| Year |
Citation |
Score |
| 2024 |
Khalid KM, Ratnayake WS, Apostolatos CA, Acevedo-Duncan M. Dual inhibition of atypical PKC signaling and PI3K/Akt signaling dysregulates c-Myc to induce apoptosis in clear cell Renal Cell Carcinoma. Frontiers in Oncology. 13: 1213715. PMID 38288105 DOI: 10.3389/fonc.2023.1213715 |
0.511 |
|
| 2021 |
Ratnayake WS, Apostolatos CA, Breedy S, Dennison CL, Hill R, Acevedo-Duncan M. Atypical PKCs activate Vimentin to facilitate prostate cancer cell motility and invasion. Cell Adhesion & Migration. PMID 33525953 DOI: 10.1080/19336918.2021.1882782 |
0.467 |
|
| 2020 |
Dey A, Islam SMA, Patel R, Acevedo-Duncan M. The interruption of atypical PKC signaling and Temozolomide combination therapy against glioblastoma. Cellular Signalling. 109819. PMID 33147518 DOI: 10.1016/j.cellsig.2020.109819 |
0.409 |
|
| 2020 |
Patel R, Islam SA, Bommareddy RR, Smalley T, Acevedo-Duncan M. Simultaneous inhibition of atypical protein kinase‑C and mTOR impedes bladder cancer cell progression. International Journal of Oncology. PMID 32236625 DOI: 10.3892/ijo.2020.5021 |
0.437 |
|
| 2020 |
Smalley T, Metcalf R, Patel R, Islam SMA, Bommareddy RR, Acevedo-Duncan M. The Atypical Protein Kinase C Small Molecule Inhibitor ζ-Stat, and Its Effects on Invasion Through Decreases in PKC-ζ Protein Expression. Frontiers in Oncology. 10: 209. PMID 32175276 DOI: 10.3389/Fonc.2020.00209 |
0.534 |
|
| 2020 |
BommaReddy RR, Patel R, Smalley T, Acevedo-Duncan M. Effects of Atypical Protein Kinase C Inhibitor (DNDA) on Lung Cancer Proliferation and Migration by PKC-ι/FAK Ubiquitination Through the Cbl-b Pathway. Oncotargets and Therapy. 13: 1661-1676. PMID 32158232 DOI: 10.2147/Ott.S224866 |
0.505 |
|
| 2020 |
Islam SMA, Dey A, Patel R, Smalley T, Acevedo-Duncan M. Atypical Protein Kinase-C inhibitors exhibit a synergistic effect in facilitating DNA damaging effect of 5-fluorouracil in colorectal cancer cells. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. 121: 109665. PMID 31810137 DOI: 10.1016/J.Biopha.2019.109665 |
0.512 |
|
| 2020 |
Breedy S, Ratnayake WS, Apostolatos C, Dey A, Acevedo-Duncan M. Abstract 5216: Atypical PKC inhibitors ICA-1S and ζ-Stat show inhibition of neuroblastoma cell proliferation Cancer Research. 80: 5216-5216. DOI: 10.1158/1538-7445.Am2020-5216 |
0.524 |
|
| 2020 |
Islam SMA, Acevedo-Duncan M. Abstract 4931: Yap1 regulates the transcription of cofilin to facilitate the metastatic movement of colorectal cancer cells Tumor Biology. DOI: 10.1158/1538-7445.Am2020-4931 |
0.384 |
|
| 2019 |
Smalley T, Islam SMA, Apostolatos C, Apostolatos A, Acevedo-Duncan M. Analysis of PKC-ζ protein levels in normal and malignant breast tissue subtypes. Oncology Letters. 17: 1537-1546. PMID 30675210 DOI: 10.3892/ol.2018.9792 |
0.307 |
|
| 2019 |
Islam SMA, Dey A, Acevedo-Duncan M. Abstract 719: Combination of atypical protein kinase-C inhibitor and 5-fluorouracil retards the proliferation of colorectal cancer cells Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-719 |
0.589 |
|
| 2019 |
Islam SMA, Patel RS, Bommareddy RR, Smalley TP, Acevedo-Duncan M. Abstract 4290: Simultaneous inhibition of Atypical Protein Kinase-C and mTOR impedes bladder canSimultaneous inhibition of atypical protein kinase-C and mTOR impedes bladder cancer cell progression of bladder cancer cell progression Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-4290 |
0.596 |
|
| 2019 |
Ratnayake WS, Breedy S, Apostolatos C, Hill R, Dennison C, Acevedo-Duncan M. Abstract 2857: Vimentin is a novel PKC-ι target facilitating migration and invasion in melanoma Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-2857 |
0.32 |
|
| 2019 |
Dey A, Patel R, Smalley T, Ratnayake WS, Islam A, Acevedo-Duncan M. Abstract 244: Inhibition of atypical PKC signaling enhances the sensitivity of glioblastoma cells towards Temozolomide therapy Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-244 |
0.418 |
|
| 2019 |
Smalley T, Patel R, Acevedo-Duncan M. Abstract 1776: An investigation of the effects of the atypical protein kinase C-ζinhibitor ζ-Stat on clear cell carcinoma ovarian cancer proliferation and invasion Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-1776 |
0.551 |
|
| 2019 |
Ratnayake WS, Apostolatos C, Breedy S, Hill R, Dennison C, Acevedo-Duncan M. Abstract 1044: PKC-ι and PKC-ζ are heavily responsible of up-regulating epithelial-mesenchymal transition (EMT) and activating Vimentin to facilitate cellular motility in prostate cancer cell lines Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-1044 |
0.502 |
|
| 2019 |
Smalley T, Patel R, Acevedo-Duncan M. Abstract B123: Full-length bio-active atypical protein kinase c ι expression and purification in a bacterial system Molecular Cancer Therapeutics. 18. DOI: 10.1158/1535-7163.Targ-19-B123 |
0.488 |
|
| 2018 |
Islam SMA, Patel R, Bommareddy RR, Khalid KM, Acevedo-Duncan M. The modulation of actin dynamics via atypical protein kinase-C activated Cofilin regulates metastasis of colorectal cancer cells. Cell Adhesion & Migration. PMID 30417717 DOI: 10.1080/19336918.2018.1546513 |
0.552 |
|
| 2018 |
Apostolatos AH, Ratnayake WS, Win-Piazza H, Apostolatos CA, Smalley T, Kang L, Salup R, Hill R, Acevedo-Duncan M. Inhibition of atypical protein kinase C‑ι effectively reduces the malignancy of prostate cancer cells by downregulating the NF-κB signaling cascade. International Journal of Oncology. PMID 30226591 DOI: 10.3892/Ijo.2018.4542 |
0.578 |
|
| 2018 |
Apostolatos AH, Apostolatos CA, Ratnayake WS, Neuger A, Sansil S, Bourgeois M, Acevedo-Duncan M. Preclinical testing of 5-amino-1-((1R,2S,3S,4R)-2,3-dihydroxy-4-methylcyclopentyl)-1H-imidazole-4-carboxamide: a potent protein kinase C-ι inhibitor as a potential prostate carcinoma therapeutic. Anti-Cancer Drugs. PMID 30204596 DOI: 10.1097/Cad.0000000000000694 |
0.445 |
|
| 2018 |
Ratnayake WS, Apostolatos CA, Apostolatos AH, Schutte RJ, Huynh MA, Ostrov DA, Acevedo-Duncan M. Oncogenic PKC-ι activates Vimentin during epithelial-mesenchymal transition in melanoma; a study based on PKC-ι and PKC-ζ specific inhibitors. Cell Adhesion & Migration. 1-17. PMID 29781749 DOI: 10.1080/19336918.2018.1471323 |
0.623 |
|
| 2018 |
Anisul Islam SM, Patel R, Acevedo-Duncan M. Protein Kinase C-ζ stimulates colorectal cancer cell carcinogenesis via PKC-ζ/Rac1/Pak1/β-Catenin signaling cascade. Biochimica Et Biophysica Acta. PMID 29408512 DOI: 10.1016/J.Bbamcr.2018.02.002 |
0.557 |
|
| 2018 |
Smalley T, Acevedo-Duncan M. Abstract A67: Effects of the atypical PKC-ι inhibitor ICA-1 on ovarian cancer proliferation and survival Clinical Cancer Research. 24. DOI: 10.1158/1557-3265.Ovca17-A67 |
0.507 |
|
| 2018 |
Islam SMA, Khalid KM, Bommareddy RR, Patel R, Acevedo-Duncan M. Abstract 5155: The modulation of actin dynamics via atypical protein kinase-C activated cofilin regulates migration of colorectal cancer cells Tumor Biology. DOI: 10.1158/1538-7445.Am2018-5155 |
0.523 |
|
| 2018 |
Ratnayake WS, Apostolatos AH, Apostolatos CA, Dey A, Patel R, Acevedo-Duncan M. Abstract 2022: Oncogenic protein kinase Cι drives melanoma cell epithelial-mesenchymal transition by activating vimentin through Par6/RhoA signaling Tumor Biology. DOI: 10.1158/1538-7445.Am2018-2022 |
0.515 |
|
| 2017 |
Ratnayake WS, Apostolatos AH, Ostrov DA, Acevedo-Duncan M. Two novel atypical PKC inhibitors; ACPD and DNDA effectively mitigate cell proliferation and epithelial to mesenchymal transition of metastatic melanoma while inducing apoptosis. International Journal of Oncology. PMID 29048609 DOI: 10.3892/Ijo.2017.4131 |
0.66 |
|
| 2017 |
Ratnayake WS, Acevedo-Duncan M. Abstract 862: Atypical protein kinase c inhibitors can repress epithelial to mesenchymal transition (type III) in malignant melanoma Cancer Research. 77: 862-862. DOI: 10.1158/1538-7445.Am2017-862 |
0.62 |
|
| 2017 |
Apostolatos AH, Ratnayake WS, Smalley T, Islam A, Acevedo-Duncan M. Abstract 2369: Transcription activators that regulate PKC-iota expression and are downstream targets of PKC-iota Cancer Research. 77: 2369-2369. DOI: 10.1158/1538-7445.Am2017-2369 |
0.47 |
|
| 2016 |
Ratnayake WS, Acevedo-Duncan M. Abstract 4569: Use of ACPD and ICA-1 as inhibitors of atypical proteinkinase C-zeta (ζ) and iota (ι) in metastasized melanoma cells Cancer Research. 76: 4569-4569. DOI: 10.1158/1538-7445.Am2016-4569 |
0.559 |
|
| 2015 |
Shah M, Apostolatos C, Apostolatos H, Acevedo-Duncan M. Abstract POSTER-THER-1428: Effects of atypical PKC inhibitors on ovarian cancer proliferation and RNA levels Clinical Cancer Research. 21. DOI: 10.1158/1557-3265.Ovcasymp14-Poster-Ther-1428 |
0.485 |
|
| 2015 |
Apostolatos AH, Apostolatos C, Acevedo-Duncan M. Abstract 3470: Atypical protein kinase C inhibition in prostate cancer cells: A study of ICA-1 and ACPD Endocrinology. DOI: 10.1158/1538-7445.Am2015-3470 |
0.589 |
|
| 2015 |
Shah M, Apostolatos C, Apostolatos H, Acevedo-Duncan M. Abstract 1037: Inverse regulation of p53 by atypical PKC inhibitors in ovarian cancer cells Cancer Research. 75: 1037-1037. DOI: 10.1158/1538-7445.Am2015-1037 |
0.574 |
|
| 2014 |
McCray AN, Desai S, Acevedo-Duncan M. The interruption of PKC-ι signaling and TRAIL combination therapy against glioblastoma cells. Neurochemical Research. 39: 1691-701. PMID 24965532 DOI: 10.1007/S11064-014-1361-8 |
0.684 |
|
| 2014 |
Sajan MP, Acevedo-Duncan ME, Standaert ML, Ivey RA, Lee M, Farese RV. Akt-dependent phosphorylation of hepatic FoxO1 is compartmentalized on a WD40/ProF scaffold and is selectively inhibited by aPKC in early phases of diet-induced obesity. Diabetes. 63: 2690-701. PMID 24705403 DOI: 10.2337/db13-1863 |
0.301 |
|
| 2013 |
McCray AN, Desai S, Acevedo-Duncan M. Abstract 2952: The PKC-iota inhibitor ICA-1 combined with TRAIL for glioblastoma therapy. Cancer Research. 73: 2952-2952. DOI: 10.1158/1538-7445.Am2013-2952 |
0.637 |
|
| 2012 |
Sajan MP, Nimal S, Mastorides S, Acevedo-Duncan M, Kahn CR, Fields AP, Braun U, Leitges M, Farese RV. Correction of metabolic abnormalities in a rodent model of obesity, metabolic syndrome, and type 2 diabetes mellitus by inhibitors of hepatic protein kinase C-ι. Metabolism: Clinical and Experimental. 61: 459-69. PMID 22225955 DOI: 10.1016/J.Metabol.2011.12.008 |
0.333 |
|
| 2012 |
Desai SR, Pillai PP, Patel RS, McCray AN, Win-Piazza HY, Acevedo-Duncan ME. Regulation of Cdk7 activity through a phosphatidylinositol (3)-kinase/PKC-ι-mediated signaling cascade in glioblastoma. Carcinogenesis. 33: 10-9. PMID 22021906 DOI: 10.1093/Carcin/Bgr231 |
0.818 |
|
| 2012 |
Desai S, Patel R, McCray AN, Pillai P, Acevedo-Duncan M. Abstract 3760: A novel PKC-iota inhibitor, ICA-1 abrogates cell proliferation in breast cancer Cancer Research. 72: 3760-3760. DOI: 10.1158/1538-7445.Am2012-3760 |
0.775 |
|
| 2012 |
McCray AN, Acevedo-Duncan M. Abstract 2821: The PKC-iota inhibitor ICA-1 overcomes chemoresistance and induces cell death in glioblastoma multiforme Cancer Research. 72: 2821-2821. DOI: 10.1158/1538-7445.Am2012-2821 |
0.486 |
|
| 2011 |
Desai S, Pillai P, Win-Piazza H, Acevedo-Duncan M. PKC-3 promotes glioblastoma cell survival by phosphorylating and inhibiting BAD through a phosphatidylinositol 3-kinase pathway Biochimica Et Biophysica Acta - Molecular Cell Research. 1813: 1190-1197. PMID 21419810 DOI: 10.1016/J.Bbamcr.2011.03.007 |
0.817 |
|
| 2011 |
Pillai P, Desai S, Patel R, Sajan M, Farese R, Ostrov D, Acevedo-Duncan M. A novel PKC-ι inhibitor abrogates cell proliferation and induces apoptosis in neuroblastoma. The International Journal of Biochemistry & Cell Biology. 43: 784-94. PMID 21315177 DOI: 10.1016/J.Biocel.2011.02.002 |
0.83 |
|
| 2011 |
Desai S, Acevedo-Duncan M. Abstract 7: PKC-ι promotes glioblastoma cell survival by phosphorylating and inhibiting BAD through a phosphotidylinositol 3-kinase pathway Cancer Research. 71: 7-7. DOI: 10.1158/1538-7445.Am2011-7 |
0.763 |
|
| 2011 |
Pillai PP, Acevedo-Duncan M. Abstract 4346: Differential response of a novel protein kinase C-iota inhibitor (ICA-1) on neuroblastoma cells Cancer Research. 71: 4346-4346. DOI: 10.1158/1538-7445.Am2011-4346 |
0.792 |
|
| 2011 |
Desai S, Acevedo-Duncan M. Abstract 2974: Regulation of cyclin dependent kinase 7 through a phosphotidylinositol 3-kinase/PKC-ι mediated cell proliferation cascade Cancer Research. 71: 2974-2974. DOI: 10.1158/1538-7445.Am2011-2974 |
0.754 |
|
| 2011 |
Pillai PPP, Acevedo-Duncan M. Abstract 273: Protein kinase C-iota self regulates its expression by regulating the activity of the transcription factor Elk-1 Cancer Research. 71: 273-273. DOI: 10.1158/1538-7445.Am2011-273 |
0.575 |
|
| 2011 |
Pillai P, Desai S, Patel R, Sajan M, Farese R, Ostrov D, Acevedo-Duncan M. Erratum to “A novel PKC-ι inhibitor abrogates cell proliferation and induces apoptosis in neuroblastoma” [Int. J. Biochem. Cell Biol. 43 (5) (2011) 784–794] The International Journal of Biochemistry & Cell Biology. 43: 1412. DOI: 10.1016/J.Biocel.2011.05.015 |
0.791 |
|
| 2010 |
Desai S, Acevedo-Duncan M. Abstract LB-113: PKC-iota induces uncontrolled glioblastoma cell survival by modulating proapoptotic function of Bad Cancer Research. 70. DOI: 10.1158/1538-7445.Am10-Lb-113 |
0.75 |
|
| 2009 |
Win HY, Acevedo-Duncan M. Role of protein kinase C-iota in transformed non-malignant RWPE-1 cells and androgen-independent prostate carcinoma DU-145 cells. Cell Proliferation. 42: 182-94. PMID 19243387 DOI: 10.1111/J.1365-2184.2009.00582.X |
0.757 |
|
| 2008 |
Win HY, Acevedo-Duncan M. Atypical protein kinase C phosphorylates IKKalphabeta in transformed non-malignant and malignant prostate cell survival. Cancer Letters. 270: 302-11. PMID 18571841 DOI: 10.1016/J.Canlet.2008.05.023 |
0.783 |
|
| 2008 |
Patel R, Win H, Desai S, Patel K, Matthews JA, Acevedo-Duncan M. Involvement of PKC-ι in glioma proliferation Cell Proliferation. 41: 122-135. PMID 18211289 DOI: 10.1111/j.1365-2184.2007.00506.x |
0.485 |
|
| 2007 |
Matthews JA, Belof JL, Acevedo-Duncan M, Potter RL. Glucosamine-induced increase in Akt phosphorylation corresponds to increased endoplasmic reticulum stress in astroglial cells. Molecular and Cellular Biochemistry. 298: 109-23. PMID 17136481 DOI: 10.1007/S11010-006-9358-5 |
0.428 |
|
| 2005 |
Matthews JA, Acevedo-Duncan M, Potter RL. Selective decrease of membrane-associated PKC-alpha and PKC-epsilon in response to elevated intracellular O-GlcNAc levels in transformed human glial cells. Biochimica Et Biophysica Acta. 1743: 305-15. PMID 15843043 DOI: 10.1016/J.Bbamcr.2004.11.001 |
0.349 |
|
| 2005 |
Russell C, Acevedo-Duncan M. Effects of the PKC inhibitor PD 406976 on cell cycle progression, proliferation, PKC isozymes and apoptosis in glioma and SVG-transformed glial cells Cell Proliferation. 38: 87-106. PMID 15842253 DOI: 10.1111/J.1365-2184.2005.00333.X |
0.428 |
|
| 2005 |
Bicaku E, Patel R, Acevedo-Duncan M. Cyclin-dependent kinase activating kinase/Cdk7 co-localizes with PKC-iota in human glioma cells. Tissue & Cell. 37: 53-8. PMID 15695176 DOI: 10.1016/J.Tice.2004.10.004 |
0.557 |
|
| 2004 |
Acevedo-Duncan M, Russell C, Patel S, Patel R. Aloe-emodin modulates PKC isozymes, inhibits proliferation, and induces apoptosis in U-373MG glioma cells. International Immunopharmacology. 4: 1775-84. PMID 15531293 DOI: 10.1016/J.Intimp.2004.07.012 |
0.556 |
|
| 2002 |
Acevedo-Duncan M, Patel R, Whelan S, Bicaku E. Human glioma PKC-ι and PKC-βII phosphorylate cyclin-dependent kinase activating kinase during the cell cycle Cell Proliferation. 35: 23-36. PMID 11856176 DOI: 10.1046/J.1365-2184.2002.00220.X |
0.789 |
|
| 2001 |
Biçaku E, Acevedo-Duncan M. Ultrastructural study of protein kinase C-βII localization during the cell cycle of human glioma cells Tissue and Cell. 33: 55-62. PMID 11292171 DOI: 10.1054/Tice.2000.0155 |
0.452 |
|
| 2001 |
Acevedo-Duncan M, Pearlman J, Zachariah B. Sensitivity of human glioma U-373mg cells to radiation and the protein kinase C inhibitor, calphostin C Cell Proliferation. 34: 31-41. PMID 11284917 DOI: 10.1046/j.1365-2184.2001.00194.x |
0.379 |
|
| 2000 |
Bai W, Oliveros-Saunders B, Wang Q, Acevedo-Duncan ME, Nicosia SV. Estrogen stimulation of ovarian surface epithelial cell proliferation. In Vitro Cellular & Developmental Biology. Animal. 36: 657-66. PMID 11229598 DOI: 10.1290/1071-2690(2000)036<0657:Esoose>2.0.Co;2 |
0.57 |
|
| 2000 |
Yamamoto M, Acevedo-Duncan M, Chalfant CE, Patel NA, Watson JE, Cooper DR. Acute glucose-induced downregulation of PKC-βII accelerates cultured VSMC proliferation American Journal of Physiology - Cell Physiology. 279. PMID 10942708 DOI: 10.1152/Ajpcell.2000.279.3.C587 |
0.4 |
|
| 1999 |
Cooper DR, Watson JE, Patel N, Illingworth P, Acevedo-Duncan M, Goodnight J, Chalfant CE, Mischak H. Ectopic expression of protein kinase CβII, -δ and -ε, but not -βI or -ζ, provide for insulin stimulation of glucose uptake in NIH-3T3 cells Archives of Biochemistry and Biophysics. 372: 69-79. PMID 10562418 DOI: 10.1006/Abbi.1999.1472 |
0.372 |
|
| 1998 |
Yamamoto M, Acevedo-Duncan M, Chalfant CE, Patel NA, Watson JE, Cooper DR. The roles of protein kinase C βI and βII in vascular smooth muscle cell proliferation Experimental Cell Research. 240: 349-358. PMID 9597008 DOI: 10.1006/Excr.1998.3999 |
0.427 |
|
| 1997 |
Acevedo-Duncan M, Zhang R, Cooper DR, Greenberg HM. Effects of interferon and PKC modulators on human glioma protein kinase C, cell proliferation, and cell cycle Neurochemical Research. 22: 775-784. PMID 9232628 DOI: 10.1023/A:1022071407268 |
0.52 |
|
| 1994 |
Acevedo-Duncan M, Zhang R. Heterogeneity of protein kinase C activity in human U-373 and G-26 mice glioma cells Biochemical and Biophysical Research Communications. 205: 127-134. PMID 7999012 DOI: 10.1006/bbrc.1994.2639 |
0.341 |
|
| 1990 |
Cozza EN, Vila MC, Acevedo-Duncan M, Farese RV, Gomez-Sanchez CE. Treatment of primary cultures of calf adrenal glomerulosa cells with adrenocorticotropin (ACTH) and phorbol esters: A comparative study of the effects on aldosterone production and ACTH signaling system Endocrinology. 126: 2169-2176. PMID 2156684 DOI: 10.1210/Endo-126-4-2169 |
0.509 |
|
| 1990 |
Cozza EN, del Carmen Vila M, Acevedo-Duncan M, Gomez-Sanchez CE, Farese RV. Acth increases de novo synthesis of diacylglycerol and translocates protein kinase C in primary cultures of calf adrenal glomerulosa cells Journal of Steroid Biochemistry. 35: 343-351. PMID 2155356 DOI: 10.1016/0022-4731(90)90294-3 |
0.446 |
|
| 1989 |
Cooper DR, Watson JE, Acevedo-Duncan M, Pollet RJ, Standaert ML, Farese RV. Retention of specific protein kinase C isozymes following chronic phorbol ester treatment in BC3H-1 myocytes. Biochemical and Biophysical Research Communications. 161: 327-34. PMID 2730662 DOI: 10.1016/0006-291X(89)91600-8 |
0.361 |
|
| 1989 |
Acevedo-Duncan M, Cooper DR, Standaert ML, Farese RV. Immunological evidence that insulin activates protein kinase C in BC3H-1 myocytes Febs Letters. 244: 174-176. PMID 2647516 DOI: 10.1016/0014-5793(89)81186-X |
0.393 |
|
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