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Jean-Paul Desaulniers, Ph.D. - Publications

Affiliations: 
2005 Wayne State University, Detroit, MI, United States 
Area:
Biochemistry, Molecular Biology
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28 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Varley A, Desaulniers JP. Synthesis of 5'-fluorophosphate-modified short-interfering RNAs. Nucleosides, Nucleotides & Nucleic Acids. 1-13. PMID 36408961 DOI: 10.1080/15257770.2022.2148693  0.326
2021 Varley AJ, Desaulniers JP. Chemical strategies for strand selection in short-interfering RNAs. Rsc Advances. 11: 2415-2426. PMID 35424193 DOI: 10.1039/d0ra07747j  0.304
2021 Hammill ML, Salim L, Tsubaki K, Varley AJ, Kitamura M, Okauchi T, Desaulniers JP. Building siRNAs with cubes: synthesis and evaluation of cubane-modified siRNAs. Chembiochem : a European Journal of Chemical Biology. PMID 34319643 DOI: 10.1002/cbic.202100334  0.367
2020 Tsubaki K, Hammill ML, Varley AJ, Kitamura M, Okauchi T, Desaulniers JP. Synthesis and Evaluation of Neutral Phosphate Triester Backbone-Modified siRNAs. Acs Medicinal Chemistry Letters. 11: 1457-1462. PMID 32676154 DOI: 10.1021/Acsmedchemlett.0C00232  0.43
2020 Hammill ML, Desaulniers JP. Synthesis of Azobenzene Derivative Phosphoramidites for Incorporation into Oligonucleotides. Current Protocols in Nucleic Acid Chemistry. 81: e107. PMID 32383810 DOI: 10.1002/Cpnc.107  0.338
2020 Hammill ML, Islam G, Desaulniers JP. Synthesis, derivatization and photochemical control of ortho-functionalized tetrachlorinated azoben---zene-modified siRNAs. Chembiochem : a European Journal of Chemical Biology. PMID 32232952 DOI: 10.1002/Cbic.202000188  0.308
2020 Varley AJ, Hammill ML, Salim L, Desaulniers JP. Effects of Chemical Modifications on siRNA Strand Selection in Mammalian Cells. Nucleic Acid Therapeutics. PMID 32175808 DOI: 10.1089/Nat.2020.0848  0.446
2019 Hammill ML, Islam G, Desaulniers JP. Reversible control of RNA interference by siRNAzos. Organic & Biomolecular Chemistry. PMID 31793617 DOI: 10.1039/C9Ob02509J  0.368
2018 Hammill ML, Patel A, Alla MA, Desaulniers JP. Stability and evaluation of siRNAs labeled at the sense strand with a 3'-azobenzene unit. Bioorganic & Medicinal Chemistry Letters. PMID 30389291 DOI: 10.1016/J.Bmcl.2018.10.044  0.349
2018 Salim L, McKim C, Desaulniers J. Effective carrier-free gene-silencing activity of cholesterol-modified siRNAs Rsc Advances. 8: 22963-22966. DOI: 10.1039/C8Ra03908A  0.403
2017 Desaulniers J, Hagen G, Anderson J, McKim C, Roberts B. Effective gene-silencing of siRNAs that contain functionalized spacer linkages within the central region Rsc Advances. 7: 3450-3454. DOI: 10.1039/C6Ra27701B  0.424
2015 Peel BJ, Hagen G, Krishnamurthy K, Desaulniers JP. Conjugation and Evaluation of Small Hydrophobic Molecules to Triazole-Linked siRNAs. Acs Medicinal Chemistry Letters. 6: 117-22. PMID 25699137 DOI: 10.1021/Ml500260J  0.412
2015 Hagen G, Peel BJ, Samis J, Desaulniers JP. Synthesis and in vitro assessment of chemically modified siRNAs targeting BCL2 that contain 2′-ribose and triazole-linked backbone modifications Medchemcomm. 6: 1210-1215. DOI: 10.1039/C5Md00147A  0.444
2014 Peel BJ, Efthymiou TC, Desaulniers JP. Synthesis of triazole-nucleoside phosphoramidites and their use in solid-phase oligonucleotide synthesis. Current Protocols in Nucleic Acid Chemistry / Edited by Serge L. Beaucage ... [Et Al.]. 55: 4.57.1-4.57.38. PMID 25631534 DOI: 10.1002/0471142700.Nc0457S55  0.316
2012 Efthymiou T, Gong W, Desaulniers JP. Chemical architecture and applications of nucleic acid derivatives containing 1,2,3-triazole functionalities synthesized via click chemistry. Molecules (Basel, Switzerland). 17: 12665-703. PMID 23103533 DOI: 10.3390/Molecules171112665  0.326
2012 Gong W, Desaulniers JP. Gene-silencing properties of siRNAs that contain internal amide-bond linkages. Bioorganic & Medicinal Chemistry Letters. 22: 6934-7. PMID 23062704 DOI: 10.1016/J.Bmcl.2012.09.009  0.465
2012 Efthymiou TC, Peel B, Huynh V, Desaulniers JP. Evaluation of siRNAs that contain internal variable-length spacer linkages. Bioorganic & Medicinal Chemistry Letters. 22: 5590-4. PMID 22850216 DOI: 10.1016/J.Bmcl.2012.07.006  0.422
2012 Gong W, Desaulniers JP. Synthesis and properties of RNAs that contain a PNA-RNA dimer. Nucleosides, Nucleotides & Nucleic Acids. 31: 389-400. PMID 22497254 DOI: 10.1080/15257770.2012.666609  0.45
2012 Efthymiou TC, Huynh V, Oentoro J, Peel B, Desaulniers JP. Efficient synthesis and cell-based silencing activity of siRNAS that contain triazole backbone linkages. Bioorganic & Medicinal Chemistry Letters. 22: 1722-6. PMID 22260772 DOI: 10.1016/J.Bmcl.2011.12.104  0.374
2011 Efthymiou TC, Desaulniers JP. Synthesis and properties of oligonucleotides that contain a triazole-linked nucleic acid dimer Journal of Heterocyclic Chemistry. 48: 533-539. DOI: 10.1002/Jhet.532  0.417
2008 Desaulniers JP, Chang YC, Aduri R, Abeysirigunawardena SC, SantaLucia J, Chow CS. Pseudouridines in rRNA helix 69 play a role in loop stacking interactions. Organic & Biomolecular Chemistry. 6: 3892-5. PMID 18931791 DOI: 10.1039/B812731J  0.641
2005 Desaulniers JP, Chui HM, Chow CS. Solution conformations of two naturally occurring RNA nucleosides: 3-methyluridine and 3-methylpseudouridine. Bioorganic & Medicinal Chemistry. 13: 6777-81. PMID 16125393 DOI: 10.1016/J.Bmc.2005.07.061  0.526
2005 Sumita M, Desaulniers JP, Chang YC, Chui HM, Clos L, Chow CS. Effects of nucleotide substitution and modification on the stability and structure of helix 69 from 28S rRNA. Rna (New York, N.Y.). 11: 1420-9. PMID 16120833 DOI: 10.1261/Rna.2320605  0.688
2005 Hamdy N, Goustin AS, Desaulniers JP, Li M, Chow CS, Al-Katib A. Sheep red blood cells armed with anti-CD20 single-chain variable fragments (scFvs) fused to a glycosylphosphatidylinositol (GPI) anchor: a strategy to target CD20-positive tumor cells. Journal of Immunological Methods. 297: 109-24. PMID 15777935 DOI: 10.1016/J.Jim.2004.12.003  0.461
2005 Esho N, Desaulniers JP, Davies B, Chui HM, Rao MS, Chow CS, Szafert S, Dembinski R. NMR conformational analysis of p-tolyl furanopyrimidine 2'-deoxyribonucleoside and crystal structure of its 3',5'-di-O-acetyl derivative. Bioorganic & Medicinal Chemistry. 13: 1231-8. PMID 15670932 DOI: 10.1016/J.Bmc.2004.11.013  0.51
2003 Desaulniers JP, Ksebati B, Chow CS. Synthesis of 15N-enriched pseudouridine derivatives. Organic Letters. 5: 4093-6. PMID 14572257 DOI: 10.1021/Ol035496E  0.525
2003 Chui HM, Desaulniers J, Scaringe SA, Chow CS. Synthesis of Helix 69 of Escherichia coli 23S rRNA Containing Its Natural Modified Nucleosides, m3Ψ and Ψ. Cheminform. 34. DOI: 10.1002/chin.200315205  0.552
2002 Chui HM, Desaulniers JP, Scaringe SA, Chow CS. Synthesis of helix 69 of Escherichia coli 23S rRNA containing its natural modified nucleosides, m(3)Psi and Psi. The Journal of Organic Chemistry. 67: 8847-54. PMID 12467398 DOI: 10.1021/Jo026364M  0.626
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