Paul Davies - Publications

Affiliations: 
Biology and Biochemistry University of Bath, Bath, England, United Kingdom 
Area:
neurodegeneration

28 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Horbert R, Pinchuk B, Davies P, Alessi D, Peifer C. Photoactivatable prodrugs of anti-melanoma agent vemurafenib. Acs Chemical Biology. PMID 26061392 DOI: 10.1021/acschembio.5b00174  0.96
2015 Evans SE, Davies P, Lubben A, Kasprzyk-Hordern B. Determination of chiral pharmaceuticals and illicit drugs in wastewater and sludge using microwave assisted extraction, solid-phase extraction and chiral liquid chromatography coupled with tandem mass spectrometry. Analytica Chimica Acta. 882: 112-26. PMID 26043098 DOI: 10.1016/j.aca.2015.03.039  0.96
2014 Bago R, Malik N, Munson MJ, Prescott AR, Davies P, Sommer E, Shpiro N, Ward R, Cross D, Ganley IG, Alessi DR. Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase. The Biochemical Journal. 463: 413-27. PMID 25177796 DOI: 10.1042/BJ20140889  0.96
2014 Santella JB, Gardner DS, Duncia JV, Wu H, Dhar M, Cavallaro C, Tebben AJ, Carter PH, Barrish JC, Yarde M, Briceno SW, Cvijic ME, Grafstrom RR, Liu R, Patel SR, ... ... Davies P, et al. Discovery of the CCR1 antagonist, BMS-817399, for the treatment of rheumatoid arthritis. Journal of Medicinal Chemistry. 57: 7550-64. PMID 25101488 DOI: 10.1021/jm5003167  0.96
2014 Houde VP, Ritorto MS, Gourlay R, Varghese J, Davies P, Shpiro N, Sakamoto K, Alessi DR. Investigation of LKB1 Ser431 phosphorylation and Cys433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity. The Biochemical Journal. 458: 41-56. PMID 24295069 DOI: 10.1042/BJ20131324  0.96
2013 Gardner DS, Santella JB, Duncia JV, Carter PH, Dhar TG, Wu H, Guo W, Cavallaro C, Van Kirk K, Yarde M, Briceno SW, Grafstrom RR, Liu R, Patel SR, Tebben AJ, ... ... Davies P, et al. The discovery of BMS-457, a potent and selective CCR1 antagonist. Bioorganic & Medicinal Chemistry Letters. 23: 3833-40. PMID 23707259 DOI: 10.1016/j.bmcl.2013.04.079  0.96
2013 Davies P, Hinkle KM, Sukar NN, Sepulveda B, Mesias R, Serrano G, Alessi DR, Beach TG, Benson DL, White CL, Cowell RM, Das SS, West AB, Melrose HL. Comprehensive characterization and optimization of anti-LRRK2 (leucine-rich repeat kinase 2) monoclonal antibodies. The Biochemical Journal. 453: 101-13. PMID 23560750 DOI: 10.1042/BJ20121742  0.96
2013 Younan ND, Sarell CJ, Davies P, Brown DR, Viles JH. The cellular prion protein traps Alzheimer's Aβ in an oligomeric form and disassembles amyloid fibers. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 1847-58. PMID 23335053 DOI: 10.1096/fj.12-222588  0.96
2012 Cavallaro CL, Briceno S, Chen J, Cvijic ME, Davies P, Hynes J, Liu RQ, Mandlekar S, Rose AV, Tebben AJ, Van Kirk K, Watson A, Wu H, Yang G, Carter PH. Discovery and lead optimization of a novel series of CC chemokine receptor 1 (CCR1)-selective piperidine antagonists via parallel synthesis. Journal of Medicinal Chemistry. 55: 9643-53. PMID 23075267 DOI: 10.1021/jm300896d  0.96
2012 Younan ND, Nadal RC, Davies P, Brown DR, Viles JH. Methionine oxidation perturbs the structural core of the prion protein and suggests a generic misfolding pathway. The Journal of Biological Chemistry. 287: 28263-75. PMID 22654104 DOI: 10.1074/jbc.M112.354779  0.96
2012 Meloni G, Crameri A, Fritz G, Davies P, Brown DR, Kroneck PM, Vašák M. The catalytic redox activity of prion protein-Cu(II) is controlled by metal exchange with the Zn(II) -thiolate clusters of Zn(7) metallothionein-3. Chembiochem : a European Journal of Chemical Biology. 13: 1261-5. PMID 22615124 DOI: 10.1002/cbic.201200198  0.96
2011 Davies P, McHugh PC, Hammond VJ, Marken F, Brown DR. Contribution of individual histidines to prion protein copper binding. Biochemistry. 50: 10781-91. PMID 22039779 DOI: 10.1021/bi2012349  0.96
2011 Younan ND, Klewpatinond M, Davies P, Ruban AV, Brown DR, Viles JH. Copper(II)-induced secondary structure changes and reduced folding stability of the prion protein. Journal of Molecular Biology. 410: 369-82. PMID 21619885 DOI: 10.1016/j.jmb.2011.05.013  0.96
2011 Deng X, Dzamko N, Prescott A, Davies P, Liu Q, Yang Q, Lee JD, Patricelli MP, Nomanbhoy TK, Alessi DR, Gray NS. Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2. Nature Chemical Biology. 7: 203-5. PMID 21378983 DOI: 10.1038/nchembio.538  0.96
2011 Davies P, Moualla D, Brown DR. Alpha-synuclein is a cellular ferrireductase. Plos One. 6: e15814. PMID 21249223 DOI: 10.1371/journal.pone.0015814  0.96
2011 Davies P, Wang X, Sarell CJ, Drewett A, Marken F, Viles JH, Brown DR. The synucleins are a family of redox-active copper binding proteins. Biochemistry. 50: 37-47. PMID 21117662 DOI: 10.1021/bi101582p  0.96
2009 Davies P, Brown DR. Manganese enhances prion protein survival in model soils and increases prion infectivity to cells. Plos One. 4: e7518. PMID 19844576 DOI: 10.1371/journal.pone.0007518  0.96
2009 Nadal RC, Davies P, Brown DR, Viles JH. Evaluation of copper2+ affinities for the prion protein. Biochemistry. 48: 8929-31. PMID 19697960 DOI: 10.1021/bi9011397  0.96
2009 Chang B, Gray P, Piltch M, Bulgin MS, Sorensen-Melson S, Miller MW, Davies P, Brown DR, Coughlin DR, Rubenstein R. Surround optical fiber immunoassay (SOFIA): an ultra-sensitive assay for prion protein detection. Journal of Virological Methods. 159: 15-22. PMID 19442839 DOI: 10.1016/j.jviromet.2009.02.019  0.96
2009 Stevens DJ, Walter ED, Rodríguez A, Draper D, Davies P, Brown DR, Millhauser GL. Early onset prion disease from octarepeat expansion correlates with copper binding properties. Plos Pathogens. 5: e1000390. PMID 19381258 DOI: 10.1371/journal.ppat.1000390  0.96
2009 Davies P, Marken F, Salter S, Brown DR. Thermodynamic and voltammetric characterization of the metal binding to the prion protein: insights into pH dependence and redox chemistry. Biochemistry. 48: 2610-9. PMID 19196019 DOI: 10.1021/bi900170n  0.96
2008 Davies P, Fontaine SN, Moualla D, Wang X, Wright JA, Brown DR. Amyloidogenic metal-binding proteins: new investigative pathways. Biochemical Society Transactions. 36: 1299-303. PMID 19021544 DOI: 10.1042/BST0361299  0.96
2008 Brazier MW, Davies P, Player E, Marken F, Viles JH, Brown DR. Manganese binding to the prion protein. The Journal of Biological Chemistry. 283: 12831-9. PMID 18332141 DOI: 10.1074/jbc.M709820200  0.96
2008 Davies P, Brown DR. The chemistry of copper binding to PrP: is there sufficient evidence to elucidate a role for copper in protein function? The Biochemical Journal. 410: 237-44. PMID 18254729 DOI: 10.1042/BJ20071477  0.96
2008 Zhu F, Davies P, Thompsett AR, Kelly SM, Tranter GE, Hecht L, Isaacs NW, Brown DR, Barron LD. Raman optical activity and circular dichroism reveal dramatic differences in the influence of divalent copper and manganese ions on prion protein folding. Biochemistry. 47: 2510-7. PMID 18205409 DOI: 10.1021/bi7022893  0.96
2008 Klewpatinond M, Davies P, Bowen S, Brown DR, Viles JH. Deconvoluting the Cu2+ binding modes of full-length prion protein. The Journal of Biological Chemistry. 283: 1870-81. PMID 18042548 DOI: 10.1074/jbc.M708472200  0.96
2007 Alderton A, Davies P, Illman K, Brown DR. Ancient conserved domain protein-1 binds copper and modifies its retention in cells. Journal of Neurochemistry. 103: 312-21. PMID 17608643 DOI: 10.1111/j.1471-4159.2007.04751.x  0.96
2007 Butowt R, Davies P, Brown DR. Anterograde axonal transport of chicken cellular prion protein (PrPc) in vivo requires its N-terminal part. Journal of Neuroscience Research. 85: 2567-79. PMID 17335074 DOI: 10.1002/jnr.21229  0.96
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