Robert P. Mecham - Publications

Affiliations: 
Washington University, Saint Louis, St. Louis, MO 
Area:
Cell Biology, Biochemistry

231 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Parrish PCR, Liu D, Knutsen RH, Billington CJ, Mecham RP, Fu YP, Kozel BA. Whole exome sequencing in patients with Williams-Beuren syndrome followed by disease modeling in mice points to four novel pathways that may modify stenosis risk. Human Molecular Genetics. PMID 32412588 DOI: 10.1093/hmg/ddaa093  0.6
2020 Broekelmann TJ, Bodmer NK, Mecham RP. Identification of the growth factor binding sequence in the extracellular matrix protein MAGP-1. The Journal of Biological Chemistry. PMID 31988245 DOI: 10.1074/jbc.RA119.010540  0.32
2019 Kozel BA, Mecham RP. Elastic Fiber Ultrastructure and Assembly. Matrix Biology : Journal of the International Society For Matrix Biology. PMID 31669522 DOI: 10.1016/j.matbio.2019.10.002  0.6
2019 Lee VS, Halabi CM, Broekelmann TJ, Trackman PC, Stitziel NO, Mecham RP. Intracellular retention of mutant lysyl oxidase leads to aortic dilation in response to increased hemodynamic stress. Jci Insight. 5. PMID 31211696 DOI: 10.1172/jci.insight.127748  0.32
2018 Huang LH, Zinselmeyer BH, Chang CH, Saunders BT, Elvington A, Baba O, Broekelmann TJ, Qi L, Rueve JS, Swartz MA, Kim BS, Mecham RP, Wiig H, Thomas MJ, Sorci-Thomas MG, et al. Interleukin-17 Drives Interstitial Entrapment of Tissue Lipoproteins in Experimental Psoriasis. Cell Metabolism. PMID 30415924 DOI: 10.1016/j.cmet.2018.10.006  0.32
2018 Craft CS, Broekelmann TJ, Mecham RP. Microfibril-associated glycoproteins MAGP-1 and MAGP-2 in disease. Matrix Biology : Journal of the International Society For Matrix Biology. PMID 29524629 DOI: 10.1016/j.matbio.2018.03.006  0.32
2018 Stoilov I, Starcher BC, Mecham RP, Broekelmann TJ. Measurement of elastin, collagen, and total protein levels in tissues. Methods in Cell Biology. 143: 133-146. PMID 29310774 DOI: 10.1016/bs.mcb.2017.08.008  0.32
2017 Dahal S, Broekelmann T, Mecham R, Ramamurthi A. Maintaining elastogenicity of mesenchymal stem cell derived smooth muscle cells in 2D culture. Tissue Engineering. Part A. PMID 29264957 DOI: 10.1089/ten.TEA.2017.0237  0.56
2017 Halabi CM, Broekelmann TJ, Lin M, Lee VS, Chu ML, Mecham RP. Fibulin-4 is essential for maintaining arterial wall integrity in conduit but not muscular arteries. Science Advances. 3: e1602532. PMID 28508064 DOI: 10.1126/sciadv.1602532  0.32
2016 Balestrini JL, Gard AL, Gerhold KA, Wilcox EC, Liu A, Schwan J, Le AV, Baevova P, Dimitrievska S, Zhao L, Sundaram S, Sun H, Rittié L, Dyal R, Broekelmann TJ, ... Mecham RP, et al. Comparative biology of decellularized lung matrix: Implications of species mismatch in regenerative medicine. Biomaterials. 102: 220-230. PMID 27344365 DOI: 10.1016/j.biomaterials.2016.06.025  0.32
2016 Jarad G, Knutsen RH, Mecham RP, Miner JH. Albumin contributes to kidney disease progression in Alport syndrome. American Journal of Physiology. Renal Physiology. ajprenal.00456.2015. PMID 27147675 DOI: 10.1152/ajprenal.00456.2015  0.32
2016 Walji TA, Turecamo SE, DeMarsilis AJ, Sakai LY, Mecham RP, Craft CS. Characterization of metabolic health in mouse models of fibrillin-1 perturbation. Matrix Biology : Journal of the International Society For Matrix Biology. PMID 26902431 DOI: 10.1016/j.matbio.2016.02.006  0.56
2016 Ferruzzi J, Bersi MR, Mecham RP, Ramirez F, Yanagisawa H, Tellides G, Humphrey JD. Loss of elastic fiber integrity compromises common carotid artery function: Implications for vascular aging Artery Research. 14: 41-52. DOI: 10.1016/j.artres.2016.04.001  0.56
2015 Balestrini JL, Liu A, Gard AL, Huie JL, Blatt KM, Schwan J, Broekelmann T, Mecham R, Wilcox EC, Zhao L, Niklason L. Sterilization of Lung Matrices by Supercritical Carbon Dioxide. Tissue Engineering. Part C, Methods. PMID 26697757 DOI: 10.1089/ten.TEC.2015.0449  0.56
2015 Halabi CM, Broekelmann TJ, Knutsen RH, Ye L, Mecham RP, Kozel BA. Chronic antihypertensive treatment improves pulse pressure but not large artery mechanics in a mouse model of congenital vascular stiffness. American Journal of Physiology. Heart and Circulatory Physiology. 309: H1008-16. PMID 26232234 DOI: 10.1152/ajpheart.00288.2015  0.56
2015 Igoucheva O, Alexeev V, Halabi CM, Adams SM, Stoilov I, Sasaki T, Arita M, Donahue A, Mecham RP, Birk DE, Chu ML. Fibulin-4 E57K Knock-in Mice Recapitulate Cutaneous, Vascular and Skeletal Defects of Recessive Cutis Laxa 1B with both Elastic Fiber and Collagen Fibril Abnormalities. The Journal of Biological Chemistry. 290: 21443-59. PMID 26178373 DOI: 10.1074/jbc.M115.640425  0.56
2015 Mecham RP, Gibson MA. The microfibril-associated glycoproteins (MAGPs) and the microfibrillar niche. Matrix Biology : Journal of the International Society For Matrix Biology. PMID 25963142 DOI: 10.1016/j.matbio.2015.05.003  0.56
2015 Hubmacher D, Wang LW, Mecham RP, Reinhardt DP, Apte SS. Adamtsl2 deletion results in bronchial fibrillin microfibril accumulation and bronchial epithelial dysplasia--a novel mouse model providing insights into geleophysic dysplasia. Disease Models & Mechanisms. 8: 487-99. PMID 25762570 DOI: 10.1242/dmm.017046  0.56
2015 Walker AE, Henson GD, Reihl KD, Morgan RG, Dobson PS, Nielson EI, Ling J, Mecham RP, Li DY, Lesniewski LA, Donato AJ. Greater impairments in cerebral artery compared with skeletal muscle feed artery endothelial function in a mouse model of increased large artery stiffness. The Journal of Physiology. 593: 1931-43. PMID 25627876 DOI: 10.1113/jphysiol.2014.285338  0.56
2015 Guzy RD, Stoilov I, Elton TJ, Mecham RP, Ornitz DM. Fibroblast growth factor 2 is required for epithelial recovery, but not for pulmonary fibrosis, in response to bleomycin. American Journal of Respiratory Cell and Molecular Biology. 52: 116-28. PMID 24988442 DOI: 10.1165/rcmb.2014-0184OC  0.56
2014 DeMarsilis AJ, Walji TA, Maedeker JA, Stoka KV, Kozel BA, Mecham RP, Wagenseil JE, Craft CS. Elastin Insufficiency Predisposes Mice to Impaired Glucose Metabolism. Journal of Molecular and Genetic Medicine : An International Journal of Biomedical Research. 8. PMID 26167199 DOI: 10.4172/1747-0862.1000129  0.56
2014 Osei-Owusu P, Knutsen RH, Kozel BA, Dietrich HH, Blumer KJ, Mecham RP. Altered reactivity of resistance vasculature contributes to hypertension in elastin insufficiency. American Journal of Physiology. Heart and Circulatory Physiology. 306: H654-66. PMID 24414067 DOI: 10.1152/ajpheart.00601.2013  0.56
2013 Beene LC, Wang LW, Hubmacher D, Keene DR, Reinhardt DP, Annis DS, Mosher DF, Mecham RP, Traboulsi EI, Apte SS. Nonselective assembly of fibrillin 1 and fibrillin 2 in the rodent ocular zonule and in cultured cells: implications for Marfan syndrome. Investigative Ophthalmology & Visual Science. 54: 8337-44. PMID 24265020 DOI: 10.1167/iovs.13-13121  0.56
2013 Shi Y, Tu Y, Mecham RP, Bassnett S. Ocular phenotype of Fbn2-null mice. Investigative Ophthalmology & Visual Science. 54: 7163-73. PMID 24130178 DOI: 10.1167/iovs.13-12687  0.56
2013 Li A, Knutsen RH, Zhang H, Osei-Owusu P, Moreno-Dominguez A, Harter TM, Uchida K, Remedi MS, Dietrich HH, Bernal-Mizrachi C, Blumer KJ, Mecham RP, Koster JC, Nichols CG. Hypotension due to Kir6.1 gain-of-function in vascular smooth muscle. Journal of the American Heart Association. 2: e000365. PMID 23974906 DOI: 10.1161/JAHA.113.000365  0.56
2013 Combs MD, Knutsen RH, Broekelmann TJ, Toennies HM, Brett TJ, Miller CA, Kober DL, Craft CS, Atkinson JJ, Shipley JM, Trask BC, Mecham RP. Microfibril-associated glycoprotein 2 (MAGP2) loss of function has pleiotropic effects in vivo. The Journal of Biological Chemistry. 288: 28869-80. PMID 23963447 DOI: 10.1074/jbc.M113.497727  0.56
2013 Zou W, Croke M, Fukunaga T, Broekelmann TJ, Mecham RP, Teitelbaum SL. Zap70 inhibits Syk-mediated osteoclast function. Journal of Cellular Biochemistry. 114: 1871-8. PMID 23494777 DOI: 10.1002/jcb.24531  0.56
2013 Shi Y, Tu Y, De Maria A, Mecham RP, Bassnett S. Development, composition, and structural arrangements of the ciliary zonule of the mouse. Investigative Ophthalmology & Visual Science. 54: 2504-15. PMID 23493297 DOI: 10.1167/iovs.13-11619  0.56
2013 Zhu T, Chappel JC, Hsu FF, Turk J, Aurora R, Hyrc K, De Camilli P, Broekelmann TJ, Mecham RP, Teitelbaum SL, Zou W. Type I phosphotidylinosotol 4-phosphate 5-kinase γ regulates osteoclasts in a bifunctional manner. The Journal of Biological Chemistry. 288: 5268-77. PMID 23300084 DOI: 10.1074/jbc.M112.446054  0.32
2012 Mecham RP. Overview of extracellular matrix. Current Protocols in Cell Biology / Editorial Board, Juan S. Bonifacino ... [Et Al.]. Unit 10.1. PMID 23208544 DOI: 10.1002/0471143030.cb1001s57  0.56
2012 Zou W, Deselm CJ, Broekelmann TJ, Mecham RP, Vande Pol S, Choi K, Teitelbaum SL. Paxillin contracts the osteoclast cytoskeleton. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 27: 2490-500. PMID 22807029 DOI: 10.1002/jbmr.1706  0.32
2012 Sugitani H, Hirano E, Knutsen RH, Shifren A, Wagenseil JE, Ciliberto C, Kozel BA, Urban Z, Davis EC, Broekelmann TJ, Mecham RP. Alternative splicing and tissue-specific elastin misassembly act as biological modifiers of human elastin gene frameshift mutations associated with dominant cutis laxa. The Journal of Biological Chemistry. 287: 22055-67. PMID 22573328 DOI: 10.1074/jbc.M111.327940  0.6
2012 Wagenseil JE, Mecham RP. Elastin in large artery stiffness and hypertension. Journal of Cardiovascular Translational Research. 5: 264-73. PMID 22290157 DOI: 10.1007/s12265-012-9349-8  0.56
2012 Zhang P, Huang A, Ferruzzi J, Mecham RP, Starcher BC, Tellides G, Humphrey JD, Giordano FJ, Niklason LE, Sessa WC. Inhibition of microRNA-29 enhances elastin levels in cells haploinsufficient for elastin and in bioengineered vessels--brief report. Arteriosclerosis, Thrombosis, and Vascular Biology. 32: 756-9. PMID 22095981 DOI: 10.1161/ATVBAHA.111.238113  0.56
2012 Craft CS, Broekelmann TJ, Zou W, Chappel JC, Teitelbaum SL, Mecham RP. Oophorectomy-induced bone loss is attenuated in MAGP1-deficient mice. Journal of Cellular Biochemistry. 113: 93-9. PMID 21898536 DOI: 10.1002/jcb.23331  0.56
2012 Cheresh DA, Mecham RP. Preface Integrins: Molecular and Biological Responses to the Extracellular Matrix. xi-xiv. DOI: 10.1016/B978-0-08-091729-0.50005-X  0.56
2012 Cheresh DA, Mecham RP. Integrins: Molecular and Biological Responses to the Extracellular Matrix Integrins: Molecular and Biological Responses to the Extracellular Matrix. 1-278.  0.56
2011 Kozel BA, Knutsen RH, Ye L, Ciliberto CH, Broekelmann TJ, Mecham RP. Genetic modifiers of cardiovascular phenotype caused by elastin haploinsufficiency act by extrinsic noncomplementation. The Journal of Biological Chemistry. 286: 44926-36. PMID 22049077 DOI: 10.1074/jbc.M111.274779  0.56
2011 Baldo G, Wu S, Howe RA, Ramamoothy M, Knutsen RH, Fang J, Mecham RP, Liu Y, Wu X, Atkinson JP, Ponder KP. Pathogenesis of aortic dilatation in mucopolysaccharidosis VII mice may involve complement activation. Molecular Genetics and Metabolism. 104: 608-19. PMID 21944884 DOI: 10.1016/j.ymgme.2011.08.018  0.32
2011 Hidalgo-Tamola J, Luttrell I, Jiang X, Li D, Mecham RP, Chitaley K. Characterization of erectile function in elastin haploinsufficicent mice. The Journal of Sexual Medicine. 8: 3075-85. PMID 21883953 DOI: 10.1111/j.1743-6109.2011.02454.x  0.56
2011 Shao JS, Sierra OL, Cohen R, Mecham RP, Kovacs A, Wang J, Distelhorst K, Behrmann A, Halstead LR, Towler DA. Vascular calcification and aortic fibrosis: a bifunctional role for osteopontin in diabetic arteriosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology. 31: 1821-33. PMID 21597007 DOI: 10.1161/ATVBAHA.111.230011  0.56
2011 Le VP, Knutsen RH, Mecham RP, Wagenseil JE. Decreased aortic diameter and compliance precedes blood pressure increases in postnatal development of elastin-insufficient mice. American Journal of Physiology. Heart and Circulatory Physiology. 301: H221-9. PMID 21536846 DOI: 10.1152/ajpheart.00119.2011  0.56
2011 Akhtar K, Broekelmann TJ, Song H, Turk J, Brett TJ, Mecham RP, Adair-Kirk TL. Oxidative modifications of the C-terminal domain of tropoelastin prevent cell binding. The Journal of Biological Chemistry. 286: 13574-82. PMID 21321118 DOI: 10.1074/jbc.M110.192088  0.56
2011 Callewaert B, Renard M, Hucthagowder V, Albrecht B, Hausser I, Blair E, Dias C, Albino A, Wachi H, Sato F, Mecham RP, Loeys B, Coucke PJ, De Paepe A, Urban Z. New insights into the pathogenesis of autosomal-dominant cutis laxa with report of five ELN mutations. Human Mutation. 32: 445-55. PMID 21309044 DOI: 10.1002/humu.21462  0.56
2011 Watts CR, Knutsen RH, Ciliberto C, Mecham RP. Evidence for heterozygous abnormalities of the elastin gene (ELN) affecting the quantity of vocal fold elastic fibers: a pilot study. Journal of Voice : Official Journal of the Voice Foundation. 25: e85-90. PMID 20926252 DOI: 10.1016/j.jvoice.2010.04.006  0.56
2010 Akhtar K, Broekelmann TJ, Miao M, Keeley FW, Starcher BC, Pierce RA, Mecham RP, Adair-Kirk TL. Oxidative and nitrosative modifications of tropoelastin prevent elastic fiber assembly in vitro. The Journal of Biological Chemistry. 285: 37396-404. PMID 20847053 DOI: 10.1074/jbc.M110.126789  0.56
2010 Weinbaum JS, Tranquillo RT, Mecham RP. The matrix-binding domain of microfibril-associated glycoprotein-1 targets active connective tissue growth factor to a fibroblast-produced extracellular matrix. Macromolecular Bioscience. 10: 1338-44. PMID 20799254 DOI: 10.1002/mabi.201000121  0.56
2010 Zou W, Zhu T, Craft CS, Broekelmann TJ, Mecham RP, Teitelbaum SL. Cytoskeletal dysfunction dominates in DAP12-deficient osteoclasts. Journal of Cell Science. 123: 2955-63. PMID 20720152 DOI: 10.1242/jcs.069872  0.56
2010 Hu Q, Shifren A, Sens C, Choi J, Szabo Z, Starcher BC, Knutsen RH, Shipley JM, Davis EC, Mecham RP, Urban Z. Mechanisms of emphysema in autosomal dominant cutis laxa. Matrix Biology : Journal of the International Society For Matrix Biology. 29: 621-8. PMID 20600892 DOI: 10.1016/j.matbio.2010.06.005  0.56
2010 Hinton RB, Adelman-Brown J, Witt S, Krishnamurthy VK, Osinska H, Sakthivel B, James JF, Li DY, Narmoneva DA, Mecham RP, Benson DW. Elastin haploinsufficiency results in progressive aortic valve malformation and latent valve disease in a mouse model. Circulation Research. 107: 549-57. PMID 20576933 DOI: 10.1161/CIRCRESAHA.110.221358  0.56
2010 Craft CS, Zou W, Watkins M, Grimston S, Brodt MD, Broekelmann TJ, Weinbaum JS, Teitelbaum SL, Pierce RA, Civitelli R, Silva MJ, Mecham RP. Microfibril-associated glycoprotein-1, an extracellular matrix regulator of bone remodeling. The Journal of Biological Chemistry. 285: 23858-67. PMID 20501659 DOI: 10.1074/jbc.M110.113019  0.56
2010 Wagenseil JE, Ciliberto CH, Knutsen RH, Levy MA, Kovacs A, Mecham RP. The importance of elastin to aortic development in mice. American Journal of Physiology. Heart and Circulatory Physiology. 299: H257-64. PMID 20495146 DOI: 10.1152/ajpheart.00194.2010  0.56
2009 Carta L, Wagenseil JE, Knutsen RH, Mariko B, Faury G, Davis EC, Starcher B, Mecham RP, Ramirez F. Discrete contributions of elastic fiber components to arterial development and mechanical compliance. Arteriosclerosis, Thrombosis, and Vascular Biology. 29: 2083-9. PMID 19850904 DOI: 10.1161/ATVBAHA.109.193227  0.56
2009 Wagenseil JE, Mecham RP. Vascular extracellular matrix and arterial mechanics. Physiological Reviews. 89: 957-89. PMID 19584318 DOI: 10.1152/physrev.00041.2008  0.56
2009 Raveaud S, Mezin P, Lavanchy N, Starcher B, Mecham RP, Verdetti J, Faury G. Effects of chronic treatment with a low dose of nicorandil on the function of the rat aorta during ageing. Clinical and Experimental Pharmacology & Physiology. 36: 988-94. PMID 19473347 DOI: 10.1111/j.1440-1681.2009.05174.x  0.56
2009 Wagenseil JE, Ciliberto CH, Knutsen RH, Levy MA, Kovacs A, Mecham RP. Reduced vessel elasticity alters cardiovascular structure and function in newborn mice. Circulation Research. 104: 1217-24. PMID 19372465 DOI: 10.1161/CIRCRESAHA.108.192054  0.56
2009 Pascual G, Rodríguez M, Mecham RP, Sommer P, Buján J, Bellón JM. Lysyl oxidase like-1 dysregulation and its contribution to direct inguinal hernia. European Journal of Clinical Investigation. 39: 328-37. PMID 19292889 DOI: 10.1111/j.1365-2362.2009.02099.x  0.56
2009 Wagenseil JE, Ciliberto CH, Knutsen RH, Levy MA, Kovacs A, Mecham RP. Developmental cardiovascular remodeling associated with reduced elastin levels in mice occurs after embryonic day 18 Proceedings of the Asme Summer Bioengineering Conference 2009, Sbc2009. 1299-1300. DOI: 10.1115/SBC2009-204476  0.56
2008 Cirulis JT, Bellingham CM, Davis EC, Hubmacher D, Reinhardt DP, Mecham RP, Keeley FW. Fibrillins, fibulins, and matrix-associated glycoprotein modulate the kinetics and morphology of in vitro self-assembly of a recombinant elastin-like polypeptide. Biochemistry. 47: 12601-13. PMID 18973305 DOI: 10.1021/bi8005384  0.56
2008 Gansner JM, Madsen EC, Mecham RP, Gitlin JD. Essential role for fibrillin-2 in zebrafish notochord and vascular morphogenesis. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 237: 2844-61. PMID 18816837 DOI: 10.1002/dvdy.21705  0.56
2008 Shifren A, Durmowicz AG, Knutsen RH, Faury G, Mecham RP. Elastin insufficiency predisposes to elevated pulmonary circulatory pressures through changes in elastic artery structure. Journal of Applied Physiology (Bethesda, Md. : 1985). 105: 1610-9. PMID 18772328 DOI: 10.1152/japplphysiol.90563.2008  0.56
2008 Weinbaum JS, Broekelmann TJ, Pierce RA, Werneck CC, Segade F, Craft CS, Knutsen RH, Mecham RP. Deficiency in microfibril-associated glycoprotein-1 leads to complex phenotypes in multiple organ systems. The Journal of Biological Chemistry. 283: 25533-43. PMID 18625713 DOI: 10.1074/jbc.M709962200  0.56
2008 Broekelmann TJ, Ciliberto CH, Shifren A, Mecham RP. Modification and functional inactivation of the tropoelastin carboxy-terminal domain in cross-linked elastin. Matrix Biology : Journal of the International Society For Matrix Biology. 27: 631-9. PMID 18602002 DOI: 10.1016/j.matbio.2008.06.001  0.56
2008 Larsson E, McLean SE, Mecham RP, Lindahl P, Nelander S. Do two mutually exclusive gene modules define the phenotypic diversity of mammalian smooth muscle? Molecular Genetics and Genomics : Mgg. 280: 127-37. PMID 18509681 DOI: 10.1007/s00438-008-0349-y  0.56
2008 Ma X, Tittiger M, Knutsen RH, Kovacs A, Schaller L, Mecham RP, Ponder KP. Upregulation of elastase proteins results in aortic dilatation in mucopolysaccharidosis I mice. Molecular Genetics and Metabolism. 94: 298-304. PMID 18479957 DOI: 10.1016/j.ymgme.2008.03.018  0.56
2008 Mecham RP. Methods in elastic tissue biology: elastin isolation and purification. Methods (San Diego, Calif.). 45: 32-41. PMID 18442703 DOI: 10.1016/j.ymeth.2008.01.007  0.56
2008 Werneck CC, Vicente CP, Weinberg JS, Shifren A, Pierce RA, Broekelmann TJ, Tollefsen DM, Mecham RP. Mice lacking the extracellular matrix protein MAGP1 display delayed thrombotic occlusion following vessel injury. Blood. 111: 4137-44. PMID 18281502 DOI: 10.1182/blood-2007-07-101733  0.56
2008 Mydel P, Shipley JM, Adair-Kirk TL, Kelley DG, Broekelmann TJ, Mecham RP, Senior RM. Neutrophil elastase cleaves laminin-332 (laminin-5) generating peptides that are chemotactic for neutrophils. The Journal of Biological Chemistry. 283: 9513-22. PMID 18178964 DOI: 10.1074/jbc.M706239200  0.56
2008 Pezet M, Jacob MP, Escoubet B, Gheduzzi D, Tillet E, Perret P, Huber P, Quaglino D, Vranckx R, Li DY, Starcher B, Boyle WA, Mecham RP, Faury G. Elastin haploinsufficiency induces alternative aging processes in the aorta. Rejuvenation Research. 11: 97-112. PMID 18173368 DOI: 10.1089/rej.2007.0587  0.56
2008 El-Bizri N, Wang L, Merklinger SL, Guignabert C, Desai T, Urashima T, Sheikh AY, Knutsen RH, Mecham RP, Mishina Y, Rabinovitch M. Smooth muscle protein 22alpha-mediated patchy deletion of Bmpr1a impairs cardiac contractility but protects against pulmonary vascular remodeling. Circulation Research. 102: 380-8. PMID 18079409 DOI: 10.1161/CIRCRESAHA.107.161059  0.56
2008 McGowan SE, Holmes AJ, Mecham RP, Ritty TM. Arg-Gly-Asp-containing domains of fibrillins-1 and -2 distinctly regulate lung fibroblast migration. American Journal of Respiratory Cell and Molecular Biology. 38: 435-45. PMID 18006876 DOI: 10.1165/rcmb.2007-0281OC  0.56
2007 Wagenseil JE, Mecham RP. New insights into elastic fiber assembly. Birth Defects Research. Part C, Embryo Today : Reviews. 81: 229-40. PMID 18228265 DOI: 10.1002/bdrc.20111  0.56
2007 Segade F, Suganuma N, Mychaleckyj JC, Mecham RP. The intracellular form of human MAGP1 elicits a complex and specific transcriptional response. The International Journal of Biochemistry & Cell Biology. 39: 2303-13. PMID 17692555 DOI: 10.1016/j.biocel.2007.06.017  0.56
2007 Hirano E, Knutsen RH, Sugitani H, Ciliberto CH, Mecham RP. Functional rescue of elastin insufficiency in mice by the human elastin gene: implications for mouse models of human disease. Circulation Research. 101: 523-31. PMID 17626896 DOI: 10.1161/CIRCRESAHA.107.153510  0.56
2007 Wagenseil JE, Knutsen RH, Li DY, Mecham RP. Elastin-insufficient mice show normal cardiovascular remodeling in 2K1C hypertension despite higher baseline pressure and unique cardiovascular architecture. American Journal of Physiology. Heart and Circulatory Physiology. 293: H574-82. PMID 17400710 DOI: 10.1152/ajpheart.00205.2007  0.56
2007 Shifren A, Durmowicz AG, Knutsen RH, Hirano E, Mecham RP. Elastin protein levels are a vital modifier affecting normal lung development and susceptibility to emphysema. American Journal of Physiology. Lung Cellular and Molecular Physiology. 292: L778-87. PMID 17142349 DOI: 10.1152/ajplung.00352.2006  0.56
2007 Lemaire R, Bayle J, Mecham RP, Lafyatis R. Microfibril-associated MAGP-2 stimulates elastic fiber assembly. The Journal of Biological Chemistry. 282: 800-8. PMID 17099216 DOI: 10.1074/jbc.M609692200  0.56
2006 Hu Q, Loeys BL, Coucke PJ, De Paepe A, Mecham RP, Choi J, Davis EC, Urban Z. Fibulin-5 mutations: mechanisms of impaired elastic fiber formation in recessive cutis laxa. Human Molecular Genetics. 15: 3379-86. PMID 17035250 DOI: 10.1093/hmg/ddl414  0.56
2006 Shifren A, Mecham RP. The stumbling block in lung repair of emphysema: elastic fiber assembly. Proceedings of the American Thoracic Society. 3: 428-33. PMID 16799087 DOI: 10.1513/pats.200601-009AW  0.56
2006 Mateev SN, Mouser R, Young DA, Mecham RP, Moore LG. Chronic hypoxia augments uterine artery distensibility and alters the circumferential wall stress-strain relationship during pregnancy. Journal of Applied Physiology (Bethesda, Md. : 1985). 100: 1842-50. PMID 16714414 DOI: 10.1152/japplphysiol.00618.2005  0.56
2006 Fu X, Wang Y, Kao J, Irwin A, d'Avignon A, Mecham RP, Parks WC, Heinecke JW. Specific sequence motifs direct the oxygenation and chlorination of tryptophan by myeloperoxidase. Biochemistry. 45: 3961-71. PMID 16548523 DOI: 10.1021/bi052339+  0.56
2006 Czirok A, Zach J, Kozel BA, Mecham RP, Davis EC, Rongish BJ. Elastic fiber macro-assembly is a hierarchical, cell motion-mediated process. Journal of Cellular Physiology. 207: 97-106. PMID 16331676 DOI: 10.1002/jcp.20573  0.56
2006 Kozel BA, Rongish BJ, Czirok A, Zach J, Little CD, Davis EC, Knutsen RH, Wagenseil JE, Levy MA, Mecham RP. Elastic fiber formation: a dynamic view of extracellular matrix assembly using timer reporters. Journal of Cellular Physiology. 207: 87-96. PMID 16261592 DOI: 10.1002/jcp.20546  0.56
2005 Segade F, Mecham RP. Regulatory elements of microfibril-associated glycoprotein-1 gene expression in muscle cells. Biochimica Et Biophysica Acta. 1731: 215-24. PMID 16321658 DOI: 10.1016/j.bbaexp.2005.10.007  0.56
2005 Thomassin L, Werneck CC, Broekelmann TJ, Gleyzal C, Hornstra IK, Mecham RP, Sommer P. The Pro-regions of lysyl oxidase and lysyl oxidase-like 1 are required for deposition onto elastic fibers. The Journal of Biological Chemistry. 280: 42848-55. PMID 16251195 DOI: 10.1074/jbc.M506832200  0.56
2005 Broekelmann TJ, Kozel BA, Ishibashi H, Werneck CC, Keeley FW, Zhang L, Mecham RP. Tropoelastin interacts with cell-surface glycosaminoglycans via its COOH-terminal domain. The Journal of Biological Chemistry. 280: 40939-47. PMID 16192266 DOI: 10.1074/jbc.M507309200  0.56
2005 Merklinger SL, Wagner RA, Spiekerkoetter E, Hinek A, Knutsen RH, Kabir MG, Desai K, Hacker S, Wang L, Cann GM, Ambartsumian NS, Lukanidin E, Bernstein D, Husain M, Mecham RP, et al. Increased fibulin-5 and elastin in S100A4/Mts1 mice with pulmonary hypertension. Circulation Research. 97: 596-604. PMID 16109920 DOI: 10.1161/01.RES.0000182425.49768.8a  0.56
2005 Kelleher CM, Silverman EK, Broekelmann T, Litonjua AA, Hernandez M, Sylvia JS, Stoler J, Reilly JJ, Chapman HA, Speizer FE, Weiss ST, Mecham RP, Raby BA. A functional mutation in the terminal exon of elastin in severe, early-onset chronic obstructive pulmonary disease. American Journal of Respiratory Cell and Molecular Biology. 33: 355-62. PMID 16081882 DOI: 10.1165/rcmb.2005-0206OC  0.56
2005 Wagenseil JE, Nerurkar NL, Knutsen RH, Okamoto RJ, Li DY, Mecham RP. Effects of elastin haploinsufficiency on the mechanical behavior of mouse arteries. American Journal of Physiology. Heart and Circulatory Physiology. 289: H1209-17. PMID 15863465 DOI: 10.1152/ajpheart.00046.2005  0.56
2005 Spencer JA, Hacker SL, Davis EC, Mecham RP, Knutsen RH, Li DY, Gerard RD, Richardson JA, Olson EN, Yanagisawa H. Altered vascular remodeling in fibulin-5-deficient mice reveals a role of fibulin-5 in smooth muscle cell proliferation and migration. Proceedings of the National Academy of Sciences of the United States of America. 102: 2946-51. PMID 15710889 DOI: 10.1073/pnas.0500058102  0.56
2005 Hofmann CS, Wang X, Sullivan CP, Toselli P, Stone PJ, McLean SE, Mecham RP, Schreiber BM, Sonenshein GE. B-Myb represses elastin gene expression in aortic smooth muscle cells. The Journal of Biological Chemistry. 280: 7694-701. PMID 15615710 DOI: 10.1074/jbc.M412501200  0.56
2005 McLean SE, Mecham BH, Kelleher CM, Mariani TJ, Mecham RP. Extracellular matrix gene expression in the developing mouse aorta Advances in Developmental Biology. 15: 81-128. DOI: 10.1016/S1574-3349(05)15003-0  0.56
2004 Ng CM, Cheng A, Myers LA, Martinez-Murillo F, Jie C, Bedja D, Gabrielson KL, Hausladen JM, Mecham RP, Judge DP, Dietz HC. TGF-beta-dependent pathogenesis of mitral valve prolapse in a mouse model of Marfan syndrome. The Journal of Clinical Investigation. 114: 1586-92. PMID 15546004 DOI: 10.1172/JCI22715  0.56
2004 Kelleher CM, McLean SE, Mecham RP. Vascular extracellular matrix and aortic development. Current Topics in Developmental Biology. 62: 153-88. PMID 15522742 DOI: 10.1016/S0070-2153(04)62006-0  0.56
2004 Wachi H, Sugitani H, Murata H, Nakazawa J, Mecham RP, Seyama Y. Tropoelastin inhibits vascular calcification via 67-kDa elastin binding protein in cultured bovine aortic smooth muscle cells. Journal of Atherosclerosis and Thrombosis. 11: 159-66. PMID 15256767  0.56
2004 Kozel BA, Ciliberto CH, Mecham RP. Deposition of tropoelastin into the extracellular matrix requires a competent elastic fiber scaffold but not live cells. Matrix Biology : Journal of the International Society For Matrix Biology. 23: 23-34. PMID 15172035 DOI: 10.1016/j.matbio.2004.02.004  0.56
2004 Zweers MC, van Vlijmen-Willems IM, van Kuppevelt TH, Mecham RP, Steijlen PM, Bristow J, Schalkwijk J. Deficiency of tenascin-X causes abnormalities in dermal elastic fiber morphology. The Journal of Investigative Dermatology. 122: 885-91. PMID 15102077 DOI: 10.1111/j.0022-202X.2004.22401.x  0.56
2004 Werneck CC, Trask BC, Broekelmann TJ, Trask TM, Ritty TM, Segade F, Mecham RP. Identification of a major microfibril-associated glycoprotein-1-binding domain in fibrillin-2. The Journal of Biological Chemistry. 279: 23045-51. PMID 15044481 DOI: 10.1074/jbc.M402656200  0.56
2004 Fu X, Kao JL, Bergt C, Kassim SY, Huq NP, d'Avignon A, Parks WC, Mecham RP, Heinecke JW. Oxidative cross-linking of tryptophan to glycine restrains matrix metalloproteinase activity: specific structural motifs control protein oxidation. The Journal of Biological Chemistry. 279: 6209-12. PMID 14670964 DOI: 10.1074/jbc.C300506200  0.56
2004 Park PW, Mecham RP. Lysostaphin Handbook of Proteolytic Enzymes: Second Edition. 1: 1004-1005. DOI: 10.1016/B978-0-12-079611-3.50314-1  0.56
2003 Faury G, Pezet M, Knutsen RH, Boyle WA, Heximer SP, McLean SE, Minkes RK, Blumer KJ, Kovacs A, Kelly DP, Li DY, Starcher B, Mecham RP. Developmental adaptation of the mouse cardiovascular system to elastin haploinsufficiency. The Journal of Clinical Investigation. 112: 1419-28. PMID 14597767 DOI: 10.1172/JCI19028  0.56
2003 Bernal-Mizrachi C, Weng S, Feng C, Finck BN, Knutsen RH, Leone TC, Coleman T, Mecham RP, Kelly DP, Semenkovich CF. Dexamethasone induction of hypertension and diabetes is PPAR-alpha dependent in LDL receptor-null mice. Nature Medicine. 9: 1069-75. PMID 12847522 DOI: 10.1038/nm898  0.56
2003 Ritty TM, Broekelmann TJ, Werneck CC, Mecham RP. Fibrillin-1 and -2 contain heparin-binding sites important for matrix deposition and that support cell attachment. The Biochemical Journal. 375: 425-32. PMID 12837131 DOI: 10.1042/BJ20030649  0.56
2003 Adair-Kirk TL, Atkinson JJ, Broekelmann TJ, Doi M, Tryggvason K, Miner JH, Mecham RP, Senior RM. A site on laminin alpha 5, AQARSAASKVKVSMKF, induces inflammatory cell production of matrix metalloproteinase-9 and chemotaxis. Journal of Immunology (Baltimore, Md. : 1950). 171: 398-406. PMID 12817023  0.56
2003 Buján J, Gimeno MJ, Jiménez JA, Kielty CM, Mecham RP, Bellón JM. Expression of elastic components in healthy and varicose veins. World Journal of Surgery. 27: 901-5. PMID 12784143 DOI: 10.1007/s00268-003-6897-8  0.56
2003 Heximer SP, Knutsen RH, Sun X, Kaltenbronn KM, Rhee MH, Peng N, Oliveira-dos-Santos A, Penninger JM, Muslin AJ, Steinberg TH, Wyss JM, Mecham RP, Blumer KJ. Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice. The Journal of Clinical Investigation. 111: 1259. PMID 12697745  0.56
2003 Kozel BA, Wachi H, Davis EC, Mecham RP. Domains in tropoelastin that mediate elastin deposition in vitro and in vivo. The Journal of Biological Chemistry. 278: 18491-8. PMID 12626514 DOI: 10.1074/jbc.M212715200  0.56
2003 Sugitani H, Wachi H, Murata H, Sato F, Mecham RP, Seyama Y. Characterization of an in vitro model of calcification in retinal pigmented epithelial cells. Journal of Atherosclerosis and Thrombosis. 10: 48-56. PMID 12621165  0.56
2003 Heximer SP, Knutsen RH, Sun X, Kaltenbronn KM, Rhee MH, Peng N, Oliveira-dos-Santos A, Penninger JM, Muslin AJ, Steinberg TH, Wyss JM, Mecham RP, Blumer KJ. Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice. The Journal of Clinical Investigation. 111: 445-52. PMID 12588882 DOI: 10.1172/JCI15598  0.56
2003 Hornstra IK, Birge S, Starcher B, Bailey AJ, Mecham RP, Shapiro SD. Lysyl oxidase is required for vascular and diaphragmatic development in mice. The Journal of Biological Chemistry. 278: 14387-93. PMID 12473682 DOI: 10.1074/jbc.M210144200  0.56
2002 Sugitani H, Wachi H, Mecham RP, Seyama Y. Accelerated calcification represses the expression of elastic fiber components and lysyl oxidase in cultured bovine aortic smooth muscle cells. Journal of Atherosclerosis and Thrombosis. 9: 292-8. PMID 12560590  0.56
2002 Davis EC, Roth RA, Heuser JE, Mecham RP. Ultrastructural properties of ciliary zonule microfibrils. Journal of Structural Biology. 139: 65-75. PMID 12406689 DOI: 10.1016/S1047-8477(02)00559-2  0.56
2002 Segade F, Trask BC, Broekelmann TJ, Pierce RA, Mecham RP. Identification of a matrix-binding domain in MAGP1 and MAGP2 and intracellular localization of alternative splice forms. The Journal of Biological Chemistry. 277: 11050-7. PMID 11796718 DOI: 10.1074/jbc.M110347200  0.56
2002 Fukui N, McAlinden A, Zhu Y, Crouch E, Broekelmann TJ, Mecham RP, Sandell LJ. Processing of type II procollagen amino propeptide by matrix metalloproteinases. The Journal of Biological Chemistry. 277: 2193-201. PMID 11705992 DOI: 10.1074/jbc.M105485200  0.56
2002 Downer R, Roche F, Park PW, Mecham RP, Foster TJ. The elastin-binding protein of Staphylococcus aureus (EbpS) is expressed at the cell surface as an integral membrane protein and not as a cell wall-associated protein. The Journal of Biological Chemistry. 277: 243-50. PMID 11684686 DOI: 10.1074/jbc.M107621200  0.56
2001 Osakabe T, Hayashi M, Hasegawa K, Okuaki T, Ritty TM, Mecham RP, Wachi H, Seyama Y. Age- and gender-related changes in ligament components Annals of Clinical Biochemistry. 38: 527-532. PMID 11587131 DOI: 10.1258/0004563011901118  0.56
2001 Trask BC, Broekelmann T, Ritty TM, Trask TM, Tisdale C, Mecham RP. Posttranslational modifications of microfibril associated glycoprotein-1 (MAGP-1). Biochemistry. 40: 4372-80. PMID 11284693 DOI: 10.1021/bi002738z  0.56
2000 Segade F, Broekelmann TJ, Pierce RA, Mecham RP. Revised genomic structure of the human MAGP1 gene and identification of alternate transcripts in human and mouse tissues Matrix Biology. 19: 671-682. PMID 11102756 DOI: 10.1016/S0945-053X(00)00115-3  0.56
2000 Dietz HC, Mecham RP. Mouse models of genetic diseases resulting from mutations in elastic fiber proteins Matrix Biology. 19: 481-488. PMID 11068202 DOI: 10.1016/S0945-053X(00)00101-3  0.56
2000 Trask TM, Trask BC, Ritty TM, Abrams WR, Rosenbloom J, Mecham RP. Interaction of tropoelastin with the amino-terminal domains of fibrillin-1 and fibrillin-2 suggests a role for the fibrillins in elastic fiber assembly. The Journal of Biological Chemistry. 275: 24400-6. PMID 10825173 DOI: 10.1074/jbc.M003665200  0.56
2000 Trask BC, Trask TM, Broekelmann T, Mecham RP. The microfibrillar proteins MAGP-1 and fibrillin-1 form a ternary complex with the chondroitin sulfate proteoglycan decorin. Molecular Biology of the Cell. 11: 1499-507. PMID 10793130  0.56
1999 Davis EC, Blattel SA, Mecham RP. Remodeling of elastic fiber components in scleroderma skin. Connective Tissue Research. 40: 113-21. PMID 10761636  0.56
1999 Robb BW, Wachi H, Schaub T, Mecham RP, Davis EC. Characterization of an in vitro model of elastic fiber assembly. Molecular Biology of the Cell. 10: 3595-605. PMID 10564258  0.56
1999 Faury G, Maher GM, Li DY, Keating MT, Mecham RP, Boyle WA. Relation between outer and luminal diameter in cannulated arteries. The American Journal of Physiology. 277: H1745-53. PMID 10564127  0.56
1999 Zhang M, Pierce RA, Wachi H, Mecham RP, Parks WC. An open reading frame element mediates posttranscriptional regulation of tropoelastin and responsiveness to transforming growth factor β1 Molecular and Cellular Biology. 19: 7314-7326. PMID 10523620  0.56
1999 Trask TM, Ritty TM, Broekelmann T, Tisdale C, Mecham RP. N-terminal domains of fibrillin 1 and fibrillin 2 direct the formation of homodimers: a possible first step in microfibril assembly. The Biochemical Journal. 340: 693-701. PMID 10359653 DOI: 10.1042/0264-6021:3400693  0.56
1999 Ritty TM, Broekelmann T, Tisdalet C, Milewicz DM, Mecham RP. Processing of the fibrillin-1 carboxyl-terminal domain Journal of Biological Chemistry. 274: 8933-8940. PMID 10085138 DOI: 10.1074/jbc.274.13.8933  0.56
1999 Park PW, Broekelmann TJ, Mecham BR, Mecham RP. Characterization of the elastin binding domain in the cell-surface 25- kDa elastin-binding protein of Staphylococcus aureus (EbpS) Journal of Biological Chemistry. 274: 2845-2850. PMID 9915819 DOI: 10.1074/jbc.274.5.2845  0.56
1998 Davis EC, Mecham RP. Intracellular trafficking of tropoelastin. Matrix Biology : Journal of the International Society For Matrix Biology. 17: 245-54. PMID 9749941 DOI: 10.1016/S0945-053X(98)90078-6  0.56
1998 Mecham RP. Conference summary: Biology and Pathobiology of the lung circulation Chest. 114. PMID 9676655  0.56
1998 Hausladen JM, Davis EC, Pierce RA, Mecham RP. Formation of the pulmonary vasculature: elastic fiber proteins as markers of cellular differentiation and vascular development. Chest. 114: 6S. PMID 9676600  0.56
1998 Ljubimov AV, Saghizadeh M, Spirin KS, Mecham RP, Sakai LY, Kenney MC. Increased expression of fibrillin-1 in human corneas with bullous keratopathy. Cornea. 17: 309-14. PMID 9603388 DOI: 10.1097/00003226-199805000-00009  0.56
1998 Faury G, Gamier S, Weiss AS, Wallach J, Fülöp T, Jacob MP, Mecham RP, Robert L, Verdetti J. Action of tropoelastin and synthetic elastin sequences on vascular tone and on free Ca2+ level in human vascular endothelial cells Circulation Research. 82: 328-336. PMID 9486661  0.56
1998 Davis EC, Broekelmann TJ, Ozawa Y, Mecham RP. Identification of tropoelastin as a ligand for the 65-kD FK506-binding protein, FKBP65, in the secretory pathway. The Journal of Cell Biology. 140: 295-303. PMID 9442105 DOI: 10.1083/jcb.140.2.295  0.56
1997 Fang J, Li X, Smiley E, Francke U, Mecham RP, Bonadio J. Mouse latent TGF-beta binding protein-2: molecular cloning and developmental expression. Biochimica Et Biophysica Acta. 1354: 219-30. PMID 9427531 DOI: 10.1016/S0167-4781(97)00104-8  0.56
1997 Mecham RP, Broekelmann TJ, Fliszar CJ, Shapiro SD, Welgus HG, Senior RM. Elastin degradation by matrix metalloproteinases: Cleavage site specificity and mechanisms of elastolysis Journal of Biological Chemistry. 272: 18071-18076. PMID 9218437 DOI: 10.1074/jbc.272.29.18071  0.56
1997 Stenmark KR, Mecham RP. Cellular and molecular mechanisms of pulmonary vascular remodeling Annual Review of Physiology. 59: 89-144. PMID 9074758 DOI: 10.1146/annurev.physiol.59.1.89  0.56
1997 Olin JM, Trask BC, Curci JA, Liao S, Mecham RP, Thompson RW. Antibodies deposited in abdominal aortic aneurysms(AAA) specifically recognize microfibril-associated glycoprotein(MAGP) Faseb Journal. 11: A138.  0.56
1996 Tanaka Y, Bernstein ML, Mecham RP, Patterson GA, Cooper JD, Botney MD. Site-specific responses to monocrotaline-induced vascular injury: evidence for two distinct mechanisms of remodeling. American Journal of Respiratory Cell and Molecular Biology. 15: 390-7. PMID 8810644 DOI: 10.1165/ajrcmb.15.3.8810644  0.56
1996 Brown-Augsburger P, Broekelmann T, Rosenbloom J, Mecham RP. Functional domains on elastin and microfibril-associated glycoprotein involved in elastic fibre assembly Biochemical Journal. 318: 149-155. PMID 8761465  0.56
1996 Park PW, Rosenbloom J, Abrams WR, Mecham RP. Molecular cloning and expression of the gene for elastin-binding protein (ebpS) in Staphylococcus aureus Journal of Biological Chemistry. 271: 15803-15809. PMID 8663124 DOI: 10.1074/jbc.271.26.15803  0.56
1996 Davis EC, Mecham RP. Selective degradation of accumulated secretory proteins in the endoplasmic reticulum. A possible clearance pathway for abnormal tropoelastin Journal of Biological Chemistry. 271: 3787-3794. PMID 8631995 DOI: 10.1074/jbc.271.7.3787  0.56
1996 Park PW, Biedermann K, Mecham L, Bissett DL, Mecham RP. Lysozyme binds to elastin and protects elastin from elastase-mediated degradation Journal of Investigative Dermatology. 106: 1075-1080. PMID 8618042  0.56
1996 Sakamoto H, Broekelmann T, Cheresh DA, Ramirez F, Rosenbloom J, Mecham RP. Cell-type specific recognition of RGD- and non-RGD-containing cell binding domains in fibrillin-1 Journal of Biological Chemistry. 271: 4916-4922. PMID 8617764 DOI: 10.1074/jbc.271.9.4916  0.56
1996 Mariani TJ, Roby JD, Mecham RP, Parks WC, Crouch E, Pierce RA. Localization of type I procollagen gene expression in silica-induced granulomatous lung disease and implication of transforming growth factor-β as a mediator of fibrosis American Journal of Pathology. 148: 151-164. PMID 8546202  0.56
1995 Mecham RP, Broekelmann T, Davis EC, Gibson MA, Brown-Augsburger P. Elastic fibre assembly: macromolecular interactions Ciba Foundation Symposium. 192: 172-181; discussion . PMID 8575256  0.56
1995 Gibson MA, Hatzinikolas G, Davis EC, Baker E, Sutherland GR, Mecham RP. Bovine latent transforming growth factor β1-binding protein 2: Molecular cloning, identification of tissue isoforms, and immunolocalization to elastin-associated microfibrils Molecular and Cellular Biology. 15: 6932-6942. PMID 8524260  0.56
1995 Shapiro SD, Fliszar CJ, Broekelmann TJ, Mecham RP, Senior RM, Welgus HG. Activation of the 92-kDa gelatinase by stromelysin and 4- aminophenylmercuric acetate. Differential processing and stabilization of the carboxyl-terminal domain by tissue inhibitor of metalloproteinases (TIMP) Journal of Biological Chemistry. 270: 6351-6356. PMID 7890773 DOI: 10.1074/jbc.270.11.6351  0.56
1995 Park PW, Senior RM, Griffin GL, Broekelmann TJ, Susan Mudd M, Mecham RP. Binding and degradation of elastin by the staphylolytic enzyme lysostaphin International Journal of Biochemistry and Cell Biology. 27: 139-146. PMID 7767782  0.56
1995 Gray AJ, Bishop JE, Reeves JT, Mecham RP, Laurent GJ. Partially degraded fibrin(ogen) stimulates fibroblast proliferation in vitro. American Journal of Respiratory Cell and Molecular Biology. 12: 684-90. PMID 7766431 DOI: 10.1165/ajrcmb.12.6.7766431  0.56
1995 Yin W, Smiley E, Germiller J, Mecham RP, Florer JB, Wenstrup RJ, Bonadio J. Isolation of a novel latent transforming growth factor-β binding protein gene (LTBP-3) Journal of Biological Chemistry. 270: 10147-10160. PMID 7730318 DOI: 10.1074/jbc.270.17.10147  0.56
1995 Brown-Augsburger P, Tisdale C, Broekelmann T, Sloan C, Mecham RP. Identification of an elastin cross-linking domain that joins three peptide chains. Possible role in nucleated assembly Journal of Biological Chemistry. 270: 17778-17783. PMID 7629078 DOI: 10.1074/jbc.270.30.17778  0.56
1995 Thompson RW, Holmes DR, Mertens RA, Liao S, Botney MD, Mecham RP, Welgus HG, Parks WC. Production and localization of 92-kilodalton gelatinase in abdominal aortic aneurysms: An elastolytic metalloproteinase expressed by aneurysm-infiltrating macrophages Journal of Clinical Investigation. 96: 318-326. PMID 7615801  0.56
1995 Gray AJ, Park PW, Broekelmann TJ, Laurent GJ, Reeves JT, Stenmark KR, Mecham RP. The mitogenic effects of the B beta chain of fibrinogen are mediated through cell surface calreticulin. The Journal of Biological Chemistry. 270: 26602-6. PMID 7592883 DOI: 10.1074/jbc.270.44.26602  0.56
1995 Mariencheck MC, Davis EC, Zhang H, Ramirez F, Rosenbloom J, Gibson MA, Parks WC, Mecham RP. Fibrillin-1 and fibrillin-2 show temporal and tissue-specific regulation of expression in developing elastic tissues Connective Tissue Research. 31: 87-97. DOI: 10.3109/03008209509028396  0.56
1995 Mecham RP. Elastic fiber assembly and organization Genetic Counseling. 6: 157-158.  0.56
1994 Lee KA, Pierce RA, Davis EC, Mecham RP, Parks WC. Conversion to an elastogenic phenotype by fetal hyaline chondrocytes is accompanied by altered expression of elastin-related macromolecules Developmental Biology. 163: 241-252. PMID 8174780 DOI: 10.1006/dbio.1994.1140  0.56
1994 Stenmark KR, Durmowicz AG, Roby JD, Mecham RP, Parks WC. Persistence of the fetal pattern of tropoelastin gene expression in severe neonatal bovine pulmonary hypertension. The Journal of Clinical Investigation. 93: 1234-42. PMID 8132763 DOI: 10.1172/JCI117077  0.56
1994 Zhang H, Apfelroth SD, Hu W, Davis EC, Sanguineti C, Bonadio J, Mecham RP, Ramirez F. Structure and expression of fibrillin-2, a novel microfibrillar component preferentially located in elastic matrices Journal of Cell Biology. 124: 855-863. PMID 8120105  0.56
1994 Lee KA, Pierce RA, Mecham RP, Parks WC. Increased mesenchymal cell density accompanies induction of tropoelastin expression in developing elastic tissue Developmental Dynamics. 200: 53-67. PMID 8081014  0.56
1994 Durmowicz AG, Parks WC, Hyde DM, Mecham RP, Stenmark KR. Persistence, re-expression, and induction of pulmonary arterial fibronectin, tropoelastin, and type I procollagen mRNA expression in neonatal hypoxic pulmonary hypertension. The American Journal of Pathology. 145: 1411-20. PMID 7992844  0.56
1994 Brown-Augsburger P, Broekelmann T, Mecham L, Mercer R, Gibson MA, Cleary EG, Abrams WR, Rosenbloom J, Mecham RP. Microfibril-associated glycoprotein binds to the carboxyl-terminal domain of tropoelastin and is a substrate for transglutaminase Journal of Biological Chemistry. 269: 28443-28449. PMID 7961786  0.56
1993 Liptay MJ, Parks WC, Mecham RP, Roby J, Kaiser LR, Cooper JD, Botney MD. Neointimal macrophages colocalize with extracellular matrix gene expression in human atherosclerotic pulmonary arteries Journal of Clinical Investigation. 91: 588-594. PMID 8432864  0.56
1993 Sires UI, Griffin GL, Broekelmann TJ, Mecham RP, Murphy G, Chung AE, Welgus HG, Senior RM. Degradation of entactin by matrix metalloproteinases. Susceptibility to matrilysin and identification of cleavage sites Journal of Biological Chemistry. 268: 2069-2074. PMID 8380588  0.56
1993 Botney MD, Liptay MJ, Kaiser LR, Cooper JD, Parks WC, Mecham RP. Active collagen synthesis by pulmonary arteries in human primary pulmonary hypertension American Journal of Pathology. 143: 121-129. PMID 7686340  0.56
1993 Stenmark KR, Dempsey EC, Badesch DB, Frid M, Mecham RP, Parks WC. Regulation of pulmonary vascular wall cell growth: Developmental and site- specific heterogeneity European Respiratory Review. 3: 629-637.  0.56
1992 Botney MD, Kaiser LR, Cooper JD, Mecham RP, Parghi D, Roby J, Parks WC. Extracellular matrix protein gene expression in atherosclerotic hypertensive pulmonary arteries American Journal of Pathology. 140: 357-364. PMID 1739129  0.56
1992 Brown PL, Mecham L, Tisdale C, Mecham RP. The cysteine residues in the carboxy terminal domain of tropoelastin form an intrachain disulfide bond that stabilizes a loop structure and positively charged pocket Biochemical and Biophysical Research Communications. 186: 549-555. PMID 1632791 DOI: 10.1016/S0006-291X(05)80843-5  0.56
1992 Botney MD, Parks WC, Crouch EC, Stenmark K, Mecham RP. Transforming growth factor-β1 is decreased in remodeling hypertensive bovine pulmonary arteries Journal of Clinical Investigation. 89: 1629-1635. PMID 1569202  0.56
1992 Hall R, Hunt PD, Carrington M, Simmons D, Williamson S, Mecham RP, Tait A. Mimicry of elastin repetitive motifs by Theileria annulata sporozoite surface antigen Molecular and Biochemical Parasitology. 53: 105-112. PMID 1501630 DOI: 10.1016/0166-6851(92)90012-9  0.56
1992 Sudbeck BD, Jeffrey JJ, Welgus HG, Mecham RP, McCourt D, Parks WC. Purification and characterization of bovine interstitial collagenase and tissue inhibitor of metalloproteinases Archives of Biochemistry and Biophysics. 293: 370-376. PMID 1311165 DOI: 10.1016/0003-9861(92)90408-O  0.56
1991 Prosser IW, Whitehouse LA, Parks WC, Stahle-Backdahl M, Hinek A, Park PW, Mecham RP. Polyclonal antibodies to tropoelastin and the specific detection and measurement of tropoelastin in vitro Connective Tissue Research. 25: 265-279. PMID 2060302 DOI: 10.3109/03008209109029162  0.56
1991 Mecham RP, Stenmark KR, Parks WC. Connective tissue production by vascular smooth muscle in development and disease Chest. 99. PMID 1997269  0.56
1991 Grosso LE, Parks WC, Wu L, Mecham RP. Fibroblast adhesion to recombinant tropoelastin expressed as a Protein A-fusion protein Biochemical Journal. 273: 517-522. PMID 1996952  0.56
1991 Stenmark KR, Aldashev AA, Orton EC, Durmowicz AG, Badesch DB, Parks WC, Mecham RP, Voelkel NF, Reeves JT. Cellular adaptation during chronic neonatal hypoxic pulmonary hypertension. The American Journal of Physiology. 261: 97-104. PMID 1928459  0.56
1991 Mecham RP. Introduction: catalyzing matrix stability American Journal of Respiratory Cell and Molecular Biology. 5: 205. PMID 1910805  0.56
1991 Mecham RP, Whitehouse L, Hay M, Hinek A, Sheetz MP. Ligand affinity of the 67-kD elastin/laminin binding protein is modulated by the protein's Lectin domain: Visualization of elastin/laminin-receptor complexes with gold-tagged ligands Journal of Cell Biology. 113: 187-194. PMID 1848864  0.56
1991 Park PW, Roberts DD, Grosso LE, Parks WC, Rosenbloom J, Abrams WR, Mecham RP. Binding of elastin to Staphylococcus aureus Journal of Biological Chemistry. 266: 23399-23406. PMID 1744133  0.56
1991 Durmowicz AG, Badesch DB, Parks WC, Mecham RP, Stenmark KR. Hypoxia-induced inhibition of tropoelastin synthesis by neonatal calf pulmonary artery smooth muscle cells. American Journal of Respiratory Cell and Molecular Biology. 5: 464-9. PMID 1718337 DOI: 10.1165/ajrcmb/5.5.464  0.56
1991 Mecham RP. Laminin receptors Annual Review of Cell Biology. 7: 71-91. PMID 1667086  0.56
1991 Hinek A, Mecham RP, Keeley F, Rabinovitch M. Impaired elastin fiber assembly related to reduced 67-kD elastin-binding protein in fetal lamb ductus arteriosus and in cultured aortic smooth muscle cells treated with chondroitin sulfate Journal of Clinical Investigation. 88: 2083-2094. PMID 1661296  0.56
1991 Mecham RP. Receptors for laminin on mammalian cells Faseb Journal. 5: 2538-2546. PMID 1651264  0.56
1991 Mecham RP. Elastin synthesis and fiber assembly Annals of the New York Academy of Sciences. 624: 137-146. PMID 1648323  0.56
1990 Mecham RP, Heuser J. Three-dimensional organization of extracellular matrix in elastic cartilage as viewed by quick freeze, deep etch electron microscopy Connective Tissue Research. 24: 83-93. PMID 2354636 DOI: 10.3109/03008209009152425  0.56
1990 Grosso LE, Whitehouse LA, Mecham RP. Immunohistochemical detection of intracellular tropoelastin: an assay for elastin production and its use in the detection and assessment of elastogenic factors American Journal of Respiratory Cell and Molecular Biology. 3: 45-49. PMID 2194520  0.56
1990 Indik Z, Abrams WR, Kucich U, Gibson CW, Mecham RP, Rosenbloom J. Production of recombinant human tropoelastin: Characterization and demonstration of immunologic and chemotactic activity Archives of Biochemistry and Biophysics. 280: 80-86. PMID 2191629 DOI: 10.1016/0003-9861(90)90521-Y  0.56
1989 Parks WC, Mecham RP, Crouch EC, Orton EC, Stenmark KR. Response of lobar vessels to hypoxic pulmonary hypertension American Review of Respiratory Disease. 140: 1455-1457. PMID 2817612  0.56
1989 Noguchi A, Reddy R, Kursar JD, Parks WC, Mecham RP. Smooth muscle isoactin and elastin in fetal bovine lung Experimental Lung Research. 15: 537-552. PMID 2767003 DOI: 10.3109/01902148909069617  0.56
1989 Prosser IW, Stenmark KR, Suthar M, Crouch EC, Mecham RP, Parks WC. Regional heterogeneity of elastin and collagen gene expression in intralobar arteries in response to hypoxic pulmonary hypertension as demonstrated by in situ hybridization American Journal of Pathology. 135: 1073-1088. PMID 2596571  0.56
1989 Senior RM, Hinek A, Griffin GL, Pipoly DJ, Crouch EC, Mecham RP. Neutrophils show chemotaxis to type IV collagen and its 7S domain and contain a 67 kD type IV collagen binding protein with lectin properties American Journal of Respiratory Cell and Molecular Biology. 1: 479-487. PMID 2561590  0.56
1989 Mecham RP, Hinek A, Griffin GL, Senior RM, Liotta LA. The elastin receptor shows structural and functional similarities to the 67-kDa tumor cell laminin receptor Journal of Biological Chemistry. 264: 16652-16657. PMID 2550450  0.56
1989 Crouch EC, Parks WC, Rosenbaum JL, Chang D, Whitehouse L, Wu LJ, Stenmark KR, Orton EC, Mecham RP. Regulation of collagen production by medial smooth muscle cells in hypoxic pulmonary hypertension. The American Review of Respiratory Disease. 140: 1045-51. PMID 2478055 DOI: 10.1164/ajrccm/140.4.1045  0.56
1989 Mecham RP, Hinek A, Entwistle R, Wrenn DS, Griffin GL, Senior RM. Elastin binds to a multifunctional 67-kilodalton peripheral membrane protein Biochemistry. 28: 3716-3722.  0.56
1988 Parks WC, Whitehouse LA, Wu LC, Mecham RP. Terminal differentiation of nuchal ligament fibroblasts: Characterization of synthetic properties and responsiveness to external stimuli Developmental Biology. 129: 555-564. PMID 3417052 DOI: 10.1016/0012-1606(88)90400-9  0.56
1988 Grosso LE, Mecham RP. In vitro processing of tropoelastin: Investigation of a possible transport function associated with the carboxy-terminal domain Biochemical and Biophysical Research Communications. 153: 545-551. PMID 3382387 DOI: 10.1016/S0006-291X(88)81129-X  0.56
1988 Parks WC, Secrist h, Wu LC, Mecham RP. Developmental regulation of tropoelastin isoforms Journal of Biological Chemistry. 263: 4416-4423. PMID 3346253  0.56
1988 Stenmark KR, Orton EC, Reeves JT, Voelkel NF, Crouch EC, Parks WC, Mecham RP. Vascular remodeling in neonatal pulmonary hypertension: Role of the smooth muscle cell Chest. 93: 127S-133S. PMID 3342691  0.56
1988 Mecham RP, Hinek A, Cleary EG, Kucich U, Lee SJ, Rosenbloom J. Development of immunoreagents to ciliary zonules that react with protein components of elastic fiber microfibrils and with elastin-producing cells Biochemical and Biophysical Research Communications. 151: 822-826. PMID 3279956 DOI: 10.1016/S0006-291X(88)80355-3  0.56
1988 Hinek A, Wrenn DS, Mecham RP, Barondes SH. The elastin receptor: a galactoside-binding protein. Science (New York, N.Y.). 239: 1539-41. PMID 2832941  0.56
1988 Wrenn DS, Hinek A, Mecham RP. Kinetics of receptor-mediated binding of tropoelastin to ligament fibroblasts Journal of Biological Chemistry. 263: 2280-2284. PMID 2828364  0.56
1987 Mecham RP. [12] Modulation of elastin synthesis: In vitro models Methods in Enzymology. 144: 232-246. PMID 3626873 DOI: 10.1016/0076-6879(87)44181-5  0.56
1987 Mecham RP, Whitehouse LA, Wrenn DS, Parks WC, Griffin GL, Senior RM, Crouch EC, Stenmark KR, Voelkel NF. Smooth muscle-mediated connective tissue remodeling in pulmonary hypertension Science. 237: 423-426. PMID 3603030  0.56
1987 Bostancioglu K, Mecham RP, Wallach JM. Elastolysis of normal and partially cross-linked elastin Biochemistry International. 15: 263-269. PMID 3435523  0.56
1987 Wrenn DS, Mecham RP. Immunology of elastin Methods in Enzymology. 144: 246-288. PMID 3306284  0.56
1987 Wrenn DS, Parks WC, Whitehouse LA, Crouch EC, Kucich U, Rosenbloom J, Mecham RP. Identification of multiple tropoelastins secreted by bovine cells Journal of Biological Chemistry. 262: 2244-2249. PMID 2434478  0.56
1987 Cox DL, Mecham RP, Koob TJ. Site-specific variation in amino acid composition of skate egg capsule (Raja erinacea Mitchell, 1825) Journal of Experimental Marine Biology and Ecology. 107: 71-74. DOI: 10.1016/0022-0981(87)90124-9  0.56
1986 Crawford SW, Mecham RP, Sage H. Structural characteristics and intermolecular organization of human pulmonary-surfactant-associated proteins Biochemical Journal. 240: 107-114. PMID 3827832  0.56
1986 Wrenn DS, Griffin GL, Senior RM, Mecham RP. Characterization of biologically active domains on elastin: Identification of a monoclonal antibody to a cell recognition site Biochemistry. 25: 5172-5176. PMID 2429696  0.56
1985 Mecham RP, Levy BD, Morris SL, Madaras JG, Wrenn DS. Increased cyclic GMP levels lead to a stimulation of elastin production in ligament fibroblasts that is reversed by cyclic AMP Journal of Biological Chemistry. 260: 3255-3258. PMID 2982853  0.56
1984 Mecham RP, Griffin GL, Madaras JG, Senior RM. Appearance of chemotactic responsiveness to elastin peptides by developing fetal bovine ligament fibroblasts parallels the onset of elastin production Journal of Cell Biology. 98: 1813-1816. PMID 6725401  0.56
1984 Mecham RP, Madaras JG, Senior RM. Extracellular matrix-specific induction of elastogenic differentiation and maintenance of phenotypic stability in bovine ligament fibroblasts Journal of Cell Biology. 98: 1804-1812. PMID 6725400  0.56
1984 Cox DL, Koob TJ, Mecham RP, Sexton OJ. External incubation alters the composition of squamate eggshells Comparative Biochemistry and Physiology -- Part B: Biochemistry And. 79: 481-487. PMID 6509937 DOI: 10.1016/0305-0491(84)90409-7  0.56
1984 Mecham RP, Morris SL, Levy BD, Wrenn DS. Glucocorticoids stimulate elastin production in differentiated bovine ligament fibroblasts but do not induce elastin synthesis in undifferentiated cells Journal of Biological Chemistry. 259: 12414-12418. PMID 6490622  0.56
1983 Clark JG, Kuhn C, McDonald JA, Mecham RP. Lung connective tissue International Review of Connective Tissue Research. 10: 249-331. PMID 6358098  0.56
1983 Mecham RP, Madaras J, McDonald JA, Ryan U. Elastin production by cultured calf pulmonary artery endothelial cells Journal of Cellular Physiology. 116: 282-288. PMID 6350324  0.56
1982 Senior RM, Griffin GL, Mecham RP. Chemotactic responses of fibroblasts to tropoelastin and elastin-derived peptides Journal of Clinical Investigation. 70: 614-618. PMID 7107897  0.56
1982 Cox DL, Mecham RP, Sexton OJ. Lysine derived cross-links are present in a non-elastin, proline-rich protein fraction of Iguana iguana eggshell Comparative Biochemistry and Physiology -- Part B: Biochemistry And. 72: 619-623. PMID 6181935 DOI: 10.1016/0305-0491(82)90515-6  0.56
1982 Mecham RP, Lange G. Antigenicity of elastin: Characterization of major antigenic determinants on purified insoluble elastin Biochemistry. 21: 669-673. PMID 6176263  0.56
1981 Mecham RP. Effects of extracellular matrix upon elastogenesis Connective Tissue Research. 8: 241-244. PMID 6455252 DOI: 10.3109/03008208109152382  0.56
1981 Mecham RP. Elastin biosynthesis: A look at the Current scene Connective Tissue Research. 8: 155-160. PMID 6455238 DOI: 10.3109/03008208109152366  0.56
1981 Mecham RP, Lange G, Madaras J, Starcher B. Elastin synthesis by ligamentum nuchae fibroblasts: Effects of culture conditions and extracellular matrix on elastin production Journal of Cell Biology. 90: 332-338. PMID 6169729  0.56
1981 Starcher BC, Mecham RP. Desmosine radioimmunoassay as a means of studying elastogenesis in cell culture Connective Tissue Research. 8: 255-258. PMID 6114811 DOI: 10.3109/03008208109152385  0.56
1980 Senior RM, Griffin GL, Mecham RP. Chemotactic activity of elastin-derived peptides Journal of Clinical Investigation. 66: 859-862. PMID 6903189  0.56
1980 Mecham RP, Lange G. Measurement by radioimmunoassay of soluble elastins from different animal species Connective Tissue Research. 7: 247-252. PMID 6450026 DOI: 10.3109/03008208009152360  0.56
1979 Foster JA, Rich CB, Berglund N, Huber S, Mecham RP, Lange G. The anti-proteolytic behavior of lathyrogens. Biochimica Et Biophysica Acta. 587: 477-83. PMID 508800 DOI: 10.1016/0304-4165(79)90001-1  0.56
1979 Mecham RP, Foster JA. Characterization of insoluble elastin from copper-deficient pigs. Its usefulness in elastin sequence studies. Biochimica Et Biophysica Acta. 577: 147-58. PMID 427211 DOI: 10.1016/0005-2795(79)90017-5  0.56
1978 Mecham RP, Foster JA. A structural model for desmosine cross-linked peptides. The Biochemical Journal. 173: 617-25. PMID 697739  0.56
1978 Foster JA, Mecham RP, Rich CB, Cronin MF, Levine A, Imberman M, Salcedo LL. Proelastin. Synthesis in cultured smooth muscle cells. The Journal of Biological Chemistry. 253: 2797-803. PMID 632303  0.56
1977 Mecham RP, Foster JA. Trypsin-like neutral protease associated with soluble elastin. Biochemistry. 16: 3825-31. PMID 901757  0.56
1976 Foster JA, Mecham RP, Franzblau C. A high molecular weight species of soluble elastin. Biochemical and Biophysical Research Communications. 72: 1399-406. PMID 826247 DOI: 10.1016/S0006-291X(76)80169-6  0.56
1976 Mecham RP, Foster JA, Franzblau C. Intrinsic enzyme activity associated with tropoelastin. Biochimica Et Biophysica Acta. 446: 245-54. PMID 823969 DOI: 10.1016/0005-2795(76)90115-X  0.56
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