| Year |
Citation |
Score |
| 2022 |
Zheng Y, Müller J, Kunz S, Siderius M, Maes L, Caljon G, Müller N, Hemphill A, Sterk GJ, Leurs R. 3-nitroimidazo[1,2-b]pyridazine as a novel scaffold for antiparasitics with sub-nanomolar anti-Giardia lamblia activity. International Journal For Parasitology. Drugs and Drug Resistance. 19: 47-55. PMID 35716585 DOI: 10.1016/j.ijpddr.2022.05.004 |
0.3 |
|
| 2022 |
Lu L, Åkerbladh L, Ahmad S, Konda V, Cao S, Vocat A, Maes L, Cole ST, Hughes D, Larhed M, Brandt P, Karlén A, Mowbray SL. Synthesis and Biological Evaluation of Quinolinyl Pyrimidines Targeting Type II NADH-Dehydrogenase (NDH-2). Acs Infectious Diseases. 8: 482-498. PMID 35184552 DOI: 10.1021/acsinfecdis.1c00413 |
0.308 |
|
| 2020 |
Silva DG, Junker A, de Melo SMG, Fumagalli F, Gillespie JR, Molasky N, Buckner FS, Matheeussen A, Caljon G, Maes L, Emery FS. Synthesis and structure-activity relationships of imidazopyridine/pyrimidine- and furopyridine-based anti-infective agents against trypanosomiases. Chemmedchem. PMID 33078573 DOI: 10.1002/cmdc.202000616 |
0.306 |
|
| 2020 |
Karpina VR, Kovalenko SS, Kovalenko SM, Drushlyak OG, Bunyatyan ND, Georgiyants VA, Ivanov VV, Langer T, Maes L. A Novel Series of [1,2,4]Triazolo[4,3-a]Pyridine Sulfonamides as Potential Antimalarial Agents: In Silico Studies, Synthesis and In Vitro Evaluation. Molecules (Basel, Switzerland). 25. PMID 33007887 DOI: 10.3390/molecules25194485 |
0.305 |
|
| 2020 |
Van Bockstal L, Hendrickx S, Maes L, Caljon G. Sand Fly Studies Predict Transmission Potential of Drug-resistant Leishmania. Trends in Parasitology. 36: 785-795. PMID 32713762 DOI: 10.1016/J.Pt.2020.06.006 |
0.328 |
|
| 2020 |
Riaz A, Hendricks S, Elbrink K, Guy C, Maes L, Ahmed N, Kiekens F, Khan GM. Preparation and Characterization of Nanostructured Lipid Carriers for Improved Topical Drug Delivery: Evaluation in Cutaneous Leishmaniasis and Vaginal Candidiasis Animal Models. Aaps Pharmscitech. 21: 185. PMID 32632542 DOI: 10.1208/S12249-020-01717-W |
0.317 |
|
| 2020 |
Van den Kerkhof M, Mabille D, Hendrickx S, Leprohon P, Mowbray CE, Braillard S, Ouellette M, Maes L, Caljon G. ANTILEISHMANIAL AMINOPYRAZOLES: STUDIES INTO MECHANISMS AND STABILITY OF EXPERIMENTAL DRUG RESISTANCE. Antimicrobial Agents and Chemotherapy. PMID 32601168 DOI: 10.1128/Aac.00152-20 |
0.334 |
|
| 2020 |
de Araújo JS, da Silva CF, Batista DDGJ, Nefertiti A, Fiuza LFA, Fonseca-Berzal CR, da Silva PB, Batista MM, Sijm M, Kalejaiye TD, de Koning HP, Maes L, Sterk GJ, Leurs R, Soeiro MNC. Efficacy of Novel Pyrazolone Phosphodiesterase Inhibitors in Experimental Mouse Models of . Antimicrobial Agents and Chemotherapy. PMID 32601163 DOI: 10.1128/Aac.00414-20 |
0.404 |
|
| 2020 |
Hulpia F, Campagnaro GD, Alzahrani KJ, Alfayez IA, Ungogo MA, Mabille D, Maes L, de Koning HP, Caljon G, Van Calenbergh S. Structure-activity relationship exploration of 3'-deoxy-7-deazapurine nucleoside analogues as anti-Trypanosoma brucei agents. Acs Infectious Diseases. PMID 32568511 DOI: 10.1021/Acsinfecdis.0C00105 |
0.384 |
|
| 2020 |
Hendrickx S, Caljon G, Maes L. In Vitro Growth Inhibition Assays of Leishmania spp. Methods in Molecular Biology (Clifton, N.J.). 2116: 791-800. PMID 32221956 DOI: 10.1007/978-1-0716-0294-2_47 |
0.353 |
|
| 2020 |
Jakubec M, Totland C, Rise F, Chamgordani EJ, Paulsen B, Maes L, Matheeussen A, Gundersen LL, Halskau Ø. Bioactive Metabolites of Marine Origin Have Unusual Effects on Model Membrane Systems. Marine Drugs. 18. PMID 32092956 DOI: 10.3390/Md18020125 |
0.352 |
|
| 2020 |
Sebastian-Perez V, García-Rubia A, Seif El-Din SH, Sabra AA, El-Lakkany NM, William S, Blundell TL, Maes L, Martinez A, Campillo NE, Botros SS, Gil C. Deciphering the enzymatic target of a new family of antischistosomal agents bearing a quinazoline scaffold using complementary computational tools. Journal of Enzyme Inhibition and Medicinal Chemistry. 35: 511-523. PMID 31939312 DOI: 10.1080/14756366.2020.1712595 |
0.355 |
|
| 2020 |
Hulpia F, Bouton J, Campagnaro GD, Alfayez IA, Mabille D, Maes L, de Koning HP, Caljon G, Van Calenbergh S. C6-O-alkylated 7-deazainosine nucleoside analogues: Discovery of potent and selective anti-sleeping sickness agents. European Journal of Medicinal Chemistry. 188: 112018. PMID 31931339 DOI: 10.1016/J.Ejmech.2019.112018 |
0.374 |
|
| 2020 |
Hendrickx S, Bockstal LV, Aslan H, Sadlova J, Maes L, Volf P, Caljon G. Transmission potential of paromomycin-resistant Leishmania infantum and Leishmania donovani Journal of Antimicrobial Chemotherapy. 75: 951-957. PMID 31886863 DOI: 10.1093/Jac/Dkz517 |
0.325 |
|
| 2019 |
Hulpia F, Mabille D, Campagnaro GD, Schumann G, Maes L, Roditi I, Hofer A, de Koning HP, Caljon G, Van Calenbergh S. Combining tubercidin and cordycepin scaffolds results in highly active candidates to treat late-stage sleeping sickness. Nature Communications. 10: 5564. PMID 31804484 DOI: 10.1038/S41467-019-13522-6 |
0.339 |
|
| 2019 |
Koovits PJ, Dessoy MA, Matheeussen A, Maes L, Caljon G, Mowbray CE, Kratz JM, Dias LC. Structure-activity relationship of 4-azaindole-2-piperidine derivatives as agents against Trypanosoma cruzi. Bioorganic & Medicinal Chemistry Letters. 126779. PMID 31706667 DOI: 10.1016/J.Bmcl.2019.126779 |
0.411 |
|
| 2019 |
Lin C, Hulpia F, da Silva CF, Batista DDGJ, Van Hecke K, Maes L, Caljon G, Soeiro MNC, Van Calenbergh S. Discovery of pyrrolo[2,3-b]pyridine (1,7-dideazapurine) nucleoside analogues as anti-Trypanosoma cruzi agents. Journal of Medicinal Chemistry. PMID 31495177 DOI: 10.1021/Acs.Jmedchem.9B01275 |
0.392 |
|
| 2019 |
Cappoen D, Torfs E, Meiresonne T, Claes P, Semina E, Holvoet F, de Macedo MB, Cools F, Piller T, Matheeussen A, Van Calster K, Caljon G, Delputte P, Maes L, Neyrolles O, et al. The synthesis and in vitro biological evaluation of novel fluorinated tetrahydrobenzo[j]phenanthridine-7,12-diones against Mycobacterium tuberculosis. European Journal of Medicinal Chemistry. 181: 111549. PMID 31376569 DOI: 10.1016/J.Ejmech.2019.07.052 |
0.336 |
|
| 2019 |
Courtens C, Risseeuw M, Caljon G, Maes L, Cos P, Martin A, Van Calenbergh S. Double prodrugs of a fosmidomycin surrogate as antimalarial and antitubercular agents. Bioorganic & Medicinal Chemistry Letters. PMID 30879839 DOI: 10.1016/J.Bmcl.2019.03.009 |
0.4 |
|
| 2019 |
Cools F, Torfs E, Aizawa J, Vanhoutte B, Maes L, Caljon G, Delputte P, Cappoen D, Cos P. Optimization and Characterization of a Larval Infection Model for Virulence Studies and the Evaluation of Therapeutics Against . Frontiers in Microbiology. 10: 311. PMID 30846978 DOI: 10.3389/Fmicb.2019.00311 |
0.318 |
|
| 2019 |
Kanyanga RC, Lumpu SN, Ehata MT, Maya BM, Munduku CK, Bool-Miting FM, Cos P, Maes L, Vlietinck AJ, Exarchou V, Tuenter E, Pieters L. In vitro and in vivo antiplasmodial activity of extracts and isolated constituents of Alstonia congensis root bark. Journal of Ethnopharmacology. PMID 30763695 DOI: 10.1016/J.Jep.2019.02.019 |
0.357 |
|
| 2019 |
Courtens C, Risseeuw M, Caljon G, Maes L, Martin A, Van Calenbergh S. Amino acid based prodrugs of a fosmidomycin surrogate as antimalarial and antitubercular agents. Bioorganic & Medicinal Chemistry. PMID 30692024 DOI: 10.1016/J.Bmc.2019.01.016 |
0.379 |
|
| 2019 |
Hulpia F, Campagnaro GD, Scortichini M, Van Hecke K, Maes L, de Koning HP, Caljon G, Van Calenbergh S. Revisiting tubercidin against kinetoplastid parasites: Aromatic substitutions at position 7 improve activity and reduce toxicity. European Journal of Medicinal Chemistry. 164: 689-705. PMID 30677668 DOI: 10.1016/J.Ejmech.2018.12.050 |
0.393 |
|
| 2019 |
de Araújo JS, Garcia-Rubia A, Sebastian-Perez V, Kalejaiye TD, Bernardino da Silva P, Fonseca-Berzal CR, Maes L, De Koning HP, Soeiro MNC, Gil C. Imidazole derivatives as promising agents for the treatment of Chagas disease. Antimicrobial Agents and Chemotherapy. PMID 30670432 DOI: 10.1128/Aac.02156-18 |
0.395 |
|
| 2019 |
Zarev Y, Foubert K, Cos P, Maes L, Elgorashi E, Apers S, Ionkova I, Pieters L. HPLC-DAD-SPE-NMR isolation of tetracyclic spiro-alkaloids with antiplasmodial activity from the seeds of Erythrina latissima. Natural Product Research. 1-4. PMID 30602319 DOI: 10.1080/14786419.2018.1539976 |
0.407 |
|
| 2018 |
Devisscher L, Van Coillie S, Hofmans S, Van Rompaey D, Goossens K, Meul E, Maes L, De Winter H, Van der Veken P, Vandenabeele P, Berghe TV, Augustyns K. Discovery of Novel, Drug-like Ferroptosis Inhibitors with In Vivo Efficacy. Journal of Medicinal Chemistry. PMID 30354101 DOI: 10.1021/Acs.Jmedchem.8B01299 |
0.376 |
|
| 2018 |
Hulpia F, Van Hecke K, França da Silva C, da Gama Jaen Batista D, Maes L, Caljon G, de Nazaré C Soeiro M, Van Calenbergh S. Discovery of Novel 7-Aryl 7-Deazapurine 3'-Deoxy-ribofuranosyl Nucleosides with Potent Activity against Trypanosoma cruzi. Journal of Medicinal Chemistry. PMID 30234983 DOI: 10.1021/Acs.Jmedchem.8B00999 |
0.398 |
|
| 2018 |
Sebastián-Pérez V, Hendrickx S, Munday JC, Kalejaiye T, Martínez A, Campillo NE, de Koning H, Caljon G, Maes L, Gil C. Cyclic nucleotide specific phosphodiesterases as potential drug targets for anti- therapy. Antimicrobial Agents and Chemotherapy. PMID 30104270 DOI: 10.1128/Aac.00603-18 |
0.408 |
|
| 2018 |
De Luca L, Ferro S, Buemi MR, Monforte AM, Gitto R, Schirmeister T, Maes L, Rescifina A, Micale N. Discovery of benzimidazole-based L. mexicana cysteine protease CPB2.8ΔCTE inhibitors as potential therapeutics for leishmaniasis. Chemical Biology & Drug Design. PMID 29729080 DOI: 10.1111/Cbdd.13326 |
0.376 |
|
| 2018 |
Thompson AM, O'Connor PD, Marshall AJ, Blaser A, Yardley V, Maes L, Gupta S, Launay D, Braillard S, Chatelain E, Wan B, Franzblau SG, Ma Z, Cooper CB, Denny WA. Development of (6R)-2-nitro-6-[4-(trifluoromethoxy)phenoxy]-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (DNDI-8219): a new lead for visceral leishmaniasis. Journal of Medicinal Chemistry. PMID 29461823 DOI: 10.1021/Acs.Jmedchem.7B01581 |
0.311 |
|
| 2018 |
Venkatraj M, Salado IG, Heeres J, Joossens J, Lewi PJ, Caljon G, Maes L, Van der Veken P, Augustyns K. Novel triazine dimers with potent antitrypanosomal activity. European Journal of Medicinal Chemistry. 143: 306-319. PMID 29197735 DOI: 10.1016/J.Ejmech.2017.11.075 |
0.393 |
|
| 2018 |
Kanyanga RC, Munduku CK, Lumpu SN, Ehata MT, Bool-Miting FM, Kabangu OK, Maya BM, Cos P, Maes L, Vlietinck AJ, Tuenter E, Foubert K, Pieters L. Isolation and structure elucidation of two antiprotozoal bisbenzylisoquinoline alkaloids from Triclisia gilletii stem bark Phytochemistry Letters. 28: 19-23. DOI: 10.1016/J.Phytol.2018.09.008 |
0.372 |
|
| 2017 |
Thompson AM, Marshall AJ, Maes L, Yarlett N, Bacchi CJ, Gaukel E, Wring SA, Launay D, Braillard S, Chatelain E, Mowbray CE, Denny WA. Assessment of a pretomanid analogue library for African trypanosomiasis: Hit-to-lead studies on 6-substituted 2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine 8-oxides. Bioorganic & Medicinal Chemistry Letters. PMID 29191556 DOI: 10.1016/J.Bmcl.2017.10.067 |
0.38 |
|
| 2017 |
Loua J, Traore MS, Camara A, Balde MA, Maes L, Pieters L, Balde AM. Biological and Phytochemical Investigations on Caesalpinia benthamiana, a Plant Traditionally Used as Antimalarial in Guinea. Evidence-Based Complementary and Alternative Medicine : Ecam. 2017: 9438607. PMID 29081823 DOI: 10.1155/2017/9438607 |
0.387 |
|
| 2017 |
Scala A, Rescifina A, Micale N, Piperno A, Schirmeister T, Maes L, Grassi G. Ensamble-based ADME-Tox profiling and virtual screening for the discovery of new inhibitors of the Leishmania mexicana cysteine protease CPB2.8ΔCTE. Chemical Biology & Drug Design. PMID 29045053 DOI: 10.1111/Cbdd.13124 |
0.361 |
|
| 2017 |
Torfs E, Vajs J, Bidart de Macedo M, Cools F, Vanhoutte B, Gorbanev Y, Bogaerts A, Verschaeve L, Caljon G, Maes L, Delputte P, Cos P, Košmrlj J, Cappoen D. Synthesis and in vitro investigation of halogenated 1,3-bis(4-nitrophenyl)triazenide salts as antitubercular compounds. Chemical Biology & Drug Design. PMID 28845550 DOI: 10.1111/Cbdd.13087 |
0.385 |
|
| 2017 |
Van der Gucht W, Leemans A, De Schryver M, Heykers A, Caljon G, Maes L, Cos P, Delputte PL. Respiratory syncytial virus (RSV) entry is inhibited by serine protease inhibitor AEBSF when present during an early stage of infection. Virology Journal. 14: 157. PMID 28818113 DOI: 10.1186/S12985-017-0824-3 |
0.304 |
|
| 2017 |
Amin A, Tuenter E, Foubert K, Iqbal J, Cos P, Maes L, Exarchou V, Apers S, Pieters L. In Vitro and In Silico Antidiabetic and Antimicrobial Evaluation of Constituents from Kickxia ramosissima (Nanorrhinum ramosissimum). Frontiers in Pharmacology. 8: 232. PMID 28507520 DOI: 10.3389/Fphar.2017.00232 |
0.425 |
|
| 2017 |
Hendrickx S, Van den Kerkhof M, Mabille D, Cos P, Delputte P, Maes L, Caljon G. Combined treatment of miltefosine and paromomycin delays the onset of experimental drug resistance in Leishmania infantum. Plos Neglected Tropical Diseases. 11: e0005620. PMID 28505185 DOI: 10.1371/Journal.Pntd.0005620 |
0.303 |
|
| 2017 |
Thompson AM, Blaser A, Palmer BD, Anderson RF, Shinde SS, Launay D, Chatelain E, Maes L, Franzblau SG, Wan B, Wang Y, Ma Z, Denny WA. 6-Nitro-2,3-dihydroimidazo[2,1-b][1,3]thiazoles: Facile synthesis and comparative appraisal against tuberculosis and neglected tropical diseases. Bioorganic & Medicinal Chemistry Letters. PMID 28462832 DOI: 10.1016/J.Bmcl.2017.03.069 |
0.332 |
|
| 2017 |
Thompson AM, O'Connor PD, Marshall AJ, Yardley V, Maes L, Gupta S, Launay D, Braillard S, Chatelain E, Franzblau SG, Wan B, Wang Y, Ma Z, Cooper CB, Denny WA. 7-Substituted 2-nitro-5,6-dihydroimidazo[2,1-b][1,3]oxazines: novel antitubercular agents lead to a new preclinical candidate for visceral leishmaniasis. Journal of Medicinal Chemistry. PMID 28459575 DOI: 10.1021/Acs.Jmedchem.7B00034 |
0.355 |
|
| 2017 |
Massai L, Messori L, Micale N, Schirmeister T, Maes L, Fregona D, Cinellu MA, Gabbiani C. Gold compounds as cysteine protease inhibitors: perspectives for pharmaceutical application as antiparasitic agents. Biometals : An International Journal On the Role of Metal Ions in Biology, Biochemistry, and Medicine. PMID 28283781 DOI: 10.1007/S10534-017-0007-0 |
0.413 |
|
| 2017 |
Tuenter E, Segers K, Kang KB, Viaene J, Sung SH, Cos P, Maes L, Heyden YV, Pieters L. Antiplasmodial Activity, Cytotoxicity and Structure-Activity Relationship Study of Cyclopeptide Alkaloids. Molecules (Basel, Switzerland). 22. PMID 28157177 DOI: 10.3390/Molecules22020224 |
0.38 |
|
| 2017 |
Urgin K, Jida M, Ehrhardt K, Müller T, Lanzer M, Maes L, Elhabiri M, Davioud-Charvet E. Pharmacomodulation of the Antimalarial Plasmodione: Synthesis of Biaryl- and N-Arylalkylamine Analogues, Antimalarial Activities and Physicochemical Properties. Molecules (Basel, Switzerland). 22. PMID 28106855 DOI: 10.3390/Molecules22010161 |
0.346 |
|
| 2016 |
Tuenter E, Exarchou V, Ahmad R, Baldé A, Cos P, Maes L, Apers S, Pieters L. Antiplasmodial activity of cyclopeptide alkaloids from Hymenocardia acida and Ziziphus oxyphylla. Planta Medica. 81: S1-S381. PMID 27976350 DOI: 10.1055/S-0036-1596169 |
0.347 |
|
| 2016 |
Tuenter E, Ahmad R, Foubert K, Amin A, Orfanoudaki M, Cos P, Maes L, Apers S, Pieters L, Exarchou V. Isolation and Structure Elucidation by LC-DAD-MS and LC-DAD-SPE-NMR of Cyclopeptide Alkaloids from the Roots of Ziziphus oxyphylla and Evaluation of Their Antiplasmodial Activity. Journal of Natural Products. 79: 2865-2872. PMID 27933893 DOI: 10.1021/Acs.Jnatprod.6B00633 |
0.371 |
|
| 2016 |
Joshi B, Hendrickx S, Magar LB, Parajuli N, Dorny P, Maes L. In vitro antileishmanial and antimalarial activity of selected plants of Nepal. Journal of Intercultural Ethnopharmacology. 5: 383-389. PMID 27757268 DOI: 10.5455/Jice.20160728031236 |
0.334 |
|
| 2016 |
Muganza DM, Fruth B, Nzunzu JL, Tuenter E, Foubert K, Cos P, Maes L, Kanyanga RC, Exarchou V, Apers S, Pieters L. In vitro antiprotozoal activity and cytotoxicity of extracts and isolated constituents from Greenwayodendron suaveolens. Journal of Ethnopharmacology. 193: 510-516. PMID 27693770 DOI: 10.1016/J.Jep.2016.09.051 |
0.353 |
|
| 2016 |
Amin A, Tuenter E, Cos P, Maes L, Exarchou V, Apers S, Pieters L. Antiprotozoal and Antiglycation Activities of Sesquiterpene Coumarins from Ferula narthex Exudate. Molecules (Basel, Switzerland). 21. PMID 27681714 DOI: 10.3390/Molecules21101287 |
0.379 |
|
| 2016 |
Sooriyaarachchi S, Chofor R, Risseeuw MD, Bergfors T, Pouyez J, Dowd CS, Maes L, Wouters J, Jones TA, Van Calenbergh S, Mowbray SL. Targeting an Aromatic Hotspot in Plasmodium falciparum 1-Deoxy-d-xylulose-5-phosphate Reductoisomerase with β-Arylpropyl Analogues of Fosmidomycin. Chemmedchem. PMID 27487410 DOI: 10.1002/Cmdc.201600249 |
0.35 |
|
| 2016 |
Van Voorhis WC, Adams JH, Adelfio R, Ahyong V, Akabas MH, Alano P, Alday A, Alemán Resto Y, Alsibaee A, Alzualde A, Andrews KT, Avery SV, Avery VM, Ayong L, Baker M, ... ... Maes L, et al. Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond. Plos Pathogens. 12: e1005763. PMID 27467575 DOI: 10.1371/Journal.Ppat.1005763 |
0.4 |
|
| 2016 |
Viira B, Gendron T, Lanfranchi DA, Cojean S, Horvath D, Marcou G, Varnek A, Maes L, Maran U, Loiseau PM, Davioud-Charvet E. In Silico Mining for Antimalarial Structure-Activity Knowledge and Discovery of Novel Antimalarial Curcuminoids. Molecules (Basel, Switzerland). 21. PMID 27367660 DOI: 10.3390/Molecules21070853 |
0.394 |
|
| 2016 |
Tuenter E, Exarchou V, Baldé A, Cos P, Maes L, Apers S, Pieters L. Cyclopeptide Alkaloids from Hymenocardia acida. Journal of Natural Products. PMID 27351950 DOI: 10.1021/Acs.Jnatprod.6B00131 |
0.378 |
|
| 2016 |
Amin A, Tuenter E, Exarchou V, Upadhyay A, Cos P, Maes L, Apers S, Pieters L. Phytochemical and Pharmacological Investigations on Nymphoides indica Leaf Extracts. Phytotherapy Research : Ptr. PMID 27282639 DOI: 10.1002/Ptr.5663 |
0.372 |
|
| 2016 |
Ezzat SM, Salama MM, Mahrous EA, Maes L, Pan CH, Abdel-Sattar E. Antiprotozoal activity of major constituents from the bioactive fraction of Verbesina encelioides. Natural Product Research. 1-5. PMID 27154232 DOI: 10.1080/14786419.2016.1180604 |
0.375 |
|
| 2016 |
Saad M, Verbueken E, Pype C, Casteleyn C, Ginneken CV, Maes L, Cos P, Cruchten SV. In vitro CYP1A activity in the zebrafish: temporal but low metabolite levels during organogenesis and lack of gender differences in the adult stage. Reproductive Toxicology (Elmsford, N.Y.). PMID 27046732 DOI: 10.1016/J.Reprotox.2016.03.049 |
0.313 |
|
| 2016 |
Horemans T, Boulet G, van Kerckhoven M, Bogers J, Thys S, Vervaet C, Vervaeck A, Delputte P, Maes L, Cos P. In-vivo evaluation of apocynin for prevention of Helicobacter pylori-induced gastric carcinogenesis. European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (Ecp). PMID 26938501 DOI: 10.1097/Cej.0000000000000233 |
0.313 |
|
| 2016 |
Veerman J, van den Bergh T, Orrling KM, Jansen C, Cos P, Maes L, Chatelain E, Ioset JR, Edink EE, Tenor H, Seebeck T, de Esch I, Leurs R, Sterk GJ. Synthesis and evaluation of analogs of the phenylpyridazinone NPD-001 as potent trypanosomal TbrPDEB1 phosphodiesterase inhibitors and in vitro trypanocidals. Bioorganic & Medicinal Chemistry. PMID 26935942 DOI: 10.1016/J.Bmc.2016.02.032 |
0.386 |
|
| 2016 |
De Vita D, Moraca F, Zamperini C, Pandolfi F, Di Santo R, Matheeussen A, Maes L, Tortorella S, Scipione L. In vitro screening of 2-(1H-imidazol-1-yl)-1-phenylethanol derivatives as antiprotozoal agents and docking studies on Trypanosoma cruzi CYP51. European Journal of Medicinal Chemistry. 113: 28-33. PMID 26922226 DOI: 10.1016/j.ejmech.2016.02.028 |
0.319 |
|
| 2016 |
Thompson AM, O'Connor PD, Blaser A, Yardley V, Maes L, Gupta S, Launay D, Martin D, Franzblau SG, Wan B, Wang Y, Ma Z, Denny WA. Repositioning antitubercular 6-nitro-2,3-dihydroimidazo[2,1-b][1,3]oxazoles for neglected tropical diseases: structure-activity studies on a preclinical candidate for visceral leishmaniasis. Journal of Medicinal Chemistry. PMID 26901446 DOI: 10.1021/Acs.Jmedchem.5B01699 |
0.365 |
|
| 2016 |
Sleven R, Lanckacker E, Delputte P, Maes L, Cos P. Evaluation of topical antifungal products in an in vitro onychomycosis model. Mycoses. PMID 26857689 DOI: 10.1111/Myc.12475 |
0.328 |
|
| 2016 |
Rotthier G, Cappoen D, Nguyen QT, Dang Thi TA, Mathys V, Nguyen VT, Huygen K, Maes L, Cos P, Abbaspour Tehrani K. Synthesis and anti-tubercular activity of N(2)-arylbenzo[g]isoquinoline-5,10-dione-3-iminium bromides. Organic & Biomolecular Chemistry. PMID 26763748 DOI: 10.1039/C5Ob02138C |
0.365 |
|
| 2016 |
Ehata MT, Lumpu SN, Munduku CK, Kabangu OK, Cos P, Maes L, Apers S, Vlietinck AJ, Pieters L, Kanyanga RC. Study of Antiparasitic and Cytotoxicity of the Aqueous, the 80% Methanol Extract and Its Fractions, and the Acute Toxicity of the Aqueous Extract of <i>Brucea sumatrana</i> (Simaroubaceae) Leaves Collected in Mai-Ndombe, Democratic Republic of Congo Chinese Medicine. 7: 93-109. DOI: 10.4236/Cm.2016.73011 |
0.369 |
|
| 2016 |
Ahmad R, Ahmad N, Naqvi AA, Cos P, Maes L, Apers S, Hermans N, Pieters L. Anti-infective, cytotoxic and antioxidant activity of Ziziphus oxyphylla and Cedrela serrata Asian Pacific Journal of Tropical Biomedicine. 6: 671-676. DOI: 10.1016/J.Apjtb.2016.04.012 |
0.368 |
|
| 2015 |
Cuesta-Rubio O, Oubada A, Bello A, Maes L, Cos P, Monzote L. Antimicrobial Assessment of Resins from Calophyllum Antillanum and Calophyllum Inophyllum. Phytotherapy Research : Ptr. PMID 26514875 DOI: 10.1002/Ptr.5506 |
0.314 |
|
| 2015 |
Hendrickx S, Leemans A, Mondelaers A, Rijal S, Khanal B, Dujardin JC, Delputte P, Cos P, Maes L. Comparative Fitness of a Parent Leishmania donovani Clinical Isolate and Its Experimentally Derived Paromomycin-Resistant Strain. Plos One. 10: e0140139. PMID 26469696 DOI: 10.1371/Journal.Pone.0140139 |
0.353 |
|
| 2015 |
Hendrickx S, Eberhardt E, Mondelaers A, Rijal S, Bhattarai NR, Dujardin JC, Delputte P, Cos P, Maes L. Lack of correlation between the promastigote back-transformation assay and miltefosine treatment outcome. The Journal of Antimicrobial Chemotherapy. 70: 3023-6. PMID 26253089 DOI: 10.1093/Jac/Dkv237 |
0.319 |
|
| 2015 |
Musuyu Muganza D, Fruth BI, Nzunzu Lami J, Cos P, Cimanga Kanyanga R, Maes L, Pieters L. In vitro antiprotozoal activity and cytotoxicity of extracts and fractions from the leaves, root bark and stem bark of Isolona hexaloba. Journal of Ethnopharmacology. 174: 187-94. PMID 26239153 DOI: 10.1016/J.Jep.2015.07.034 |
0.336 |
|
| 2015 |
Hendrickx S, Mondelaers A, Eberhardt E, Delputte P, Cos P, Maes L. In Vivo Selection of Paromomycin and Miltefosine Resistance in Leishmania donovani and L. infantum in a Syrian Hamster Model. Antimicrobial Agents and Chemotherapy. 59: 4714-8. PMID 26014955 DOI: 10.1128/Aac.00707-15 |
0.317 |
|
| 2015 |
Hendrickx S, Mondelaers A, Eberhardt E, Lachaud L, Delputte P, Cos P, Maes L. Intracellular amastigote replication may not be required for successful in vitro selection of miltefosine resistance in Leishmania infantum. Parasitology Research. 114: 2561-5. PMID 25877390 DOI: 10.1007/S00436-015-4460-9 |
0.32 |
|
| 2015 |
Chofor R, Sooriyaarachchi S, Risseeuw MD, Bergfors T, Pouyez J, Johny C, Haymond A, Everaert A, Dowd CS, Maes L, Coenye T, Alex A, Couch RD, Jones TA, Wouters J, et al. Synthesis and bioactivity of β-substituted fosmidomycin analogues targeting 1-deoxy-D-xylulose-5-phosphate reductoisomerase. Journal of Medicinal Chemistry. 58: 2988-3001. PMID 25781377 DOI: 10.1021/Jm5014264 |
0.325 |
|
| 2015 |
Sahar Traoré M, Aliou Baldé M, Camara A, Saïdou Baldé E, Diané S, Telly Diallo MS, Keita A, Cos P, Maes L, Pieters L, Mamadou Baldé A. The malaria co-infection challenge: An investigation into the antimicrobial activity of selected Guinean medicinal plants. Journal of Ethnopharmacology. 174: 576-81. PMID 25773488 DOI: 10.1016/J.Jep.2015.03.008 |
0.331 |
|
| 2015 |
Sleven R, Lanckacker E, Boulet G, Delputte P, Maes L, Cos P. Development of a novel in vitro onychomycosis model for the evaluation of topical antifungal activity. Journal of Microbiological Methods. 112: 73-5. PMID 25772040 DOI: 10.1016/J.Mimet.2015.03.009 |
0.353 |
|
| 2015 |
Kaiser M, Maes L, Tadoori LP, Spangenberg T, Ioset JR. Repurposing of the Open Access Malaria Box for Kinetoplastid Diseases Identifies Novel Active Scaffolds against Trypanosomatids. Journal of Biomolecular Screening. 20: 634-45. PMID 25690568 DOI: 10.1177/1087057115569155 |
0.387 |
|
| 2015 |
Brücher K, Gräwert T, Konzuch S, Held J, Lienau C, Behrendt C, Illarionov B, Maes L, Bacher A, Wittlin S, Mordmüller B, Fischer M, Kurz T. Prodrugs of reverse fosmidomycin analogues. Journal of Medicinal Chemistry. 58: 2025-35. PMID 25633870 DOI: 10.1021/Jm5019719 |
0.406 |
|
| 2015 |
Paulussen C, Boulet G, Bosschaerts T, Cos P, Fortin A, Maes L. Efficacy of oleylphosphocholine (OlPC) in vitro and in a mouse model of invasive aspergillosis. Mycoses. 58: 127-32. PMID 25590577 DOI: 10.1111/Myc.12286 |
0.372 |
|
| 2015 |
Bardiot D, Thevissen K, De Brucker K, Peeters A, Cos P, Taborda CP, McNaughton M, Maes L, Chaltin P, Cammue BP, Marchand A. 2-(2-oxo-morpholin-3-yl)-acetamide derivatives as broad-spectrum antifungal agents. Journal of Medicinal Chemistry. 58: 1502-12. PMID 25585716 DOI: 10.1021/Jm501814X |
0.363 |
|
| 2015 |
Blaazer AR, Orrling KM, Shanmugham A, Jansen C, Maes L, Edink E, Sterk GJ, Siderius M, England P, Bailey D, de Esch IJ, Leurs R. Fragment-based screening in tandem with phenotypic screening provides novel antiparasitic hits. Journal of Biomolecular Screening. 20: 131-40. PMID 25231971 DOI: 10.1177/1087057114549735 |
0.325 |
|
| 2015 |
Kanyanga CR, Ehata TM, Lumpu NS, Munduku KC, Phuati MA, Kabangu KO, Cos P, Maes L, Apers S, Vlietinck AJ, Pieters L. Antiprotozoal and cytotoxic activities, and the acute toxicity of extracts from of Brucea sumatrana Roxb. (Simaroubaceae) leaves collected in Mai-Ndombe, Democratic Republic of Congo Journal of Pharmacognosy and Phytotherapy. 7: 35-44. DOI: 10.5897/Jpp2014.0321 |
0.39 |
|
| 2014 |
Venkatraj M, Ariën KK, Heeres J, Joossens J, Dirié B, Lyssens S, Michiels J, Cos P, Lewi PJ, Vanham G, Maes L, Van der Veken P, Augustyns K. From human immunodeficiency virus non-nucleoside reverse transcriptase inhibitors to potent and selective antitrypanosomal compounds. Bioorganic & Medicinal Chemistry. 22: 5241-8. PMID 25199582 DOI: 10.1016/J.Bmc.2014.08.005 |
0.363 |
|
| 2014 |
Traore MS, Diane S, Diallo MS, Balde ES, Balde MA, Camara A, Diallo A, Keita A, Cos P, Maes L, Pieters L, Balde AM. In vitro antiprotozoal and cytotoxic activity of ethnopharmacologically selected guinean plants. Planta Medica. 80: 1340-4. PMID 25180493 DOI: 10.1055/S-0034-1383047 |
0.361 |
|
| 2014 |
Mothana RA, Al-Musayeib NM, Al-Ajmi MF, Cos P, Maes L. Evaluation of the in vitro antiplasmodial, antileishmanial, and antitrypanosomal activity of medicinal plants used in saudi and yemeni traditional medicine. Evidence-Based Complementary and Alternative Medicine : Ecam. 2014: 905639. PMID 24963330 DOI: 10.1155/2014/905639 |
0.38 |
|
| 2014 |
Montrieux E, Perera WH, García M, Maes L, Cos P, Monzote L. In vitro and in vivo activity of major constituents from Pluchea carolinensis against Leishmania amazonensis. Parasitology Research. 113: 2925-32. PMID 24906989 DOI: 10.1007/S00436-014-3954-1 |
0.351 |
|
| 2014 |
Mothana RA, Al-Said MS, Al-Musayeib NM, El Gamal AA, Al-Massarani SM, Al-Rehaily AJ, Abdulkader M, Maes L. In vitro antiprotozoal activity of abietane diterpenoids isolated from Plectranthus barbatus Andr. International Journal of Molecular Sciences. 15: 8360-71. PMID 24823881 DOI: 10.3390/Ijms15058360 |
0.406 |
|
| 2014 |
Cretton S, Bartholomeusz TA, Mehl F, Allenbach Y, Matheeussen A, Cos P, Maes L, Christen P. Synthesis and in vitro evaluation of tropane halogenated-derivatives against malaria, sleeping sickness, Chagas disease and leishmaniasis. Medicinal Chemistry (ShāRiqah (United Arab Emirates)). 10: 753-8. PMID 24813684 DOI: 10.2174/1573406410666140507095430 |
0.372 |
|
| 2014 |
Verbeeck S, Yadav AK, Maes BU, Augustyns K, Van Der Veken P, Cos P, Maes L, Pieters L. Antiprotozoal activity of synthetic amino substituted 1-methyl-1 H-alpha-carbolines. Die Pharmazie. 69: 83-5. PMID 24640594 DOI: 10.1691/Ph.2014.3748 |
0.324 |
|
| 2014 |
Jansen K, Heirbaut L, Verkerk R, Cheng JD, Joossens J, Cos P, Maes L, Lambeir AM, De Meester I, Augustyns K, Van Der Veken P. Extended structure-activity relationship and pharmacokinetic investigation of (4-quinolinoyl)glycyl-2-cyanopyrrolidine inhibitors of fibroblast activation protein (FAP) Journal of Medicinal Chemistry. 57: 3053-3074. PMID 24617858 DOI: 10.1021/Jm500031W |
0.365 |
|
| 2014 |
Hendrickx S, Boulet G, Mondelaers A, Dujardin JC, Rijal S, Lachaud L, Cos P, Delputte P, Maes L. Experimental selection of paromomycin and miltefosine resistance in intracellular amastigotes of Leishmania donovani and L. infantum. Parasitology Research. 113: 1875-81. PMID 24615359 DOI: 10.1007/S00436-014-3835-7 |
0.327 |
|
| 2014 |
Nühs A, Schäfer C, Zander D, Trübe L, Tejera Nevado P, Schmidt S, Arevalo J, Adaui V, Maes L, Dujardin JC, Clos J. A novel marker, ARM58, confers antimony resistance to Leishmania spp. International Journal For Parasitology. Drugs and Drug Resistance. 4: 37-47. PMID 24596667 DOI: 10.1016/J.Ijpddr.2013.11.004 |
0.312 |
|
| 2014 |
Paulussen C, de Wit K, Boulet G, Cos P, Meerpoel L, Maes L. Pyrrolo[1,2-α][1,4]benzodiazepines show potent in vitro antifungal activity and significant in vivo efficacy in a Microsporum canis dermatitis model in guinea pigs. The Journal of Antimicrobial Chemotherapy. 69: 1608-10. PMID 24535279 DOI: 10.1093/Jac/Dku034 |
0.41 |
|
| 2014 |
Clais S, Boulet G, Kerstens M, Horemans T, Teughels W, Quirynen M, Lanckacker E, De Meester I, Lambeir AM, Delputte P, Maes L, Cos P. Importance of biofilm formation and dipeptidyl peptidase IV for the pathogenicity of clinical Porphyromonas gingivalis isolates. Pathogens and Disease. 70: 408-13. PMID 24532232 DOI: 10.1111/2049-632X.12156 |
0.326 |
|
| 2014 |
Monzote L, García M, Pastor J, Gil L, Scull R, Maes L, Cos P, Gille L. Essential oil from Chenopodium ambrosioides and main components: activity against Leishmania, their mitochondria and other microorganisms. Experimental Parasitology. 136: 20-6. PMID 24184772 DOI: 10.1016/J.Exppara.2013.10.007 |
0.385 |
|
| 2014 |
Falcão SI, Vale N, Cos P, Gomes P, Freire C, Maes L, Vilas-Boas M. In vitro evaluation of Portuguese propolis and floral sources for antiprotozoal, antibacterial and antifungal activity. Phytotherapy Research : Ptr. 28: 437-43. PMID 23722631 DOI: 10.1002/Ptr.5013 |
0.402 |
|
| 2014 |
Amin A, Upadhyay A, Zafar M, Cos P, Maes L, Apers S, Exarchou V, Pieters L. Antibacterial, antifungal, cytotoxic, antioxidant and antidiabetic compounds from Nymphoides indica; the first comprehensive phytochemical and pharmacological study Planta Medica. 80. DOI: 10.1055/S-0034-1394772 |
0.376 |
|
| 2014 |
Musayeib NMA, Mothana RA, Mohamed GA, Ibrahim SRM, Maes L. Hypoestenonols A and B, new fusicoccane diterpenes from Hypoestes forskalei Phytochemistry Letters. 10: 23-27. DOI: 10.1016/J.Phytol.2014.06.020 |
0.374 |
|
| 2013 |
Jansen K, Heirbaut L, Cheng JD, Joossens J, Ryabtsova O, Cos P, Maes L, Lambeir AM, De Meester I, Augustyns K, Van der Veken P. Selective Inhibitors of Fibroblast Activation Protein (FAP) with a (4-Quinolinoyl)-glycyl-2-cyanopyrrolidine Scaffold. Acs Medicinal Chemistry Letters. 4: 491-6. PMID 24900696 DOI: 10.1021/Ml300410D |
0.33 |
|
| 2013 |
Al-Massarani SM, El Gamal AA, Al-Musayeib NM, Mothana RA, Basudan OA, Al-Rehaily AJ, Farag M, Assaf MH, El Tahir KH, Maes L. Phytochemical, antimicrobial and antiprotozoal evaluation of Garcinia mangostana pericarp and α-mangostin, its major xanthone derivative. Molecules (Basel, Switzerland). 18: 10599-608. PMID 24002136 DOI: 10.3390/Molecules180910599 |
0.336 |
|
| 2013 |
Al Musayeib NM, Mothana RA, Gamal AA, Al-Massarani SM, Maes L. In vitro antiprotozoal activity of triterpenoid constituents of Kleinia odora growing in Saudi Arabia. Molecules (Basel, Switzerland). 18: 9207-18. PMID 23912274 DOI: 10.3390/Molecules18089207 |
0.379 |
|
| 2013 |
Kikueta CM, Kambu OK, Mbenza AP, Mavinga ST, Mbamu BM, Cos P, Maes L, Apers S, Pieters L, Cimanga RK. In vitro and in vivo antimalarial activity and cytotoxicity of extracts and fractions from the leaves, root-bark and stem-bark of Triclisia gilletii. Journal of Ethnopharmacology. 149: 438-42. PMID 23876596 DOI: 10.1016/J.Jep.2013.06.043 |
0.365 |
|
| 2013 |
Lauinger IL, Vivas L, Perozzo R, Stairiker C, Tarun A, Zloh M, Zhang X, Xu H, Tonge PJ, Franzblau SG, Pham DH, Esguerra CV, Crawford AD, Maes L, Tasdemir D. Potential of lichen secondary metabolites against Plasmodium liver stage parasites with FAS-II as the potential target. Journal of Natural Products. 76: 1064-70. PMID 23806111 DOI: 10.1021/Np400083K |
0.373 |
|
| 2013 |
Lumpu SL, Kikueta CM, Tshodi ME, Mbenza AP, Kambu OK, Mbamu BM, Cos P, Maes L, Apers S, Pieters L, Cimanga RK. Antiprotozoal screening and cytotoxicity of extracts and fractions from the leaves, stem bark and root bark of Alstonia congensis. Journal of Ethnopharmacology. 148: 724-7. PMID 23612422 DOI: 10.1016/J.Jep.2013.04.016 |
0.322 |
|
| 2013 |
Kulshrestha A, Bhandari V, Mukhopadhyay R, Ramesh V, Sundar S, Maes L, Dujardin JC, Roy S, Salotra P. Validation of a simple resazurin-based promastigote assay for the routine monitoring of miltefosine susceptibility in clinical isolates of Leishmania donovani. Parasitology Research. 112: 825-8. PMID 23239091 DOI: 10.1007/S00436-012-3212-3 |
0.337 |
|
| 2013 |
Abouzid SF, Wahba HM, Elshamy A, Cos P, Maes L, Apers S, Pieters L, Shahat AA. Antimicrobial activity of some Clerodendrum species from Egypt. Natural Product Research. 27: 1032-6. PMID 22594542 DOI: 10.1080/14786419.2012.686905 |
0.393 |
|
| 2013 |
Mothana R, Al-Musayeib N, Matheeussen A, Cos P, Maes L. Evaluation of the in vitro antiplasmodial, antileishmanial and antitrypanosomal activities of selected medicinal plants from the Arabian Peninsula Planta Medica. 79. DOI: 10.1055/S-0033-1351928 |
0.326 |
|
| 2013 |
Zou Y, Foubert K, Tuenter E, Lemière F, Cos P, Maes L, Smits JM, de Gelder R, Apers S, Pieters L. Antiplasmodial and cytotoxic activities of Striga asiatica and Sauropus spatulifolius extracts, and their isolated constituents Phytochemistry Letters. 6: 53-58. DOI: 10.1016/J.Phytol.2012.10.018 |
0.361 |
|
| 2012 |
Monzote L, Cuesta-Rubio O, Campo Fernandez M, Márquez Hernandez I, Fraga J, Pérez K, Kerstens M, Maes L, Cos P. In vitro antimicrobial assessment of Cuban propolis extracts. MemóRias Do Instituto Oswaldo Cruz. 107: 978-84. PMID 23295746 DOI: 10.1590/S0074-02762012000800003 |
0.403 |
|
| 2012 |
Mothana RA, Al-Musayeib NM, Matheeussen A, Cos P, Maes L. Assessment of the in vitro antiprotozoal and cytotoxic potential of 20 selected medicinal plants from the island of Soqotra. Molecules (Basel, Switzerland). 17: 14349-60. PMID 23208469 DOI: 10.3390/Molecules171214349 |
0.416 |
|
| 2012 |
Deprez-Poulain R, Flipo M, Piveteau C, Leroux F, Dassonneville S, Florent I, Maes L, Cos P, Deprez B. Structure-activity relationships and blood distribution of antiplasmodial aminopeptidase-1 inhibitors. Journal of Medicinal Chemistry. 55: 10909-17. PMID 23176597 DOI: 10.1021/Jm301506H |
0.376 |
|
| 2012 |
Al-Musayeib NM, Mothana RA, Al-Massarani S, Matheeussen A, Cos P, Maes L. Study of the in vitro antiplasmodial, antileishmanial and antitrypanosomal activities of medicinal plants from Saudi Arabia. Molecules (Basel, Switzerland). 17: 11379-90. PMID 23011279 DOI: 10.3390/Molecules171011379 |
0.393 |
|
| 2012 |
Orrling KM, Jansen C, Vu XL, Balmer V, Bregy P, Shanmugham A, England P, Bailey D, Cos P, Maes L, Adams E, van den Bogaart E, Chatelain E, Ioset JR, van de Stolpe A, et al. Catechol pyrazolinones as trypanocidals: fragment-based design, synthesis, and pharmacological evaluation of nanomolar inhibitors of trypanosomal phosphodiesterase B1. Journal of Medicinal Chemistry. 55: 8745-56. PMID 22963052 DOI: 10.1021/Jm301059B |
0.333 |
|
| 2012 |
Fortin A, Hendrickx S, Yardley V, Cos P, Jansen H, Maes L. Efficacy and tolerability of oleylphosphocholine (OLPC) in a laboratory model of visceral leishmaniasis Journal of Antimicrobial Chemotherapy. 67: 2707-2712. PMID 22782488 DOI: 10.1093/Jac/Dks273 |
0.35 |
|
| 2012 |
Deschacht M, Van Assche T, Hendrickx S, Bult H, Maes L, Cos P. Role of oxidative stress and apoptosis in the cellular response of murine macrophages upon Leishmania infection. Parasitology. 139: 1429-37. PMID 22776404 DOI: 10.1017/S003118201200073X |
0.301 |
|
| 2012 |
Brackman G, Risseeuw M, Celen S, Cos P, Maes L, Nelis HJ, Van Calenbergh S, Coenye T. Synthesis and evaluation of the quorum sensing inhibitory effect of substituted triazolyldihydrofuranones. Bioorganic & Medicinal Chemistry. 20: 4737-43. PMID 22748377 DOI: 10.1016/J.Bmc.2012.06.009 |
0.375 |
|
| 2012 |
Brücher K, Illarionov B, Held J, Tschan S, Kunfermann A, Pein MK, Bacher A, Gräwert T, Maes L, Mordmüller B, Fischer M, Kurz T. α-Substituted β-oxa isosteres of fosmidomycin: synthesis and biological evaluation. Journal of Medicinal Chemistry. 55: 6566-75. PMID 22731758 DOI: 10.1021/Jm300652F |
0.409 |
|
| 2012 |
Hendrickx S, Inocêncio da Luz RA, Bhandari V, Kuypers K, Shaw CD, Lonchamp J, Salotra P, Carter K, Sundar S, Rijal S, Dujardin JC, Cos P, Maes L. Experimental induction of paromomycin resistance in antimony-resistant strains of L. donovani: outcome dependent on in vitro selection protocol. Plos Neglected Tropical Diseases. 6: e1664. PMID 22666513 DOI: 10.1371/Journal.Pntd.0001664 |
0.321 |
|
| 2012 |
Van de Ven H, Paulussen C, Feijens PB, Matheeussen A, Rombaut P, Kayaert P, Van den Mooter G, Weyenberg W, Cos P, Maes L, Ludwig A. PLGA nanoparticles and nanosuspensions with amphotericin B: Potent in vitro and in vivo alternatives to Fungizone and AmBisome. Journal of Controlled Release : Official Journal of the Controlled Release Society. 161: 795-803. PMID 22641062 DOI: 10.1016/J.Jconrel.2012.05.037 |
0.364 |
|
| 2012 |
Al-Musayeib NM, Mothana RA, Matheeussen A, Cos P, Maes L. In vitro antiplasmodial, antileishmanial and antitrypanosomal activities of selected medicinal plants used in the traditional Arabian Peninsular region. Bmc Complementary and Alternative Medicine. 12: 49. PMID 22520595 DOI: 10.1186/1472-6882-12-49 |
0.386 |
|
| 2012 |
Musuyu Muganza D, Fruth BI, Nzunzu Lami J, Mesia GK, Kambu OK, Tona GL, Cimanga Kanyanga R, Cos P, Maes L, Apers S, Pieters L. In vitro antiprotozoal and cytotoxic activity of 33 ethonopharmacologically selected medicinal plants from Democratic Republic of Congo. Journal of Ethnopharmacology. 141: 301-8. PMID 22394563 DOI: 10.1016/J.Jep.2012.02.035 |
0.357 |
|
| 2012 |
Beghyn TB, Charton J, Leroux F, Henninot A, Reboule I, Cos P, Maes L, Deprez B. Drug-to-genome-to-drug, step 2: reversing selectivity in a series of antiplasmodial compounds. Journal of Medicinal Chemistry. 55: 1274-86. PMID 22204607 DOI: 10.1021/Jm201422E |
0.388 |
|
| 2012 |
Ehata MT, Phuati AM, Lumpu SN, Munduki CK, Phongi DB, Lutete GT, Kabangu OK, Kanyanga RC, Matheeussen A, Cos P, Apers S, Pieters L, Maes L, Vlietinck AJ. <i>In Vitro</i> Antiprotozoal and Cytotoxic Activity of the Aqueous Extract, the 80% Methanol Extract and Its Fractions from the Seeds of <i>Brucea sumatrana</i> Roxb. (Simaroubaceae) Growing in Democratic Republic of Congo Chinese Medicine. 3: 65-71. DOI: 10.4236/Cm.2012.31011 |
0.364 |
|
| 2011 |
Nwaka S, Besson D, Ramirez B, Maes L, Matheeussen A, Bickle Q, Mansour NR, Yousif F, Townson S, Gokool S, Cho-Ngwa F, Samje M, Misra-Bhattacharya S, Murthy PK, Fakorede F, et al. Integrated dataset of screening hits against multiple neglected disease pathogens. Plos Neglected Tropical Diseases. 5: e1412. PMID 22247786 DOI: 10.1371/Journal.Pntd.0001412 |
0.359 |
|
| 2011 |
Cocquyt K, Cos P, Herdewijn P, Maes L, Van den Steen PE, Laekeman G. Ajuga remota Benth.: from ethnopharmacology to phytomedical perspective in the treatment of malaria. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology. 18: 1229-37. PMID 22015320 DOI: 10.1016/J.Phymed.2011.08.063 |
0.413 |
|
| 2011 |
Adaui V, Maes I, Huyse T, Van den Broeck F, Talledo M, Kuhls K, De Doncker S, Maes L, Llanos-Cuentas A, Schönian G, Arevalo J, Dujardin JC. Multilocus genotyping reveals a polyphyletic pattern among naturally antimony-resistant Leishmania braziliensis isolates from Peru. Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases. 11: 1873-80. PMID 21871584 DOI: 10.1016/J.Meegid.2011.08.008 |
0.3 |
|
| 2011 |
Vanaerschot M, De Doncker S, Rijal S, Maes L, Dujardin JC, Decuypere S. Antimonial resistance in Leishmania donovani is associated with increased in vivo parasite burden. Plos One. 6: e23120. PMID 21829701 DOI: 10.1371/Journal.Pone.0023120 |
0.34 |
|
| 2011 |
Bénéré E, VAN Assche T, Cos P, Maes L. Variation in growth and drug susceptibility among Giardia duodenalis assemblages A, B and E in axenic in vitro culture and in the gerbil model. Parasitology. 138: 1354-61. PMID 21819642 DOI: 10.1017/S0031182011001223 |
0.325 |
|
| 2011 |
Fernández-Calienes A, Pellón R, Docampo M, Fascio M, D'Accorso N, Maes L, Mendiola J, Monzote L, Gille L, Rojas L. Antimalarial activity of new acridinone derivatives Biomedicine and Pharmacotherapy. 65: 210-214. PMID 21641752 DOI: 10.1016/J.Biopha.2011.04.001 |
0.454 |
|
| 2011 |
Van Assche T, Deschacht M, da Luz RA, Maes L, Cos P. Leishmania-macrophage interactions: insights into the redox biology. Free Radical Biology & Medicine. 51: 337-51. PMID 21620959 DOI: 10.1016/J.Freeradbiomed.2011.05.011 |
0.31 |
|
| 2011 |
Foubert K, Cuyckens F, Matheeussen A, Vlietinck A, Apers S, Maes L, Pieters L. Antiprotozoal and antiangiogenic saponins from Apodytes dimidiata. Phytochemistry. 72: 1414-23. PMID 21601896 DOI: 10.1016/J.Phytochem.2011.04.009 |
0.333 |
|
| 2011 |
Thevissen K, Pellens K, De Brucker K, François IE, Chow KK, Meert EM, Meert W, Van Minnebruggen G, Borgers M, Vroome V, Levin J, De Vos D, Maes L, Cos P, Cammue BP. Novel fungicidal benzylsulfanyl-phenylguanidines. Bioorganic & Medicinal Chemistry Letters. 21: 3686-92. PMID 21576022 DOI: 10.1016/J.Bmcl.2011.04.075 |
0.402 |
|
| 2011 |
Beghyn TB, Charton J, Leroux F, Laconde G, Bourin A, Cos P, Maes L, Deprez B. Drug to genome to drug: discovery of new antiplasmodial compounds. Journal of Medicinal Chemistry. 54: 3222-40. PMID 21504142 DOI: 10.1021/Jm1014617 |
0.392 |
|
| 2011 |
Oduor RO, Ojo KK, Williams GP, Bertelli F, Mills J, Maes L, Pryde DC, Parkinson T, Van Voorhis WC, Holler TP. Trypanosoma brucei glycogen synthase kinase-3, a target for anti-trypanosomal drug development: a public-private partnership to identify novel leads. Plos Neglected Tropical Diseases. 5: e1017. PMID 21483717 DOI: 10.1371/Journal.Pntd.0001017 |
0.309 |
|
| 2011 |
Brackman G, Cos P, Maes L, Nelis HJ, Coenye T. Quorum sensing inhibitors increase the susceptibility of bacterial biofilms to antibiotics in vitro and in vivo. Antimicrobial Agents and Chemotherapy. 55: 2655-61. PMID 21422204 DOI: 10.1128/Aac.00045-11 |
0.319 |
|
| 2011 |
Monzote L, Cuesta-Rubio O, Matheeussen A, Van Assche T, Maes L, Cos P. Antimicrobial evaluation of the polyisoprenylated benzophenones nemorosone and guttiferone A. Phytotherapy Research : Ptr. 25: 458-62. PMID 21259352 DOI: 10.1002/Ptr.3401 |
0.404 |
|
| 2011 |
Brackman G, Celen S, Hillaert U, Van Calenbergh S, Cos P, Maes L, Nelis HJ, Coenye T. Structure-activity relationship of cinnamaldehyde analogs as inhibitors of AI-2 based quorum sensing and their effect on virulence of Vibrio spp. Plos One. 6: e16084. PMID 21249192 DOI: 10.1371/Journal.Pone.0016084 |
0.376 |
|
| 2011 |
Foubert K, Cuyckens F, Matheeussen A, Vlietinck A, Apers S, Maes L, Pieters L. Biologically active saponins from Apodytes dimidiata Planta Medica. 77. DOI: 10.1055/S-0031-1282489 |
0.324 |
|
| 2010 |
Tangmouo JG, Ho R, Matheeussen A, Lannang AM, Komguem J, Messi BB, Maes L, Hostettmann K. Antimalarial activity of extract and norbergenin derivatives from the stem bark of Diospyros sanza-minika A. Chevalier (Ebenaceae). Phytotherapy Research : Ptr. 24: 1676-9. PMID 21031627 DOI: 10.1002/Ptr.3192 |
0.365 |
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| 2010 |
Vanaerschot M, Maes I, Ouakad M, Adaui V, Maes L, De Doncker S, Rijal S, Chappuis F, Dujardin JC, Decuypere S. Linking in vitro and in vivo survival of clinical Leishmania donovani strains. Plos One. 5: e12211. PMID 20808916 DOI: 10.1371/Journal.Pone.0012211 |
0.328 |
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| 2010 |
de Wit K, Paulussen C, Matheeussen A, van Rossem K, Cos P, Maes L. In vitro profiling of pramiconazole and in vivo evaluation in Microsporum canis dermatitis and Candida albicans vaginitis laboratory models. Antimicrobial Agents and Chemotherapy. 54: 4927-9. PMID 20805398 DOI: 10.1128/Aac.00730-10 |
0.37 |
|
| 2010 |
Steert K, Berg M, Mottram JC, Westrop GD, Coombs GH, Cos P, Maes L, Joossens J, Van der Veken P, Haemers A, Augustyns K. α-ketoheterocycles as inhibitors of Leishmania mexicana cysteine protease CPB. Chemmedchem. 5: 1734-48. PMID 20799311 DOI: 10.1002/Cmdc.201000265 |
0.346 |
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| 2010 |
Behrendt CT, Kunfermann A, Illarionova V, Matheeussen A, Gräwert T, Groll M, Rohdich F, Bacher A, Eisenreich W, Fischer M, Maes L, Kurz T. Synthesis and antiplasmodial activity of highly active reverse analogues of the antimalarial drug candidate fosmidomycin Chemmedchem. 5: 1673-1676. PMID 20718073 DOI: 10.1002/Cmdc.201000276 |
0.363 |
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| 2010 |
Verbrugghen T, Cos P, Maes L, Van Calenbergh S. Synthesis and evaluation of alpha-halogenated analogues of 3-(acetylhydroxyamino)propylphosphonic acid (FR900098) as antimalarials. Journal of Medicinal Chemistry. 53: 5342-6. PMID 20568776 DOI: 10.1021/Jm100211E |
0.342 |
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| 2010 |
Baldé ES, Megalizzi V, Traoré MS, Cos P, Maes L, Decaestecker C, Pieters L, Baldé AM. In vitro antiprotozoal, antimicrobial and antitumor activity of Pavetta crassipes K. Schum leaf extracts. Journal of Ethnopharmacology. 130: 529-35. PMID 20561931 DOI: 10.1016/J.Jep.2010.05.042 |
0.333 |
|
| 2010 |
Mesia K, Cimanga RK, Dhooghe L, Cos P, Apers S, Totté J, Tona GL, Pieters L, Vlietinck AJ, Maes L. Antimalarial activity and toxicity evaluation of a quantified Nauclea pobeguinii extract. Journal of Ethnopharmacology. 131: 10-6. PMID 20470876 DOI: 10.1016/J.Jep.2010.05.008 |
0.36 |
|
| 2010 |
Toté K, Horemans T, Vanden Berghe D, Maes L, Cos P. Inhibitory effect of biocides on the viable masses and matrices of Staphylococcus aureus and Pseudomonas aeruginosa biofilms. Applied and Environmental Microbiology. 76: 3135-42. PMID 20363795 DOI: 10.1128/Aem.02095-09 |
0.309 |
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| 2010 |
Wenzel NI, Chavain N, Wang Y, Friebolin W, Maes L, Pradines B, Lanzer M, Yardley V, Brun R, Herold-Mende C, Biot C, Tóth K, Davioud-Charvet E. Antimalarial versus cytotoxic properties of dual drugs derived from 4-aminoquinolines and Mannich bases: interaction with DNA. Journal of Medicinal Chemistry. 53: 3214-26. PMID 20329733 DOI: 10.1021/Jm9018383 |
0.414 |
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| 2010 |
Berg M, Kohl L, Van der Veken P, Joossens J, Al-Salabi MI, Castagna V, Giannese F, Cos P, Versées W, Steyaert J, Grellier P, Haemers A, Degano M, Maes L, de Koning HP, et al. Evaluation of nucleoside hydrolase inhibitors for treatment of African trypanosomiasis. Antimicrobial Agents and Chemotherapy. 54: 1900-8. PMID 20194690 DOI: 10.1128/Aac.01787-09 |
0.381 |
|
| 2010 |
Dhooghe L, Maregesi S, Mincheva I, Ferreira D, Marais JP, Lemière F, Matheeussen A, Cos P, Maes L, Vlietinck A, Apers S, Pieters L. Antiplasmodial activity of (I-3,II-3)-biflavonoids and other constituents from Ormocarpum kirkii. Phytochemistry. 71: 785-91. PMID 20189612 DOI: 10.1016/J.Phytochem.2010.02.005 |
0.371 |
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| 2010 |
Berg M, Van der Veken P, Joossens J, Muthusamy V, Breugelmans M, Moss CX, Rudolf J, Cos P, Coombs GH, Maes L, Haemers A, Mottram JC, Augustyns K. Design and evaluation of Trypanosoma brucei metacaspase inhibitors. Bioorganic & Medicinal Chemistry Letters. 20: 2001-6. PMID 20167486 DOI: 10.1016/J.Bmcl.2010.01.099 |
0.342 |
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| 2010 |
Cretton S, Glauser G, Humam M, Jeannerat D, Muñoz O, Maes L, Christen P, Hostettmann K. Isomeric tropane alkaloids from the aerial parts of Schizanthus tricolor. Journal of Natural Products. 73: 844-7. PMID 20166702 DOI: 10.1021/Np900780W |
0.301 |
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| 2010 |
Abdel-Sattar E, Maes L, Salama MM. In vitro activities of plant extracts from Saudi Arabia against malaria, leishmaniasis, sleeping sickness and Chagas disease. Phytotherapy Research : Ptr. 24: 1322-8. PMID 20127723 DOI: 10.1002/Ptr.3108 |
0.391 |
|
| 2010 |
Fotie J, Kaiser M, Delfín DA, Manley J, Reid CS, Paris JM, Wenzler T, Maes L, Mahasenan KV, Li C, Werbovetz KA. Antitrypanosomal activity of 1,2-dihydroquinolin-6-ols and their ester derivatives. Journal of Medicinal Chemistry. 53: 966-82. PMID 20047276 DOI: 10.1021/Jm900723W |
0.351 |
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| 2010 |
Bradacs G, Maes L, Heilmann J. In vitro cytotoxic, antiprotozoal and antimicrobial activities of medicinal plants from Vanuatu Phytotherapy Research. 24: 800-809. PMID 20014163 DOI: 10.1002/Ptr.2981 |
0.366 |
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| 2009 |
Van Baelen G, Hostyn S, Dhooghe L, Tapolcsányi P, Mátyus P, Lemière G, Dommisse R, Kaiser M, Brun R, Cos P, Maes L, Hajós G, Riedl Z, Nagy I, Maes BU, et al. Structure-activity relationship of antiparasitic and cytotoxic indoloquinoline alkaloids, and their tricyclic and bicyclic analogues. Bioorganic & Medicinal Chemistry. 17: 7209-17. PMID 19781948 DOI: 10.1016/J.Bmc.2009.08.057 |
0.42 |
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| 2009 |
da Luz RI, Vermeersch M, Dujardin JC, Cos P, Maes L. In vitro sensitivity testing of Leishmania clinical field isolates: preconditioning of promastigotes enhances infectivity for macrophage host cells. Antimicrobial Agents and Chemotherapy. 53: 5197-203. PMID 19752271 DOI: 10.1128/Aac.00866-09 |
0.364 |
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| 2009 |
Nwaka S, Ramirez B, Brun R, Maes L, Douglas F, Ridley R. Advancing drug innovation for neglected diseases-criteria for lead progression. Plos Neglected Tropical Diseases. 3: e440. PMID 19707561 DOI: 10.1371/Journal.Pntd.0000440 |
0.31 |
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| 2009 |
Vermeersch M, da Luz RI, Toté K, Timmermans JP, Cos P, Maes L. In vitro susceptibilities of Leishmania donovani promastigote and amastigote stages to antileishmanial reference drugs: practical relevance of stage-specific differences. Antimicrobial Agents and Chemotherapy. 53: 3855-9. PMID 19546361 DOI: 10.1128/Aac.00548-09 |
0.374 |
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| 2009 |
El Sayed I, Van der Veken P, Steert K, Dhooghe L, Hostyn S, Van Baelen G, Lemière G, Maes BU, Cos P, Maes L, Joossens J, Haemers A, Pieters L, Augustyns K. Synthesis and antiplasmodial activity of aminoalkylamino-substituted neocryptolepine derivatives. Journal of Medicinal Chemistry. 52: 2979-88. PMID 19364118 DOI: 10.1021/Jm801490Z |
0.346 |
|
| 2009 |
Vermeersch M, Foubert K, da Luz RI, Van Puyvelde L, Pieters L, Cos P, Maes L. Selective antileishmania activity of 13,28-epoxy-oleanane and related triterpene saponins from the plant families Myrsinaceae, Primulaceae, Aceraceae and Icacinaceae. Phytotherapy Research : Ptr. 23: 1404-10. PMID 19274770 DOI: 10.1002/Ptr.2788 |
0.384 |
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| 2009 |
Foubert K, Vermeersch M, Theunis M, Apers S, Cos P, Claeys M, Van Puyvelde L, Pieters L, Maes L. LC-MS analysis of 13,28-epoxy-oleanane saponins in Maesa spp. extracts with antileishmanial activity. Phytochemical Analysis : Pca. 20: 159-67. PMID 19219852 DOI: 10.1055/S-0028-1084526 |
0.331 |
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| 2009 |
Wenzel IN, Wong PE, Maes L, Müller TJ, Krauth-Siegel RL, Barrett MP, Davioud-Charvet E. Unsaturated Mannich bases active against multidrug-resistant Trypanosoma brucei brucei strains. Chemmedchem. 4: 339-51. PMID 19219843 DOI: 10.1002/Cmdc.200800360 |
0.36 |
|
| 2009 |
Vik A, Proszenyák A, Vermeersch M, Cos P, Maes L, Gundersen LL. Screening of agelasine D and analogs for inhibitory activity against pathogenic protozoa; identification of hits for visceral leishmaniasis and Chagas disease. Molecules (Basel, Switzerland). 14: 279-88. PMID 19136916 DOI: 10.3390/Molecules14010279 |
0.421 |
|
| 2009 |
Simões-Pires CA, Vargas S, Marston A, Ioset J, Paulo MQ, Matheeussen A, Maes L. Ellagic acid derivatives from Syzygium cumini stem bark: investigation of their antiplasmodial activity. Natural Product Communications. 4: 1371-1376. DOI: 10.1177/1934578X0900401012 |
0.304 |
|
| 2009 |
Simões-Pires C, Diop E, Ioset J, Falquet J, Matheeussen A, Maes L, Hostettmann K. Bioguided fractionation of the antimalarial plant Argemone mexicana: isolation and quantification of active compounds from effective clinical batches Planta Medica. 75. DOI: 10.1055/S-0029-1234501 |
0.363 |
|
| 2008 |
Valdés AF, MartÃnez JM, Lizama RS, Vermeersch M, Cos P, Maes L. In vitro anti-microbial activity of the Cuban medicinal plants Simarouba glauca DC, Melaleuca leucadendron L and Artemisia absinthium L. Memã³Rias Do Instituto Oswaldo Cruz. 103: 615-8. PMID 18949336 DOI: 10.1590/S0074-02762008000600019 |
0.393 |
|
| 2008 |
Cos P, Maes L, Vlietinck A, Pieters L. Plant-derived leading compounds for chemotherapy of human immunodeficiency virus (HIV) infection - an update (1998 - 2007). Planta Medica. 74: 1323-37. PMID 18671200 DOI: 10.1055/S-2008-1081314 |
0.318 |
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| 2008 |
Delarue-Cochin S, Grellier P, Maes L, Mouray E, Sergheraert C, Melnyk P. Synthesis and antimalarial activity of carbamate and amide derivatives of 4-anilinoquinoline. European Journal of Medicinal Chemistry. 43: 2045-55. PMID 18226428 DOI: 10.1016/j.ejmech.2007.11.003 |
0.311 |
|
| 2008 |
Delarue-Cochin S, Paunescu E, Maes L, Mouray E, Sergheraert C, Grellier P, Melnyk P. Synthesis and antimalarial activity of new analogues of amodiaquine. European Journal of Medicinal Chemistry. 43: 252-60. PMID 17485145 DOI: 10.1016/j.ejmech.2007.03.008 |
0.305 |
|
| 2007 |
Mesia GK, Tona GL, Nanga TH, Cimanga RK, Apers S, Cos P, Maes L, Pieters L, Vlietinck AJ. Antiprotozoal and cytotoxic screening of 45 plant extracts from Democratic Republic of Congo. Journal of Ethnopharmacology. 115: 409-15. PMID 18068320 DOI: 10.1016/J.Jep.2007.10.028 |
0.347 |
|
| 2007 |
Bénéré E, Luz RAId, Vermeersch M, Cos P, Maes L. A new quantitative in vitro microculture method for Giardia duodenalis trophozoites. Journal of Microbiological Methods. 71: 101-106. PMID 17888535 DOI: 10.1016/J.Mimet.2007.07.014 |
0.347 |
|
| 2007 |
Hermans N, Cos P, Maes L, Bruyne TD, Berghe DV, Vlietinck AJ, Pieters L. Challenges and Pitfalls in Antioxidant Research Current Medicinal Chemistry. 14: 417-430. PMID 17305543 DOI: 10.2174/092986707779941005 |
0.336 |
|
| 2006 |
Kapingu MC, Mbwambo ZH, Moshi MJ, Magadula JJ, Cos P, Berghe DV, Maes L, Theunis M, Apers S, Pieters L, Vlietinck A. A novel isoflavonoid from Millettia puguensis. Planta Medica. 72: 1341-3. PMID 17054049 DOI: 10.1055/S-2006-951689 |
0.388 |
|
| 2006 |
Cos P, Vlietinck AJ, Berghe DV, Maes L. Anti-infective potential of natural products: how to develop a stronger in vitro 'proof-of-concept'. Journal of Ethnopharmacology. 106: 290-302. PMID 16698208 DOI: 10.1016/J.Jep.2006.04.003 |
0.409 |
|
| 2006 |
Mbwambo ZH, Kapingu MC, Moshi MJ, Machumi F, Apers S, Cos P, Ferreira D, Marais JP, Vanden Berghe D, Maes L, Vlietinck A, Pieters L. Antiparasitic activity of some xanthones and biflavonoids from the root bark of Garcinia livingstonei. Journal of Natural Products. 69: 369-72. PMID 16562837 DOI: 10.1021/Np050406V |
0.362 |
|
| 2006 |
Pieters L, Mbwambo Z, Kapingu M, Moshi M, Machumi F, Apers S, Cos P, Ferreira D, Marais J, Vanden Berghe D, Maes L, Vlietinck A. Antiparasitic Activity of Some Xanthones and Biflavonoids and Identification of a New Biflavanoid from the Root Bark of Garcinia livingstonei Planta Medica. 72. DOI: 10.1055/S-2006-949803 |
0.324 |
|
| 2006 |
Maes L, Kuypers K, Vermeersch M, Cos P, Pieters L, Puyvelde LV. Structure-activity-relationship (SAR) for in vitro antileishmanial activity of maesabalide (PX-6518) analogue natural products Planta Medica. 72. DOI: 10.1055/S-2006-949761 |
0.335 |
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| 2005 |
Germonprez N, Maes L, Van Puyvelde L, Van Tri M, Tuan DA, De Kimpe N. In vitro and in vivo anti-leishmanial activity of triterpenoid saponins isolated from Maesa balansae and some chemical derivatives. Journal of Medicinal Chemistry. 48: 32-7. PMID 15633999 DOI: 10.1021/Jm031150Y |
0.438 |
|
| 2004 |
Van Miert S, Jonckers T, Cimanga K, Maes L, Maes B, Lemière G, Dommisse R, Vlietinck A, Pieters L. In vitro inhibition of beta-haematin formation, DNA interactions, antiplasmodial activity, and cytotoxicity of synthetic neocryptolepine derivatives. Experimental Parasitology. 108: 163-8. PMID 15582513 DOI: 10.1016/J.Exppara.2004.08.006 |
0.383 |
|
| 2004 |
Maes L, Germonprez N, Quirijnen L, Puyvelde LV, Cos P, Berghe DV. Comparative Activities of the Triterpene Saponin Maesabalide III and Liposomal Amphotericin B (AmBisome) against Leishmania donovani in Hamsters Antimicrobial Agents and Chemotherapy. 48: 2056-2060. PMID 15155199 DOI: 10.1128/Aac.48.6.2056-2060.2004 |
0.303 |
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| 2004 |
Maes L, Vanden Berghe D, Germonprez N, Quirijnen L, Cos P, De Kimpe N, Van Puyvelde L. In vitro and in vivo activities of a triterpenoid saponin extract (PX-6518) from the plant Maesa balansae against visceral leishmania species. Antimicrobial Agents and Chemotherapy. 48: 130-6. PMID 14693530 DOI: 10.1128/Aac.48.1.130-136.2004 |
0.367 |
|
| 2003 |
Cos P, Hermans N, Calomme M, Maes L, Bruyne TD, Pieters L, Vlietinck AJ, Berghe DV. Comparative study of eight well-known polyphenolic antioxidants. Journal of Pharmacy and Pharmacology. 55: 1291-1297. PMID 14604473 DOI: 10.1211/0022357021693 |
0.378 |
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| 2003 |
Yazwinski TA, Chapman HD, Davis RB, Letonja T, Pote L, Maes L, Vercruysse J, Jacobs DE. World Association for the Advancement of Veterinary Parasitology (WAAVP) guidelines for evaluating the effectiveness of anthelmintics in chickens and turkeys. Veterinary Parasitology. 116: 159-73. PMID 14519320 DOI: 10.1016/S0304-4017(03)00264-4 |
0.3 |
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| 2003 |
Ryckebusch A, Deprez-Poulain R, Maes L, Debreu-Fontaine M, Mouray E, Grellier P, Sergheraert C. Synthesis and in vitro and in vivo antimalarial activity of N1-(7-chloro-4-quinolyl)-1,4-bis(3-aminopropyl)piperazine derivatives. Journal of Medicinal Chemistry. 46: 542-557. PMID 12570376 DOI: 10.1021/Jm020960R |
0.417 |
|
| 2002 |
Jonckers TH, van Miert S, Cimanga K, Bailly C, Colson P, De Pauw-Gillet MC, van den Heuvel H, Claeys M, Lemière F, Esmans EL, Rozenski J, Quirijnen L, Maes L, Dommisse R, Lemière GL, et al. Synthesis, cytotoxicity, and antiplasmodial and antitrypanosomal activity of new neocryptolepine derivatives. Journal of Medicinal Chemistry. 45: 3497-508. PMID 12139461 DOI: 10.1021/Jm011102I |
0.426 |
|
| 2002 |
Kuria KAM, Chepkwony H, Govaerts C, Roets E, Busson R, Witte PD, Zupko I, Hoornaert G, Quirynen L, Maes L, Janssens L, Hoogmartens J, Laekeman G. The antiplasmodial activity of isolates from Ajuga remota. Journal of Natural Products. 65: 789-793. PMID 12027771 DOI: 10.1021/Np0104626 |
0.346 |
|
| 2001 |
Davioud-Charvet E, Delarue S, Biot C, Schwöbel B, Boehme C, Müssigbrodt A, Maes L, Sergheraert C, Grellier P, Schirmer RH, Becker K. A prodrug form of a Plasmodium falciparum glutathione reductase inhibitor conjugated with a 4-anilinoquinoline Journal of Medicinal Chemistry. 44: 4268-4276. PMID 11708927 DOI: 10.1021/Jm010268G |
0.375 |
|
| 2001 |
Delarue S, Girault S, Maes L, Debreu-Fontaine MA, Labaeïd M, Grellier P, Sergheraert C. Synthesis and in vitro and in vivo antimalarial activity of new 4-anilinoquinolines. Journal of Medicinal Chemistry. 44: 2827-33. PMID 11495593 DOI: 10.1021/JM010842O |
0.301 |
|
| 2001 |
Girault S, Grellier P, Berecibar A, Maes L, Lemiere P, Mouray E, Davioud-Charvet E, Sergheraert C. Antiplasmodial activity and cytotoxicity of bis-, tris-, and tetraquinolines with linear or cyclic amino linkers. Journal of Medicinal Chemistry. 44: 1658-1665. PMID 11356101 DOI: 10.1021/Jm001096A |
0.388 |
|
| 2000 |
Girault S, Grellier P, Berecibar A, Maes L, Mouray E, Lemière P, Debreu M, Davioud-Charvet E, Sergheraert C. Antimalarial, antitrypanosomal, and antileishmanial activities and cytotoxicity of bis(9-amino-6-chloro-2-methoxyacridines): influence of the linker. Journal of Medicinal Chemistry. 43: 2646-2654. PMID 10893302 DOI: 10.1021/Jm990946N |
0.397 |
|
| 1999 |
Chowdhury SF, Villamor VB, Guerrero RH, Leal I, Brun R, Croft SL, Goodman JM, Maes L, Ruiz-Perez LM, Pacanowska DG, Gilbert IH. Design, synthesis, and evaluation of inhibitors of trypanosomal and leishmanial dihydrofolate reductase. Journal of Medicinal Chemistry. 42: 4300-12. PMID 10543874 DOI: 10.1021/jm981130 |
0.395 |
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