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Chenglong Li, Ph.D. - Publications

Affiliations: 
University of Florida, Gainesville, Gainesville, FL, United States 
 2000 Cornell University, Ithaca, NY, United States 
Area:
Structure and function of proteins using X-ray crystallography
Website:
http://pharmacy.ufl.edu/faculty/chenglong-li/
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52 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Zhao C, Xiao H, Wu X, Li C, Liang G, Yang S, Lin J. Rational combination of MEK inhibitor and the STAT3 pathway modulator for the therapy in K-Ras mutated pancreatic and colon cancer cells. Oncotarget. 6: 14472-87. PMID 25961376  0.48
2015 Wang Z, Chen G, Chen L, Liu X, Fu W, Zhang Y, Li C, Liang G, Cai Y. Insights into the binding mode of curcumin to MD-2: studies from molecular docking, molecular dynamics simulations and experimental assessments. Molecular Biosystems. 11: 1933-8. PMID 25923908 DOI: 10.1039/c5mb00085h  0.48
2015 Zuo M, Li C, Lin J, Javle M. LLL12, a novel small inhibitor targeting STAT3 for hepatocellular carcinoma therapy. Oncotarget. 6: 10940-9. PMID 25883212  0.48
2015 Alinari L, Mahasenan KV, Yan F, Karkhanis V, Chung JH, Smith EM, Quinion C, Smith PL, Kim L, Patton JT, Lapalombella R, Yu B, Wu Y, Roy S, De Leo A, ... ... Li C, et al. Selective inhibition of protein arginine methyltransferase 5 blocks initiation and maintenance of B-cell transformation. Blood. 125: 2530-43. PMID 25742700 DOI: 10.1182/blood-2014-12-619783  0.48
2015 Xiao H, Bid HK, Jou D, Wu X, Yu W, Li C, Houghton PJ, Lin J. A novel small molecular STAT3 inhibitor, LY5, inhibits cell viability, cell migration, and angiogenesis in medulloblastoma cells. The Journal of Biological Chemistry. 290: 3418-29. PMID 25313399 DOI: 10.1074/jbc.M114.616748  0.48
2014 Harvey W, Park IH, Rübel O, Pascucci V, Bremer PT, Li C, Wang Y. A collaborative visual analytics suite for protein folding research. Journal of Molecular Graphics & Modelling. 53: 59-71. PMID 25068440 DOI: 10.1016/j.jmgm.2014.06.003  0.48
2014 Wang XR, Li C. Decoding F508del misfolding in cystic fibrosis. Biomolecules. 4: 498-509. PMID 24970227 DOI: 10.3390/biom4020498  0.48
2014 Kim TD, Fuchs JR, Schwartz E, Abdelhamid D, Etter J, Berry WL, Li C, Ihnat MA, Li PK, Janknecht R. Pro-growth role of the JMJD2C histone demethylase in HCT-116 colon cancer cells and identification of curcuminoids as JMJD2 inhibitors. American Journal of Translational Research. 6: 236-47. PMID 24936217  0.48
2014 Zhang M, Xiang S, Joo HY, Wang L, Williams KA, Liu W, Hu C, Tong D, Haakenson J, Wang C, Zhang S, Pavlovicz RE, Jones A, Schmidt KH, Tang J, ... ... Li C, et al. HDAC6 deacetylates and ubiquitinates MSH2 to maintain proper levels of MutSα. Molecular Cell. 55: 31-46. PMID 24882211 DOI: 10.1016/j.molcel.2014.04.028  0.48
2014 Lai H, Gallucci JC, Li C. N-[2-(9H-Carbazol-9-yl)eth-yl]-4-(methyl-sulfon-yl)aniline. Acta Crystallographica. Section E, Structure Reports Online. 70: o332. PMID 24765027 DOI: 10.1107/S1600536814003614  0.48
2014 Lai H, Gallucci JC, Li C. (E)-3-(9-Ethyl-9H-carbazol-3-yl)-1-(2-meth-oxy-phen-yl)prop-2-en-1-one. Acta Crystallographica. Section E, Structure Reports Online. 70: o190. PMID 24764901 DOI: 10.1107/S1600536814001263  0.48
2014 Rao W, Zhang W, Poventud-Fuentes I, Wang Y, Lei Y, Agarwal P, Weekes B, Li C, Lu X, Yu J, He X. Thermally responsive nanoparticle-encapsulated curcumin and its combination with mild hyperthermia for enhanced cancer cell destruction. Acta Biomaterialia. 10: 831-42. PMID 24516867 DOI: 10.1016/j.actbio.2013.10.020  0.48
2014 Li H, Xiao H, Lin L, Jou D, Kumari V, Lin J, Li C. Drug design targeting protein-protein interactions (PPIs) using multiple ligand simultaneous docking (MLSD) and drug repositioning: discovery of raloxifene and bazedoxifene as novel inhibitors of IL-6/GP130 interface. Journal of Medicinal Chemistry. 57: 632-41. PMID 24456369 DOI: 10.1021/jm401144z  0.48
2014 Yan F, Alinari L, Lustberg ME, Martin LK, Cordero-Nieves HM, Banasavadi-Siddegowda Y, Virk S, Barnholtz-Sloan J, Bell EH, Wojton J, Jacob NK, Chakravarti A, Nowicki MO, Wu X, Lapalombella R, ... ... Li C, et al. Genetic validation of the protein arginine methyltransferase PRMT5 as a candidate therapeutic target in glioblastoma. Cancer Research. 74: 1752-65. PMID 24453002 DOI: 10.1158/0008-5472.CAN-13-0884  0.48
2013 Lin L, Hutzen B, Lee HF, Peng Z, Wang W, Zhao C, Lin HJ, Sun D, Li PK, Li C, Korkaya H, Wicha MS, Lin J. Evaluation of STAT3 signaling in ALDH+ and ALDH+/CD44+/CD24- subpopulations of breast cancer cells. Plos One. 8: e82821. PMID 24376586 DOI: 10.1371/journal.pone.0082821  0.48
2013 Li J, Pan L, Deng Y, Muñoz-Acuña U, Yuan C, Lai H, Chai H, Chagwedera TE, Farnsworth NR, Carcache de Blanco EJ, Li C, Soejarto DD, Kinghorn AD. Sphenostylisins A-K: bioactive modified isoflavonoid constituents of the root bark of Sphenostylis marginata ssp. erecta. The Journal of Organic Chemistry. 78: 10166-77. PMID 24044416 DOI: 10.1021/jo401573h  0.48
2013 Frey EN, Pavlovicz RE, Wegman CJ, Li C, Askwith CC. Conformational changes in the lower palm domain of ASIC1a contribute to desensitization and RFamide modulation. Plos One. 8: e71733. PMID 23977127 DOI: 10.1371/journal.pone.0071733  0.48
2013 Chettiar SN, Cooley JV, Park IH, Bhasin D, Chakravarti A, Li PK, Li C, Jacob NK. Design, synthesis and biological studies of survivin dimerization modulators that prolong mitotic cycle. Bioorganic & Medicinal Chemistry Letters. 23: 5429-33. PMID 23968825 DOI: 10.1016/j.bmcl.2013.07.034  0.48
2013 Kroon P, Berry PA, Stower MJ, Rodrigues G, Mann VM, Simms M, Bhasin D, Chettiar S, Li C, Li PK, Maitland NJ, Collins AT. JAK-STAT blockade inhibits tumor initiation and clonogenic recovery of prostate cancer stem-like cells. Cancer Research. 73: 5288-98. PMID 23824741 DOI: 10.1158/0008-5472.CAN-13-0874  0.48
2013 Yi B, Long S, González-Cestari TF, Henderson BJ, Pavlovicz RE, Werbovetz K, Li C, McKay DB. Discovery of benzamide analogs as negative allosteric modulators of human neuronal nicotinic receptors: pharmacophore modeling and structure-activity relationship studies. Bioorganic & Medicinal Chemistry. 21: 4730-43. PMID 23757208 DOI: 10.1016/j.bmc.2013.03.082  0.48
2013 Yu W, Xiao H, Lin J, Li C. Discovery of novel STAT3 small molecule inhibitors via in silico site-directed fragment-based drug design. Journal of Medicinal Chemistry. 56: 4402-12. PMID 23651330 DOI: 10.1021/jm400080c  0.48
2013 Yu W, Li C. 4-Nitro-phenyl N-(2-sulfamoylphen-yl)carbamate. Acta Crystallographica. Section E, Structure Reports Online. 69: o355. PMID 23476546 DOI: 10.1107/S1600536813003310  0.48
2013 Liu MJ, Bao S, Gálvez-Peralta M, Pyle CJ, Rudawsky AC, Pavlovicz RE, Killilea DW, Li C, Nebert DW, Wewers MD, Knoell DL. ZIP8 regulates host defense through zinc-mediated inhibition of NF-κB. Cell Reports. 3: 386-400. PMID 23403290 DOI: 10.1016/j.celrep.2013.01.009  0.48
2013 Still PC, Yi B, González-Cestari TF, Pan L, Pavlovicz RE, Chai HB, Ninh TN, Li C, Soejarto DD, McKay DB, Kinghorn AD. Alkaloids from Microcos paniculata with cytotoxic and nicotinic receptor antagonistic activities. Journal of Natural Products. 76: 243-9. PMID 23327794 DOI: 10.1021/np3007414  0.48
2013 Guvenc H, Pavlyukov MS, Joshi K, Kurt H, Banasavadi-Siddegowda YK, Mao P, Hong C, Yamada R, Kwon CH, Bhasin D, Chettiar S, Kitange G, Park IH, Sarkaria JN, Li C, et al. Impairment of glioma stem cell survival and growth by a novel inhibitor for Survivin-Ran protein complex. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 631-42. PMID 23251006 DOI: 10.1158/1078-0432.CCR-12-0647  0.48
2013 Endeshaw M, Zhu X, He S, Pandharkar T, Cason E, Mahasenan KV, Agarwal H, Li C, Munde M, Wilson WD, Bahar M, Doskotch RW, Kinghorn AD, Kaiser M, Brun R, et al. 8,8-dialkyldihydroberberines with potent antiprotozoal activity. Journal of Natural Products. 76: 311-5. PMID 23167812 DOI: 10.1021/np300638f  0.48
2013 Gaudio E, Paduano F, Ngankeu A, Lovat F, Fabbri M, Sun HL, Gasparini P, Efanov A, Peng Y, Zanesi N, Shuaib MA, Rassenti LZ, Kipps TJ, Li C, Aqeilan RI, et al. Heat shock protein 70 regulates Tcl1 expression in leukemia and lymphomas. Blood. 121: 351-9. PMID 23160471 DOI: 10.1182/blood-2012-09-457374  0.48
2012 Liu A, Liu Y, Jin Z, Hu Q, Lin L, Jou D, Yang J, Xu Z, Wang H, Li C, Lin J. XZH-5 inhibits STAT3 phosphorylation and enhances the cytotoxicity of chemotherapeutic drugs in human breast and pancreatic cancer cells. Plos One. 7: e46624. PMID 23056374 DOI: 10.1371/journal.pone.0046624  0.48
2012 Henderson BJ, González-Cestari TF, Yi B, Pavlovicz RE, Boyd RT, Li C, Bergmeier SC, McKay DB. Defining the putative inhibitory site for a selective negative allosteric modulator of human α4β2 neuronal nicotinic receptors. Acs Chemical Neuroscience. 3: 682-92. PMID 23019495 DOI: 10.1021/cn300035f  0.48
2012 Koval OM, Snyder JS, Wolf RM, Pavlovicz RE, Glynn P, Curran J, Leymaster ND, Dun W, Wright PJ, Cardona N, Qian L, Mitchell CC, Boyden PA, Binkley PF, Li C, et al. Ca2+/calmodulin-dependent protein kinase II-based regulation of voltage-gated Na+ channel in cardiac disease. Circulation. 126: 2084-94. PMID 23008441 DOI: 10.1161/CIRCULATIONAHA.112.105320  0.48
2012 Bill MA, Nicholas C, Mace TA, Etter JP, Li C, Schwartz EB, Fuchs JR, Young GS, Lin L, Lin J, He L, Phelps M, Li PK, Lesinski GB. Structurally modified curcumin analogs inhibit STAT3 phosphorylation and promote apoptosis of human renal cell carcinoma and melanoma cell lines. Plos One. 7: e40724. PMID 22899991 DOI: 10.1371/journal.pone.0040724  0.48
2012 Mahasenan KV, Li C. Novel inhibitor discovery through virtual screening against multiple protein conformations generated via ligand-directed modeling: a maternal embryonic leucine zipper kinase example. Journal of Chemical Information and Modeling. 52: 1345-55. PMID 22540736 DOI: 10.1021/ci300040c  0.48
2012 Bid HK, Oswald D, Li C, London CA, Lin J, Houghton PJ. Anti-angiogenic activity of a small molecule STAT3 inhibitor LLL12. Plos One. 7: e35513. PMID 22530037 DOI: 10.1371/journal.pone.0035513  0.48
2012 Dewan V, Liu T, Chen KM, Qian Z, Xiao Y, Kleiman L, Mahasenan KV, Li C, Matsuo H, Pei D, Musier-Forsyth K. Cyclic peptide inhibitors of HIV-1 capsid-human lysyl-tRNA synthetase interaction. Acs Chemical Biology. 7: 761-9. PMID 22276994 DOI: 10.1021/cb200450w  0.48
2012 Lin L, Benson DM, DeAngelis S, Bakan CE, Li PK, Li C, Lin J. A small molecule, LLL12 inhibits constitutive STAT3 and IL-6-induced STAT3 signaling and exhibits potent growth suppressive activity in human multiple myeloma cells. International Journal of Cancer. Journal International Du Cancer. 130: 1459-69. PMID 21520044 DOI: 10.1002/ijc.26152  0.48
2012 Onimoe GI, Liu A, Lin L, Wei CC, Schwartz EB, Bhasin D, Li C, Fuchs JR, Li PK, Houghton P, Termuhlen A, Gross T, Lin J. Small molecules, LLL12 and FLLL32, inhibit STAT3 and exhibit potent growth suppressive activity in osteosarcoma cells and tumor growth in mice. Investigational New Drugs. 30: 916-26. PMID 21340507 DOI: 10.1007/s10637-011-9645-1  0.48
2011 Mahasenan KV, Pavlovicz RE, Henderson BJ, González-Cestari TF, Yi B, McKay DB, Li C. Discovery of Novel α4β2 Neuronal Nicotinic Receptor Modulators through Structure-Based Virtual Screening. Acs Medicinal Chemistry Letters. 2: 855-60. PMID 24936233 DOI: 10.1021/ml2001714  0.48
2011 Lin L, Fuchs J, Li C, Olson V, Bekaii-Saab T, Lin J. STAT3 signaling pathway is necessary for cell survival and tumorsphere forming capacity in ALDH⁺/CD133⁺ stem cell-like human colon cancer cells. Biochemical and Biophysical Research Communications. 416: 246-51. PMID 22074823 DOI: 10.1016/j.bbrc.2011.10.112  0.48
2011 Henderson BJ, Carper DJ, González-Cestari TF, Yi B, Mahasenan K, Pavlovicz RE, Dalefield ML, Coleman RS, Li C, McKay DB. Structure-activity relationship studies of sulfonylpiperazine analogues as novel negative allosteric modulators of human neuronal nicotinic receptors. Journal of Medicinal Chemistry. 54: 8681-92. PMID 22060139 DOI: 10.1021/jm201294r  0.48
2011 Pavlovicz RE, Henderson BJ, Bonnell AB, Boyd RT, McKay DB, Li C. Identification of a negative allosteric site on human α4β2 and α3β4 neuronal nicotinic acetylcholine receptors. Plos One. 6: e24949. PMID 21949802 DOI: 10.1371/journal.pone.0024949  0.48
2011 Lin L, Liu A, Peng Z, Lin HJ, Li PK, Li C, Lin J. STAT3 is necessary for proliferation and survival in colon cancer-initiating cells. Cancer Research. 71: 7226-37. PMID 21900397 DOI: 10.1158/0008-5472.CAN-10-4660  0.48
2011 Zhang Y, Zhang J, Yuan C, Hard RL, Park IH, Li C, Bell C, Pei D. Simultaneous binding of two peptidyl ligands by a SRC homology 2 domain. Biochemistry. 50: 7637-46. PMID 21800896 DOI: 10.1021/bi200439v  0.48
2011 Liu A, Liu Y, Li PK, Li C, Lin J. LLL12 inhibits endogenous and exogenous interleukin-6-induced STAT3 phosphorylation in human pancreatic cancer cells. Anticancer Research. 31: 2029-35. PMID 21737619  0.48
2011 West MB, Wickham S, Quinalty LM, Pavlovicz RE, Li C, Hanigan MH. Autocatalytic cleavage of human gamma-glutamyl transpeptidase is highly dependent on N-glycosylation at asparagine 95. The Journal of Biological Chemistry. 286: 28876-88. PMID 21712391 DOI: 10.1074/jbc.M111.248823  0.48
2011 Li H, Liu A, Zhao Z, Xu Y, Lin J, Jou D, Li C. Fragment-based drug design and drug repositioning using multiple ligand simultaneous docking (MLSD): identifying celecoxib and template compounds as novel inhibitors of signal transducer and activator of transcription 3 (STAT3). Journal of Medicinal Chemistry. 54: 5592-6. PMID 21678971 DOI: 10.1021/jm101330h  0.48
2011 Ball S, Li C, Li PK, Lin J. The small molecule, LLL12, inhibits STAT3 phosphorylation and induces apoptosis in medulloblastoma and glioblastoma cells. Plos One. 6: e18820. PMID 21526200 DOI: 10.1371/journal.pone.0018820  0.48
2011 Liu Y, Liu A, Li H, Li C, Lin J. Celecoxib inhibits interleukin-6/interleukin-6 receptor-induced JAK2/STAT3 phosphorylation in human hepatocellular carcinoma cells. Cancer Prevention Research (Philadelphia, Pa.). 4: 1296-305. PMID 21490132 DOI: 10.1158/1940-6207.CAPR-10-0317  0.48
2011 Fossey SL, Bear MD, Lin J, Li C, Schwartz EB, Li PK, Fuchs JR, Fenger J, Kisseberth WC, London CA. The novel curcumin analog FLLL32 decreases STAT3 DNA binding activity and expression, and induces apoptosis in osteosarcoma cell lines. Bmc Cancer. 11: 112. PMID 21443800 DOI: 10.1186/1471-2407-11-112  0.48
2011 Liu A, Liu Y, Xu Z, Yu W, Wang H, Li C, Lin J. Novel small molecule, XZH-5, inhibits constitutive and interleukin-6-induced STAT3 phosphorylation in human rhabdomyosarcoma cells. Cancer Science. 102: 1381-7. PMID 21435102 DOI: 10.1111/j.1349-7006.2011.01932.x  0.48
2011 Reed S, Li H, Li C, Lin J. Celecoxib inhibits STAT3 phosphorylation and suppresses cell migration and colony forming ability in rhabdomyosarcoma cells. Biochemical and Biophysical Research Communications. 407: 450-5. PMID 21397587 DOI: 10.1016/j.bbrc.2011.03.014  0.48
2011 Park IH, Li C. Characterization of molecular recognition of STAT3 SH2 domain inhibitors through molecular simulation. Journal of Molecular Recognition : Jmr. 24: 254-65. PMID 21360612 DOI: 10.1002/jmr.1047  0.48
2003 Bennett EM, Li C, Allan PW, Parker WB, Ealick SE. Structural basis for substrate specificity of Escherichia coli purine nucleoside phosphorylase. The Journal of Biological Chemistry. 278: 47110-8. PMID 12937174 DOI: 10.1074/jbc.M304622200  0.48
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