak KR, Fourie A, Polakis P, Khawli LA, Lin K. Differential effects of predosing on tumor and tissue uptake of an 111In-labeled anti-TENB2 antibody-drug conjugate. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 53: 1454-61. PMID 22872740 DOI: 10.2967/jnumed.112.103168  0.52
2012 Boswell CA, Bumbaca D, Fielder PJ, Khawli LA. Compartmental tissue distribution of antibody therapeutics: experimental approaches and interpretations. The Aaps Journal. 14: 612-8. PMID 22648903 DOI: 10.1208/s12248-012-9374-1  0.52
2012 Bumbaca D, Boswell CA, Fielder PJ, Khawli LA. Physiochemical and biochemical factors influencing the pharmacokinetics of antibody therapeutics. The Aaps Journal. 14: 554-8. PMID 22610647 DOI: 10.1208/s12248-012-9369-y  0.52
2012 Zheng Y, Tesar DB, Benincosa L, Birnböck H, Boswell CA, Bumbaca D, Cowan KJ, Danilenko DM, Daugherty AL, Fielder PJ, Grimm HP, Joshi A, Justies N, Kolaitis G, Lewin-Koh N, et al. Minipig as a potential translatable model for monoclonal antibody pharmacokinetics after intravenous and subcutaneous administration. Mabs. 4: 243-55. PMID 22453096 DOI: 10.4161/mabs.4.2.19387  0.52
2012 Pastuskovas CV, Mundo EE, Williams SP, Nayak TK, Ho J, Ulufatu S, Clark S, Ross S, Cheng E, Parsons-Reponte K, Cain G, Van Hoy M, Majidy N, Bheddah S, dela Cruz Chuh J, ... ... Boswell CA, et al. Effects of anti-VEGF on pharmacokinetics, biodistribution, and tumor penetration of trastuzumab in a preclinical breast cancer model. Molecular Cancer Therapeutics. 11: 752-62. PMID 22222630 DOI: 10.1158/1535-7163.MCT-11-0742-T  0.52
2012 Bumbaca D, Xiang H, Boswell CA, Port RE, Stainton SL, Mundo EE, Ulufatu S, Bagri A, Theil FP, Fielder PJ, Khawli LA, Shen BQ. Maximizing tumour exposure to anti-neuropilin-1 antibody requires saturation of non-tumour tissue antigenic sinks in mice. British Journal of Pharmacology. 166: 368-77. PMID 22074316 DOI: 10.1111/j.1476-5381.2011.01777.x  0.52
2011 Prabhu S, Boswell CA, Leipold D, Khawli LA, Li D, Lu D, Theil FP, Joshi A, Lum BL. Antibody delivery of drugs and radionuclides: factors influencing clinical pharmacology. Therapeutic Delivery. 2: 769-91. PMID 22822508 DOI: 10.4155/tde.11.41  0.52
2011 Boswell CA, Mundo EE, Zhang C, Bumbaca D, Valle NR, Kozak KR, Fourie A, Chuh J, Koppada N, Saad O, Gill H, Shen BQ, Rubinfeld B, Tibbitts J, Kaur S, et al. Impact of drug conjugation on pharmacokinetics and tissue distribution of anti-STEAP1 antibody-drug conjugates in rats. Bioconjugate Chemistry. 22: 1994-2004. PMID 21913715 DOI: 10.1021/bc200212a  0.52
2011 Boswell CA, Ferl GZ, Mundo EE, Bumbaca D, Schweiger MG, Theil FP, Fielder PJ, Khawli LA. Effects of anti-VEGF on predicted antibody biodistribution: roles of vascular volume, interstitial volume, and blood flow. Plos One. 6: e17874. PMID 21436893 DOI: 10.1371/journal.pone.0017874  0.52
2010 Boswell CA, Tesar DB, Mukhyala K, Theil FP, Fielder PJ, Khawli LA. Effects of charge on antibody tissue distribution and pharmacokinetics. Bioconjugate Chemistry. 21: 2153-63. PMID 21053952 DOI: 10.1021/bc100261d  0.52
2010 Boswell CA, Ferl GZ, Mundo EE, Schweiger MG, Marik J, Reich MP, Theil FP, Fielder PJ, Khawli LA. Development and evaluation of a novel method for preclinical measurement of tissue vascular volume. Molecular Pharmaceutics. 7: 1848-57. PMID 20704296 DOI: 10.1021/mp100183k  0.52
2009 Boswell CA, Regino CA, Baidoo KE, Wong KJ, Milenic DE, Kelley JA, Lai CC, Brechbiel MW. A novel side-bridged hybrid phosphonate/acetate pendant cyclam: synthesis, characterization, and 64Cu small animal PET imaging. Bioorganic & Medicinal Chemistry. 17: 548-52. PMID 19101152 DOI: 10.1016/j.bmc.2008.11.073  0.52
2008 Boswell CA, Regino CA, Baidoo KE, Wong KJ, Bumb A, Xu H, Milenic DE, Kelley JA, Lai CC, Brechbiel MW. Synthesis of a cross-bridged cyclam derivative for peptide conjugation and 64Cu radiolabeling. Bioconjugate Chemistry. 19: 1476-84. PMID 18597510 DOI: 10.1021/bc800039e  0.52
2008 Boswell CA, Eck PK, Regino CA, Bernardo M, Wong KJ, Milenic DE, Choyke PL, Brechbiel MW. Synthesis, characterization, and biological evaluation of integrin alphavbeta3-targeted PAMAM dendrimers. Molecular Pharmaceutics. 5: 527-39. PMID 18537262 DOI: 10.1021/mp800022a  0.52
2007 Boswell CA, Brechbiel MW. Development of radioimmunotherapeutic and diagnostic antibodies: an inside-out view. Nuclear Medicine and Biology. 34: 757-78. PMID 17921028 DOI: 10.1016/j.nucmedbio.2007.04.001  0.52
2007 Xu H, Baidoo K, Gunn AJ, Boswell CA, Milenic DE, Choyke PL, Brechbiel MW. Design, synthesis, and characterization of a dual modality positron emission tomography and fluorescence imaging agent for monoclonal antibody tumor-targeted imaging. Journal of Medicinal Chemistry. 50: 4759-65. PMID 17725340 DOI: 10.1021/jm070657w  0.52
2007 Hartl T, Boswell C, Orr-Weaver TL, Bosco G. Developmentally regulated histone modifications in Drosophila follicle cells: initiation of gene amplification is associated with histone H3 and H4 hyperacetylation and H1 phosphorylation. Chromosoma. 116: 197-214. PMID 17219175 DOI: 10.1007/s00412-006-0092-2  0.52
2007 Keller LMM, Boswell CA, Milenic DE, Brady ED, Brechbiel MW. Monoclonal antibody targeted radiation cancer therapy Biologics in General Medicine. 50-58. DOI: 10.1007/978-3-540-29018-6_6  0.52
2006 McNamara G, Gupta A, Reynaert J, Coates TD, Boswell C. Spectral imaging microscopy web sites and data. Cytometry. Part a : the Journal of the International Society For Analytical Cytology. 69: 863-71. PMID 16969821 DOI: 10.1002/cyto.a.20304  0.52
2006 Clifford T, Boswell CA, Biddlecombe GB, Lewis JS, Brechbiel MW. Validation of a novel CHX-A'' derivative suitable for peptide conjugation: small animal PET/CT imaging using yttrium-86-CHX-A''-octreotide. Journal of Medicinal Chemistry. 49: 4297-304. PMID 16821789 DOI: 10.1021/jm060317v  0.52
2006 Shen X, Boswell CA, Wong EH, Weisman GR, Anderson CJ, Tomellini SA. Investigation of copper-azamacrocyclic complexes by high-performance liquid chromatography. Biomedical Chromatography : Bmc. 20: 37-47. PMID 15954159 DOI: 10.1002/bmc.525  0.52
2005 Boswell CA, Brechbiel MW. Auger electrons: lethal, low energy, and coming soon to a tumor cell nucleus near you. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 46: 1946-7. PMID 16330556  0.52
2005 Boswell CA, McQuade P, Weisman GR, Wong EH, Anderson CJ. Optimization of labeling and metabolite analysis of copper-64-labeled azamacrocyclic chelators by radio-LC-MS. Nuclear Medicine and Biology. 32: 29-38. PMID 15691659 DOI: 10.1016/j.nucmedbio.2004.09.004  0.52
2005 Woodin KS, Heroux KJ, Boswell CA, Wong EH, Weisman GR, Niu W, Tomellini SA, Anderson CJ, Zakharov LN, Rheingold AL. Kinetic inertness and electrochemical behavior of copper(II) tetraazamacrocyclic complexes: Possible implications for in vivo stability European Journal of Inorganic Chemistry. 4829-4833. DOI: 10.1002/ejic.200500579  0.52
2004 Boswell CA, Sun X, Niu W, Weisman GR, Wong EH, Rheingold AL, Anderson CJ. Comparative in vivo stability of copper-64-labeled cross-bridged and conventional tetraazamacrocyclic complexes. Journal of Medicinal Chemistry. 47: 1465-74. PMID 14998334 DOI: 10.1021/jm030383m  0.52
2003 Scappaticci FA, Contreras A, Boswell CA, Lewis JS, Nolan G. Polyclonal antibodies to xenogeneic endothelial cells induce apoptosis and block support of tumor growth in mice. Vaccine. 21: 2667-77. PMID 12744904 DOI: 10.1016/S0264-410X(02)00693-X  0.52
2003 Auchus RJ, Kumar AS, Boswell CA, Gupta MK, Bruce K, Rath NP, Covey DF. The enantiomer of progesterone (ent-progesterone) is a competitive inhibitor of human cytochromes P450c17 and P450c21 Archives of Biochemistry and Biophysics. 409: 134-144. PMID 12464252 DOI: 10.1016/S0003-9861(02)00491-5  0.52
2002 Sun X, Wuest M, Weisman GR, Wong EH, Reed DP, Boswell CA, Motekaitis R, Martell AE, Welch MJ, Anderson CJ. Radiolabeling and in vivo behavior of copper-64-labeled cross-bridged cyclam ligands. Journal of Medicinal Chemistry. 45: 469-77. PMID 11784151 DOI: 10.1021/jm0103817  0.52
2001 Lewis MR, Boswell CA, Laforest R, Buettner TL, Ye D, Connett JM, Anderson CJ. Conjugation of monoclonal antibodies with TETA using activated esters: biological comparison of 64Cu-TETA-1A3 with 64Cu-BAT-2IT-1A3. Cancer Biotherapy & Radiopharmaceuticals. 16: 483-94. PMID 11789025 DOI: 10.1089/10849780152752083  0.52
2001 Carter WB, Hoying JB, Boswell C, Williams SK. HER2/neu over-expression induces endothelial cell retraction. International Journal of Cancer. Journal International Du Cancer. 91: 295-9. PMID 11169950 DOI: 10.1002/1097-0215(200002)9999:9999<::AID-IJC1061>3.0.CO;2-Y  0.52
2000 Boswell C, Curvall M, Elswick R.K. J, Leyden D. Modelling nicotine intake in smokers and snuff users using biological fluid nicotine metabolites Biomarkers. 5: 341-354.  0.52
1999 Boswell CA, Noecker RJ, Mac M, Snyder RW, Williams SK. Evaluation of an aqueous drainage glaucoma device constructed of ePTFE. Journal of Biomedical Materials Research. 48: 591-5. PMID 10490671 DOI: 10.1002/(SICI)1097-4636(1999)48:5<591::AID-JBM1>3.0.CO;2-9  0.52
1999 Gentile AT, Mills JL, Westerband A, Gooden MA, Berman SS, Boswell CA, Williams SK. Characterization of cellular density and determination of neointimal extracellular matrix constituents in human lower extremity vein graft stenoses. Cardiovascular Surgery (London, England). 7: 464-9. PMID 10430532 DOI: 10.1016/S0967-2109(98)00093-3  0.52
1999 Boswell CA, Williams SK. Denucleation promotes neovascularization of ePTFE in vivo. Journal of Biomaterials Science. Polymer Edition. 10: 319-29. PMID 10189100  0.52
1999 Mac M, Snyder R, Boswell C. Expanded polytetrafluoroethylene makes an improved aqueous shunt Journal of Investigative Medicine. 47: 92A.  0.52
1996 Carter WB, Crowell SL, Boswell CA, Williams SK. Stimulation of angiogenesis by canine parathyroid tissue. Surgery. 120: 1089-94. PMID 8957500  0.52
1996 Hoying JB, Boswell CA, Williams SK. Angiogenic potential of microvessel fragments established in three-dimensional collagen gels. In Vitro Cellular & Developmental Biology. Animal. 32: 409-19. PMID 8856341  0.52
1996 Carter WB, Boswell CA, Crowell SL, Williams SK. Her-2/neu expression enhances endo1helial cell retraction, a mechanistic step in breast cancer cell transmigration Faseb Journal. 10: A758.  0.52
1996 Boswell CA, Williams SK. Angiostatin does not block angiogenesis in a novel in vitro 3-D angiogenesis model Faseb Journal. 10: A544.  0.52
1994 Doukas J, Cutler AH, Boswell CA, Joris I, Maino G. Reversible endothelial cell relaxation induced by oxygen and glucose deprivation. A model of ischemia in vitro. The American Journal of Pathology. 145: 211-9. PMID 8030750  0.52
1992 Boswell CA, Majno G, Joris I, Ostrom KA. Acute endothelial cell contraction in vitro: a comparison with vascular smooth muscle cells and fibroblasts. Microvascular Research. 43: 178-91. PMID 1584060 DOI: 10.1016/0026-2862(92)90015-H  0.52
1992 Boswell CA, Joris I, Majno G. The concept of cellular tone: reflections on the endothelium, fibroblasts, and smooth muscle cells. Perspectives in Biology and Medicine. 36: 79-86. PMID 1475161  0.52
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