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Andreas Goutopoulos, Ph.D. - Publications

Affiliations: 
2000 University of Connecticut, Storrs, CT, United States 
Area:
Pharmaceutical Chemistry
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13/28 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2004 Fegley D, Kathuria S, Mercier R, Li C, Goutopoulos A, Makriyannis A, Piomelli D. Anandamide transport is independent of fatty-acid amide hydrolase activity and is blocked by the hydrolysis-resistant inhibitor AM1172. Proceedings of the National Academy of Sciences of the United States of America. 101: 8756-61. PMID 15138300 DOI: 10.1073/Pnas.0400997101  0.442
2002 Goutopoulos A, Makriyannis A. From cannabis to cannabinergics: new therapeutic opportunities. Pharmacology & Therapeutics. 95: 103-17. PMID 12182958 DOI: 10.1016/S0163-7258(02)00250-4  0.524
2001 Goutopoulos A, Fan P, Khanolkar AD, Xie XQ, Lin S, Makriyannis A. Stereochemical selectivity of methanandamides for the CB1 and CB2 cannabinoid receptors and their metabolic stability. Bioorganic & Medicinal Chemistry. 9: 1673-84. PMID 11425567 DOI: 10.1016/S0968-0896(01)00088-8  0.538
2000 Lamb RJ, Järbe TU, Makriyannis A, Lin S, Goutopoulos A. Effects of Delta 9-tetrahydrocannabinol, (R)-methanandamide, SR 141716,and d-amphetamine before and during daily Delta 9-tetrahydrocannabinol dosing. European Journal of Pharmacology. 398: 251-8. PMID 10854837 DOI: 10.1016/S0014-2999(00)00318-6  0.456
1999 Gifford AN, Bruneus M, Lin S, Goutopoulos A, Makriyannis A, Volkow ND, Gatley SJ. Potentiation of the action of anandamide on hippocampal slices by the fatty acid amide hydrolase inhibitor, palmitylsulphonyl fluoride (AM 374). European Journal of Pharmacology. 383: 9-14. PMID 10556675 DOI: 10.1016/S0014-2999(99)00609-3  0.475
1999 Piomelli D, Beltramo M, Glasnapp S, Lin SY, Goutopoulos A, Xie XQ, Makriyannis A. Structural determinants for recognition and translocation by the anandamide transporter. Proceedings of the National Academy of Sciences of the United States of America. 96: 5802-7. PMID 10318965 DOI: 10.1073/pnas.96.10.5802  0.411
1999 Lang W, Qin C, Lin S, Khanolkar AD, Goutopoulos A, Fan P, Abouzid K, Meng Z, Biegel D, Makriyannis A. Substrate Specificity and Stereoselectivity of Rat Brain Microsomal Anandamide Amidohydrolase. Journal of Medicinal Chemistry. 42: 1682. PMID 10231226 DOI: 10.1021/jm990139o  0.38
1999 Lang W, Qin C, Lin S, Khanolkar AD, Goutopoulos A, Fan P, Abouzid K, Meng Z, Biegel D, Makriyannis A. Substrate specificity and stereoselectivity of rat brain microsomal anandamide amidohydrolase. Journal of Medicinal Chemistry. 42: 896-902. PMID 10072686 DOI: 10.1021/Jm980461J  0.58
1998 Järbe TU, Sheppard R, Lamb RJ, Makriyannis A, Lin S, Goutopoulos A. Effects of delta-9-tetrahydrocannabinol and (R)-methanandamide on open-field behavior in rats. Behavioural Pharmacology. 9: 169-74. PMID 10065936  0.445
1998 Järbe TU, Lamb RJ, Makriyannis A, Lin S, Goutopoulos A. Delta9-THC training dose as a determinant for (R)-methanandamide generalization in rats. Psychopharmacology. 140: 519-22. PMID 9888629 DOI: 10.1007/S002130050797  0.486
1998 Lin S, Khanolkar AD, Fan P, Goutopoulos A, Qin C, Papahadjis D, Makriyannis A. Novel analogues of arachidonylethanolamide (anandamide): affinities for the CB1 and CB2 cannabinoid receptors and metabolic stability. Journal of Medicinal Chemistry. 41: 5353-61. PMID 9876105 DOI: 10.1021/Jm970257G  0.542
1998 Qin C, Lin S, Lang W, Goutopoulos A, Pavlopoulos S, Mauri F, Makriyannis A. Determination of anandamide amidase activity using ultraviolet-active amine derivatives and reverse-phase high-performance liquid chromatography. Analytical Biochemistry. 261: 8-15. PMID 9683506 DOI: 10.1006/Abio.1998.2713  0.479
1998 Papahatjis DP, Kourouli T, Abadji V, Goutopoulos A, Makriyannis A. Pharmacophoric requirements for cannabinoid side chains: multiple bond and C1'-substituted delta 8-tetrahydrocannabinols. Journal of Medicinal Chemistry. 41: 1195-200. PMID 9544219 DOI: 10.1021/Jm970277I  0.473
Low-probability matches (unlikely to be authored by this person)
2014 Jiang X, Fischer D, Chen X, McKenna SD, Liu H, Sriraman V, Yu HN, Goutopoulos A, Arkinstall S, He X. Evidence for Follicle-stimulating Hormone Receptor as a Functional Trimer. The Journal of Biological Chemistry. 289: 14273-82. PMID 24692546 DOI: 10.1074/Jbc.M114.549592  0.275
2019 Xiao Y, Karra S, Goutopoulos A, Morse NT, Zhang S, Dhanabal M, Tian H, Seenisamy J, Jayaadevan J, Caldwell R, Potnick J, Bleich M, Chekler E, Sherer B. Synthesis and SAR development of quinoline analogs as novel P2X7 receptor antagonists. Bioorganic & Medicinal Chemistry Letters. PMID 31031055 DOI: 10.1016/j.bmcl.2019.04.033  0.263
2014 Yu HN, Richardson TE, Nataraja S, Fischer DJ, Sriraman V, Jiang X, Bharathi P, Foglesong RJ, Haxell TF, Heasley BH, Jenks M, Li J, Dugas MS, Collis R, Tian H, ... ... Goutopoulos A, et al. Discovery of substituted benzamides as follicle stimulating hormone receptor allosteric modulators. Bioorganic & Medicinal Chemistry Letters. 24: 2168-72. PMID 24685543 DOI: 10.1016/J.Bmcl.2014.03.018  0.25
2021 Qiu H, Ali Z, Bender A, Caldwell R, Chen YY, Fang Z, Gardberg A, Glaser N, Goettsche A, Goutopoulos A, Grenningloh R, Hanschke B, Head J, Johnson T, Jones C, et al. Discovery of potent and selective reversible Bruton's tyrosine kinase inhibitors. Bioorganic & Medicinal Chemistry. 40: 116163. PMID 33932711 DOI: 10.1016/j.bmc.2021.116163  0.211
2021 Qiu H, Ali Z, Bowlan J, Caldwell R, Gardberg A, Glaser N, Goutopoulos A, Head J, Johnson T, Maurer C, Georgi K, Grenningloh R, Fang Z, Morandi F, Rohdich F, et al. Discovery of novel covalent BTK inhibitors with reduced CYP2C8 inhibitory activity. Chemmedchem. PMID 34582626 DOI: 10.1002/cmdc.202100453  0.204
2013 Karra S, Xiao Y, Chen X, Liu-Bujalski L, Huck B, Sutton A, Goutopoulos A, Askew B, Josephson K, Jiang X, Shutes A, Shankar V, Noonan T, Garcia-Berrios G, Dong R, et al. SAR and evaluation of novel 5H-benzo[c][1,8]naphthyridin-6-one analogs as Aurora kinase inhibitors. Bioorganic & Medicinal Chemistry Letters. 23: 3081-7. PMID 23570792 DOI: 10.1016/j.bmcl.2013.03.008  0.188
2018 Qiu H, Caldwell R, Liu-Bujalski L, Goutopoulos A, Jones R, Potnick J, Sherer B, Bender A, Grenningloh R, Xu D, Johnson T, Follis AV, Head J, Morandi F. Discovery of affinity-based probes for Btk occupancy assay. Chemmedchem. PMID 30521698 DOI: 10.1002/Cmdc.201800714  0.179
2018 Caldwell R, Liu-Bujalski L, Qiu H, Mochalkin I, Jones R, Neagu C, Goutopoulos A, Grenningloh R, Johnson T, Sherer B, Gardberg A, Follis AV, Morandi F, Head J. Discovery of a novel series of pyridine and pyrimidine carboxamides as potent and selective covalent inhibitors of Btk. Bioorganic & Medicinal Chemistry Letters. PMID 30290988 DOI: 10.1016/J.Bmcl.2018.09.033  0.174
2021 Xiao Y, Huck BR, Lan R, DeSelm L, Chen X, Qiu H, Neagu C, Johnson T, Mochalkin I, Gardberg A, Jiang X, Tian H, Dutt V, Santos D, Head J, ... ... Goutopoulos A, et al. Discovery of 4-Aminopyrimidine Analogs as highly Potent Dual P70S6K/Akt Inhibitors. Bioorganic & Medicinal Chemistry Letters. 128352. PMID 34481987 DOI: 10.1016/j.bmcl.2021.128352  0.17
2018 Qiu H, Liu-Bujalski L, Caldwell RD, Viacava Follis A, Gardberg A, Goutopoulos A, Grenningloh R, Head J, Johnson T, Jones CCV, Jones R, Mochalkin I, Morandi F, Neagu C, Potnick J, et al. Optimization of the efflux ratio and permeability of covalent irreversible BTK inhibitors. Bioorganic & Medicinal Chemistry Letters. PMID 30243592 DOI: 10.1016/J.Bmcl.2018.09.018  0.165
2019 Caldwell R, Qiu H, Askew BC, Bender AT, Brugger N, Camps M, Dhanabal M, Dutt V, Eichhorn T, Gardberg AS, Goutopoulos A, Grenningloh R, Head J, Healey B, Hodous BL, et al. Discovery of Evobrutinib: An Oral, Potent and Highly Selective, Covalent Bruton's Tyrosine Kinase (BTK) Inhibitor for the Treatment of Immunological Diseases. Journal of Medicinal Chemistry. PMID 31368705 DOI: 10.1021/Acs.Jmedchem.9B00794  0.165
2018 Qiu H, Liu-Bujalski L, Caldwell RD, Follis AV, Gardberg A, Goutopoulos A, Grenningloh R, Head J, Johnson T, Jones R, Mochalkin I, Morandi F, Neagu C, Sherer B. Discovery of potent, highly selective covalent irreversible BTK inhibitors from a fragment hit. Bioorganic & Medicinal Chemistry Letters. 28: 2939-2944. PMID 30122225 DOI: 10.1016/J.Bmcl.2018.07.008  0.164
2022 Xiao Y, Huck BR, Lan R, DeSelm L, Chen X, Qiu H, Neagu C, Johnson T, Mochalkin I, Gardberg A, Jiang X, Tian H, Dutt V, Santos D, Head J, ... ... Goutopoulos A, et al. Corrigendum to "Discovery of 4-aminopyrimidine analogs as highly potent dual P70S6K/Akt inhibitors" [Bioorgan. Med. Chem. Lett. 50 (2021) 128352]. Bioorganic & Medicinal Chemistry Letters. 128758. PMID 35484006 DOI: 10.1016/j.bmcl.2022.128758  0.152
2010 Kim K, Kong SY, Fulciniti M, Li X, Song W, Nahar S, Burger P, Rumizen MJ, Podar K, Chauhan D, Hideshima T, Munshi NC, Richardson P, Clark A, Ogden J, ... Goutopoulos A, et al. Blockade of the MEK/ERK signalling cascade by AS703026, a novel selective MEK1/2 inhibitor, induces pleiotropic anti-myeloma activity in vitro and in vivo. British Journal of Haematology. 149: 537-49. PMID 20331454 DOI: 10.1111/J.1365-2141.2010.08127.X  0.14
2021 DeSelm L, Huck B, Lan R, Neagu C, Potnick J, Xiao Y, Chen X, Jones R, Richardson TE, Heasley BH, Haxell T, Moore J, Tian H, Georgi K, Rohdich F, ... ... Goutopoulos A, et al. Identification of Clinical Candidate M2698, a Dual p70S6K and Akt Inhibitor, for Treatment of PAM Pathway-Altered Cancers. Journal of Medicinal Chemistry. PMID 34596404 DOI: 10.1021/acs.jmedchem.1c01087  0.114
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