Christiaan Leeuwenburgh - Publications

University of Florida, Gainesville, Gainesville, FL, United States 
Animal Physiology Biology, Biochemistry

214 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Picca A, Saini SK, Mankowski RT, Kamenov G, Anton SD, Manini TM, Buford TW, Wohlgemuth SE, Xiao R, Calvani R, Coelho-Júnior HJ, Landi F, Bernabei R, Hood DA, Marzetti E, ... Leeuwenburgh C, et al. Altered Expression of Mitoferrin and Frataxin, Larger Labile Iron Pool and Greater Mitochondrial DNA Damage in the Skeletal Muscle of Older Adults. Cells. 9. PMID 33276460 DOI: 10.3390/cells9122579  0.32
2020 Saini SK, McDermott MM, Picca A, Li L, Wohlgemuth SE, Kosmac K, Peterson CA, Tian L, Ferrucci L, Guralnik JM, Sufit RL, Leeuwenburgh C. Mitochondrial DNA damage in calf skeletal muscle and walking performance in people with peripheral artery disease. Free Radical Biology & Medicine. PMID 32911084 DOI: 10.1016/j.freeradbiomed.2020.09.004  0.32
2020 Giovannini S, Carter CS, Leeuwenburgh C, Flex A, Biscetti F, Morgan D, Laudisio A, Coraci D, Maccauro G, Zuccalà G, Caliandro P, Bernabei R, Marzetti E. Effects of aging and life-long moderate calorie restriction on IL-15 signaling in the rat white adipose tissue. European Review For Medical and Pharmacological Sciences. 24: 2738-2749. PMID 32196625 DOI: 10.26355/eurrev_202003_20547  0.32
2019 Picca A, Mankowski RT, Kamenov G, Anton SD, Manini TM, Buford TW, Saini SK, Calvani R, Landi F, Bernabei R, Marzetti E, Leeuwenburgh C. Advanced Age Is Associated with Iron Dyshomeostasis and Mitochondrial DNA Damage in Human Skeletal Muscle. Cells. 8. PMID 31783583 DOI: 10.3390/cells8121525  0.32
2019 Stortz JA, Hollen MK, Nacionales DC, Horiguchi H, Ungaro R, Dirain ML, Wang Z, Wu Q, Wu KK, Kumar A, Foster TC, Stewart BD, Ross JA, Segal M, Bihorac A, ... ... Leeuwenburgh C, et al. Old Mice Demonstrate Organ Dysfunction as well as Prolonged Inflammation, Immunosuppression, and Weight Loss in a Modified Surgical Sepsis Model. Critical Care Medicine. PMID 31389840 DOI: 10.1097/CCM.0000000000003926  0.32
2019 Chimienti G, Picca A, Fracasso F, Marzetti E, Calvani R, Leeuwenburgh C, Russo F, Lezza AMS, Pesce V. Differences in Liver TFAM Binding to mtDNA and mtDNA Damage between Aged and Extremely Aged Rats. International Journal of Molecular Sciences. 20. PMID 31137890 DOI: 10.3390/ijms20102601  0.32
2019 Picca A, Calvani R, Leeuwenburgh C, Coelho-Junior HJ, Bernabei R, Landi F, Marzetti E. Targeting mitochondrial quality control for treating sarcopenia: lessons from physical exercise. Expert Opinion On Therapeutic Targets. 23: 153-160. PMID 30580640 DOI: 10.1080/14728222.2019.1559827  0.32
2018 Picca A, Sirago G, Pesce V, Lezza AMS, Calvani R, Bossola M, Villani ER, Landi F, Leeuwenburgh C, Bernabei R, Carter CS, Marzetti E. Administration of Enalapril Started Late in Life Attenuates Hypertrophy and Oxidative Stress Burden, Increases Mitochondrial Mass, and Modulates Mitochondrial Quality Control Signaling in the Rat Heart. Biomolecules. 8. PMID 30563025 DOI: 10.3390/biom8040177  0.32
2018 Picca A, Mankowski RT, Burman JL, Donisi L, Kim JS, Marzetti E, Leeuwenburgh C. Mitochondrial quality control mechanisms as molecular targets in cardiac ageing. Nature Reviews. Cardiology. PMID 30042431 DOI: 10.1038/s41569-018-0059-z  0.32
2018 Chimienti G, Picca A, Sirago G, Fracasso F, Calvani R, Bernabei R, Russo F, Carter CS, Leeuwenburgh C, Pesce V, Marzetti E, Lezza AMS. Increased TFAM binding to mtDNA damage hot spots is associated with mtDNA loss in aged rat heart. Free Radical Biology & Medicine. PMID 29969715 DOI: 10.1016/j.freeradbiomed.2018.06.041  0.32
2018 Calvani R, Picca A, Marini F, Biancolillo A, Cesari M, Pesce V, Lezza AMS, Bossola M, Leeuwenburgh C, Bernabei R, Landi F, Marzetti E. The "BIOmarkers associated with Sarcopenia and PHysical frailty in EldeRly pErsons" (BIOSPHERE) study: Rationale, design and methods. European Journal of Internal Medicine. PMID 29753582 DOI: 10.1016/j.ejim.2018.05.001  0.32
2017 Picca A, Lezza AMS, Leeuwenburgh C, Pesce V, Calvani R, Bossola M, Manes-Gravina E, Landi F, Bernabei R, Marzetti E. Circulating mitochondrial DNA at the crossroads of mitochondrial dysfunction and inflammation during aging and muscle wasting disorders. Rejuvenation Research. PMID 29125070 DOI: 10.1089/rej.2017.1989  0.32
2017 Picca A, Lezza AMS, Leeuwenburgh C, Pesce V, Calvani R, Landi F, Bernabei R, Marzetti E. Fueling Inflamm-Aging through Mitochondrial Dysfunction: Mechanisms and Molecular Targets. International Journal of Molecular Sciences. 18. PMID 28452964 DOI: 10.3390/ijms18050933  0.32
2016 Calvani R, Marini F, Cesari M, Buford TW, Manini TM, Pahor M, Leeuwenburgh C, Bernabei R, Landi F, Marzetti E. Systemic inflammation, body composition, and physical performance in old community-dwellers. Journal of Cachexia, Sarcopenia and Muscle. PMID 27897412 DOI: 10.1002/jcsm.12134  0.32
2016 Marzetti E, D'Angelo E, Savera G, Leeuwenburgh C, Calvani R. Integrated control of brown adipose tissue. Heart and Metabolism : Management of the Coronary Patient. 69: 9-14. PMID 27524955  0.32
2016 Flores-Toro JA, Go KL, Leeuwenburgh C, Kim JS. Autophagy in the liver: cell's cannibalism and beyond. Archives of Pharmacal Research. PMID 27515049 DOI: 10.1007/s12272-016-0807-8  1
2016 Marzetti E, D'Angelo E, Savera G, Leeuwenburgh C, Calvani R. Integrated control of brown adipose tissue Heart and Metabolism. 9-14.  0.32
2015 Seo AY, Leeuwenburgh C. The Role of Genome Instability in Frailty: Mitochondria versus Nucleus. Nestlé Nutrition Institute Workshop Series. 83: 19-27. PMID 26524430 DOI: 10.1159/000382055  0.4
2015 Anton SD, Woods AJ, Ashizawa T, Barb D, Buford TW, Carter CS, Clark DJ, Cohen RA, Corbett DB, Cruz-Almeida Y, Dotson V, Ebner N, Efron PA, Fillingim RB, Foster TC, ... ... Leeuwenburgh C, et al. Successful aging: Advancing the science of physical independence in older adults. Ageing Research Reviews. PMID 26462882 DOI: 10.1016/j.arr.2015.09.005  1
2015 Wallet MA, Buford TW, Joseph AM, Sankuratri M, Leeuwenburgh C, Pahor M, Manini T, Sleasman JW, Goodenow MM. Increased inflammation but similar physical composition and function in older-aged, HIV-1 infected subjects. Bmc Immunology. 16: 43. PMID 26204934 DOI: 10.1186/s12865-015-0106-z  1
2015 Vanzant EL, Hilton RE, Lopez CM, Zhang J, Ungaro RF, Gentile LF, Szpila BE, Maier RV, Cuschieri J, Bihorac A, Leeuwenburgh C, Moore FA, Baker HV, Moldawer LL, Brakenridge SC, et al. Advanced age is associated with worsened outcomes and a unique genomic response in severely injured patients with hemorrhagic shock. Critical Care (London, England). 19: 77. PMID 25880307 DOI: 10.1186/s13054-015-0788-x  1
2015 Mankowski RT, Anton SD, Buford TW, Leeuwenburgh C. Dietary Antioxidants as Modifiers of Physiologic Adaptations to Exercise. Medicine and Science in Sports and Exercise. 47: 1857-68. PMID 25606815 DOI: 10.1249/MSS.0000000000000620  1
2015 Wegman MP, Guo MH, Bennion DM, Shankar MN, Chrzanowski SM, Goldberg LA, Xu J, Williams TA, Lu X, Hsu SI, Anton SD, Leeuwenburgh C, Brantly ML. Practicality of intermittent fasting in humans and its effect on oxidative stress and genes related to aging and metabolism. Rejuvenation Research. 18: 162-72. PMID 25546413 DOI: 10.1089/rej.2014.1624  1
2015 Aris JP, Fishwick LK, Marraffini ML, Seo AY, Leeuwenburgh C, Dunn WA. Amino acid homeostasis and chronological longevity in Saccharomyces cerevisiae Sub-Cellular Biochemistry. 57: 161-186. PMID 22094422 DOI: 10.1007/978-94-007-2561-4_8  1
2015 Seo AY, Leeuwenburgh C. The Role of Genome Instability in Frailty: Mitochondria versus Nucleus Nestle Nutrition Institute Workshop Series. 83: 19-27. DOI: 10.1159/000382055  0.4
2015 Elabed K, Trabelsi K, Ghlissi Z, Stannard SR, Leeuwenburgh C, Jamoussi K, Sahnoun Z, Zeghal KM, Hakim A. Effect of resistance training during the month of Ramadan on antioxidants and oxidative stress biomarkers in recreational bodybuilders Biological Rhythm Research. 46: 459-470. DOI: 10.1080/09291016.2015.1015232  1
2014 Marzetti E, Landi F, Marini F, Cesari M, Buford TW, Manini TM, Onder G, Pahor M, Bernabei R, Leeuwenburgh C, Calvani R. Patterns of circulating inflammatory biomarkers in older persons with varying levels of physical performance: a partial least squares-discriminant analysis approach. Frontiers in Medicine. 1: 27. PMID 25593902 DOI: 10.3389/fmed.2014.00027  0.32
2014 Calvani R, Leeuwenburgh C, Marzetti E. Brown adipose tissue and the cold war against obesity. Diabetes. 63: 3998-4000. PMID 25414014 DOI: 10.2337/db14-1373  0.32
2014 Ahn B, Beaver T, Martin T, Hess P, Brumback BA, Ahmed S, Smith BK, Leeuwenburgh C, Martin AD, Ferreira LF. Phrenic nerve stimulation increases human diaphragm fiber force after cardiothoracic surgery. American Journal of Respiratory and Critical Care Medicine. 190: 837-9. PMID 25271750 DOI: 10.1164/rccm.201405-0993LE  1
2014 Martin D, Leeuwenburgh C, Beaver T, Smith B. The authors reply Critical Care Medicine. 42. PMID 25126819 DOI: 10.1097/CCM.0000000000000482  1
2014 Dutta D, Dutta D, Xu J, Dirain ML, Leeuwenburgh C. Calorie restriction combined with resveratrol induces autophagy and protects 26-month-old rat hearts from doxorubicin-induced toxicity. Free Radical Biology & Medicine. 74: 252-62. PMID 24975655 DOI: 10.1016/j.freeradbiomed.2014.06.011  1
2014 Anton SD, Embry C, Marsiske M, Lu X, Doss H, Leeuwenburgh C, Manini TM. Safety and metabolic outcomes of resveratrol supplementation in older adults: results of a twelve-week, placebo-controlled pilot study. Experimental Gerontology. 57: 181-7. PMID 24866496 DOI: 10.1016/j.exger.2014.05.015  1
2014 Gentile LF, Nacionales DC, Lopez MC, Vanzant E, Cuenca A, Szpila BE, Cuenca AG, Joseph A, Moore FA, Leeuwenburgh C, Baker HV, Moldawer LL, Efron PA. Host responses to sepsis vary in different low-lethality murine models. Plos One. 9: e94404. PMID 24788351 DOI: 10.1371/journal.pone.0094404  1
2014 Picca A, Pesce V, Fracasso F, Joseph AM, Leeuwenburgh C, Lezza AM. A comparison among the tissue-specific effects of aging and calorie restriction on TFAM amount and TFAM-binding activity to mtDNA in rat. Biochimica Et Biophysica Acta. 1840: 2184-91. PMID 24631828 DOI: 10.1016/j.bbagen.2014.03.004  1
2014 Gentile LF, Nacionales DC, Lopez MC, Vanzant E, Cuenca A, Cuenca AG, Ungaro R, Szpila BE, Larson S, Joseph A, Moore FA, Leeuwenburgh C, Baker HV, Moldawer LL, Efron PA. Protective immunity and defects in the neonatal and elderly immune response to sepsis. Journal of Immunology (Baltimore, Md. : 1950). 192: 3156-65. PMID 24591376 DOI: 10.4049/jimmunol.1301726  1
2014 Vanzant EL, Lopez CM, Ozrazgat-Baslanti T, Ungaro R, Davis R, Cuenca AG, Gentile LF, Nacionales DC, Cuenca AL, Bihorac A, Leeuwenburgh C, Lanz J, Baker HV, McKinley B, Moldawer LL, et al. Persistent inflammation, immunosuppression, and catabolism syndrome after severe blunt trauma. The Journal of Trauma and Acute Care Surgery. 76: 21-9; discussion 29-. PMID 24368353 DOI: 10.1097/TA.0b013e3182ab1ab5  1
2014 Nacionales DC, Gentile LF, Vanzant E, Lopez MC, Cuenca A, Cuenca AG, Ungaro R, Li Y, Baslanti TO, Bihorac A, Moore FA, Baker HV, Leeuwenburgh C, Moldawer LL, Efron PA. Aged mice are unable to mount an effective myeloid response to sepsis. Journal of Immunology (Baltimore, Md. : 1950). 192: 612-22. PMID 24337739 DOI: 10.4049/jimmunol.1302109  1
2014 Martin AD, Joseph AM, Beaver TM, Smith BK, Martin TD, Berg K, Hess PJ, Deoghare HV, Leeuwenburgh C. Effect of intermittent phrenic nerve stimulation during cardiothoracic surgery on mitochondrial respiration in the human diaphragm. Critical Care Medicine. 42: e152-6. PMID 24126442 DOI: 10.1097/CCM.0b013e3182a63fdf  1
2014 Buford TW, MacNeil RG, Clough LG, Dirain M, Sandesara B, Pahor M, Manini TM, Leeuwenburgh C. Active muscle regeneration following eccentric contraction-induced injury is similar between healthy young and older adults. Journal of Applied Physiology (Bethesda, Md. : 1985). 116: 1481-90. PMID 23493365 DOI: 10.1152/japplphysiol.01350.2012  1
2014 Marzetti E, Bernabei R, Lorenzi M, Leeuwenburgh C, Calvani R. Role of Impaired Mitochondrial Autophagy in Cardiac Aging: Mechanisms and Therapeutic Implications Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging. 4: 253-265. DOI: 10.1016/B978-0-12-405528-5.00017-1  0.32
2013 Calvani R, Miccheli A, Landi F, Bossola M, Cesari M, Leeuwenburgh C, Sieber CC, Bernabei R, Marzetti E. Current nutritional recommendations and novel dietary strategies to manage sarcopenia. The Journal of Frailty & Aging. 2: 38-53. PMID 26082911  0.32
2013 Picca A, Pesce V, Fracasso F, Joseph AM, Leeuwenburgh C, Lezza AM. Aging and calorie restriction oppositely affect mitochondrial biogenesis through TFAM binding at both origins of mitochondrial DNA replication in rat liver. Plos One. 8: e74644. PMID 24058615 DOI: 10.1371/journal.pone.0074644  1
2013 Joseph AM, Adhihetty PJ, Wawrzyniak NR, Wohlgemuth SE, Picca A, Kujoth GC, Prolla TA, Leeuwenburgh C. Dysregulation of mitochondrial quality control processes contribute to sarcopenia in a mouse model of premature aging. Plos One. 8: e69327. PMID 23935986 DOI: 10.1371/journal.pone.0069327  1
2013 Marzetti E, Calvani R, Cesari M, Buford TW, Lorenzi M, Behnke BJ, Leeuwenburgh C. Mitochondrial dysfunction and sarcopenia of aging: from signaling pathways to clinical trials. The International Journal of Biochemistry & Cell Biology. 45: 2288-301. PMID 23845738 DOI: 10.1016/j.biocel.2013.06.024  1
2013 Marzetti E, Csiszar A, Dutta D, Balagopal G, Calvani R, Leeuwenburgh C. Role of mitochondrial dysfunction and altered autophagy in cardiovascular aging and disease: From mechanisms to therapeutics American Journal of Physiology - Heart and Circulatory Physiology. 305. PMID 23748424 DOI: 10.1152/ajpheart.00936.2012  1
2013 Joseph AM, Malamo AG, Silvestre J, Wawrzyniak N, Carey-Love S, Nguyen LM, Dutta D, Xu J, Leeuwenburgh C, Adhihetty PJ. Short-term caloric restriction, resveratrol, or combined treatment regimens initiated in late-life alter mitochondrial protein expression profiles in a fiber-type specific manner in aged animals. Experimental Gerontology. 48: 858-68. PMID 23747682 DOI: 10.1016/j.exger.2013.05.061  1
2013 Anton S, Leeuwenburgh C. Fasting or caloric restriction for healthy aging. Experimental Gerontology. 48: 1003-5. PMID 23639403 DOI: 10.1016/j.exger.2013.04.011  1
2013 Fletcher QE, Selman C, Boutin S, McAdam AG, Woods SB, Seo AY, Leeuwenburgh C, Speakman JR, Humphries MM. Oxidative damage increases with reproductive energy expenditure and is reduced by food-supplementation. Evolution; International Journal of Organic Evolution. 67: 1527-36. PMID 23617928 DOI: 10.1111/evo.12014  1
2013 Aris JP, Alvers AL, Ferraiuolo RA, Fishwick LK, Hanvivatpong A, Hu D, Kirlew C, Leonard MT, Losin KJ, Marraffini M, Seo AY, Swanberg V, Westcott JL, Wood MS, Leeuwenburgh C, et al. Autophagy and leucine promote chronological longevity and respiration proficiency during calorie restriction in yeast. Experimental Gerontology. 48: 1107-19. PMID 23337777 DOI: 10.1016/j.exger.2013.01.006  1
2013 Dutta D, Xu J, Kim JS, Dunn WA, Leeuwenburgh C. Upregulated autophagy protects cardiomyocytes from oxidative stress-induced toxicity. Autophagy. 9: 328-44. PMID 23298947 DOI: 10.4161/auto.22971  1
2013 Dannecker EA, Liu Y, Rector RS, Thomas TR, Sayers SP, Leeuwenburgh C, Ray BK. The effect of fasting on indicators of muscle damage. Experimental Gerontology. 48: 1101-6. PMID 23266375 DOI: 10.1016/j.exger.2012.12.006  1
2013 Calvani R, Joseph AM, Adhihetty PJ, Miccheli A, Bossola M, Leeuwenburgh C, Bernabei R, Marzetti E. Mitochondrial pathways in sarcopenia of aging and disuse muscle atrophy. Biological Chemistry. 394: 393-414. PMID 23154422 DOI: 10.1515/hsz-2012-0247  1
2013 Coen PM, Jubrias SA, Distefano G, Amati F, Mackey DC, Glynn NW, Manini TM, Wohlgemuth SE, Leeuwenburgh C, Cummings SR, Newman AB, Ferrucci L, Toledo FG, Shankland E, Conley KE, et al. Skeletal muscle mitochondrial energetics are associated with maximal aerobic capacity and walking speed in older adults. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 68: 447-55. PMID 23051977 DOI: 10.1093/gerona/gls196  1
2013 Picca A, Fracasso F, Pesce V, Cantatore P, Joseph AM, Leeuwenburgh C, Gadaleta MN, Lezza AM. Age- and calorie restriction-related changes in rat brain mitochondrial DNA and TFAM binding. Age (Dordrecht, Netherlands). 35: 1607-20. PMID 22945739 DOI: 10.1007/s11357-012-9465-z  1
2012 Chmielewski TL, Trumble TN, Joseph AM, Shuster J, Indelicato PA, Moser MW, Cicuttini FM, Leeuwenburgh C. Urinary CTX-II concentrations are elevated and associated with knee pain and function in subjects with ACL reconstruction. Osteoarthritis and Cartilage / Oars, Osteoarthritis Research Society. 20: 1294-301. PMID 22863613 DOI: 10.1016/j.joca.2012.07.014  1
2012 Joseph AM, Adhihetty PJ, Buford TW, Wohlgemuth SE, Lees HA, Nguyen LM, Aranda JM, Sandesara BD, Pahor M, Manini TM, Marzetti E, Leeuwenburgh C. The impact of aging on mitochondrial function and biogenesis pathways in skeletal muscle of sedentary high- and low-functioning elderly individuals. Aging Cell. 11: 801-9. PMID 22681576 DOI: 10.1111/j.1474-9726.2012.00844.x  1
2012 Dutta D, Calvani R, Bernabei R, Leeuwenburgh C, Marzetti E. Contribution of impaired mitochondrial autophagy to cardiac aging: Mechanisms and therapeutic opportunities Circulation Research. 110: 1125-1138. PMID 22499902 DOI: 10.1161/CIRCRESAHA.111.246108  1
2012 Xu J, Jia Z, Knutson MD, Leeuwenburgh C. Impaired iron status in aging research. International Journal of Molecular Sciences. 13: 2368-86. PMID 22408459 DOI: 10.3390/ijms13022368  1
2012 Marzetti E, Lees HA, Manini TM, Buford TW, Aranda JM, Calvani R, Capuani G, Marsiske M, Lott DJ, Vandenborne K, Bernabei R, Pahor M, Leeuwenburgh C, Wohlgemuth SE. Skeletal muscle apoptotic signaling predicts thigh muscle volume and gait speed in community-dwelling older persons: an exploratory study. Plos One. 7: e32829. PMID 22389725 DOI: 10.1371/journal.pone.0032829  1
2012 Sibille KT, Langaee T, Burkley B, Gong Y, Glover TL, King C, Riley JL, Leeuwenburgh C, Staud R, Bradley LA, Fillingim RB. Chronic pain, perceived stress, and cellular aging: an exploratory study. Molecular Pain. 8: 12. PMID 22325162 DOI: 10.1186/1744-8069-8-12  1
2012 Wang JH, Behrns KE, Leeuwenburgh C, Kim JS. Critical role of autophagy in ischemia/reperfusion injury to aged livers Autophagy. 8: 140-141. PMID 22170150 DOI: 10.4161/auto.8.1.18391  1
2012 Xu J, Hwang JC, Lees HA, Wohlgemuth SE, Knutson MD, Judge AR, Dupont-Versteegden EE, Marzetti E, Leeuwenburgh C. Long-term perturbation of muscle iron homeostasis following hindlimb suspension in old rats is associated with high levels of oxidative stress and impaired recovery from atrophy. Experimental Gerontology. 47: 100-8. PMID 22085543 DOI: 10.1016/j.exger.2011.10.011  1
2012 Buford TW, Lott DJ, Marzetti E, Wohlgemuth SE, Vandenborne K, Pahor M, Leeuwenburgh C, Manini TM. Age-related differences in lower extremity tissue compartments and associations with physical function in older adults. Experimental Gerontology. 47: 38-44. PMID 22015325 DOI: 10.1016/j.exger.2011.10.001  1
2012 Muller-Delp JM, Gurovich AN, Christou DD, Leeuwenburgh C. Redox balance in the aging microcirculation: new friends, new foes, and new clinical directions. Microcirculation (New York, N.Y. : 1994). 19: 19-28. PMID 21954960 DOI: 10.1111/j.1549-8719.2011.00139.x  1
2012 Marzetti E, Calvani R, Bernabei R, Leeuwenburgh C. Apoptosis in skeletal myocytes: A potential target for interventions against sarcopenia and physical frailty - A mini-review Gerontology. 58: 99-106. PMID 21952604 DOI: 10.1159/000330064  1
2012 Carter CS, Marzetti E, Leeuwenburgh C, Manini T, Foster TC, Groban L, Scarpace PJ, Morgan D. Usefulness of preclinical models for assessing the efficacy of late-life interventions for sarcopenia. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 67: 17-27. PMID 21636833 DOI: 10.1093/gerona/glr042  1
2011 Anton SD, Shuster J, Leeuwenburgh C. Investigations of botanicals on food intake, satiety, weight loss and oxidative stress: study protocol of a double-blind, placebo-controlled, crossover study. Zhong Xi Yi Jie He Xue Bao = Journal of Chinese Integrative Medicine. 9: 1190-8. PMID 22088584 DOI: 10.3736/jcim20111106  1
2011 Nocera J, Buford TW, Manini TM, Naugle K, Leeuwenburgh C, Pahor M, Perri MG, Anton SD. The impact of behavioral intervention on obesity mediated declines in mobility function: implications for longevity. Journal of Aging Research. 2011: 392510. PMID 22013527 DOI: 10.4061/2011/392510  1
2011 Wang JH, Ahn IS, Fischer TD, Byeon JI, Dunn WA, Behrns KE, Leeuwenburgh C, Kim JS. Autophagy suppresses age-dependent ischemia and reperfusion injury in livers of mice. Gastroenterology. 141: 2188-2199.e6. PMID 21854730 DOI: 10.1053/j.gastro.2011.08.005  1
2011 Leeuwenburgh C, Pamplona R, Sanz A. Mitochondria and aging. Journal of Aging Research. 2011: 782946. PMID 21808737 DOI: 10.4061/2011/782946  0.4
2011 Gesing A, Masternak MM, Wang F, Joseph AM, Leeuwenburgh C, Westbrook R, Lewinski A, Karbownik-Lewinska M, Bartke A. Expression of key regulators of mitochondrial biogenesis in growth hormone receptor knockout (GHRKO) mice is enhanced but is not further improved by other potential life-extending interventions. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 66: 1062-76. PMID 21788651 DOI: 10.1093/gerona/glr080  1
2011 Anton SD, Manini TM, Milsom VA, Dubyak P, Cesari M, Cheng J, Daniels MJ, Marsiske M, Pahor M, Leeuwenburgh C, Perri MG. Effects of a weight loss plus exercise program on physical function in overweight, older women: a randomized controlled trial. Clinical Interventions in Aging. 6: 141-9. PMID 21753869 DOI: 10.2147/CIA.S17001  1
2011 Kim JM, Heo HS, Choi YJ, Ye BH, Mi Ha Y, Seo AY, Yu BP, Leeuwenburgh C, Chung HY, Carter CS. Inhibition of NF-κB-induced inflammatory responses by angiotensin II antagonists in aged rat kidney. Experimental Gerontology. 46: 542-8. PMID 21377515 DOI: 10.1016/j.exger.2011.02.011  1
2011 Manini TM, Vincent KR, Leeuwenburgh CL, Lees HA, Kavazis AN, Borst SE, Clark BC. Myogenic and proteolytic mRNA expression following blood flow restricted exercise. Acta Physiologica (Oxford, England). 201: 255-63. PMID 20653608 DOI: 10.1111/j.1748-1716.2010.02172.x  1
2011 Leeuwenburgh C, Pamplona R, Sanz A. Mitochondria and ageing Journal of Aging Research. 2011. DOI: 10.4061/2011/782946  1
2010 Marzetti E, Wohlgemuth SE, Aulisa AG, Bernabei R, Pahor M, Leeuwenburgh C. Calorie restriction for optimal cardiovascular aging: the weight of evidence. Current Cardiovascular Risk Reports. 4: 340-346. PMID 26388964 DOI: 10.1007/s12170-010-0114-8  1
2010 Someya S, Yu W, Hallows WC, Xu J, Vann JM, Leeuwenburgh C, Tanokura M, Denu JM, Prolla TA. Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction. Cell. 143: 802-12. PMID 21094524 DOI: 10.1016/j.cell.2010.10.002  1
2010 Seo AY, Joseph AM, Dutta D, Hwang JC, Aris JP, Leeuwenburgh C. New insights into the role of mitochondria in aging: mitochondrial dynamics and more. Journal of Cell Science. 123: 2533-42. PMID 20940129 DOI: 10.1242/jcs.070490  1
2010 Baur JA, Chen D, Chini EN, Chua K, Cohen HY, de Cabo R, Deng C, Dimmeler S, Gius D, Guarente LP, Helfand SL, Imai S, Itoh H, Kadowaki T, Koya D, ... Leeuwenburgh C, et al. Dietary restriction: standing up for sirtuins. Science (New York, N.Y.). 329: 1012-3; author reply. PMID 20798296 DOI: 10.1126/science.329.5995.1012  1
2010 Hiona A, Sanz A, Kujoth GC, Pamplona R, Seo AY, Hofer T, Someya S, Miyakawa T, Nakayama C, Samhan-Arias AK, Servais S, Barger JL, Portero-Otín M, Tanokura M, Prolla TA, ... Leeuwenburgh C, et al. Mitochondrial DNA mutations induce mitochondrial dysfunction, apoptosis and sarcopenia in skeletal muscle of mitochondrial DNA mutator mice. Plos One. 5: e11468. PMID 20628647 DOI: 10.1371/journal.pone.0011468  1
2010 Giovannini S, Cesari M, Marzetti E, Leeuwenburgh C, Maggio M, Pahor M. Effects of ACE-inhibition on IGF-1 and IGFBP-3 concentrations in older adults with high cardiovascular risk profile Journal of Nutrition, Health and Aging. 14: 457-460. PMID 20617288 DOI: 10.1007/s12603-010-0036-7  1
2010 Predmore BL, Alendy MJ, Ahmed KI, Leeuwenburgh C, Julian D. The hydrogen sulfide signaling system: Changes during aging and the benefits of caloric restriction Age. 32: 467-481. PMID 20502969 DOI: 10.1007/s11357-010-9150-z  1
2010 Xu J, Seo AY, Vorobyeva DA, Carter CS, Anton SD, Lezza AM, Leeuwenburgh C. Beneficial effects of a Q-ter based nutritional mixture on functional performance, mitochondrial function, and oxidative stress in rats. Plos One. 5: e10572. PMID 20485503 DOI: 10.1371/journal.pone.0010572  1
2010 Buford TW, Anton SD, Judge AR, Marzetti E, Wohlgemuth SE, Carter CS, Leeuwenburgh C, Pahor M, Manini TM. Models of accelerated sarcopenia: critical pieces for solving the puzzle of age-related muscle atrophy. Ageing Research Reviews. 9: 369-83. PMID 20438881 DOI: 10.1016/j.arr.2010.04.004  1
2010 Xu J, Marzetti E, Seo AY, Kim JS, Prolla TA, Leeuwenburgh C. The emerging role of iron dyshomeostasis in the mitochondrial decay of aging. Mechanisms of Ageing and Development. 131: 487-93. PMID 20434480 DOI: 10.1016/j.mad.2010.04.007  1
2010 Opalach K, Rangaraju S, Madorsky I, Leeuwenburgh C, Notterpek L. Lifelong calorie restriction alleviates age-related oxidative damage in peripheral nerves. Rejuvenation Research. 13: 65-74. PMID 20230280 DOI: 10.1089/rej.2009.0892  1
2010 Marzetti E, Privitera G, Simili V, Wohlgemuth SE, Aulisa L, Pahor M, Leeuwenburgh C. Multiple pathways to the same end: mechanisms of myonuclear apoptosis in sarcopenia of aging. Thescientificworldjournal. 10: 340-9. PMID 20191247 DOI: 10.1100/tsw.2010.27  1
2010 Giovannini S, Onder G, Leeuwenburgh C, Carter C, Marzetti E, Russo A, Capoluongo E, Pahor M, Bernabei R, Landi F. Myeloperoxidase levels and mortality in frail community-living elderly individuals Journals of Gerontology - Series a Biological Sciences and Medical Sciences. 65: 369-376. PMID 20064836 DOI: 10.1093/gerona/glp183  1
2010 Buford TW, Cooke MB, Manini TM, Leeuwenburgh C, Willoughby DS. Effects of age and sedentary lifestyle on skeletal muscle NF-kappaB signaling in men. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 65: 532-7. PMID 20045871 DOI: 10.1093/gerona/glp196  1
2010 Wohlgemuth SE, Seo AY, Marzetti E, Lees HA, Leeuwenburgh C. Skeletal muscle autophagy and apoptosis during aging: effects of calorie restriction and life-long exercise. Experimental Gerontology. 45: 138-48. PMID 19903516 DOI: 10.1016/j.exger.2009.11.002  1
2010 Marzetti E, Hwang JC, Lees HA, Wohlgemuth SE, Dupont-Versteegden EE, Carter CS, Bernabei R, Leeuwenburgh C. Mitochondrial death effectors: relevance to sarcopenia and disuse muscle atrophy. Biochimica Et Biophysica Acta. 1800: 235-44. PMID 19450666 DOI: 10.1016/j.bbagen.2009.05.007  1
2010 Joyner-Matos J, Predmore BL, Stein JR, Leeuwenburgh C, Julian D. Hydrogen Sulfide Induces Oxidative Damage to RNA and DNA in a Sulfide-Tolerant Marine Invertebrate Physiological and Biochemical Zoology. 83: 356-365. PMID 19327040 DOI: 10.1086/597529  1
2009 Marzetti E, Wohlgemuth SE, Anton SD, Bernabei R, Carter CS, Leeuwenburgh C. Cellular mechanisms of cardioprotection by calorie restriction: state of the science and future perspectives. Clinics in Geriatric Medicine. 25: 715-32, ix. PMID 19944269 DOI: 10.1016/j.cger.2009.07.002  1
2009 Someya S, Xu J, Kondo K, Ding D, Salvi RJ, Yamasoba T, Rabinovitch PS, Weindruch R, Leeuwenburgh C, Tanokura M, Prolla TA. Age-related hearing loss in C57BL/6J mice is mediated by Bak-dependent mitochondrial apoptosis. Proceedings of the National Academy of Sciences of the United States of America. 106: 19432-7. PMID 19901338 DOI: 10.1073/pnas.0908786106  1
2009 Hofer T, Servais S, Seo AY, Marzetti E, Hiona A, Upadhyay SJ, Wohlgemuth SE, Leeuwenburgh C. Bioenergetics and permeability transition pore opening in heart subsarcolemmal and interfibrillar mitochondria: effects of aging and lifelong calorie restriction. Mechanisms of Ageing and Development. 130: 297-307. PMID 19428447 DOI: 10.1016/j.mad.2009.01.004  1
2009 Carter CS, Leeuwenburgh C, Daniels M, Foster TC. Influence of calorie restriction on measures of age-related cognitive decline: role of increased physical activity. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 64: 850-9. PMID 19420296 DOI: 10.1093/gerona/glp060  1
2009 Marzetti E, Carter CS, Wohlgemuth SE, Lees HA, Giovannini S, Anderson B, Quinn LS, Leeuwenburgh C. Changes in IL-15 expression and death-receptor apoptotic signaling in rat gastrocnemius muscle with aging and life-long calorie restriction. Mechanisms of Ageing and Development. 130: 272-80. PMID 19396981 DOI: 10.1016/j.mad.2008.12.008  1
2009 Marzetti E, Lees HA, Wohlgemuth SE, Leeuwenburgh C. Sarcopenia of aging: underlying cellular mechanisms and protection by calorie restriction. Biofactors (Oxford, England). 35: 28-35. PMID 19319843 DOI: 10.1002/biof.5  1
2009 Kim JY, Kim DH, Choi J, Park JK, Jeong KS, Leeuwenburgh C, Yu BP, Chung HY. Changes in lipid distribution during aging and its modulation by calorie restriction. Age (Dordrecht, Netherlands). 31: 127-42. PMID 19277901 DOI: 10.1007/s11357-009-9089-0  1
2009 Bailey LJ, Cluett TJ, Reyes A, Prolla TA, Poulton J, Leeuwenburgh C, Holt IJ. Mice expressing an error-prone DNA polymerase in mitochondria display elevated replication pausing and chromosomal breakage at fragile sites of mitochondrial DNA. Nucleic Acids Research. 37: 2327-35. PMID 19244310 DOI: 10.1093/nar/gkp091  1
2009 Rangaraju S, Hankins D, Madorsky I, Madorsky E, Lee WH, Carter CS, Leeuwenburgh C, Notterpek L. Molecular architecture of myelinated peripheral nerves is supported by calorie restriction with aging. Aging Cell. 8: 178-91. PMID 19239416 DOI: 10.1111/j.1474-9726.2009.00460.x  1
2009 Chung HY, Cesari M, Anton S, Marzetti E, Giovannini S, Seo AY, Carter C, Yu BP, Leeuwenburgh C. Molecular inflammation: Underpinnings of aging and age-related diseases Ageing Research Reviews. 8: 18-30. PMID 18692159 DOI: 10.1016/j.arr.2008.07.002  1
2009 Cui L, Hofer T, Rani A, Leeuwenburgh C, Foster TC. Comparison of lifelong and late life exercise on oxidative stress in the cerebellum. Neurobiology of Aging. 30: 903-9. PMID 17976863 DOI: 10.1016/j.neurobiolaging.2007.09.005  1
2009 Roark AM, Bjorndal KA, Bolten AB, Leeuwenburgh C. Biochemical indices as correlates of recent growth in juvenile green turtles (Chelonia mydas) Journal of Experimental Marine Biology and Ecology. 376: 59-67. DOI: 10.1016/j.jembe.2009.06.004  1
2009 Sanz A, Barja G, Pamplona R, Leeuwenburgh C. Free Radicals and Mammalian Aging Redox Signaling and Regulation in Biology and Medicine. 433-472. DOI: 10.1002/9783527627585.ch19  1
2009 Xu J, Seo AY, Vorobyeva DA, Seo D, Carter CS, Lezza AMS, Leeuwenburgh C. Beneficial effects of a nutritional formulation QTer®, creatine and ginseng on function performance, mitochondrial function and oxidative stress Giornale Di Gerontologia. 57: 333-334.  1
2008 Lezza AMS, Fallacara FP, Pesce V, Leeuwenburgh C, Cantatore P, Gadaleta MN. Localization of abasic sites and single-strand breaks in mitochondrial DNA from brain of aged rat, treated or not with caloric restriction diet Neurochemical Research. 33: 2609-2614. PMID 18946734 DOI: 10.1007/s11064-008-9866-7  1
2008 Seo AY, Xu J, Servais S, Hofer T, Marzetti E, Wohlgemuth SE, Knutson MD, Chung HY, Leeuwenburgh C. Mitochondrial iron accumulation with age and functional consequences. Aging Cell. 7: 706-16. PMID 18843794 DOI: 10.1111/j.1474-9726.2008.00418.x  1
2008 Knutson MD, Leeuwenburgh C. Resveratrol and novel potent activators of SIRT1: Effects on aging and age-related diseases Nutrition Reviews. 66: 591-596. PMID 18826454 DOI: 10.1111/j.1753-4887.2008.00109.x  1
2008 Giovannini S, Marzetti E, Borst SE, Leeuwenburgh C. Modulation of GH/IGF-1 axis: Potential strategies to counteract sarcopenia in older adults Mechanisms of Ageing and Development. 129: 593-601. PMID 18762207 DOI: 10.1016/j.mad.2008.08.001  1
2008 Hofer T, Fontana L, Anton SD, Weiss EP, Villareal D, Malayappan B, Leeuwenburgh C. Long-term effects of caloric restriction or exercise on DNA and RNA oxidation levels in white blood cells and urine in humans. Rejuvenation Research. 11: 793-9. PMID 18729811 DOI: 10.1089/rej.2008.0712  1
2008 Xu J, Knutson MD, Carter CS, Leeuwenburgh C. Iron accumulation with age, oxidative stress and functional decline. Plos One. 3: e2865. PMID 18682742 DOI: 10.1371/journal.pone.0002865  1
2008 Marzetti E, Wohlgemuth SE, Lees HA, Chung HY, Giovannini S, Leeuwenburgh C. Age-related activation of mitochondrial caspase-independent apoptotic signaling in rat gastrocnemius muscle. Mechanisms of Ageing and Development. 129: 542-9. PMID 18579179 DOI: 10.1016/j.mad.2008.05.005  1
2008 Barger JL, Kayo T, Vann JM, Arias EB, Wang J, Hacker TA, Wang Y, Raederstorff D, Morrow JD, Leeuwenburgh C, Allison DB, Saupe KW, Cartee GD, Weindruch R, Prolla TA. A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice. Plos One. 3: e2264. PMID 18523577 DOI: 10.1371/journal.pone.0002264  1
2008 Hofer T, Marzetti E, Xu J, Seo AY, Gulec S, Knutson MD, Leeuwenburgh C, Dupont-Versteegden EE. Increased iron content and RNA oxidative damage in skeletal muscle with aging and disuse atrophy. Experimental Gerontology. 43: 563-70. PMID 18395385 DOI: 10.1016/j.exger.2008.02.007  1
2008 Kim JH, Kwak HB, Leeuwenburgh C, Lawler JM. Lifelong exercise and mild (8%) caloric restriction attenuate age-induced alterations in plantaris muscle morphology, oxidative stress and IGF-1 in the Fischer-344 rat Experimental Gerontology. 43: 317-329. PMID 18313875 DOI: 10.1016/j.exger.2007.12.012  1
2008 Chung JH, Seo AY, Chung SW, Kim MK, Leeuwenburgh C, Yu BP, Chung HY. Molecular mechanism of PPAR in the regulation of age-related inflammation Ageing Research Reviews. 7: 126-136. PMID 18313368 DOI: 10.1016/j.arr.2008.01.001  1
2008 Marzetti E, Lawler JM, Hiona A, Manini T, Seo AY, Leeuwenburgh C. Modulation of age-induced apoptotic signaling and cellular remodeling by exercise and calorie restriction in skeletal muscle Free Radical Biology and Medicine. 44: 160-168. PMID 18191752 DOI: 10.1016/j.freeradbiomed.2007.05.028  1
2008 Dirks Naylor AJ, Leeuwenburgh C. Sarcopenia: The role of apoptosis and modulation by caloric restriction Exercise and Sport Sciences Reviews. 36: 19-24. PMID 18156949 DOI: 10.1097/jes.0b013e31815ddd9d  1
2008 Marzetti E, Groban L, Wohlgemuth SE, Lees HA, Lin M, Jobe H, Giovannini S, Leeuwenburgh C, Carter CS. Effects of short-term GH supplementation and treadmill exercise training on physical performance and skeletal muscle apoptosis in old rats. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 294: R558-67. PMID 18003794 DOI: 10.1152/ajpregu.00620.2007  1
2008 Hiona A, Leeuwenburgh C. The role of mitochondrial DNA mutations in aging and sarcopenia: Implications for the mitochondrial vicious cycle theory of aging Experimental Gerontology. 43: 24-33. PMID 17997255 DOI: 10.1016/j.exger.2007.10.001  1
2008 Raghavan S, Kristinsson HG, Leeuwenburgh C. Radical scavenging and reducing ability of tilapia (Oreochromis niloticus) protein hydrolysates Journal of Agricultural and Food Chemistry. 56: 10359-10367. DOI: 10.1021/jf8017194  1
2007 Carter CS, Hofer T, Seo AY, Leeuwenburgh C. Molecular mechanisms of life- and health-span extension: role of calorie restriction and exercise intervention. Applied Physiology, Nutrition, and Metabolism = Physiologie AppliquéE, Nutrition Et MéTabolisme. 32: 954-66. PMID 18059622 DOI: 10.1139/H07-085  1
2007 Malayappan B, Garrett TJ, Segal M, Leeuwenburgh C. Urinary analysis of 8-oxoguanine, 8-oxoguanosine, fapy-guanine and 8-oxo-2'-deoxyguanosine by high-performance liquid chromatography-electrospray tandem mass spectrometry as a measure of oxidative stress. Journal of Chromatography. A. 1167: 54-62. PMID 17765254 DOI: 10.1016/j.chroma.2007.08.024  1
2007 Wohlgemuth SE, Julian D, Akin DE, Fried J, Toscano K, Leeuwenburgh C, Dunn WA. Autophagy in the heart and liver during normal aging and calorie restriction. Rejuvenation Research. 10: 281-92. PMID 17665967 DOI: 10.1089/rej.2006.0535  1
2007 Erdös B, Broxson CS, Landa T, Scarpace PJ, Leeuwenburgh C, Zhang Y, Tümer N. Effects of life-long caloric restriction and voluntary exercise on age-related changes in levels of catecholamine biosynthetic enzymes and angiotensin II receptors in the rat adrenal medulla and hypothalamus. Experimental Gerontology. 42: 745-52. PMID 17540525 DOI: 10.1016/j.exger.2007.04.007  1
2007 Borst SE, Conover CF, Carter CS, Gregory CM, Marzetti E, Leeuwenburgh C, Vandenborne K, Wronski TJ. Anabolic effects of testosterone are preserved during inhibition of 5alpha-reductase. American Journal of Physiology. Endocrinology and Metabolism. 293: E507-14. PMID 17488806 DOI: 10.1152/ajpendo.00130.2007  1
2007 Judge S, Leeuwenburgh C. Cardiac mitochondrial bioenergetics, oxidative stress, and aging American Journal of Physiology - Cell Physiology. 292. PMID 17344313 DOI: 10.1152/ajpcell.00285.2006  1
2007 Sanz A, Hiona A, Kujoth GC, Seo AY, Hofer T, Kouwenhoven E, Kalani R, Prolla TA, Barja G, Leeuwenburgh C. Evaluation of sex differences on mitochondrial bioenergetics and apoptosis in mice Experimental Gerontology. 42: 173-182. PMID 17118599 DOI: 10.1016/j.exger.2006.10.003  1
2007 Joyner-Matos J, Chapman LJ, Downs CA, Hofer T, Leeuwenburgh C, Julian D. Stress response of a freshwater clam along an abiotic gradient: Too much oxygen may limit distribution Functional Ecology. 21: 344-355. DOI: 10.1111/j.1365-2435.2007.01230.x  1
2006 Marzetti E, Leeuwenburgh C. Skeletal muscle apoptosis, sarcopenia and frailty at old age Experimental Gerontology. 41: 1234-1238. PMID 17052879 DOI: 10.1016/j.exger.2006.08.011  1
2006 Kujoth GC, Leeuwenburgh C, Prolla TA. Mitochondrial DNA mutations and apoptosis in mammalian aging Cancer Research. 66: 7386-7389. PMID 16885331 DOI: 10.1158/0008-5472.CAN-05-4670  1
2006 Cassano P, Sciancalepore AG, Lezza AMS, Leeuwenburgh C, Cantatore P, Gadaleta MN. Tissue-specific effect of age and caloric restriction diet on mitochondrial DNA content Rejuvenation Research. 9: 211-214. PMID 16706645 DOI: 10.1089/rej.2006.9.211  1
2006 Cesari M, Leeuwenburgh C, Lauretani F, Onder G, Bandinelli S, Maraldi C, Guralnik JM, Pahor M, Ferrucci L. Frailty syndrome and skeletal muscle: Results from the Invecchiare in Chianti study American Journal of Clinical Nutrition. 83: 1142-1148. PMID 16685058  1
2006 Cesari M, Kritchevsky SB, Leeuwenburgh C, Pahor M. Oxidative damage and platelet activation as new predictors of mobility disability and mortality in elders Antioxidants and Redox Signaling. 8: 609-619. PMID 16677104 DOI: 10.1089/ars.2006.8.609  1
2006 Deruisseau KC, Kavazis AN, Judge S, Murlasits Z, Deering MA, Quindry JC, Lee Y, Falk DJ, Leeuwenburgh C, Powers SK. Moderate caloric restriction increases diaphragmatic antioxidant enzyme mRNA, but not when combined with lifelong exercise. Antioxidants & Redox Signaling. 8: 539-47. PMID 16677098 DOI: 10.1089/ars.2006.8.539  1
2006 Seo AY, Hofer T, Sung B, Judge S, Chung HY, Leeuwenburgh C. Hepatic oxidative stress during aging: Effects of 8% long-term calorie restriction and lifelong exercise Antioxidants and Redox Signaling. 8: 529-538. PMID 16677097 DOI: 10.1089/ars.2006.8.529  1
2006 Leeuwenburgh C, Prolla TA. Genetics, redox signaling, oxidative stress, and apoptosis in mammalian aging Antioxidants and Redox Signaling. 8: 503-505. PMID 16677094 DOI: 10.1089/ars.2006.8.503  1
2006 Dirks AJ, Hofer T, Marzetti E, Pahor M, Leeuwenburgh C. Mitochondrial DNA mutations, energy metabolism and apoptosis in aging muscle Ageing Research Reviews. 5: 179-195. PMID 16647308 DOI: 10.1016/j.arr.2006.03.002  1
2006 Kalani R, Judge S, Carter C, Pahor M, Leeuwenburgh C. Effects of caloric restriction and exercise on age-related, chronic inflammation assessed by C-reactive protein and interleukin-6 Journals of Gerontology - Series a Biological Sciences and Medical Sciences. 61: 211-217. PMID 16567369  1
2006 Obisesan TO, Leeuwenburgh C, Ferrell RE, Phares DA, McKenzie JA, Prior SJ, Hagberg JM. C-reactive protein genotype affects exercise training-induced changes in insulin sensitivity. Metabolism: Clinical and Experimental. 55: 453-60. PMID 16546475 DOI: 10.1016/j.metabol.2005.10.006  1
2006 Dirks AJ, Leeuwenburgh C. Tumor necrosis factor α signaling in skeletal muscle: effects of age and caloric restriction Journal of Nutritional Biochemistry. 17: 501-508. PMID 16517142 DOI: 10.1016/j.jnutbio.2005.11.002  1
2006 Hofer T, Seo AY, Prudencio M, Leeuwenburgh C. A method to determine RNA and DNA oxidation simultaneously by HPLC-ECD: greater RNA than DNA oxidation in rat liver after doxorubicin administration. Biological Chemistry. 387: 103-11. PMID 16497170 DOI: 10.1515/BC.2006.014  1
2006 Dirks AJ, Leeuwenburgh C. Caloric restriction in humans: Potential pitfalls and health concerns Mechanisms of Ageing and Development. 127: 1-7. PMID 16226298 DOI: 10.1016/j.mad.2005.09.001  1
2005 Kakarla P, Vadluri G, Reddy KS, Leeuwenburgh C. Vulnerability of the mid aged rat myocardium to the age-induced oxidative stress: Influence of exercise training on antioxidant defense system Free Radical Research. 39: 1211-1217. PMID 16298747 DOI: 10.1080/10715760500315118  1
2005 Hiona A, Leeuwenburgh C. WITHDRAWN: Life-long caloric restriction counteracts apoptotic effects of aging in the brain and bolsters the action of apoptosis inhibitors. Neurobiology of Aging. PMID 16198026 DOI: 10.1016/j.neurobiolaging.2005.08.006  1
2005 Judge S, Jang YM, Smith A, Selman C, Phillips T, Speakman JR, Hagen T, Leeuwenburgh C. Exercise by lifelong voluntary wheel running reduces subsarcolemmal and interfibrillar mitochondrial hydrogen peroxide production in the heart American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 289. PMID 16051717 DOI: 10.1152/ajpregu.00396.2005  1
2005 Kujoth GC, Hiona A, Pugh TD, Someya S, Panzer K, Wohlgemuth SE, Hofer T, Seo AY, Sullivan R, Jobling WA, Morrow JD, Van Remmen H, Sedivy JM, Yamasoba T, Tanokura M, ... ... Leeuwenburgh C, et al. Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging. Science (New York, N.Y.). 309: 481-4. PMID 16020738 DOI: 10.1126/science.1112125  1
2005 Dirks AJ, Leeuwenburgh C. The role of apoptosis in age-related skeletal muscle atrophy Sports Medicine. 35: 473-483. PMID 15974633 DOI: 10.2165/00007256-200535060-00002  1
2005 Selman C, Phillips T, Staib JL, Duncan JS, Leeuwenburgh C, Speakman JR. Energy expenditure of calorically restricted rats is higher than predicted from their altered body composition Mechanisms of Ageing and Development. 126: 783-793. PMID 15888333 DOI: 10.1016/j.mad.2005.02.004  1
2005 Philips T, Leeuwenburgh C. Muscle fiber specific apoptosis and TNF-α signaling in sarcopenia are attenuated by life-long calorie restriction Faseb Journal. 19: 668-670. PMID 15665035 DOI: 10.1096/fj.04-2870fje  1
2005 Selsby JT, Judge AR, Yimlamai T, Leeuwenburgh C, Dodd SL. Life long calorie restriction increases heat shock proteins and proteasome activity in soleus muscles of Fisher 344 rats Experimental Gerontology. 40: 37-42. PMID 15664730 DOI: 10.1016/j.exger.2004.08.012  1
2005 Leeuwenburgh C, Gurley CM, Strotman BA, Dupont-Versteegden EE. Age-related differences in apoptosis with disuse atrophy in soleus muscle American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 288. PMID 15650125 DOI: 10.1152/ajpregu.00576.2004  1
2005 Judge S, Young MJ, Smith A, Hagen T, Leeuwenburgh C. Age-associated increases in oxidative stress and antioxidant enzyme activities in cardiac interfibrillar mitochondria: Implications for the mitochondrial theory of aging Faseb Journal. 19: 419-421. PMID 15642720 DOI: 10.1096/fj.04-2622fje  1
2005 Dirks AJ, Leeuwenburgh C. Skeletal muscle apoptosis in aging and exercise Deutsche Zeitschrift Fur Sportmedizin. 56: 62-67.  1
2004 Phillips T, Leeuwenburgh C. Lifelong aspirin supplementation as a means to extending life span Rejuvenation Research. 7: 243-251. PMID 15671726  1
2004 Drew B, Leeuwenburgh C. Ageing and subcellular distribution of mitochondria: Role of mitochondrial DNA deletions and energy production Acta Physiologica Scandinavica. 182: 333-341. PMID 15569094 DOI: 10.1111/j.1365-201X.2004.01371.x  1
2004 Jang YM, Kendaiah S, Drew B, Phillips T, Selman C, Julian D, Leeuwenburgh C. Doxorubicin treatment in vivo activates caspase-12 mediated cardiac apoptosis in both male and female rats Febs Letters. 577: 483-490. PMID 15556633 DOI: 10.1016/j.febslet.2004.10.053  1
2004 Obisesan TO, Leeuwenburgh C, Phillips T, Ferrell RE, Phares DA, Prior SJ, Hagberg JM. C-reactive protein genotypes affect baseline, but not exercise training-induced changes, in C-reactive protein levels. Arteriosclerosis, Thrombosis, and Vascular Biology. 24: 1874-9. PMID 15271790 DOI: 10.1161/01.ATV.0000140060.13203.22  1
2004 Gredilla R, Phaneuf S, Selman C, Kendaiah S, Leeuwenburgh C, Barja G. Short-term caloric restriction and sites of oxygen radical generation in kidney and skeletal muscle mitochondria Annals of the New York Academy of Sciences. 1019: 333-342. PMID 15247039 DOI: 10.1196/annals.1297.057  1
2004 Cassano P, Lezza AMS, Leeuwenburgh C, Cantatore P, Gadaleta MN. Measurement of the 4,834-bp mitochondrial DNA deletion level in aging rat liver and brain subjected or not to caloric restriction diet Annals of the New York Academy of Sciences. 1019: 269-273. PMID 15247027 DOI: 10.1196/annals.1297.045  1
2004 Hiona A, Leeuwenburgh C. Effects of age and caloric restriction on brain neuronal cell death/survival Annals of the New York Academy of Sciences. 1019: 96-105. PMID 15247000 DOI: 10.1196/annals.1297.018  1
2004 Short KR, Drew B, Leeuwenburgh C. Mitochondrial ATP measurements (multiple letters) American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 287. PMID 15191927 DOI: 10.1152/ajpregu.00606.2003  1
2004 Itoh M, Oh-Ishi S, Hatao H, Leeuwenburgh C, Selman C, Ohno H, Kizaki T, Nakamura H, Matsuoka T. Effects of dietary calcium restriction and acute exercise on the antioxidant enzyme system and oxidative stress in rat diaphragm American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 287. PMID 14764436 DOI: 10.1152/ajpregu.00598.2003  1
2004 Dirks AJ, Leeuwenburgh C. Aging and lifelong calorie restriction result in adaptations of skeletal muscle apoptosis repressor, apoptosis-inducing factor, X-linked inhibitor of apoptosis, caspase-3, and caspase-12 Free Radical Biology and Medicine. 36: 27-39. PMID 14732288 DOI: 10.1016/j.freeradbiomed.2003.10.003  1
2004 Julian D, Leeuwenburgh C. Linkage between insulin and the free radical theory of aging American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 286. PMID 14660473  1
2004 Judge S, Judge A, Grune T, Leeuwenburgh C. Short-term CR decreases cardiac mitochondrial oxidant production but increases carbonyl content American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 286. PMID 14592935  1
2003 Phillips T, Childs AC, Dreon DM, Phinney S, Leeuwenburgh C. A Dietary Supplement Attenuates IL-6 and CRP after Eccentric Exercise in Untrained Males Medicine and Science in Sports and Exercise. 35: 2032-2037. PMID 14652498 DOI: 10.1249/01.MSS.0000099112.32342.10  1
2003 Leeuwenburgh C. Role of Apoptosis in Sarcopenia Journals of Gerontology - Series a Biological Sciences and Medical Sciences. 58: 999-1001. PMID 14630880  1
2003 Payne AM, Dodd SL, Leeuwenburgh C. Life-long calorie restriction in Fischer 344 rats attenuates age-related loss in skeletal muscle-specific force and reduces extracellular space Journal of Applied Physiology. 95: 2554-2562. PMID 12972444  1
2003 Selman C, Kendaiah S, Gredilla R, Leeuwenburgh C. Increased hepatic apoptosis during short-term caloric restriction is not associated with an enhancement in caspase levels Experimental Gerontology. 38: 897-903. PMID 12915211 DOI: 10.1016/S0531-5565(03)00091-3  1
2003 Drew B, Leeuwenburgh C. Method for measuring ATP production in isolated mitochondria: ATP production in brain and liver mitochondria of Fischer-344 rats with age and caloric restriction American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 285. PMID 12855419  1
2003 Selman C, Leeuwenburgh C. The role of Id2 and apoptosis during skeletal muscle remodeling American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 284. PMID 12529289  1
2003 Shelke RR, Leeuwenburgh C. Lifelong caloric restriction increases expression of apoptosis repressor with a caspase recruitment domain (ARC) in the brain. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 17: 494-6. PMID 12514107 DOI: 10.1096/fj.02-0803fje  1
2003 Drew B, Dirks PA, Selman C, Gredilla R, Lezza A, Barja G, Leeuwenburgh C. Effects of aging and caloric restriction on mitochondrial energy production in gastrocnemius muscle and heart American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 284. PMID 12388443  1
2002 Green PS, Leeuwenburgh C. Mitochondrial dysfunction is an early indicator of doxorubicin-induced apoptosis Biochimica Et Biophysica Acta - Molecular Basis of Disease. 1588: 94-101. PMID 12379319 DOI: 10.1016/S0925-4439(02)00144-8  1
2002 Childs AC, Phaneuf SL, Dirks AJ, Phillips T, Leeuwenburgh C. Doxorubicin treatment in vivo causes cytochrome c release and cardiomyocyte apoptosis, as well as increased mitochondrial efficiency, superoxide dismutase activity, and Bcl-2:Bax ratio Cancer Research. 62: 4592-4598. PMID 12183413  1
2002 Pollack M, Phaneuf S, Dirks A, Leeuwenburgh C. The role of apoptosis in the normal aging brain, skeletal muscle, and heart. Annals of the New York Academy of Sciences. 959: 93-107. PMID 11976189  1
2002 Drew B, Leeuwenburgh C. Aging and the role of reactive nitrogen species Annals of the New York Academy of Sciences. 959: 66-81. PMID 11976187  1
2002 Dirks A, Leeuwenburgh C. Apoptosis in skeletal muscle with aging American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 282. PMID 11792662  1
2002 Phaneuf S, Leeuwenburgh C. Cytochrome c release from mitochondria in the aging heart: A possible mechanism for apoptosis with age American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 282. PMID 11792651  1
2001 Pollack M, Leeuwenburgh C. Apoptosis and aging: Role of the mitochondria Journals of Gerontology - Series a Biological Sciences and Medical Sciences. 56. PMID 11682568  1
2001 Childs A, Jacobs C, Kaminski T, Halliwell B, Leeuwenburgh C. Supplementation with vitamin C and N-acetyl-cysteine increases oxidative stress in humans after an acute muscle injury induced by eccentric exercise Free Radical Biology and Medicine. 31: 745-753. PMID 11557312 DOI: 10.1016/S0891-5849(01)00640-2  1
2001 Adams S, Green P, Claxton R, Simcox S, Williams MV, Walsh K, Leeuwenburgh C. Reactive carbonyl formation by oxidative and non-oxidative pathways Frontiers in Bioscience : a Journal and Virtual Library. 6. PMID 11487471  1
2001 Leeuwenburgh C, Heinecke JW. Oxidative stress and antioxidants in exercise. Current Medicinal Chemistry. 8: 829-38. PMID 11375753  1
2001 Leichtweis S, Leeuwenburgh C, Bejma J, Ji LL. Aged rat hearts are not more susceptible to ischemia-reperfusion injury in vivo: Role of glutathione Mechanisms of Ageing and Development. 122: 503-518. PMID 11295168 DOI: 10.1016/S0047-6374(00)00253-0  1
2001 Pennathur S, Wagner JD, Leeuwenburgh C, Litwak KN, Heinecke JW. A hydroxyl radical-like species oxidizes cynomolgus monkey artery wall proteins in early diabetic vascular disease. The Journal of Clinical Investigation. 107: 853-60. PMID 11285304 DOI: 10.1172/JCI11194  1
2001 Phaneuf S, Leeuwenburgh C. Apoptosis and exercise Medicine and Science in Sports and Exercise. 33: 393-396. PMID 11252065  1
2000 Manary MJ, Leeuwenburgh C, Heinecke JW. Increased oxidative stress in kwashiorkor. The Journal of Pediatrics. 137: 421-4. PMID 10969271 DOI: 10.1067/mpd.2000.107512  1
1999 Leeuwenburgh C, Hansen PA, Holloszy JO, Heinecke JW. Hydroxyl radical generation during exercise increases mitochondrial protein oxidation and levels of urinary dityrosine. Free Radical Biology & Medicine. 27: 186-92. PMID 10443935 DOI: 10.1016/S0891-5849(99)00071-4  1
1999 Powers SK, Ji LL, Leeuwenburgh C. Exercise training-induced alterations in skeletal muscle antioxidant capacity: A brief review Medicine and Science in Sports and Exercise. 31: 987-997. PMID 10416560 DOI: 10.1097/00005768-199907000-00011  1
1999 Gokce N, Keaney JF, Frei B, Holbrook M, Olesiak M, Zachariah BJ, Leeuwenburgh C, Heinecke JW, Vita JA. Long-term ascorbic acid administration reverses endothelial vasomotor dysfunction in patients with coronary artery disease. Circulation. 99: 3234-40. PMID 10385496 DOI: 10.1161/01.CIR.99.25.3234  1
1999 Heinecke JW, Hsu FF, Crowley JR, Hazen SL, Leeuwenburgh C, Mueller DM, Rasmussen JE, Turk J. Detecting oxidative modification of biomolecules with isotope dilution mass spectrometry: sensitive and quantitative assays for oxidized amino acids in proteins and tissues. Methods in Enzymology. 300: 124-44. PMID 9919517 DOI: 10.1016/S0076-6879(99)00121-4  1
1999 Leeuwenburgh C, Hansen PA, Holloszy JO, Heinecke JW. Oxidized amino acids in the urine of aging rats: potential markers for assessing oxidative stress in vivo. The American Journal of Physiology. 276: R128-35. PMID 9887186 DOI: 10.1152/ajpregu.1999.276.1.R128  1
1998 Gore M, Fiebig R, Hollander J, Leeuwenburgh C, Ohno H, Ji LL. Endurance training alters antioxidant enzyme gene expression in rat skeletal muscle Canadian Journal of Physiology and Pharmacology. 76: 1139-1145. PMID 10326836 DOI: 10.1139/cjpp-76-12-1139  1
1998 Ji LL, Leeuwenburgh C, Leichtweis S, Gore M, Fiebig R, Hollander J, Bejma J. Oxidative stress and aging. Role of exercise and its influences on antioxidant systems Annals of the New York Academy of Sciences. 854: 102-117. PMID 9928424 DOI: 10.1111/j.1749-6632.1998.tb09896.x  1
1998 Leeuwenburgh C, Ji LL. Glutathone and glutathione ethyl ester supplementation of mice alter glutathione homeostasis during exercise Journal of Nutrition. 128: 2420-2426. PMID 9868190  1
1998 Crowley JR, Yarasheski K, Leeuwenburgh C, Turk J, Heinecke JW. Isotope dilution mass spectrometric quantification of 3-nitrotyrosine in proteins and tissues is facilitated by reduction to 3-aminotyrosine. Analytical Biochemistry. 259: 127-35. PMID 9606153 DOI: 10.1006/abio.1998.2635  1
1998 Leeuwenburgh C, Hansen P, Shaish A, Holloszy JO, Heinecke JW. Markers of protein oxidation by hydroxyl radical and reactive nitrogen species in tissues of aging rats. The American Journal of Physiology. 274: R453-61. PMID 9486304  1
1998 Chandwaney R, Leichtweis S, Leeuwenburgh C, Li Li Ji. Oxidative stress and mitochondrial function in skeletal muscle: Effects of aging and exercise training Age. 21: 109-117.  1
1997 Leeuwenburgh C, Wagner P, Holloszy JO, Sohal RS, Heinecke JW. Caloric restriction attenuates dityrosine cross-linking of cardiac and skeletal muscle proteins in aging mice. Archives of Biochemistry and Biophysics. 346: 74-80. PMID 9328286 DOI: 10.1006/abbi.1997.0297  1
1997 Tribble DL, Gong EL, Leeuwenburgh C, Heinecke JW, Carlson EL, Verstuyft JG, Epstein CJ. Fatty streak formation in fat-fed mice expressing human copper-zinc superoxide dismutase. Arteriosclerosis, Thrombosis, and Vascular Biology. 17: 1734-40. PMID 9327771 DOI: 10.1161/01.ATV.17.9.1734  1
1997 Leichtweis SB, Leeuwenburgh C, Parmelee DJ, Fiebig R, Ji LL. Rigorous swim training impairs mitochondrial function in post-ischaemic rat heart Acta Physiologica Scandinavica. 160: 139-148. PMID 9208040  1
1997 Leeuwenburgh C, Hollander J, Leichtweis S, Griffiths M, Gore M, Ji LL. Adaptations of glutathione antioxidant system to endurance training are tissue and muscle fiber specific American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 272. PMID 9039030  1
1997 Leeuwenburgh C, Rasmussen JE, Hsu FF, Mueller DM, Pennathur S, Heinecke JW. Mass spectrometric quantification of markers for protein oxidation by tyrosyl radical, copper, and hydroxyl radical in low density lipoprotein isolated from human atherosclerotic plaques. The Journal of Biological Chemistry. 272: 3520-6. PMID 9013599 DOI: 10.1074/jbc.272.6.3520  1
1997 Leeuwenburgh C, Hardy MM, Hazen SL, Wagner P, Oh-ishi S, Steinbrecher UP, Heinecke JW. Reactive nitrogen intermediates promote low density lipoprotein oxidation in human atherosclerotic intima. The Journal of Biological Chemistry. 272: 1433-6. PMID 8999808 DOI: 10.1074/jbc.272.3.1433  1
1996 Leichtweis SB, Leeuwenburgh C, Chandwaney R, Parmelee DJ, Ji LL. Ischaemia-reperfusion induced alterations of mitochondrial function in hypertrophied rat heart Acta Physiologica Scandinavica. 156: 51-60. PMID 8866886  1
1996 Leeuwenburgh C, Leichtweis S, Hollander J, Fiebig R, Gore M, Ji LL. Effect of acute exercise on glutathione deficient heart Molecular and Cellular Biochemistry. 156: 17-24. PMID 8709971  1
1996 Leeuwenburgh C, Ji LL. Alteration of glutathione and antioxidant status with exercise in unfed and refed rats Journal of Nutrition. 126: 1833-1843. PMID 8683345  1
1996 Fiebig R, Gore MT, Chandwaney R, Leeuwenburgh C, Ji LL. Alteration of myocardial antioxidant enzyme activity and glutathione content with aging and exercise training Age. 19: 83-89. DOI: 10.1007/BF02434087  1
1996 Leeuwenburgh C, Hansen P, Holloszy JO, Heinecke JW. Mass spectrometrlt analysis reveals significant decreases in tissue levels of dityrosine, a specific marker of oxidation, in rats treated with antioxidants Faseb Journal. 10.  1
1996 Hollander J, Gore M, Fiebig R, Powers D, Hulling M, Legichtweis S, Leeuwenburgh C, Ji LL. Effect of microgravity on antioxidant defense and oxidative stress in rat liver Faseb Journal. 10.  1
1995 Leeuwenburgh C, Ji LL. Glutathione Depletion in Rested and Exercised Mice: Biochemical Consequence and Adaptation Archives of Biochemistry and Biophysics. 316: 941-949. PMID 7864653 DOI: 10.1006/abbi.1995.1125  1
1994 Leeuwenburgh C, Fiebig R, Chandwaney R, Ji Li Li. Aging and exercise training in skeletal muscle: Responses of glutathione and antioxidant enzyme systems Am.J.Physiol.. 267.  1
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