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Richard Brust, Ph.D. - Publications

Affiliations: 
2013 Chemistry Stony Brook University, Stony Brook, NY, United States 
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20 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Shang J, Mosure SA, Zheng J, Brust R, Bass J, Nichols A, Solt LA, Griffin PR, Kojetin DJ. A molecular switch regulating transcriptional repression and activation of PPAR gamma. Nature Communications. 11: 956-956. DOI: 10.2210/Pdb6Oni/Pdb  0.304
2019 Mosure S, Shang J, Eberhardt J, Brust R, Zheng J, Griffin PR, Forli S, Kojetin DJ. Structural basis of altered potency and efficacy displayed by a major in vivo metabolite of the anti-diabetic PPARγ drug pioglitazone. Journal of Medicinal Chemistry. PMID 30676741 DOI: 10.1021/Acs.Jmedchem.8B01573  0.332
2018 Brust R, Shang J, Fuhrmann J, Mosure SA, Bass J, Cano A, Heidari Z, Chrisman IM, Nemetchek MD, Blayo AL, Griffin PR, Kamenecka TM, Hughes TS, Kojetin DJ. A structural mechanism for directing corepressor-selective inverse agonism of PPARγ. Nature Communications. 9: 4687. PMID 30409975 DOI: 10.1038/S41467-018-07133-W  0.329
2018 Zheng J, Corzo C, Chang MR, Shang J, Lam VQ, Brust R, Blayo AL, Bruning JB, Kamenecka TM, Kojetin DJ, Griffin PR. Chemical Crosslinking Mass Spectrometry Reveals the Conformational Landscape of the Activation Helix of PPARγ; a Model for Ligand-Dependent Antagonism. Structure (London, England : 1993). PMID 30146169 DOI: 10.1016/J.Str.2018.07.007  0.32
2017 Gil AA, Laptenok SP, Iuliano JN, Lukacs A, Verma A, Hall CR, Yoon E, Brust R, Greetham GM, Towrie M, French JB, Meech SR, Tonge PJ. Photoactivation of the BLUF protein PixD Probed by the Site-Specific Incorporation of Fluorotyrosine Residues. Journal of the American Chemical Society. PMID 28876066 DOI: 10.1021/Jacs.7B07849  0.715
2016 Hughes TS, Shang J, Brust R, de Vera IM, Fuhrmann J, Ruiz C, Cameron MD, Kamenecka TM, Kojetin DJ. Probing the Complex Binding Modes of the PPARγ Partial Agonist 2-chloro-N-(3-chloro-4-((5-chlorobenzo[d]thiazol-2-yl)thio)phenyl)-4-(trifluoromethyl)benzenesulfonamide (T2384) to Orthosteric and Allosteric Sites with NMR Spectroscopy. Journal of Medicinal Chemistry. PMID 27783520 DOI: 10.1021/Acs.Jmedchem.6B01340  0.301
2015 Gil AA, Haigney AL, Laptenok SP, Brust RJ, Lukacs A, Iuliano J, Jeng J, Melief E, Zhao RK, Yoon E, Clark IP, Towrie M, Greetham GM, Ng A, Truglio JJ, et al. The Mechanism of the AppABLUF Photocycle Probed by Site-Specific Incorporation of Fluorotyrosine Residues: The Effect of the Y21 pKa on the Forward and Reverse Ground State Reactions. Journal of the American Chemical Society. PMID 26708408 DOI: 10.1021/Jacs.5B11115  0.748
2015 Laptenok SP, Lukacs A, Gil A, Brust R, Sazanovich IV, Greetham GM, Tonge PJ, Meech SR. Complete Proton Transfer Cycle in GFP and Its T203V and S205V Mutants. Angewandte Chemie (International Ed. in English). 54: 9303-7. PMID 26087935 DOI: 10.1002/Anie.201503672  0.619
2015 Laptenok SP, Lukacs A, Brust R, Haigney A, Gil A, Towrie M, Greetham GM, Tonge PJ, Meech SR. Electron transfer quenching in light adapted and mutant forms of the AppA BLUF domain. Faraday Discussions. 177: 293-311. PMID 25633480 DOI: 10.1039/C4Fd00189C  0.823
2014 Brust R, Haigney A, Lukacs A, Gil A, Hossain S, Addison K, Lai CT, Towrie M, Greetham GM, Clark IP, Illarionov B, Bacher A, Kim RR, Fischer M, Simmerling C, et al. Ultrafast Structural Dynamics of BlsA, a Photoreceptor from the Pathogenic Bacterium Acinetobacter baumannii. The Journal of Physical Chemistry Letters. 5: 220-224. PMID 24723998 DOI: 10.1021/Jz4023738  0.798
2014 Lukacs A, Brust R, Haigney A, Laptenok SP, Addison K, Gil A, Towrie M, Greetham GM, Tonge PJ, Meech SR. BLUF domain function does not require a metastable radical intermediate state. Journal of the American Chemical Society. 136: 4605-15. PMID 24579721 DOI: 10.1021/Ja4121082  0.809
2013 Brust R, Lukacs A, Haigney A, Addison K, Gil A, Towrie M, Clark IP, Greetham GM, Tonge PJ, Meech SR. Proteins in action: femtosecond to millisecond structural dynamics of a photoactive flavoprotein. Journal of the American Chemical Society. 135: 16168-74. PMID 24083781 DOI: 10.1021/Ja407265P  0.79
2013 Lukacs A, Haigney A, Brust R, Addison K, Towrie M, Greetham GM, Jones GA, Miyawaki A, Tonge PJ, Meech SR. Protein photochromism observed by ultrafast vibrational spectroscopy. The Journal of Physical Chemistry. B. 117: 11954-9. PMID 24033093 DOI: 10.1021/Jp406142G  0.811
2013 Lukacs A, Haigney A, Brust R, Zhao R, Greetham G, Towrie M, Tonge PJ, Meech SR. Transient IR study of blue light sensing proteins Epj Web of Conferences. 41. DOI: 10.1051/epjconf/20134107009  0.778
2012 Haigney A, Lukacs A, Brust R, Zhao RK, Towrie M, Greetham GM, Clark I, Illarionov B, Bacher A, Kim RR, Fischer M, Meech SR, Tonge PJ. Vibrational assignment of the ultrafast infrared spectrum of the photoactivatable flavoprotein AppA. The Journal of Physical Chemistry. B. 116: 10722-9. PMID 22871066 DOI: 10.1021/Jp305220M  0.83
2012 Lukacs A, Zhao RK, Haigney A, Brust R, Greetham GM, Towrie M, Tonge PJ, Meech SR. Excited state structure and dynamics of the neutral and anionic flavin radical revealed by ultrafast transient mid-IR to visible spectroscopy. The Journal of Physical Chemistry. B. 116: 5810-8. PMID 22515837 DOI: 10.1021/Jp2116559  0.815
2011 Lukacs A, Haigney A, Brust R, Zhao RK, Stelling AL, Clark IP, Towrie M, Greetham GM, Meech SR, Tonge PJ. Photoexcitation of the blue light using FAD photoreceptor AppA results in ultrafast changes to the protein matrix. Journal of the American Chemical Society. 133: 16893-900. PMID 21899315 DOI: 10.1021/Ja2060098  0.788
2011 Zhao RK, Lukacs A, Haigney A, Brust R, Greetham GM, Towrie M, Tonge PJ, Meech SR. Ultrafast transient mid IR to visible spectroscopy of fully reduced flavins. Physical Chemistry Chemical Physics : Pccp. 13: 17642-8. PMID 21887430 DOI: 10.1039/C1Cp22097G  0.809
2011 Haigney A, Lukacs A, Zhao RK, Stelling AL, Brust R, Kim RR, Kondo M, Clark I, Towrie M, Greetham GM, Illarionov B, Bacher A, Römisch-Margl W, Fischer M, Meech SR, et al. Ultrafast infrared spectroscopy of an isotope-labeled photoactivatable flavoprotein Biochemistry. 50: 1321-1328. PMID 21218799 DOI: 10.1021/Bi101589A  0.805
2010 Lukacs A, Haigney A, Kondo M, Brust R, Gretham G, Towrie M, Tonge PJ, TongeMeech SR. Ultrafast dynamics of the BLUF mutant dAppA Q63E revealed by TRIR and fluorescent upconversion Optics Infobase Conference Papers.  0.796
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