Dale L. Boger - Publications

Affiliations: 
Scripps Research Institute, La Jolla, La Jolla, CA, United States 
Area:
synthetic organic chemistry
Website:
https://www.scripps.edu/faculty/boger/

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Year Citation  Score
2021 Zhang J, Paladugu SR, Gillard RM, Sarkar A, Boger DL. Tris(4-bromophenyl)aminium Hexachloroantimonate-Mediated Intermolecular C(sp)-C(sp) Free Radical Coupling of Vindoline with β-Ketoesters and Related Compounds. Journal of the American Chemical Society. PMID 34963278 DOI: 10.1021/jacs.1c10971  0.591
2021 Litwin K, Crowley VM, Suciu RM, Boger DL, Cravatt BF. Chemical proteomic identification of functional cysteines with atypical electrophile reactivities. Tetrahedron Letters. 67. PMID 33776155 DOI: 10.1016/j.tetlet.2021.152861  0.394
2020 Moore MJ, Qu S, Tan C, Cai Y, Mogi Y, Jamin Keith D, Boger DL. Next-Generation Total Synthesis of Vancomycin. Journal of the American Chemical Society. PMID 32885969 DOI: 10.1021/Jacs.0C07433  0.402
2020 Wu ZC, Cameron MD, Boger DL. Vancomycin C-Terminus Guanidine Modifications and Further Insights into an Added Mechanism of Action Imparted by a Peripheral Structural Modification. Acs Infectious Diseases. PMID 32598127 DOI: 10.1021/Acsinfecdis.0C00258  0.323
2020 Kok BP, Ghimire S, Kim W, Chatterjee S, Johns T, Kitamura S, Eberhardt J, Ogasawara D, Xu J, Sukiasyan A, Kim SM, Godio C, Bittencourt JM, Cameron M, Galmozzi A, ... ... Boger DL, et al. Discovery of small-molecule enzyme activators by activity-based protein profiling. Nature Chemical Biology. PMID 32514184 DOI: 10.1038/S41589-020-0555-4  0.469
2019 Isley NA, Endo Y, Wu ZC, Covington BC, Bushin LB, Seyedsayamdost MR, Boger DL. Total Synthesis and Stereochemical Assignment of Streptide. Journal of the American Chemical Society. PMID 31577142 DOI: 10.1021/Jacs.9B09067  0.364
2019 Plewe MB, Whitby LR, Naik S, Brown ER, Sokolova NV, Gantla VR, York J, Nunberg JH, Zhang L, Kalveram B, Freiberg AN, Boger DL, Henkel G, McCormack K. SAR studies of 4-acyl-1,6-dialkylpiperazin-2-one arenavirus cell entry inhibitors. Bioorganic & Medicinal Chemistry Letters. 126620. PMID 31537423 DOI: 10.1016/J.Bmcl.2019.08.024  0.724
2019 Wu ZC, Boger DL. Synthesis, characterization, and cycloaddition reactivity of a monocyclic aromatic 1,2,3,5-tetrazine. Journal of the American Chemical Society. PMID 31524389 DOI: 10.1021/Jacs.9B07744  0.358
2019 Boon BA, Boger DL. Triarylaminium Radical Cation Promoted Coupling of Catharanthine with Vindoline: Diastereospecific Synthesis of Anhydrovinblastine and Reaction Scope. Journal of the American Chemical Society. PMID 31442047 DOI: 10.1021/Jacs.9B06968  0.36
2019 Ozog S, Timberlake ND, Hermann K, Garijo O, Haworth KG, Shi G, Glinkerman CM, Schefter LE, D'Souza S, Simpson E, Sghia-Hughes G, Carillo RR, Boger DL, Kiem HP, Slukvin I, et al. Resveratrol trimer enhances gene delivery to hematopoietic stem cells by reducing antiviral restriction at endosomes. Blood. PMID 31416800 DOI: 10.1182/Blood.2019000040  0.461
2019 Wu ZC, Boger DL. Exploration of the site-specific nature and generalizability of a trimethylammonium salt modification on vancomycin: A-ring derivatives. Tetrahedron. 75: 3160-3165. PMID 31327878 DOI: 10.1016/J.Tet.2019.02.008  0.35
2019 Zhang J, Shukla V, Boger DL. Inverse electron demand Diels-Alder reactions of heterocyclic azadienes, 1-aza-1,3-butadienes, cyclopropenone ketals and related systems. A retrospective. The Journal of Organic Chemistry. PMID 31062977 DOI: 10.1021/Acs.Joc.9B00834  0.659
2019 Radakovic A, Boger DL. Ultra-potent vinblastine analogues improve on-target activity of the parent microtubulin-targeting compound. Bioorganic & Medicinal Chemistry Letters. PMID 30952593 DOI: 10.1016/J.Bmcl.2019.03.036  0.313
2019 Otrubova K, Chatterjee S, Ghimire S, Cravatt BF, Boger DL. N-Acyl pyrazoles: Effective and tunable inhibitors of serine hydrolases. Bioorganic & Medicinal Chemistry. PMID 30879861 DOI: 10.1016/J.Bmc.2019.03.020  0.521
2019 Boger DL, Garbaccio RM. A Novel Class of CC-1065 and Duocarmycin Analogues Subject to Mitomycin-Related Reductive Activation. The Journal of Organic Chemistry. 64: 8350-8362. PMID 11674758 DOI: 10.1021/Jo991301Y  0.337
2019 Boger DL, Garbaccio RM. Are the Duocarmycin and CC-1065 DNA Alkylation Reactions Acid-Catalyzed? Solvolysis pH-Rate Profiles Suggest They Are Not. The Journal of Organic Chemistry. 64: 5666-5669. PMID 11674637 DOI: 10.1021/Jo990762G  0.315
2019 Boger DL, Schüle G. Synthesis of Acyclic Precursors to (3S,4S)-4-Hydroxy-2,3,4,5-tetrahydropyridazine-3-carboxylic Acid and Incorporation into a Luzopeptin/Quinoxapeptin Dipeptide. The Journal of Organic Chemistry. 63: 6421-6424. PMID 11672282 DOI: 10.1021/Jo980765D  0.311
2019 Boger DL, Schaum RP, Garbaccio RM. Regioselective Inverse Electron Demand Diels-Alder Reactions of N-Acyl 6-Amino-3-(methylthio)-1,2,4,5-tetrazines. The Journal of Organic Chemistry. 63: 6329-6337. PMID 11672266 DOI: 10.1021/Jo980795G  0.354
2019 Boger DL, McKie JA, Cai H, Cacciari B, Baraldi PG. Synthesis and Properties of Substituted CBI Analogs of CC-1065 and the Duocarmycins Incorporating the 7-Methoxy-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (MCBI) Alkylation Subunit: Magnitude of Electronic Effects on the Functional Reactivity. The Journal of Organic Chemistry. 61: 1710-1729. PMID 11667041 DOI: 10.1021/Jo952033G  0.443
2018 Wu ZC, Isley NA, Boger DL. N-Terminus alkylation of vancomycin: ligand binding affinity, antimicrobial activity, and site specific nature of quaternary trimethylammonium salt modification. Acs Infectious Diseases. PMID 30067012 DOI: 10.1021/Acsinfecdis.8B00152  0.34
2018 Glinkerman CM, Boger DL. Synthesis, Characterization, and Rapid Cycloadditions of 5-Nitro-1,2,3-triazine. Organic Letters. PMID 29659291 DOI: 10.1021/Acs.Orglett.8B00825  0.385
2017 Boger DL. The Difference a Single Atom Can Make: Synthesis and Design at the Chemistry-Biology Interface. The Journal of Organic Chemistry. PMID 28945374 DOI: 10.1021/Acs.Joc.7B02088  0.305
2017 Lukesh JC, Carney DW, Dong H, Cross RM, Shukla V, Duncan KK, Yang S, Brody DM, Brütsch MM, Radakovic A, Boger DL. Vinblastine 20' Amides: Synthetic Analogues That Maintain or Improve Potency and Simultaneously Overcome Pgp-Derived Efflux and Resistance. Journal of Medicinal Chemistry. PMID 28857558 DOI: 10.1021/acs.jmedchem.7b00958  0.754
2017 Quiñones RE, Glinkerman CM, Zhu K, Boger DL. Direct Synthesis of β-Aminoenals through Reaction of 1,2,3-Triazine with Secondary Amines. Organic Letters. PMID 28657329 DOI: 10.1021/Acs.Orglett.7B01543  0.596
2017 Allemann O, Cross RM, Brütsch MM, Radakovic A, Boger DL. Key analogs of a uniquely potent synthetic vinblastine that contain modifications of the C20' ethyl substituent. Bioorganic & Medicinal Chemistry Letters. PMID 28551101 DOI: 10.1016/J.Bmcl.2017.05.058  0.365
2017 Kornahrens AF, Cognetta AB, Brody DM, Matthews ML, Cravatt BF, Boger DL. Design of Benzoxathiazin-3-one 1,1-Dioxides as a New Class of Irreversible Serine Hydrolase Inhibitors: Discovery of a Uniquely Selective PNPLA4 Inhibitor. Journal of the American Chemical Society. PMID 28498651 DOI: 10.1021/Jacs.7B02985  0.666
2017 Okano A, Isley NA, Boger DL. Total Syntheses of Vancomycin-Related Glycopeptide Antibiotics and Key Analogues. Chemical Reviews. PMID 28437097 DOI: 10.1021/Acs.Chemrev.6B00820  0.316
2017 Yang S, Sankar K, Skepper CK, Barker TJ, Lukesh JC, Brody DM, Brütsch MM, Boger DL. Total synthesis of a key series of vinblastines modified at C4 that define the importance and surprising trends in activity. Chemical Science. 8: 1560-1569. PMID 28194270 DOI: 10.1039/C6Sc04146A  0.791
2016 Glinkerman CM, Boger DL. Catalysis of Heterocyclic Azadiene Cycloaddition Reactions by Solvent Hydrogen Bonding: Concise Total Synthesis of Methoxatin. Journal of the American Chemical Society. PMID 27571404 DOI: 10.1021/Jacs.6B05438  0.361
2016 Carney DW, Lukesh JC, Brody DM, Brütsch MM, Boger DL. Ultrapotent vinblastines in which added molecular complexity further disrupts the target tubulin dimer-dimer interface. Proceedings of the National Academy of Sciences of the United States of America. PMID 27512044 DOI: 10.1073/Pnas.1611405113  0.774
2016 Allemann O, Brutsch M, Lukesh JC, Brody DM, Boger DL. Synthesis of a Potent Vinblastine: Rationally Designed Added Benign Complexity. Journal of the American Chemical Society. PMID 27356080 DOI: 10.1021/Jacs.6B04330  0.776
2016 Chanda PB, Boyle KE, Brody DM, Shukla V, Boger DL. Synthesis and evaluation of duocarmycin SA analogs incorporating the methyl 1,2,8,8a-tetrahydrocyclopropa[c]imidazolo[4,5-e]indol-4-one-6-carboxylate (CImI) alkylation subunit. Bioorganic & Medicinal Chemistry. PMID 27221071 DOI: 10.1016/J.Bmc.2016.04.050  0.369
2016 Shankar S, Whitby LR, Casquilho-Gray HE, York J, Boger DL, Nunberg JH. Small-molecule fusion inhibitors bind the pH-sensing SSP-GP2 subunit interface of the Lassa virus envelope glycoprotein. Journal of Virology. PMID 27194767 DOI: 10.1128/Jvi.00597-16  0.728
2016 Wang Y, Su L, Morin MD, Jones BT, Whitby LR, Surakattula MMRP, Huang H, Shi H, Choi JH, Wang KW, Moresco EMY, Berger M, Zhan X, Zhang H, Boger DL, et al. Erratum: TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS (Proceedings of the National Academy of Sciences of the United States of America (2016) 113 (E884-E893)) Proceedings of the National Academy of Sciences of the United States of America. 113. PMID 27036010 DOI: 10.1073/Pnas.1603716113  0.702
2016 Wang Y, Su L, Morin MD, Jones BT, Whitby LR, Surakattula MM, Huang H, Shi H, Choi JH, Wang KW, Moresco EM, Berger M, Zhan X, Zhang H, Boger DL, et al. TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS. Proceedings of the National Academy of Sciences of the United States of America. PMID 26831104 DOI: 10.1073/Pnas.1525639113  0.713
2016 Sears JE, Boger DL. Tandem Intramolecular Diels-Alder/1,3-Dipolar Cycloaddition Cascade of 1,3,4-Oxadiazoles: Initial Scope and Applications. Accounts of Chemical Research. PMID 26813287 DOI: 10.1021/Acs.Accounts.5B00510  0.414
2015 Janssen FJ, Baggelaar MP, Hummel JJ, Overkleeft HS, Cravatt BF, Boger DL, van der Stelt M. Comprehensive Analysis of Structure Activity Relationships of α-Ketoheterocycles as sn-1-Diacylglycerol Lipase α Inhibitors. Journal of Medicinal Chemistry. PMID 26584396 DOI: 10.1021/Acs.Jmedchem.5B01627  0.495
2015 Sears JE, Barker TJ, Boger DL. Total Synthesis of (-)-Vindoline and (+)-4-epi-Vindoline Based on a 1,3,4-Oxadiazole Tandem Intramolecular [4 + 2]/[3 + 2] Cycloaddition Cascade Initiated by an Allene Dienophile. Organic Letters. 17: 5460-3. PMID 26457536 DOI: 10.1021/Acs.Orglett.5B02818  0.416
2015 Lee K, Poudel YB, Glinkerman CM, Boger DL. Total synthesis of dihydrolysergic acid and dihydrolysergol: development of a divergent synthetic strategy applicable to rapid assembly of D-ring analogs. Tetrahedron. 71: 5897-5905. PMID 26273113 DOI: 10.1016/J.Tet.2015.05.093  0.821
2015 Glinkerman CM, Boger DL. Cycloadditions of 1,2,3-Triazines Bearing C5-Electron Donating Substituents: Robust Pyrimidine Synthesis. Organic Letters. PMID 26172042 DOI: 10.1021/Acs.Orglett.5B01870  0.389
2015 Lee K, Boger DL. Total synthesis of (-)-kopsinine and ent-(+)-kopsinine. Tetrahedron. 71: 3741-3746. PMID 26074629 DOI: 10.1016/J.Tet.2014.07.094  0.585
2015 Uematsu M, Brody DM, Boger DL. A five-membered lactone prodrug of CBI-based analogs of the duocarmycins. Tetrahedron Letters. 56: 3101-3104. PMID 26069351 DOI: 10.1016/J.Tetlet.2014.11.038  0.319
2015 Okano A, Nakayama A, Wu K, Lindsey EA, Schammel AW, Feng Y, Collins KC, Boger DL. Total syntheses and initial evaluation of [Ψ[C(═S)NH]Tpg⁴]vancomycin, [Ψ[C(═NH)NH]Tpg⁴]vancomycin, [Ψ[CH₂NH]Tpg⁴]vancomycin, and their (4-chlorobiphenyl)methyl derivatives: synergistic binding pocket and peripheral modifications for the glycopeptide antibiotics. Journal of the American Chemical Society. 137: 3693-704. PMID 25750995 DOI: 10.1021/Jacs.5B01008  0.311
2015 Sears JE, Boger DL. Total synthesis of vinblastine, related natural products, and key analogues and development of inspired methodology suitable for the systematic study of their structure-function properties. Accounts of Chemical Research. 48: 653-62. PMID 25586069 DOI: 10.1021/Ar500400W  0.367
2015 Zhao N, Darby CM, Small J, Bachovchin DA, Jiang X, Burns-Huang KE, Botella H, Ehrt S, Boger DL, Anderson ED, Cravatt BF, Speers AE, Fernandez-Vega V, Hodder PS, Eberhart C, et al. Target-based screen against a periplasmic serine protease that regulates intrabacterial pH homeostasis in Mycobacterium tuberculosis. Acs Chemical Biology. 10: 364-71. PMID 25457457 DOI: 10.1021/Cb500746Z  0.72
2015 Lee K, Poudel YB, Glinkerman CM, Boger DL. Total synthesis of dihydrolysergic acid and dihydrolysergol: Development of a divergent synthetic strategy applicable to rapid assembly of D-ring analogs Tetrahedron. DOI: 10.1016/j.tet.2015.05.093  0.797
2014 Uematsu M, Boger DL. Asymmetric synthesis of a CBI-based cyclic N-acyl O-amino phenol duocarmycin prodrug. The Journal of Organic Chemistry. 79: 9699-703. PMID 25247380 DOI: 10.1021/Jo501839X  0.319
2014 Anderson ED, Duerfeldt AS, Zhu K, Glinkerman CM, Boger DL. Cycloadditions of noncomplementary substituted 1,2,3-triazines. Organic Letters. 16: 5084-7. PMID 25222918 DOI: 10.1021/Ol502436N  0.794
2014 Otrubova K, Srinivasan V, Boger DL. Discovery libraries targeting the major enzyme classes: the serine hydrolases. Bioorganic & Medicinal Chemistry Letters. 24: 3807-13. PMID 25037918 DOI: 10.1016/J.Bmcl.2014.06.063  0.328
2014 Nakayama A, Okano A, Feng Y, Collins JC, Collins KC, Walsh CT, Boger DL. Enzymatic glycosylation of vancomycin aglycon: completion of a total synthesis of vancomycin and N- and C-terminus substituent effects of the aglycon substrate. Organic Letters. 16: 3572-5. PMID 24954524 DOI: 10.1021/Ol501568T  0.381
2014 Sanchez-Cespedes J, Moyer CL, Whitby LR, Boger DL, Nemerow GR. Inhibition of adenovirus replication by a trisubstituted piperazin-2-one derivative. Antiviral Research. 108: 65-73. PMID 24907427 DOI: 10.1016/J.Antiviral.2014.05.010  0.727
2014 Duncan KK, Otrubova K, Boger DL. α-Ketoheterocycle inhibitors of fatty acid amide hydrolase: exploration of conformational constraints in the acyl side chain. Bioorganic & Medicinal Chemistry. 22: 2763-70. PMID 24690529 DOI: 10.1016/J.Bmc.2014.03.013  0.348
2014 Lee K, Boger DL. Total syntheses of (-)-kopsifoline D and (-)-deoxoapodine: divergent total synthesis via late-stage key strategic bond formation. Journal of the American Chemical Society. 136: 3312-7. PMID 24499015 DOI: 10.1021/Ja500548E  0.54
2014 Otrubova K, Cravatt BF, Boger DL. Design, synthesis, and characterization of α-ketoheterocycles that additionally target the cytosolic port Cys269 of fatty acid amide hydrolase. Journal of Medicinal Chemistry. 57: 1079-89. PMID 24456116 DOI: 10.1021/Jm401820Q  0.512
2014 Dreyton CJ, Anderson ED, Subramanian V, Boger DL, Thompson PR. Insights into the mechanism of streptonigrin-induced protein arginine deiminase inactivation. Bioorganic & Medicinal Chemistry. 22: 1362-9. PMID 24440480 DOI: 10.1016/J.Bmc.2013.12.064  0.336
2014 Duerfeldt AS, Boger DL. Total syntheses of (-)-pyrimidoblamic acid and P-3A. Journal of the American Chemical Society. 136: 2119-25. PMID 24410439 DOI: 10.1021/Ja412298C  0.809
2014 MacMillan KS, Nguyen T, Hwang I, Boger DL. Correction to “Total Synthesis and Evaluation of iso-Duocarmycin SA and iso-Yatakemycin” Journal of the American Chemical Society. 136: 16947-16947. DOI: 10.1021/Ja510706X  0.318
2014 Duerfeldt AS, Boger DL. ChemInform Abstract: Total Syntheses of (-)-Pyrimidoblamic Acid and P-3A. Cheminform. 45: no-no. DOI: 10.1002/chin.201434217  0.774
2013 Campbell EL, Skepper CK, Sankar K, Duncan KK, Boger DL. Transannular Diels-Alder/1,3-dipolar cycloaddition cascade of 1,3,4-oxadiazoles: total synthesis of a unique set of vinblastine analogues. Organic Letters. 15: 5306-9. PMID 24087969 DOI: 10.1021/Ol402549N  0.389
2013 Wolfe AL, Duncan KK, Lajiness JP, Zhu K, Duerfeldt AS, Boger DL. A fundamental relationship between hydrophobic properties and biological activity for the duocarmycin class of DNA-alkylating antitumor drugs: hydrophobic-binding-driven bonding. Journal of Medicinal Chemistry. 56: 6845-57. PMID 23944748 DOI: 10.1021/Jm400665C  0.792
2013 Gochin M, Whitby LR, Phillips AH, Boger DL. NMR-assisted computational studies of peptidomimetic inhibitors bound in the hydrophobic pocket of HIV-1 glycoprotein 41. Journal of Computer-Aided Molecular Design. 27: 569-82. PMID 23893342 DOI: 10.1007/S10822-013-9662-6  0.737
2013 Pinchman JR, Boger DL. Investigation into the functional impact of the vancomycin C-ring aryl chloride. Bioorganic & Medicinal Chemistry Letters. 23: 4817-9. PMID 23880541 DOI: 10.1016/J.Bmcl.2013.06.080  0.803
2013 Connelly S, DeMartino JK, Boger DL, Wilson IA. Biological and structural evaluation of 10R- and 10S-methylthio-DDACTHF reveals a new role for sulfur in inhibition of glycinamide ribonucleotide transformylase. Biochemistry. 52: 5133-44. PMID 23869564 DOI: 10.1021/Bi4005182  0.338
2013 Vielhauer GA, Swink M, Parelkar NK, Lajiness JP, Wolfe AL, Boger D. Evaluation of a reductively activated duocarmycin prodrug against murine and human solid cancers. Cancer Biology & Therapy. 14: 527-36. PMID 23760495 DOI: 10.4161/Cbt.24348  0.622
2013 Wolfe AL, Duncan KK, Parelkar NK, Brown D, Vielhauer GA, Boger DL. Efficacious cyclic N-acyl O-amino phenol duocarmycin prodrugs. Journal of Medicinal Chemistry. 56: 4104-15. PMID 23627265 DOI: 10.1021/Jm400413R  0.64
2013 Pinchman JR, Boger DL. Probing the role of the vancomycin e-ring aryl chloride: selective divergent synthesis and evaluation of alternatively substituted E-ring analogues. Journal of Medicinal Chemistry. 56: 4116-24. PMID 23617725 DOI: 10.1021/Jm4004494  0.81
2013 Otrubova K, Brown M, McCormick MS, Han GW, O'Neal ST, Cravatt BF, Stevens RC, Lichtman AH, Boger DL. Rational design of fatty acid amide hydrolase inhibitors that act by covalently bonding to two active site residues. Journal of the American Chemical Society. 135: 6289-99. PMID 23581831 DOI: 10.1021/Ja4014997  0.491
2013 Turner TC, Shibayama K, Boger DL. Hypervalent iodine(III)-promoted intermolecular C-C coupling of vindoline with β-ketoesters and related substrates. Organic Letters. 15: 1100-3. PMID 23421318 DOI: 10.1021/Ol400135N  0.35
2013 Xie J, Wolfe AL, Boger DL. Total synthesis of kopsinine. Organic Letters. 15: 868-70. PMID 23391149 DOI: 10.1021/Ol303573F  0.701
2013 Breazzano SP, Poudel YB, Boger DL. A Pd(0)-mediated indole (macro)cyclization reaction. Journal of the American Chemical Society. 135: 1600-6. PMID 23298368 DOI: 10.1021/Ja3121394  0.803
2013 Schleicher KD, Sasaki Y, Tam A, Kato D, Duncan KK, Boger DL. Total synthesis and evaluation of vinblastine analogues containing systematic deep-seated modifications in the vindoline subunit ring system: core redesign. Journal of Medicinal Chemistry. 56: 483-95. PMID 23252481 DOI: 10.1021/Jm3014376  0.392
2013 Leggans EK, Duncan KK, Barker TJ, Schleicher KD, Boger DL. A remarkable series of vinblastine analogues displaying enhanced activity and an unprecedented tubulin binding steric tolerance: C20' urea derivatives. Journal of Medicinal Chemistry. 56: 628-39. PMID 23244701 DOI: 10.1021/Jm3015684  0.367
2013 Xie J, Wolfe AL, Boger DL. ChemInform Abstract: Total Synthesis of Kopsinine (I). Cheminform. 44: no-no. DOI: 10.1002/chin.201327191  0.655
2012 Gotoh H, Sears JE, Eschenmoser A, Boger DL. New insights into the mechanism and an expanded scope of the Fe(III)-mediated vinblastine coupling reaction. Journal of the American Chemical Society. 134: 13240-3. PMID 22856867 DOI: 10.1021/Ja306229X  0.336
2012 Whitby LR, Boger DL. Comprehensive peptidomimetic libraries targeting protein-protein interactions. Accounts of Chemical Research. 45: 1698-709. PMID 22799570 DOI: 10.1021/Ar300025N  0.74
2012 Wolfe AL, Duncan KK, Parelkar NK, Weir SJ, Vielhauer GA, Boger DL. A novel, unusually efficacious duocarmycin carbamate prodrug that releases no residual byproduct. Journal of Medicinal Chemistry. 55: 5878-86. PMID 22650244 DOI: 10.1021/Jm300330B  0.622
2012 Otrubova K, Boger DL. α-Ketoheterocycle-based Inhibitors of Fatty Acid Amide Hydrolase (FAAH). Acs Chemical Neuroscience. 3: 340-348. PMID 22639704 DOI: 10.1021/Cn2001206  0.352
2012 Okano A, James RC, Pierce JG, Xie J, Boger DL. Silver(I)-promoted conversion of thioamides to amidines: divergent synthesis of a key series of vancomycin aglycon residue 4 amidines that clarify binding behavior to model ligands. Journal of the American Chemical Society. 134: 8790-3. PMID 22568755 DOI: 10.1021/Ja302808P  0.614
2012 Lajiness JP, Jiang W, Boger DL. Divergent total syntheses of (-)-aspidospermine and (+)-spegazzinine. Organic Letters. 14: 2078-81. PMID 22480368 DOI: 10.1021/Ol300599P  0.374
2012 Whitby LR, Boyle KE, Cai L, Yu X, Gochin M, Boger DL. Discovery of HIV fusion inhibitors targeting gp41 using a comprehensive α-helix mimetic library. Bioorganic & Medicinal Chemistry Letters. 22: 2861-5. PMID 22424973 DOI: 10.1016/J.Bmcl.2012.02.062  0.732
2012 Leggans EK, Barker TJ, Duncan KK, Boger DL. Iron(III)/NaBH4-mediated additions to unactivated alkenes: synthesis of novel 20'-vinblastine analogues. Organic Letters. 14: 1428-31. PMID 22369097 DOI: 10.1021/Ol300173V  0.327
2012 James RC, Pierce JG, Okano A, Xie J, Boger DL. Redesign of glycopeptide antibiotics: back to the future. Acs Chemical Biology. 7: 797-804. PMID 22330049 DOI: 10.1021/Cb300007J  0.542
2012 Xie J, Okano A, Pierce JG, James RC, Stamm S, Crane CM, Boger DL. Total synthesis of [Ψ[C(═S)NH]Tpg4]vancomycin aglycon, [Ψ[C(═NH)NH]Tpg4]vancomycin aglycon, and related key compounds: reengineering vancomycin for dual D-Ala-D-Ala and D-Ala-D-Lac binding. Journal of the American Chemical Society. 134: 1284-97. PMID 22188323 DOI: 10.1021/Ja209937S  0.624
2012 Booker L, Kinsey SG, Abdullah RA, Blankman JL, Long JZ, Ezzili C, Boger DL, Cravatt BF, Lichtman AH. The fatty acid amide hydrolase (FAAH) inhibitor PF-3845 acts in the nervous system to reverse LPS-induced tactile allodynia in mice. British Journal of Pharmacology. 165: 2485-96. PMID 21506952 DOI: 10.1111/J.1476-5381.2011.01445.X  0.672
2011 Gotoh H, Duncan KK, Robertson WM, Boger DL. 10'-Fluorovinblastine and 10'-Fluorovincristine: Synthesis of a Key Series of Modified Vinca Alkaloids. Acs Medicinal Chemistry Letters. 2: 948-952. PMID 22247789 DOI: 10.1021/Ml200236A  0.351
2011 Breazzano SP, Boger DL. Synthesis and stereochemical determination of complestatin A and B (neuroprotectin A and B). Journal of the American Chemical Society. 133: 18495-502. PMID 21991993 DOI: 10.1021/Ja208570Q  0.78
2011 Xie J, Pierce JG, James RC, Okano A, Boger DL. A redesigned vancomycin engineered for dual D-Ala-D-ala And D-Ala-D-Lac binding exhibits potent antimicrobial activity against vancomycin-resistant bacteria. Journal of the American Chemical Society. 133: 13946-9. PMID 21823662 DOI: 10.1021/Ja207142H  0.549
2011 Anderson ED, Boger DL. Inverse electron demand Diels-Alder reactions of 1,2,3-triazines: pronounced substituent effects on reactivity and cycloaddition scope. Journal of the American Chemical Society. 133: 12285-92. PMID 21736324 DOI: 10.1021/Ja204856A  0.368
2011 Whitby LR, Ando Y, Setola V, Vogt PK, Roth BL, Boger DL. Design, synthesis, and validation of a β-turn mimetic library targeting protein-protein and peptide-receptor interactions. Journal of the American Chemical Society. 133: 10184-94. PMID 21609016 DOI: 10.1021/Ja201878V  0.75
2011 Anderson ED, Boger DL. Scope of the inverse electron demand Diels-Alder reactions of 1,2,3-triazine. Organic Letters. 13: 2492-4. PMID 21488676 DOI: 10.1021/Ol2007428  0.31
2011 Ezzili C, Mileni M, McGlinchey N, Long JZ, Kinsey SG, Hochstatter DG, Stevens RC, Lichtman AH, Cravatt BF, Bilsky EJ, Boger DL. Reversible competitive α-ketoheterocycle inhibitors of fatty acid amide hydrolase containing additional conformational constraints in the acyl side chain: orally active, long-acting analgesics. Journal of Medicinal Chemistry. 54: 2805-22. PMID 21428410 DOI: 10.1021/Jm101597X  0.711
2011 Mileni M, Garfunkle J, Ezzili C, Cravatt BF, Stevens RC, Boger DL. Fluoride-mediated capture of a noncovalent bound state of a reversible covalent enzyme inhibitor: X-ray crystallographic analysis of an exceptionally potent α-ketoheterocycle inhibitor of fatty acid amide hydrolase. Journal of the American Chemical Society. 133: 4092-100. PMID 21355555 DOI: 10.1021/Ja110877Y  0.494
2011 Lajiness JP, Boger DL. Asymmetric synthesis of 1,2,9,9a-tetrahydrocyclopropa[c]benzo[e]indol-4-one (CBI). The Journal of Organic Chemistry. 76: 583-7. PMID 21192653 DOI: 10.1021/Jo102136W  0.39
2011 Ezzili C, Mileni M, McGlinchey N, Long JZ, Kinsey SG, Hochstatter DG, Stevens RC, Lichtman AH, Cravatt BF, Bilsky EJ, Boger DL. alpha-Ketoheterocycle Inhibitors of Fatty Acid Amide Hydrolase Containing Additional Conformational Contraints in the Acyl Side Chain Journal of Medicinal Chemistry. 54: 2805-2822. DOI: 10.2210/Pdb3Oj8/Pdb  0.689
2010 Lajiness JP, Robertson WM, Dunwiddie I, Broward MA, Vielhauer GA, Weir SJ, Boger DL. Design, synthesis, and evaluation of duocarmycin O-amino phenol prodrugs subject to tunable reductive activation. Journal of Medicinal Chemistry. 53: 7731-8. PMID 20942408 DOI: 10.1021/Jm1010397  0.32
2010 Tam A, Gotoh H, Robertson WM, Boger DL. Catharanthine C16 substituent effects on the biomimetic coupling with vindoline: preparation and evaluation of a key series of vinblastine analogues. Bioorganic & Medicinal Chemistry Letters. 20: 6408-10. PMID 20932748 DOI: 10.1016/J.Bmcl.2010.09.091  0.355
2010 Ambrus G, Whitby LR, Singer EL, Trott O, Choi E, Olson AJ, Boger DL, Gerace L. Small molecule peptidomimetic inhibitors of importin α/β mediated nuclear transport. Bioorganic & Medicinal Chemistry. 18: 7611-20. PMID 20869252 DOI: 10.1016/J.Bmc.2010.08.038  0.739
2010 Crane CM, Pierce JG, Leung SS, Tirado-Rives J, Jorgensen WL, Boger DL. Synthesis and evaluation of selected key methyl ether derivatives of vancomycin aglycon. Journal of Medicinal Chemistry. 53: 7229-35. PMID 20853900 DOI: 10.1021/Jm100946E  0.665
2010 Lajiness JP, Boger DL. Synthesis and characterization of a cyclobutane duocarmycin derivative incorporating the 1,2,10,11-tetrahydro-9H-cyclobuta[c]benzo[e]indol-4-one (CbBI) alkylation subunit. Journal of the American Chemical Society. 132: 13936-40. PMID 20839806 DOI: 10.1021/Ja106986F  0.395
2010 Sasaki Y, Kato D, Boger DL. Asymmetric total synthesis of vindorosine, vindoline, and key vinblastine analogues. Journal of the American Chemical Society. 132: 13533-44. PMID 20809620 DOI: 10.1021/Ja106284S  0.434
2010 Burke CP, Swingle MR, Honkanen RE, Boger DL. Total synthesis and evaluation of phostriecin and key structural analogues. The Journal of Organic Chemistry. 75: 7505-13. PMID 20669916 DOI: 10.1021/Jo1010203  0.389
2010 Patel PR, Boger DL. Intramolecular Diels-Alder reactions of cyclopropenone ketals. Organic Letters. 12: 3540-3. PMID 20614867 DOI: 10.1021/Ol101375A  0.34
2010 Patel PR, Boger DL. Intramolecular [1 + 2] and [3 + 2] cycloaddition reactions of cyclopropenone ketals. Journal of the American Chemical Society. 132: 8527-9. PMID 20527885 DOI: 10.1021/Ja103933N  0.37
2010 Va P, Campbell EL, Robertson WM, Boger DL. Total synthesis and evaluation of a key series of C5-substituted vinblastine derivatives. Journal of the American Chemical Society. 132: 8489-95. PMID 20518465 DOI: 10.1021/Ja1027748  0.308
2010 Chang MW, Giffin MJ, Muller R, Savage J, Lin YC, Hong S, Jin W, Whitby LR, Elder JH, Boger DL, Torbett BE. Identification of broad-based HIV-1 protease inhibitors from combinatorial libraries. The Biochemical Journal. 429: 527-32. PMID 20507280 DOI: 10.1042/Bj20091645  0.777
2010 Shimamura H, Breazzano SP, Garfunkle J, Kimball FS, Trzupek JD, Boger DL. Total synthesis of complestatin: development of a Pd(0)-mediated indole annulation for macrocyclization. Journal of the American Chemical Society. 132: 7776-83. PMID 20469945 DOI: 10.1021/Ja102304P  0.816
2010 Robertson WM, Kastrinsky DB, Hwang I, Boger DL. Synthesis and evaluation of a series of C5'-substituted duocarmycin SA analogs. Bioorganic & Medicinal Chemistry Letters. 20: 2722-5. PMID 20381346 DOI: 10.1016/J.Bmcl.2010.03.078  0.764
2010 Kato D, Sasaki Y, Boger DL. Asymmetric total synthesis of vindoline. Journal of the American Chemical Society. 132: 3685-7. PMID 20187641 DOI: 10.1021/Ja910695E  0.423
2010 Boyle KE, MacMillan KS, Ellis DA, Lajiness JP, Robertson WM, Boger DL. Synthesis and evaluation of duocarmycin SA analogs incorporating the methyl 1,2,8,8a-tetrahydrocyclopropa[c]oxazolo[2,3-e]indol-4-one-6-carboxylate (COI) alkylation subunit. Bioorganic & Medicinal Chemistry Letters. 20: 1854-7. PMID 20171886 DOI: 10.1016/J.Bmcl.2010.01.145  0.36
2010 Campbell EL, Zuhl AM, Liu CM, Boger DL. Total synthesis of (+)-fendleridine (aspidoalbidine) and (+)-1-acetylaspidoalbidine. Journal of the American Chemical Society. 132: 3009-12. PMID 20148585 DOI: 10.1021/Ja908819Q  0.393
2010 Oakdale JS, Boger DL. Total synthesis of lycogarubin C and lycogalic acid. Organic Letters. 12: 1132-4. PMID 20148525 DOI: 10.1021/Ol100146B  0.328
2010 Burke CP, Haq N, Boger DL. Total synthesis, assignment of the relative and absolute stereochemistry, and structural reassignment of phostriecin (aka Sultriecin). Journal of the American Chemical Society. 132: 2157-9. PMID 20108904 DOI: 10.1021/Ja9097252  0.412
2010 Mileni M, Garfunkle J, Ezzili C, Kimball FS, Cravatt BF, Stevens RC, Boger DL. X-ray crystallographic analysis of alpha-ketoheterocycle inhibitors bound to a humanized variant of fatty acid amide hydrolase. Journal of Medicinal Chemistry. 53: 230-40. PMID 19924997 DOI: 10.1021/Jm9012196  0.493
2010 Campbell EL, Zuhl AM, Lui CM, Boger DL. Synthesis of (+)-Fendleridine and (+)-1-Acetylaspidoalbidine Synfacts. 2010: 620-620. DOI: 10.1055/S-0029-1219856  0.372
2010 Burke CP, Haq N, Boger DL. Synthesis of Phostriecin and Sultriecin Synfacts. 2010: 626-626. DOI: 10.1055/S-0029-1219853  0.372
2010 Garfunkle J, Kimball FS, Trzupek JD, Takizawa S, Shimamura H, Tomishima M, Boger DL. Synthesis of Chloropeptin II Synfacts. 2010: 263-263. DOI: 10.1055/S-0029-1219254  0.73
2010 Gochin M, Zhou G, Wu D, Whitby L, Boger D, Chung T. Screening and Rational Design of Low Molecular Weight HIV Fusion Inhibitors Antiviral Research. 86: A55. DOI: 10.1016/J.Antiviral.2010.02.436  0.704
2010 Krenitsky PJ, Boger DL. ChemInform Abstract: Preparation of the 14-Membered L,L-Cycloisodityrosine Subunit of RP 66453. Cheminform. 33: no-no. DOI: 10.1002/chin.200216213  0.748
2010 Boger DL, Miyazaki S, Kim SH, Wu JH, Castle SL, Loiseleur O, Jin Q. ChemInform Abstract: Total Synthesis of the Vancomycin Aglycon. Cheminform. 31: no-no. DOI: 10.1002/chin.200006233  0.612
2010 Boger DL, Hong J, Hikota M, Ishida M. ChemInform Abstract: Total Synthesis of Phomazarin. Cheminform. 30: no-no. DOI: 10.1002/chin.199929225  0.529
2010 Boger DL, Miyazaki S, Kim SH, Wu JH, Loiseleur O, Castle SL. ChemInform Abstract: Diastereoselective Total Synthesis of the Vancomycin Aglycon with Ordered Atropisomer Equilibrations. Cheminform. 30: no-no. DOI: 10.1002/chin.199929189  0.597
2010 BOGER DL, HONG J. ChemInform Abstract: Total Synthesis of Nothapodytine B and (-)-Mappicine. Cheminform. 29: no-no. DOI: 10.1002/chin.199826279  0.481
2010 PATTERSON JE, OLLMANN IR, CRAVATT BF, BOGER DL, WONG C, LERNER RA. ChemInform Abstract: Inhibition of Oleamide Hydrolase Catalyzed Hydrolysis of the Endogenous Sleep-Inducing Lipid cis-9-Octadecenamide. Cheminform. 27: no-no. DOI: 10.1002/chin.199640217  0.513
2010 BOGER DL, LERNER RA, CRAVATT BF. ChemInform Abstract: Synthesis of a Functionalized Rigid Bicyclo(2.2.1)heptane: A Useful Hapten for Eliciting Catalytic Antibodies. Cheminform. 26: no-no. DOI: 10.1002/chin.199511111  0.546
2010 BOGER DL, YOHANNES D, ZHOU J, PATANE MA. ChemInform Abstract: Total Synthesis of Cycloisodityrosine, RA-VII, Deoxybouvardin, and N29- Desmethyl-RA-VII: Identification of the Pharmacophore and Reversal of the Subunit Functional Roles. Cheminform. 24: no-no. DOI: 10.1002/chin.199336264  0.579
2010 BOGER DL, SAKYA SM, YOHANNES D. ChemInform Abstract: Total Synthesis of Combretastatin D-2: Intramolecular Ullmann Macrocyclization Reaction. Cheminform. 22: no-no. DOI: 10.1002/chin.199146326  0.642
2010 BOGER DL, YOHANNES D. ChemInform Abstract: Intramolecular Ullmann Condensation Reaction: An Effective Approach to Macrocyclic Diaryl Ethers. Cheminform. 22: no-no. DOI: 10.1002/chin.199130240  0.633
2010 BOGER DL, YOHANNES D. ChemInform Abstract: Total Synthesis of Deoxybouvardin and RA-VII: Macrocyclization via an Intramolecular Ullmann Reaction. Cheminform. 22: no-no. DOI: 10.1002/chin.199125242  0.625
2010 Boger DL. Diels-alder Reactions of Azadienes: Scope and Applications Bulletin Des SociéTéS Chimiques Belges. 99: 599-615. DOI: 10.1002/Bscb.19900990902  0.303
2009 Clark RC, Lee SY, Hwang I, Searcey M, Boger DL. Evaluation of Chlorofusin, its Seven Chromophore Diastereomers, and Key Analogues. Tetrahedron Letters. 50: 3151-3153. PMID 20161293 DOI: 10.1016/J.Tetlet.2009.01.081  0.335
2009 Gauss CM, Hamasaki A, Parrish JP, Macmillan KS, Rayl TJ, Hwang I, Boger DL. Synthesis and Preliminary Evaluation of Duocarmycin Analogues Incorporating the 1,2,11,11a-Tetrahydrocyclopropa[c]naphtho[2,3-e]indol-4-one (CNI) and 1,2,11,11a-Tetrahydrocyclopropa[c]naphtho[1,2-e]indol-4-one (iso-CNI) Alkylation Subunits. Tetrahedron. 65: 6591-6599. PMID 20161204 DOI: 10.1016/J.Tet.2009.02.065  0.303
2009 MacMillan KS, Lajiness JP, Cara CL, Romagnoli R, Robertson WM, Hwang I, Baraldi PG, Boger DL. Synthesis and evaluation of a thio analogue of duocarmycin SA. Bioorganic & Medicinal Chemistry Letters. 19: 6962-5. PMID 19879753 DOI: 10.1016/J.Bmcl.2009.10.063  0.363
2009 Garfunkle J, Kimball FS, Trzupek JD, Takizawa S, Shimamura H, Tomishima M, Boger DL. Total synthesis of chloropeptin II (complestatin) and chloropeptin I. Journal of the American Chemical Society. 131: 16036-8. PMID 19839632 DOI: 10.1021/Ja907193B  0.78
2009 Shi J, Stover JS, Whitby LR, Vogt PK, Boger DL. Small molecule inhibitors of Myc/Max dimerization and Myc-induced cell transformation. Bioorganic & Medicinal Chemistry Letters. 19: 6038-41. PMID 19800226 DOI: 10.1016/J.Bmcl.2009.09.044  0.727
2009 Fang X, Nam J, Shin D, Rew Y, Boger DL, Walker S. Functional and biochemical analysis of a key series of ramoplanin analogues. Bioorganic & Medicinal Chemistry Letters. 19: 6189-91. PMID 19783144 DOI: 10.1016/J.Bmcl.2009.09.001  0.304
2009 Mileni M, Garfunkle J, DeMartino JK, Cravatt BF, Boger DL, Stevens RC. Binding and inactivation mechanism of a humanized fatty acid amide hydrolase by alpha-ketoheterocycle inhibitors revealed from cocrystal structures. Journal of the American Chemical Society. 131: 10497-506. PMID 19722626 DOI: 10.1021/Ja902694N  0.511
2009 Clark RC, Lee SY, Searcey M, Boger DL. The isolation, total synthesis and structure elucidation of chlorofusin, a natural product inhibitor of the p53-mDM2 protein-protein interaction. Natural Product Reports. 26: 465-77. PMID 19642417 DOI: 10.1039/B821676B  0.304
2009 Swingle MR, Amable L, Lawhorn BG, Buck SB, Burke CP, Ratti P, Fischer KL, Boger DL, Honkanen RE. Structure-activity relationship studies of fostriecin, cytostatin, and key analogs, with PP1, PP2A, PP5, and( beta12-beta13)-chimeras (PP1/PP2A and PP5/PP2A), provide further insight into the inhibitory actions of fostriecin family inhibitors. The Journal of Pharmacology and Experimental Therapeutics. 331: 45-53. PMID 19592665 DOI: 10.1124/Jpet.109.155630  0.339
2009 Kinsey SG, Long JZ, O'Neal ST, Abdullah RA, Poklis JL, Boger DL, Cravatt BF, Lichtman AH. Blockade of endocannabinoid-degrading enzymes attenuates neuropathic pain. The Journal of Pharmacology and Experimental Therapeutics. 330: 902-10. PMID 19502530 DOI: 10.1124/Jpet.109.155465  0.68
2009 Whitby LR, Lee AM, Kunz S, Oldstone MB, Boger DL. Characterization of lassa virus cell entry inhibitors: determination of the active enantiomer by asymmetric synthesis. Bioorganic & Medicinal Chemistry Letters. 19: 3771-4. PMID 19428249 DOI: 10.1016/J.Bmcl.2009.04.098  0.754
2009 Shaginian A, Whitby LR, Hong S, Hwang I, Farooqi B, Searcey M, Chen J, Vogt PK, Boger DL. Design, synthesis, and evaluation of an alpha-helix mimetic library targeting protein-protein interactions. Journal of the American Chemical Society. 131: 5564-72. PMID 19334711 DOI: 10.1021/Ja810025G  0.776
2009 Ishikawa H, Colby DA, Seto S, Va P, Tam A, Kakei H, Rayl TJ, Hwang I, Boger DL. Total synthesis of vinblastine, vincristine, related natural products, and key structural analogues. Journal of the American Chemical Society. 131: 4904-16. PMID 19292450 DOI: 10.1021/Ja809842B  0.678
2009 Stover JS, Shi J, Jin W, Vogt PK, Boger DL. Discovery of inhibitors of aberrant gene transcription from Libraries of DNA binding molecules: inhibition of LEF-1-mediated gene transcription and oncogenic transformation. Journal of the American Chemical Society. 131: 3342-8. PMID 19216569 DOI: 10.1021/Ja809083D  0.318
2009 Crane CM, Boger DL. Synthesis and evaluation of vancomycin aglycon analogues that bear modifications in the N-terminal D-leucyl amino acid. Journal of Medicinal Chemistry. 52: 1471-6. PMID 19209892 DOI: 10.1021/Jm801549B  0.316
2009 Schlosburg JE, Boger DL, Cravatt BF, Lichtman AH. Endocannabinoid modulation of scratching response in an acute allergenic model: a new prospective neural therapeutic target for pruritus. The Journal of Pharmacology and Experimental Therapeutics. 329: 314-23. PMID 19168707 DOI: 10.1124/Jpet.108.150136  0.442
2009 MacMillan KS, Nguyen T, Nguyen T, Hwang I, Boger DL. Total synthesis and evaluation of iso-duocarmycin SA and iso-yatakemycin. Journal of the American Chemical Society. 131: 1187-94. PMID 19154178 DOI: 10.1021/Ja808108Q  0.361
2009 Ishikawa H, Boger DL. Total synthesis of vindoline and related alkaloids Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry. 67: 123-133. DOI: 10.5059/Yukigoseikyokaishi.67.123  0.337
2009 Ishikawa H, Colby DA, Seto S, Va P, Tam A, Kakei H, Rayl TJ, Hwang I, Boger DL. Synthesis of Vinblastine Synfacts. 2009: 944-944. DOI: 10.1055/S-0029-1217622  0.683
2008 MacMillan KS, Boger DL. An additional spirocyclization for duocarmycin SA. Journal of the American Chemical Society. 130: 16521-3. PMID 19554689 DOI: 10.1021/Ja806593W  0.399
2008 Clark RC, Lee SY, Boger DL. Total synthesis of chlorofusin, its seven chromophore diastereomers, and key partial structures. Journal of the American Chemical Society. 130: 12355-69. PMID 18712872 DOI: 10.1021/Ja8012819  0.388
2008 DeMartino JK, Hwang I, Connelly S, Wilson IA, Boger DL. Asymmetric synthesis of inhibitors of glycinamide ribonucleotide transformylase. Journal of Medicinal Chemistry. 51: 5441-8. PMID 18686942 DOI: 10.1021/Jm800555H  0.332
2008 Slaymaker IM, Bracey M, Mileni M, Garfunkle J, Cravatt BF, Boger DL, Stevens RC. Correlation of inhibitor effects on enzyme activity and thermal stability for the integral membrane protein fatty acid amide hydrolase. Bioorganic & Medicinal Chemistry Letters. 18: 5847-50. PMID 18644727 DOI: 10.1016/J.Bmcl.2008.06.086  0.463
2008 DeMartino JK, Garfunkle J, Hochstatter DG, Cravatt BF, Boger DL. Exploration of a fundamental substituent effect of alpha-ketoheterocycle enzyme inhibitors: Potent and selective inhibitors of fatty acid amide hydrolase. Bioorganic & Medicinal Chemistry Letters. 18: 5842-6. PMID 18639454 DOI: 10.1016/J.Bmcl.2008.06.084  0.491
2008 Garfunkle J, Ezzili C, Rayl TJ, Hochstatter DG, Hwang I, Boger DL. Optimization of the central heterocycle of alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase. Journal of Medicinal Chemistry. 51: 4392-403. PMID 18630870 DOI: 10.1021/Jm800136B  0.359
2008 Tichenor MS, Boger DL. Yatakemycin: total synthesis, DNA alkylation, and biological properties. Natural Product Reports. 25: 220-6. PMID 18389136 DOI: 10.1039/B705665F  0.336
2008 Kimball FS, Romero FA, Ezzili C, Garfunkle J, Rayl TJ, Hochstatter DG, Hwang I, Boger DL. Optimization of alpha-ketooxazole inhibitors of fatty acid amide hydrolase. Journal of Medicinal Chemistry. 51: 937-47. PMID 18247553 DOI: 10.1021/Jm701210Y  0.352
2008 Ishikawa H, Colby DA, Boger DL. Direct coupling of catharanthine and vindoline to provide vinblastine: total synthesis of (+)- and ent-(-)-vinblastine. Journal of the American Chemical Society. 130: 420-1. PMID 18081297 DOI: 10.1021/Ja078192M  0.661
2007 Jin W, Trzupek JD, Rayl TJ, Broward MA, Vielhauer GA, Weir SJ, Hwang I, Boger DL. A unique class of duocarmycin and CC-1065 analogues subject to reductive activation. Journal of the American Chemical Society. 129: 15391-7. PMID 18020335 DOI: 10.1021/Ja075398E  0.729
2007 Tichenor MS, MacMillan KS, Stover JS, Wolkenberg SE, Pavani MG, Zanella L, Zaid AN, Spalluto G, Rayl TJ, Hwang I, Baraldi PG, Boger DL. Rational design, synthesis, and evaluation of key analogues of CC-1065 and the duocarmycins. Journal of the American Chemical Society. 129: 14092-9. PMID 17948994 DOI: 10.1021/Ja073989Z  0.715
2007 Tichenor MS, MacMillan KS, Trzupek JD, Rayl TJ, Hwang I, Boger DL. Systematic exploration of the structural features of yatakemycin impacting DNA alkylation and biological activity. Journal of the American Chemical Society. 129: 10858-69. PMID 17691783 DOI: 10.1021/Ja072777Z  0.76
2007 Lee SY, Clark RC, Boger DL. Total synthesis, stereochemical reassignment, and absolute configuration of chlorofusin. Journal of the American Chemical Society. 129: 9860-1. PMID 17637057 DOI: 10.1021/Ja073264V  0.372
2007 Nam J, Shin D, Rew Y, Boger DL. Alanine scan of [L-Dap(2)]ramoplanin A2 aglycon: assessment of the importance of each residue. Journal of the American Chemical Society. 129: 8747-55. PMID 17592838 DOI: 10.1021/Ja068573K  0.31
2007 Hardouin C, Kelso MJ, Romero FA, Rayl TJ, Leung D, Hwang I, Cravatt BF, Boger DL. Structure-activity relationships of alpha-ketooxazole inhibitors of fatty acid amide hydrolase. Journal of Medicinal Chemistry. 50: 3359-68. PMID 17559203 DOI: 10.1021/Jm061414R  0.522
2007 Xu L, Chong Y, Hwang I, D'Onofrio A, Amore K, Beardsley GP, Li C, Olson AJ, Boger DL, Wilson IA. Structure-based design, synthesis, evaluation, and crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase. The Journal of Biological Chemistry. 282: 13033-46. PMID 17324932 DOI: 10.1074/Jbc.M607293200  0.357
2007 Eubanks LM, Hixon MS, Jin W, Hong S, Clancy CM, Tepp WH, Baldwin MR, Malizio CJ, Goodnough MC, Barbieri JT, Johnson EA, Boger DL, Dickerson TJ, Janda KD. An in vitro and in vivo disconnect uncovered through high-throughput identification of botulinum neurotoxin A antagonists. Proceedings of the National Academy of Sciences of the United States of America. 104: 2602-7. PMID 17293454 DOI: 10.1073/Pnas.0611213104  0.51
2007 Romero FA, Du W, Hwang I, Rayl TJ, Kimball FS, Leung D, Hoover HS, Apodaca RL, Breitenbucher JG, Cravatt BF, Boger DL. Potent and selective alpha-ketoheterocycle-based inhibitors of the anandamide and oleamide catabolizing enzyme, fatty acid amide hydrolase. Journal of Medicinal Chemistry. 50: 1058-68. PMID 17279740 DOI: 10.1021/Jm0611509  0.525
2007 Ishikawa H, Boger DL. Total synthesis of (-)-and ent-(+)-4 -desacetoxy -5 -desethylvindoline Heterocycles. 72: 95-102. DOI: 10.3987/Com-06-S(K)8  0.403
2007 Boger D, Lawhorn B, Boga S, Wolkenberg S, Colby D, Gauss C, Swingle M, Amable L, Honkanen R. Synthesis of Cytostatin Synfacts. 2007: 0456-0456. DOI: 10.1055/S-2007-968390  0.794
2006 Lawhorn BG, Boga SB, Wolkenberg SE, Colby DA, Gauss CM, Swingle MR, Amable L, Honkanen RE, Boger DL. Total synthesis and evaluation of cytostatin, its C10-C11 diastereomers, and additional key analogues: impact on PP2A inhibition. Journal of the American Chemical Society. 128: 16720-32. PMID 17177422 DOI: 10.1021/Ja066477D  0.794
2006 Tichenor MS, Trzupek JD, Kastrinsky DB, Shiga F, Hwang I, Boger DL. Asymmetric total synthesis of (+)- and ent-(-)-yatakemycin and duocarmycin SA: evaluation of yatakemycin key partial structures and its unnatural enantiomer. Journal of the American Chemical Society. 128: 15683-96. PMID 17147378 DOI: 10.1021/Ja064228J  0.816
2006 Romero FA, Hwang I, Boger DL. Delineation of a fundamental alpha-ketoheterocycle substituent effect for use in the design of enzyme inhibitors. Journal of the American Chemical Society. 128: 14004-5. PMID 17061864 DOI: 10.1021/Ja064522B  0.342
2006 Schnermann MJ, Romero FA, Hwang I, Nakamaru-Ogiso E, Yagi T, Boger DL. Total synthesis of piericidin A1 and B1 and key analogues. Journal of the American Chemical Society. 128: 11799-807. PMID 16953619 DOI: 10.1021/Ja0632862  0.685
2006 Ishikawa H, Elliott GI, Velcicky J, Choi Y, Boger DL. Total synthesis of (-)- and ent-(+)-vindoline and related alkaloids. Journal of the American Chemical Society. 128: 10596-612. PMID 16895428 DOI: 10.1021/Ja061256T  0.418
2006 Elliott GI, Fuchs JR, Blagg BS, Ishikawa H, Tao H, Yuan ZQ, Boger DL. Intramolecular diels-alder/1,3-dipolar cycloaddition cascade of 1,3,4-oxadiazoles. Journal of the American Chemical Society. 128: 10589-95. PMID 16895427 DOI: 10.1021/Ja0612549  0.776
2006 Fang X, Tiyanont K, Zhang Y, Wanner J, Boger D, Walker S. The mechanism of action of ramoplanin and enduracidin. Molecular Biosystems. 2: 69-76. PMID 16880924 DOI: 10.1039/B515328J  0.323
2006 DeMartino JK, Hwang I, Xu L, Wilson IA, Boger DL. Discovery of a potent, nonpolyglutamatable inhibitor of glycinamide ribonucleotide transformylase. Journal of Medicinal Chemistry. 49: 2998-3002. PMID 16686541 DOI: 10.1021/Jm0601147  0.332
2006 Crowley BM, Boger DL. Total synthesis and evaluation of [Psi[CH2NH]Tpg4]vancomycin aglycon: reengineering vancomycin for dual D-Ala-D-Ala and D-Ala-D-Lac binding. Journal of the American Chemical Society. 128: 2885-92. PMID 16506767 DOI: 10.1021/Ja0572912  0.647
2006 Clark RC, Pfeiffer SS, Boger DL. Diastereoselective Diels-Alder reactions of N-sulfonyl-1-aza-1,3-butadienes with optically active enol ethers: an asymmetric variant of the 1-azadiene Diels-Alder reaction. Journal of the American Chemical Society. 128: 2587-93. PMID 16492042 DOI: 10.1021/Ja0571646  0.364
2006 Trzupek JD, Gottesfeld JM, Boger DL. Alkylation of duplex DNA in nucleosome core particles by duocarmycin SA and yatakemycin. Nature Chemical Biology. 2: 79-82. PMID 16415862 DOI: 10.1038/Nchembio761  0.744
2006 Hamasaki A, Ducray R, Boger DL. Two novel 1,2,4,5-tetrazines that participate in inverse electron demand Diels-Alder reactions with an unexpected regioselectivity. The Journal of Organic Chemistry. 71: 185-93. PMID 16388634 DOI: 10.1021/Jo051832O  0.344
2006 Elliott GI, Velcicky J, Ishikawa H, Li Y, Boger DL. Total synthesis of (-)- and ent-(+)-vindorosine: tandem intramolecular Diels-Alder/1,3-dipolar cycloaddition of 1,3,4-oxadiazoles. Angewandte Chemie (International Ed. in English). 45: 620-2. PMID 16355429 DOI: 10.1002/Anie.200503024  0.406
2006 Lawhorn BG, Boga SB, Wolkenberg SE, Boger DL. Total synthesis of cytostatin Heterocycles. 70: 65-70. DOI: 10.3987/Com-06-S(W)13  0.713
2006 Hamasaki A, Ducray R, Boger DL. Synthesis of Pyridazines by a Diels-Alder Strategy Synfacts. 2006: 209-209. DOI: 10.1055/S-2006-931971  0.369
2005 Tse WC, Boger DL. A fluorescent intercalator displacement assay for establishing DNA binding selectivity and affinity. Current Protocols in Nucleic Acid Chemistry / Edited by Serge L. Beaucage ... [Et Al.]. Unit 8.5. PMID 18428943 DOI: 10.1002/0471142700.Nc0805S20  0.713
2005 Guimarães CR, Boger DL, Jorgensen WL. Elucidation of fatty acid amide hydrolase inhibition by potent alpha-ketoheterocycle derivatives from Monte Carlo simulations. Journal of the American Chemical Society. 127: 17377-84. PMID 16332087 DOI: 10.1021/Ja055438J  0.49
2005 Schnermann MJ, Boger DL. Total synthesis of piericidin A1 and B1. Journal of the American Chemical Society. 127: 15704-5. PMID 16277503 DOI: 10.1021/Ja055041F  0.703
2005 Choi Y, Ishikawa H, Velcicky J, Elliott GI, Miller MM, Boger DL. Total synthesis of (-)- and ent-(+)-vindoline. Organic Letters. 7: 4539-42. PMID 16178578 DOI: 10.1021/Ol051975X  0.401
2005 Hamasaki A, Zimpleman JM, Hwang I, Boger DL. Total synthesis of ningalin D. Journal of the American Chemical Society. 127: 10767-70. PMID 16045367 DOI: 10.1021/Ja0526416  0.389
2005 Capps KJ, Humiston J, Dominique R, Hwang I, Boger DL. Discovery of AICAR Tfase inhibitors that disrupt requisite enzyme dimerization. Bioorganic & Medicinal Chemistry Letters. 15: 2840-4. PMID 15911265 DOI: 10.1016/J.Bmcl.2005.03.094  0.783
2005 Chou TC, Guan Y, Soenen DR, Danishefsky SJ, Boger DL. Potent reversal of multidrug resistance by ningalins and its use in drug combinations against human colon carcinoma xenograft in nude mice. Cancer Chemotherapy and Pharmacology. 56: 379-90. PMID 15875185 DOI: 10.1007/S00280-005-1019-Y  0.77
2005 Cheng H, Hwang I, Chong Y, Tavassoli A, Webb ME, Zhang Y, Wilson IA, Benkovic SJ, Boger DL. Synthesis and biological evaluation of N-[4-[5-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-2-(2,2,2-trifluoroacetyl)pentyl]benzoyl]-L-glutamic acid as a potential inhibitor of GAR Tfase and the de novo purine biosynthetic pathway. Bioorganic & Medicinal Chemistry. 13: 3593-9. PMID 15848772 DOI: 10.1016/J.Bmc.2004.11.049  0.368
2005 Boger DL, Miyauchi H, Du W, Hardouin C, Fecik RA, Cheng H, Hwang I, Hedrick MP, Leung D, Acevedo O, Guimarães CR, Jorgensen WL, Cravatt BF. Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics. Journal of Medicinal Chemistry. 48: 1849-56. PMID 15771430 DOI: 10.1021/Jm049614V  0.586
2005 Leung D, Du W, Hardouin C, Cheng H, Hwang I, Cravatt BF, Boger DL. Discovery of an exceptionally potent and selective class of fatty acid amide hydrolase inhibitors enlisting proteome-wide selectivity screening: concurrent optimization of enzyme inhibitor potency and selectivity. Bioorganic & Medicinal Chemistry Letters. 15: 1423-8. PMID 15713400 DOI: 10.1016/J.Bmcl.2004.12.085  0.473
2005 Yuan ZQ, Ishikawa H, Boger DL. Total synthesis of natural (+)- [corrected] and ent-(-)-4-desacetoxy-6,7-dihydrovindorosine [corrected] and natural and ent-minovine: oxadiazole tandem intramolecular Diels-Alder/1,3-dipolar cycloaddition reaction. Organic Letters. 7: 741-4. PMID 15704939 DOI: 10.1021/Ol050017S  0.389
2005 Yuan ZQ, Ishikawa H, Boger DL. Total Synthesis of (-)-Minovine Synfacts. 2005: 7-7. DOI: 10.1055/S-2005-865350  0.365
2005 Yuan ZQ, Ishikawa H, Boger DL. Total Synthesis of Natural (−)- andent-(+)-4-Desacetoxy-6,7-dihydrovindorosine and Natural andent-Minovine:  Oxadiazole Tandem Intramolecular Diels−Alder/1,3-Dipolar Cycloaddition Reaction Organic Letters. 7: 2079-2079. DOI: 10.1021/Ol0507423  0.377
2004 Tse WC, Boger DL. Sequence-selective DNA recognition: natural products and nature's lessons. Chemistry & Biology. 11: 1607-17. PMID 15610844 DOI: 10.1016/J.Chembiol.2003.08.012  0.728
2004 Parrish JP, Trzupek JD, Hughes TV, Hwang I, Boger DL. Synthesis and evaluation of N-aryl and N-alkenyl CBI derivatives. Bioorganic & Medicinal Chemistry. 12: 5845-56. PMID 15498660 DOI: 10.1016/J.Bmc.2004.08.032  0.758
2004 Lee PS, Du W, Boger DL, Jorgensen WL. Energetic preferences for alpha,beta versus beta,gamma unsaturation. The Journal of Organic Chemistry. 69: 5448-53. PMID 15287795 DOI: 10.1021/Jo049363Y  0.44
2004 Ham YW, Boger DL. A powerful selection assay for mixture libraries of DNA alkylating agents. Journal of the American Chemical Society. 126: 9194-5. PMID 15281804 DOI: 10.1021/Ja0477930  0.303
2004 Tichenor MS, Kastrinsky DB, Boger DL. Total synthesis, structure revision, and absolute configuration of (+)-yatakemycin. Journal of the American Chemical Society. 126: 8396-8. PMID 15237994 DOI: 10.1021/Ja0472735  0.752
2004 Lichtman AH, Leung D, Shelton CC, Saghatelian A, Hardouin C, Boger DL, Cravatt BF. Reversible inhibitors of fatty acid amide hydrolase that promote analgesia: evidence for an unprecedented combination of potency and selectivity. The Journal of Pharmacology and Experimental Therapeutics. 311: 441-8. PMID 15229230 DOI: 10.1124/Jpet.104.069401  0.654
2004 Chen L, Yuan Y, Helm JS, Hu Y, Rew Y, Shin D, Boger DL, Walker S. Dissecting ramoplanin: mechanistic analysis of synthetic ramoplanin analogues as a guide to the design of improved antibiotics. Journal of the American Chemical Society. 126: 7462-3. PMID 15198592 DOI: 10.1021/Ja047879T  0.367
2004 Crowley BM, Mori Y, McComas CC, Tang D, Boger DL. Total synthesis of the ristocetin aglycon. Journal of the American Chemical Society. 126: 4310-7. PMID 15053621 DOI: 10.1021/Ja039795A  0.707
2004 Kastrinsky DB, Boger DL. Effective asymmetric synthesis of 1,2,9,9a-tetrahydrocyclopropa[c]benzo[e]indol-4-one (CBI). The Journal of Organic Chemistry. 69: 2284-9. PMID 15049620 DOI: 10.1021/Jo035465X  0.748
2004 Rew Y, Shin D, Hwang I, Boger DL. Total synthesis and examination of three key analogues of ramoplanin: a lipoglycodepsipeptide with potent antibiotic activity. Journal of the American Chemical Society. 126: 1041-3. PMID 14746470 DOI: 10.1021/Ja039671Y  0.391
2004 Tse WC, Boger DL. A fluorescent intercalator displacement assay for establishing DNA binding selectivity and affinity. Accounts of Chemical Research. 37: 61-9. PMID 14730995 DOI: 10.1021/Ar030113Y  0.712
2004 Parrish JP, Hughes TV, Hwang I, Boger DL. Establishing the Parabolic Relationship between Reactivity and Activity for Derivatives and Analogues of the Duocarmycin and CC-1065 Alkylation Subunits Journal of the American Chemical Society. 126: 80-81. PMID 14709069 DOI: 10.1021/Ja038162T  0.375
2003 Desai P, Pfeiffer SS, Boger DL. Synthesis of the chlorofusin cyclic peptide: assignment of the asparagine stereochemistry. Organic Letters. 5: 5047-50. PMID 14682761 DOI: 10.1021/Ol036083G  0.31
2003 Buck SB, Hardouin C, Ichikawa S, Soenen DR, Gauss CM, Hwang I, Swingle MR, Bonness KM, Honkanen RE, Boger DL. Fundamental role of the fostriecin unsaturated lactone and implications for selective protein phosphatase inhibition. Journal of the American Chemical Society. 125: 15694-5. PMID 14677930 DOI: 10.1021/Ja038672N  0.797
2003 Bassarello C, Cimino P, Bifulco G, Boger DL, Smith JA, Chazin WJ, Gomez-Paloma L. NMR Structure of the (+)-CPI-indole/d(GACTAATTGAC)-d(GTCAATTAGTC) Covalent Complex Chembiochem. 4: 1188-1193. PMID 14613110 DOI: 10.1002/Cbic.200300642  0.347
2003 McComas CC, Crowley BM, Hwang I, Boger DL. Synthesis and evaluation of methyl ether derivatives of the vancomycin, teicoplanin, and ristocetin aglycon methyl esters. Bioorganic & Medicinal Chemistry Letters. 13: 2933-6. PMID 14611861 DOI: 10.1016/S0960-894X(03)00513-4  0.65
2003 Parrish JP, Kastrinsky DB, Hwang I, Boger DL. Synthesis and evaluation of duocarmycin and CC-1065 analogues incorporating the 1,2,9,9a-tetrahydrocyclopropa[c]benz[e]-3-azaindol-4-one (CBA) alkylation subunit. The Journal of Organic Chemistry. 68: 8984-90. PMID 14604371 DOI: 10.1021/Jo035119F  0.761
2003 Ham YW, Tse WC, Boger DL. High-resolution assessment of protein DNA binding affinity and selectivity utilizing a fluorescent intercalator displacement (FID) assay. Bioorganic & Medicinal Chemistry Letters. 13: 3805-7. PMID 14552784 DOI: 10.1016/J.Bmcl.2003.06.002  0.72
2003 Yeung BK, Tse WC, Boger DL. Determination of binding affinities of triplex forming oligonucleotides using a fluorescent intercalator displacement (FID) assay. Bioorganic & Medicinal Chemistry Letters. 13: 3801-4. PMID 14552783 DOI: 10.1016/J.Bmcl.2003.07.005  0.698
2003 Boger DL, Desharnais J, Capps K. Solution-phase combinatorial libraries: modulating cellular signaling by targeting protein-protein or protein-DNA interactions. Angewandte Chemie (International Ed. in English). 42: 4138-76. PMID 14502729 DOI: 10.1002/Anie.200300574  0.775
2003 Desharnais J, Hwang I, Zhang Y, Tavassoli A, Baboval J, Benkovic SJ, Wilson IA, Boger DL. Design, synthesis and biological evaluation of 10-CF3CO-DDACTHF analogues and derivatives as inhibitors of GAR Tfase and the de novo purine biosynthetic pathway. Bioorganic & Medicinal Chemistry. 11: 4511-21. PMID 13129587 DOI: 10.1016/S0968-0896(03)00458-9  0.36
2003 Marsilje TH, Hedrick MP, Desharnais J, Capps K, Tavassoli A, Zhang Y, Wilson IA, Benkovic SJ, Boger DL. 10-(2-benzoxazolcarbonyl)-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid: a potential inhibitor of GAR transformylase and AICAR transformylase. Bioorganic & Medicinal Chemistry. 11: 4503-9. PMID 13129586 DOI: 10.1016/S0968-0896(03)00457-7  0.787
2003 Marsilje TH, Hedrick MP, Desharnais J, Tavassoli A, Zhang Y, Wilson IA, Benkovic SJ, Boger DL. Design, synthesis, and biological evaluation of simplified alpha-keto heterocycle, trifluoromethyl ketone, and formyl substituted folate analogues as potential inhibitors of GAR transformylase and AICAR transformylase. Bioorganic & Medicinal Chemistry. 11: 4487-501. PMID 13129585 DOI: 10.1016/S0968-0896(03)00456-5  0.35
2003 Tse WC, Ishii T, Boger DL. Comprehensive high-resolution analysis of hairpin polyamides utilizing a fluorescent intercalator displacement (FID) assay. Bioorganic & Medicinal Chemistry. 11: 4479-86. PMID 13129584 DOI: 10.1016/S0968-0896(03)00455-3  0.726
2003 Parrish JP, Kastrinsky DB, Wolkenberg SE, Igarashi Y, Boger DL. DNA alkylation properties of yatakemycin. Journal of the American Chemical Society. 125: 10971-6. PMID 12952479 DOI: 10.1021/Ja035984H  0.802
2003 Parrish JP, Kastrinsky DB, Stauffer F, Hedrick MP, Hwang I, Boger DL. Establishment of substituent effects in the DNA binding subunit of CBI analogues of the duocarmycins and CC-1065. Bioorganic & Medicinal Chemistry. 11: 3815-38. PMID 12901927 DOI: 10.1016/S0968-0896(03)00194-9  0.743
2003 McComas CC, Crowley BM, Boger DL. Partitioning the loss in vancomycin binding affinity for D-Ala-D-Lac into lost H-bond and repulsive lone pair contributions. Journal of the American Chemical Society. 125: 9314-5. PMID 12889959 DOI: 10.1021/Ja035901X  0.616
2003 Parrish JP, Kastrinsky DB, Boger DL. Synthesis and X-ray analysis of an unprecedented and stable 2-aza-4,4-spirocyclopropacyclohexadienone. Organic Letters. 5: 2577-9. PMID 12841785 DOI: 10.1021/Ol035000T  0.743
2003 Yeung BKS, Boger DL. Synthesis of isochrysohermidin - Distamycin hybrids Journal of Organic Chemistry. 68: 5249-5253. PMID 12816485 DOI: 10.1021/Jo034326C  0.344
2003 Zhang Y, Desharnais J, Marsilje TH, Li C, Hedrick MP, Gooljarsingh LT, Tavassoli A, Benkovic SJ, Olson AJ, Boger DL, Wilson IA. Rational design, synthesis, evaluation, and crystal structure of a potent inhibitor of human GAR Tfase: 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid. Biochemistry. 42: 6043-56. PMID 12755606 DOI: 10.1021/Bi034219C  0.344
2003 Leung D, Hardouin C, Boger DL, Cravatt BF. Discovering potent and selective reversible inhibitors of enzymes in complex proteomes. Nature Biotechnology. 21: 687-91. PMID 12740587 DOI: 10.1038/Nbt826  0.495
2003 Soenen DR, Hwang I, Hedrick MP, Boger DL. Multidrug resistance reversal activity of key ningalin analogues. Bioorganic & Medicinal Chemistry Letters. 13: 1777-81. PMID 12729663 DOI: 10.1016/S0960-894X(03)00294-4  0.774
2003 Soenen DR, Zimpleman JM, Boger DL. Synthesis and inverse electron demand Diels-Alder reactions of 3,6-bis(3,4-dimethoxybenzoyl)-1,2,4,5-tetrazine. The Journal of Organic Chemistry. 68: 3593-8. PMID 12713365 DOI: 10.1021/Jo020713V  0.8
2003 Wanner J, Tang D, McComas CC, Crowley BM, Jiang W, Moss J, Boger DL. A new and improved method for deglycosidation of glycopeptide antibiotics exemplified with vancomycin, ristocetin, and ramoplanin. Bioorganic & Medicinal Chemistry Letters. 13: 1169-73. PMID 12643936 DOI: 10.1016/S0960-894X(03)00051-9  0.62
2003 McComas CC, Crowley BM, Hwang I, Boger DL. Synthesis and evaluation of methyl ether derivatives of the vancomycin, teicoplanin, and ristocetin aglycon methyl esters [Bioorg. Med. Chem. Lett. 13 (2003) 2933] Bioorganic & Medicinal Chemistry Letters. 13: 4163. DOI: 10.1016/J.Bmcl.2003.09.021  0.647
2003 Krenitsky PJ, Boger DL. Synthesis of the (S,S,S)-diastereomer of the 15-membered biaryl ring system of RP 66453 Tetrahedron Letters. 44: 4019-4022. DOI: 10.1002/CHIN.200335179  0.795
2003 Boger DL, Desharnais J, Capps K. Kombinatorische Flüssigphasensynthese von Bibliotheken: auf der Suche nach Modulatoren für Protein-Protein- und Protein-DNA-Wechselwirkungen in der zellulären Signaltransduktion Angewandte Chemie. 115: 4270-4309. DOI: 10.1002/Ange.200300574  0.76
2003 Boger DL, Panek JS, Patel M. Preparation and Diels‐Alder Reaction of a Reactive, Electron‐Deficient Heterocyclic Azadiene: Dimethyl 1,2,4,5‐Tetrazine‐3,6‐Dicarboxylate. 1,2‐Diazine (Dimethyl 4‐Phenyl‐1,2‐Diazine‐3,6‐Dicarboxylate) and Pyrrole (Dimethyl 3‐Phenylpyrrole‐2,5‐Dicarboxylate) Introduction Organic Syntheses. 79-79. DOI: 10.1002/0471264180.Os070.10  0.397
2003 Boger DL, Panek JS, Yasuda M. Preparation and Inverse‐Electron‐Demand Diels–Alder Reaction of an Electron‐Deficient Heterocyclic Azadiene: Triethyl 1,2,4‐Triazine‐3,5,6‐Tricarboxylate and 2,3,6‐Tricarboethoxypyridine Organic Syntheses. 142-142. DOI: 10.1002/0471264180.Os066.19  0.685
2003 Boger DL, Mullican MD. Preparation and Inverse‐Electron‐Demand Diels–Alder Reaction of an Electron‐Deficient Diene: Methyl 2‐Oxo‐5,6,7,8‐Tetrahydro‐2H‐1‐Benzopyran‐3‐Carboxylate and 6‐Methoxy‐7‐Methoxycarbonyl‐1,2,3,4‐Tetrahydronaphthalane Organic Syntheses. 98-98. DOI: 10.1002/0471264180.Os065.14  0.335
2003 Boger DL, Brotherton CE, Georg GI. Preparation and Three‐Carbon + Two‐Carbon Cycloaddition of Cyclopropenone 1,3‐propanediol ketal: 5,5‐Dicyano‐4‐phenyl‐2‐cyclopenten‐1‐one 1,3‐propanediol ketal Organic Syntheses. 32-32. DOI: 10.1002/0471264180.Os065.06  0.568
2002 Ambroise Y, Yaspan B, Ginsberg MH, Boger DL. Inhibitors of cell migration that inhibit intracellular Paxillin/α4 binding: A well-documented use of positional scanning libraries Chemistry and Biology. 9: 1219-1226. PMID 12445772 DOI: 10.1016/S1074-5521(02)00246-6  0.32
2002 Wolkenberg SE, Boger DL. Total synthesis of anhydrolycorinone utilizing sequential intramolecular Diels-Alder reactions of a 1,3,4-oxadiazole. The Journal of Organic Chemistry. 67: 7361-4. PMID 12375965 DOI: 10.1021/Jo020437K  0.723
2002 Lewy DS, Gauss CM, Soenen DR, Boger DL. Fostriecin: chemistry and biology. Current Medicinal Chemistry. 9: 2005-32. PMID 12369868 DOI: 10.2174/0929867023368809  0.799
2002 Wilkie GD, Elliott GI, Blagg BS, Wolkenberg SE, Soenen DR, Miller MM, Pollack S, Boger DL. Intramolecular Diels-Alder and tandem intramolecular Diels-Alder/1,3-dipolar cycloaddition reactions of 1,3,4-oxadiazoles. Journal of the American Chemical Society. 124: 11292-4. PMID 12236743 DOI: 10.1021/Ja027533N  0.796
2002 Woods CR, Ishii T, Boger DL. Synthesis and DNA binding properties of iminodiacetic acid-linked polyamides: characterization of cooperative extended 2:1 side-by-side parallel binding. Journal of the American Chemical Society. 124: 10676-82. PMID 12207521 DOI: 10.1021/Ja026588M  0.31
2002 Woods CR, Faucher N, Eschgfaller B, Bair KW, Boger DL. Synthesis and DNA binding properties of saturated distamycin analogues. Bioorganic & Medicinal Chemistry Letters. 12: 2647-50. PMID 12182879 DOI: 10.1016/S0960-894X(02)00467-5  0.316
2002 Wolkenberg SE, Boger DL. Mechanisms of in situ activation for DNA-targeting antitumor agents. Chemical Reviews. 102: 2477-95. PMID 12105933 DOI: 10.1021/Cr010046Q  0.651
2002 Marsilje TH, Labroli MA, Hedrick MP, Jin Q, Desharnais J, Baker SJ, Gooljarsingh LT, Ramcharan J, Tavassoli A, Zhang Y, Wilson IA, Beardsley GP, Benkovic SJ, Boger DL. 10-Formyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid (10-formyl-DDACTHF): a potent cytotoxic agent acting by selective inhibition of human GAR Tfase and the de novo purine biosynthetic pathway. Bioorganic & Medicinal Chemistry. 10: 2739-49. PMID 12057663 DOI: 10.1016/S0968-0896(02)00102-5  0.324
2002 Chen Y, Bilban M, Foster CA, Boger DL. Solution-phase parallel synthesis of a pharmacophore library of HUN-7293 analogues: a general chemical mutagenesis approach to defining structure-function properties of naturally occurring cyclic (depsi)peptides. Journal of the American Chemical Society. 124: 5431-40. PMID 11996584 DOI: 10.1021/Ja020166V  0.363
2002 Jiang W, Wanner J, Lee RJ, Bounaud PY, Boger DL. Total synthesis of the ramoplanin A2 and ramoplanose aglycon. Journal of the American Chemical Society. 124: 5288-90. PMID 11996568 DOI: 10.1021/Ja020237Q  0.371
2002 McAtee JJ, Castle SL, Jin Q, Boger DL. Synthesis and evaluation of vancomycin and vancomycin aglycon analogues that bear modifications in the residue 3 asparagine. Bioorganic & Medicinal Chemistry Letters. 12: 1319-22. PMID 11965380 DOI: 10.1016/S0960-894X(02)00130-0  0.644
2002 Ambroise Y, Boger DL. The DNA phosphate backbone is not involved in catalysis of the duocarmycin and CC-1065 DNA alkylation reaction. Bioorganic & Medicinal Chemistry Letters. 12: 303-6. PMID 11814783 DOI: 10.1016/S0960-894X(01)00740-5  0.339
2002 Goldberg J, Jin Q, Ambroise Y, Satoh S, Desharnais J, Capps K, Boger DL. Erythropoietin mimetics derived from solution phase combinatorial libraries. Journal of the American Chemical Society. 124: 544-55. PMID 11804483 DOI: 10.1021/Ja0118789  0.792
2002 Boger DL, Schmitt HW, Fink BE, Hedrick MP. Parallel synthesis and evaluation of 132 (+)-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (CBI) analogues of CC-1065 and the duocarmycins defining the contribution of the DNA-binding domain. The Journal of Organic Chemistry. 66: 6654-61. PMID 11578217 DOI: 10.1021/Jo010454U  0.362
2002 Boger DL, Miyauchi H, Hedrick MP. alpha-Keto heterocycle inhibitors of fatty acid amide hydrolase: carbonyl group modification and alpha-substitution. Bioorganic & Medicinal Chemistry Letters. 11: 1517-20. PMID 11412972 DOI: 10.1016/S0960-894X(01)00211-6  0.31
2002 Krenitsky PJ, Boger DL. Preparation of the 14-membered l,l-cycloisodityrosine subunit of RP 66453 Tetrahedron Letters. 43: 407-410. DOI: 10.1016/S0040-4039(01)02194-3  0.772
2002 Blagg BSJ, Boger DL. Total synthesis of (+)-camptothecin Tetrahedron. 58: 6343-6349. DOI: 10.1016/S0040-4020(02)00633-6  0.733
2001 Greasley SE, Marsilje TH, Cai H, Baker S, Benkovic SJ, Boger DL, Wilson IA. Unexpected formation of an epoxide-derived multisubstrate adduct inhibitor on the active site of GAR transformylase Biochemistry. 40: 13538-13547. PMID 11695901 DOI: 10.1021/Bi011482+  0.337
2001 Ellis DA, Wolkenberg SE, Boger DL. Metal cation complexation and activation of reversed CPyI analogues of CC-1065 and duocarmycin SA: partitioning the effects of binding and catalysis. Journal of the American Chemical Society. 123: 9299-306. PMID 11562212 DOI: 10.1021/Ja010769R  0.696
2001 Boger DL, Tse WC. Thiazole orange as the fluorescent intercalator in a high resolution fid assay for determining DNA binding affinity and sequence selectivity of small molecules. Bioorganic & Medicinal Chemistry. 9: 2511-8. PMID 11553493 DOI: 10.1016/S0968-0896(01)00243-7  0.718
2001 Boger DL, Hong J. Asymmetric total synthesis of ent-(-)-roseophilin: assignment of absolute configuration. Journal of the American Chemical Society. 123: 8515-9. PMID 11525659 DOI: 10.1021/Ja011271S  0.622
2001 Boger DL, Brunette SR, Garbaccio RM. Synthesis and evaluation of a series of C3-substituted CBI analogues of CC-1065 and the duocarmycins. The Journal of Organic Chemistry. 66: 5163-73. PMID 11463270 DOI: 10.1021/Jo010309G  0.408
2001 Boger DL, Ichikawa S, Zhong W. Total synthesis of fostriecin (CI-920). Journal of the American Chemical Society. 123: 4161-7. PMID 11457179 DOI: 10.1021/Ja010195Q  0.339
2001 Boger DL, Kim SH, Mori Y, Weng JH, Rogel O, Castle SL, McAtee JJ. First and second generation total synthesis of the teicoplanin aglycon. Journal of the American Chemical Society. 123: 1862-71. PMID 11456806 DOI: 10.1021/Ja003835I  0.669
2001 Boger DL, Ichikawa S, Tse WC, Hedrick MP, Jin Q. Total syntheses of thiocoraline and BE-22179 and assessment of their DNA binding and biological properties. Journal of the American Chemical Society. 123: 561-8. PMID 11456568 DOI: 10.1021/Ja003602R  0.769
2001 Boger DL, Stauffer F, Hedrick MP. Substituent effects within the DNA binding subunit of CBI analogues of the duocarmycins and CC-1065. Bioorganic & Medicinal Chemistry Letters. 11: 2021-4. PMID 11454471 DOI: 10.1016/S0960-894X(01)00372-9  0.338
2001 Boger DL, Fink BE, Brunette SR, Tse WC, Hedrick MP. A simple, high-resolution method for establishing DNA binding affinity and sequence selectivity. Journal of the American Chemical Society. 123: 5878-91. PMID 11414820 DOI: 10.1021/Ja010041A  0.724
2001 Boger DL, Hughes TV, Hedrick MP. Synthesis, chemical properties, and biological evaluation of CC-1065 and duocarmycin analogues incorporating the 5-methoxycarbonyl-1,2,9,9a-tetrahydrocyclopropa. The Journal of Organic Chemistry. 66: 2207-16. PMID 11281757 DOI: 10.1021/Jo001772G  0.404
2001 Boger DL, Dechantsreiter MA, Ishii T, Fink BE, Hedrick MP. Assessment of solution-phase positional scanning libraries based on distamycin A for the discovery of new DNA binding agents. Bioorganic & Medicinal Chemistry. 8: 2049-57. PMID 11003149 DOI: 10.1016/S0968-0896(00)00137-1  0.36
2001 Mori Y, McAtee J, Rogel O, Boger DL. Alternative synthesis and thermal atropisomerism of a fully functionalized DEFG ring system of teicoplanin Tetrahedron Letters. 42: 6061-6064. DOI: 10.1016/S0040-4039(01)01199-6  0.348
2001 Boger DL, Weng J, Miyazaki S, McAtee JJ, Castle SL, Kim SH, Mori Y, Rogel O, Strittmatter H, Jin Q. ChemInform Abstract: Thermal Atropisomerism of Teicoplanin Aglycon Derivatives. Preparation of the P,P,P and M,P,P Atropisomers of the Teicoplanin Aglycon via Selective Equilibration of the DE Ring System. Cheminform. 32: no-no. DOI: 10.1002/chin.200108186  0.528
2000 Boger DL, Wolkenberg SE. Total synthesis of Amaryllidaceae alkaloids utilizing sequential intramolecular heterocyclic azadiene Diels-Alder reactions of an unsymmetrical 1,2,4,5-tetrazine. The Journal of Organic Chemistry. 65: 9120-4. PMID 11149859 DOI: 10.1021/Jo0012546  0.711
2000 Boger DL, Fecik RA, Patterson JE, Miyauchi H, Patricelli MP, Cravatt BF. Fatty acid amide hydrolase substrate specificity. Bioorganic & Medicinal Chemistry Letters. 10: 2613-6. PMID 11128635 DOI: 10.1016/S0960-894X(00)00528-X  0.7
2000 Boger DL, Lee JK. Development of a solution-phase synthesis of minor groove binding bis-intercalators based on triostin A suitable for combinatorial synthesis. The Journal of Organic Chemistry. 65: 5996-6000. PMID 10987932 DOI: 10.1021/Jo000382R  0.318
2000 Boger DL, Chen Y, Foster CA. Synthesis and evaluation of aza HUN-7293. Bioorganic & Medicinal Chemistry Letters. 10: 1741-4. PMID 10937737 DOI: 10.1016/S0960-894X(00)00336-X  0.341
2000 Smith JA, Bifulco G, Case DA, Boger DL, Gomez-Paloma L, Chazin WJ. The structural basis for in Situ activation of DNA alkylation by duocarmycin SA Journal of Molecular Biology. 300: 1195-1204. PMID 10903864 DOI: 10.1006/Jmbi.2000.3887  0.349
2000 Boger DL, Marsilje TH, Castro RA, Hedrick MP, Jin Q, Baker SJ, Shim JH, Benkovic SJ. Design, synthesis, and biological evaluation of fluoronitrophenyl substituted folate analogues as potential inhibitors of GAR transformylase and AICAR transformylase Bioorganic and Medicinal Chemistry Letters. 10: 1471-1475. PMID 10888335 DOI: 10.1016/S0960-894X(00)00271-7  0.386
2000 Boger DL, Labroli MA, Marsilje TH, Jin Q, Hedrick MP, Baker SJ, Shim JH, Benkovic SJ. Conformationally restricted analogues designed for selective inhibition of GAR Tfase versus thymidylate synthase or dihydrofolate reductase Bioorganic and Medicinal Chemistry. 8: 1075-1086. PMID 10882019 DOI: 10.1016/S0968-0896(00)00051-1  0.361
2000 Boger DL, Santillán A, Searcey M, Brunette SR, Wolkenberg SE, Hedrick MP, Jin Q. Synthesis and evaluation of 1,2,8, 8a-Tetrahydrocyclopropa[c]pyrrolo[3,2-e]indol-4(5H)-one, the parent alkylation subunit of CC-1065 and the duocarmycins: impact of the alkylation subunit substituents and its implications for DNA alkylation catalysis. The Journal of Organic Chemistry. 65: 4101-11. PMID 10866627 DOI: 10.1021/Jo000297J  0.71
2000 Boger DL, Boyce CW. Selective metal cation activation of a DNA alkylating agent: Synthesis and evaluation of methyl 1,2,9,9a-tetrahydrocyclopropa[c]pyrido[3,2-e]indol-4-one-7-carboxylate (CPyI) Journal of Organic Chemistry. 65: 4088-4100. PMID 10866626 DOI: 10.1021/Jo000177B  0.422
2000 Boger DL, Lee JK, Goldberg J, Jin Q. Two comparisons of the performance of positional scanning and deletion synthesis for the identification of active constituents in mixture combinatorial libraries. The Journal of Organic Chemistry. 65: 1467-74. PMID 10814111 DOI: 10.1021/Jo9916481  0.327
2000 Boger DL, Sato H, Lerner AE, Hedrick MP, Fecik RA, Miyauchi H, Wilkie GD, Austin BJ, Patricelli MP, Cravatt BF. Exceptionally potent inhibitors of fatty acid amide hydrolase: the enzyme responsible for degradation of endogenous oleamide and anandamide. Proceedings of the National Academy of Sciences of the United States of America. 97: 5044-9. PMID 10805767 DOI: 10.1073/Pnas.97.10.5044  0.782
2000 Boger DL, Soenen DR, Boyce CW, Hedrick MP, Jin Q. Total synthesis of ningalin B utilizing a heterocyclic azadiene Diels-Alder reaction and discovery of a new class of potent multidrug resistant (MDR) reversal agents. The Journal of Organic Chemistry. 65: 2479-83. PMID 10789460 DOI: 10.1021/Jo9916535  0.8
2000 Boger DL, Searcey M, Tse WC, Jin Q. Bifunctional alkylating agents derived from duocarmycin SA: potent antitumor activity with altered sequence selectivity. Bioorganic & Medicinal Chemistry Letters. 10: 495-8. PMID 10743956 DOI: 10.1016/S0960-894X(00)00042-1  0.747
2000 Boger DL, Fink BE, Hedrick MP. Total Synthesis of Distamycin A and 2640 Analogues:  A Solution-Phase Combinatorial Approach to the Discovery of New, Bioactive DNA Binding Agents and Development of a Rapid, High-Throughput Screen for Determining Relative DNA Binding Affinity or DNA Binding Sequence Selectivity Journal of the American Chemical Society. 122: 6382-6394. DOI: 10.1021/Ja994192D  0.359
2000 Boger DL, Ichikawa S, Jiang H. Total Synthesis of the Rubrolone Aglycon Journal of the American Chemical Society. 122: 12169-12173. DOI: 10.1021/Ja002997B  0.39
2000 Boger DL, Weng JH, Miyazaki S, McAtee JJ, Castle SL, Kim SH, Mori Y, Rogel O, Strittmatter H, Jin Q. Thermal atropisomerism of teicoplanin aglycon derivatives: Preparation of the P,P,P and M,P,P atropisomers of the teicoplanin aglycon via selective equilibration of the DE ring system Journal of the American Chemical Society. 122: 10047-10055. DOI: 10.1021/Ja002376I  0.623
2000 Boger DL, Kim SH, Miyazaki S, Strittmatter H, Weng JH, Mori Y, Rogel O, Castle SL, McAtee JJ. Total synthesis of the teicoplanin aglycon [16] Journal of the American Chemical Society. 122: 7416-7417. DOI: 10.1021/Ja001663J  0.647
2000 Boger DL, Wolkenberg SE, Boyce CW. A new method of in situ activation for a novel class of DNA alkylating agents: Tunable metal cation complexation and activation [20] Journal of the American Chemical Society. 122: 6325-6326. DOI: 10.1021/Ja000653F  0.66
2000 Boger DL, Aquila BM, Tse WC, Searcey M. Synthesis and evaluation of a novel bleomycin A2 analogue: continuing assessment of the linker domain Tetrahedron Letters. 41: 9493-9498. DOI: 10.1016/S0040-4039(00)01633-6  0.747
2000 Boger DL, Kim SH, Miyazaki S, Strittmatter H, Weng J, Mori Y, Rogel O, Castle SL, McAtee JJ. ChemInform Abstract: Total Synthesis of the Teicoplanin Aglycon. Cheminform. 31: no-no. DOI: 10.1002/chin.200045243  0.613
2000 Boger D, Goldberg J, Satoh S, Ambroise Y, Cohen S, Vogt P. Non-Amide-Based Combinatorial Libraries Derived fromN-Boc-Iminodiacetic Acid: Solution-Phase Synthesis of Piperazinone Libraries with Activity Against LEF-1/β-Catenin-Mediated Transcription Helvetica Chimica Acta. 83: 1825-1845. DOI: 10.1002/1522-2675(20000809)83:8<1825::Aid-Hlca1825>3.0.Co;2-4  0.384
1999 Boger DL, Cai H. Bleomycin: Synthetic and Mechanistic Studies. Angewandte Chemie (International Ed. in English). 38: 448-476. PMID 29711767 DOI: 10.1002/(Sici)1521-3773(19990215)38:4<448::Aid-Anie448>3.0.Co;2-W  0.315
1999 Boger DL, Castle SL, Miyazaki S, Wu JH, Beresis RT, Loiseleur O. Vancomycin CD and DE Macrocyclization and Atropisomerism Studies. The Journal of Organic Chemistry. 64: 70-80. PMID 11674087 DOI: 10.1021/Jo980880O  0.654
1999 Greasley SE, Yamashita MM, Cai H, Benkovic SJ, Boger DL, Wilson IA. New insights into inhibitor design from the crystal structure and NMR studies of Escherichia coli GAR transformylase in complex with beta-GAR and 10-formyl-5,8,10-trideazafolic acid. Biochemistry. 38: 16783-93. PMID 10606510 DOI: 10.1021/Bi991888A  0.327
1999 Baraldi PG, Cacciari B, Romagnoli R, Spalluto G, Boyce CW, Boger DL. Resolution of a CPzI precursor, synthesis and biological evaluation of (+) and (-)-N-Boc-CPzI: a further validation of the relationship between chemical solvolytic stability and cytotoxicity. Bioorganic & Medicinal Chemistry Letters. 9: 3087-92. PMID 10560730 DOI: 10.1016/S0960-894X(99)00533-8  0.328
1999 Boger DL, Ledeboer MW, Kume M, Jin Q. Total Synthesis of Quinoxapeptin A-C: Establishment of Absolute Stereochemistry. Angewandte Chemie. 38: 2424-2426. PMID 10458810 DOI: 10.1002/(Sici)1521-3773(19990816)38:16<2424::Aid-Anie2424>3.0.Co;2-9  0.333
1999 Boger DL, Sato H, Lerner AE, Austin BJ, Patterson JE, Patricelli MP, Cravatt BF. Trifluoromethyl ketone inhibitors of fatty acid amide hydrolase: a probe of structural and conformational features contributing to inhibition. Bioorganic & Medicinal Chemistry Letters. 9: 265-70. PMID 10021942 DOI: 10.1016/S0960-894X(98)00734-3  0.734
1999 Boger DL, Jiang W, Goldberg J. Convergent Solution-Phase Combinatorial Synthesis with Multiplication of Diversity through Rigid Biaryl and Diarylacetylene Couplings The Journal of Organic Chemistry. 64: 7094-7100. DOI: 10.1021/Jo990639P  0.369
1999 Boger DL, Santillán A, Searcey M, Jin Q. Synthesis and Evaluation of Duocarmycin and CC-1065 Analogues Containing Modifications in the Subunit Linking Amide The Journal of Organic Chemistry. 64: 5241-5244. DOI: 10.1021/Jo990452Y  0.348
1999 Boger DL, Ledeboer MW, Kume M, Searcey M, Jin Q. Total Synthesis and Comparative Evaluation of Luzopeptin A−C and Quinoxapeptin A−C Journal of the American Chemical Society. 121: 11375-11383. DOI: 10.1021/Ja993019E  0.423
1999 Boger DL, Miyazaki S, Kim SH, Wu JH, Castle SL, Loiseleur O, Jin Q. Total synthesis of the vancomycin aglycon Journal of the American Chemical Society. 121: 10004-10011. DOI: 10.1021/Ja992577Q  0.649
1999 Boger DL, Keim H, Oberhauser B, Schreiner EP, Foster CA. Total synthesis of HUN-7293 Journal of the American Chemical Society. 121: 6197-6205. DOI: 10.1021/Ja990918U  0.358
1999 Boger DL, Miyazaki S, Kim SH, Wu JH, Loiseleur O, Castle SL. Diastereoselective total synthesis of the vancomycin aglycon with ordered atropisomer equilibrations [5] Journal of the American Chemical Society. 121: 3226-3227. DOI: 10.1021/Ja990189I  0.63
1999 Boger DL, Ledeboer MW, Kume M. Total Synthesis of Luzopeptins A−C Journal of the American Chemical Society. 121: 1098-1099. DOI: 10.1021/Ja983925B  0.365
1999 Boger DL, Hong J, Hikota M, Ishida M. Total Synthesis of Phomazarin Journal of the American Chemical Society. 121: 2471-2477. DOI: 10.1021/Ja983631Q  0.623
1999 Schnell JR, Ketchem RR, Boger DL, Chazin WJ. Binding-induced activation of DNA alkylation by duocarmycin SA: Insights from the structure of an indole derivative - DNA adduct Journal of the American Chemical Society. 121: 5645-5652. DOI: 10.1021/Ja983556J  0.334
1999 Boger DL, Boyce CW, Labroli MA, Sehon CA, Jin Q. Total syntheses of ningalin A, lamellarin O, lukianol A, and permethyl storniamide A utilizing heterocyclic azadiene Diels - Alder reactions Journal of the American Chemical Society. 121: 54-62. DOI: 10.1021/Ja982078+  0.314
1999 Boger DL, Cai H. Bleomycin: Untersuchungen zu Synthese und Wirkungsmechanismus Angewandte Chemie. 111: 470-500. DOI: 10.1002/(Sici)1521-3757(19990215)111:4<470::Aid-Ange470>3.0.Co;2-M  0.328
1998 Boger DL, Henriksen SJ, Cravatt BF. Oleamide: an endogenous sleep-inducing lipid and prototypical member of a new class of biological signaling molecules. Current Pharmaceutical Design. 4: 303-14. PMID 10197045  0.382
1998 Patricelli MP, Patterson JE, Boger DL, Cravatt BF. An endogenous sleep-inducing compound is a novel competitive inhibitor of fatty acid amide hydrolase. Bioorganic & Medicinal Chemistry Letters. 8: 613-8. PMID 9871570 DOI: 10.1016/S0960-894X(98)00073-0  0.712
1998 Boger DL, Beresis RT, Loiseleur O, Wu JH, Castle SL. Synthesis of the vancomycin CDE ring system. Bioorganic & Medicinal Chemistry Letters. 8: 721-4. PMID 9871529 DOI: 10.1016/S0960-894X(98)00110-3  0.643
1998 Boger DL, Goldberg J, Jiang W, Chai W, Ducray P, Lee JK, Ozer RS, Andersson CM. Higher order iminodiacetic acid libraries for probing protein-protein interactions. Bioorganic & Medicinal Chemistry. 6: 1347-78. PMID 9784874 DOI: 10.1016/S0968-0896(98)00128-X  0.325
1998 Boger DL, Kochanny MJ, Cai H, Wyatt D, Kitos PA, Warren MS, Ramcharan J, Gooljarsingh LT, Benkovic SJ. Design, synthesis, and evaluation of potential GAR and AICAR transformylase inhibitors. Bioorganic & Medicinal Chemistry. 6: 643-59. PMID 9681131 DOI: 10.1016/S0968-0896(98)00040-6  0.334
1998 Boger DL, Patterson JE, Guan X, Cravatt BF, Lerner RA, Gilula NB. Chemical requirements for inhibition of gap junction communication by the biologically active lipid oleamide. Proceedings of the National Academy of Sciences of the United States of America. 95: 4810-5. PMID 9560184 DOI: 10.1073/Pnas.95.9.4810  0.603
1998 Boger DL, Chen JH, Saionz KW, Jin Q. Synthesis of key sandramycin analogs: systematic examination of the intercalation chromophore. Bioorganic & Medicinal Chemistry. 6: 85-102. PMID 9502108 DOI: 10.1016/S0968-0896(97)10014-1  0.328
1998 Boger DL, Turnbull P. Synthesis and Evaluation of a Carbocyclic Analogue of the CC-1065 and Duocarmycin Alkylation Subunits:  Role of the Vinylogous Amide and Implications on DNA Alkylation Catalysis The Journal of Organic Chemistry. 63: 8004-8011. DOI: 10.1021/Jo981698Q  0.414
1998 Boger DL, Miyazaki S, Loiseleur O, Beresis RT, Castle SL, Wu JH, Jin Q. Thermal Atropisomerism of Aglucovancomycin Derivatives:  Preparation of (M,M,M)- and (P,M,M)-Aglucovancomycins Journal of the American Chemical Society. 120: 8920-8926. DOI: 10.1021/Ja981928I  0.591
1998 Boger DL, Santillán A, Searcey M, Jin Q. Critical Role of the Linking Amide in CC-1065 and the Duocarmycins:  Implications on the Source of DNA Alkylation Catalysis Journal of the American Chemical Society. 120: 11554-11557. DOI: 10.1021/Ja9818093  0.334
1998 Boger DL, Ramsey TM, Cai H, Hoehn ST, Stubbe J. Definition of the Effect and Role of the Bleomycin A2Valerate Substituents:  Preorganization of a Rigid, Compact Conformation Implicated in Sequence-Selective DNA Cleavage Journal of the American Chemical Society. 120: 9149-9158. DOI: 10.1021/Ja9816640  0.359
1998 Boger DL, Ramsey TM, Cai H, Hoehn ST, Stubbe J. A Systematic Evaluation of the Bleomycin A2l-Threonine Side Chain:  Its Role in Preorganization of a Compact Conformation Implicated in Sequence-Selective DNA Cleavage Journal of the American Chemical Society. 120: 9139-9148. DOI: 10.1021/Ja9816638  0.325
1998 Boger DL, Chai W, Jin Q. Multistep Convergent Solution-Phase Combinatorial Synthesis and Deletion Synthesis Deconvolution Journal of the American Chemical Society. 120: 7220-7225. DOI: 10.1021/Ja9803557  0.342
1998 Boger DL, Hong J. Total Synthesis of Nothapodytine B and (−)-Mappicine Journal of the American Chemical Society. 120: 1218-1222. DOI: 10.1021/Ja973007Y  0.527
1998 Wu W, Vanderwall DE, Teramoto S, Lui SM, Hoehn ST, Tang XJ, Turner CJ, Boger DL, Kozarich JW, Stubbe J. NMR studies of Co·deglycobleomycin A2 green and its complex with d(CCAGGCCTGG) Journal of the American Chemical Society. 120: 2239-2250. DOI: 10.1021/Ja972125I  0.305
1998 Boger DL, Ramsey TM, Cai H, Hoehn ST, Kozarich JW, Stubbe J. Assessment of the Role of the Bleomycin A2Pyrimidoblamic Acid C4 Amino Group Journal of the American Chemical Society. 120: 53-65. DOI: 10.1021/Ja971889V  0.36
1998 Boger DL, Boyce CW, Garbaccio RM, Searcey M. Synthesis of CC-1065 and duocarmycin analogs via intramolecular aryl radical cyclization of a tethered vinyl chloride Tetrahedron Letters. 39: 2227-2230. DOI: 10.1016/S0040-4039(98)00232-9  0.386
1998 Boger DL, Chai W. Solution-phase combinatorial synthesis: Convergent multiplication of diversity via the olefin metathesis reaction Tetrahedron. 54: 3955-3970. DOI: 10.1016/S0040-4020(98)00128-8  0.361
1998 Boger DL. Heterocyclic and acyclic azadiene diels-alder reactions: Total synthesis of nothapodytine B Journal of Heterocyclic Chemistry. 35: 1003-1011. DOI: 10.1002/Jhet.5570350502  0.375
1997 Boger DL, Zhou J, Borzilleri RM, Nukui S, Castle SL. Synthesis of (9R,12S)- and (9S,12S)-Cycloisodityrosine and Their N-Methyl Derivatives. The Journal of Organic Chemistry. 62: 2054-2069. PMID 11671510 DOI: 10.1021/Jo961346O  0.656
1997 Guan X, Cravatt BF, Ehring GR, Hall JE, Boger DL, Lerner RA, Gilula NB. The sleep-inducing lipid oleamide deconvolutes gap junction communication and calcium wave transmission in glial cells. The Journal of Cell Biology. 139: 1785-92. PMID 9412472 DOI: 10.1083/Jcb.139.7.1785  0.544
1997 Boger DL, Haynes NE, Warren MS, Ramcharan J, Kitos PA, Benkovic SJ. Multisubstrate analogue based on 5,8,10-trideazafolate. Bioorganic & Medicinal Chemistry. 5: 1853-7. PMID 9354241 DOI: 10.1016/S0968-0896(97)00124-7  0.321
1997 Boger DL, Haynes NE, Warren MS, Ramcharan J, Marolewski AE, Kitos PA, Benkovic SJ. Abenzyl 10-formyl-trideazafolic acid (abenzyl 10-formyl-TDAF): an effective inhibitor of glycinamide ribonucleotide transformylase. Bioorganic & Medicinal Chemistry. 5: 1847-52. PMID 9354240 DOI: 10.1016/S0968-0896(97)00123-5  0.355
1997 Boger DL, Haynes NE, Warren MS, Ramcharan J, Kitos PA, Benkovic SJ. Functionalized analogues of 5,8,10-trideazafolate: development of an enzyme-assembled tight binding inhibitor of GAR Tfase and a potential irreversible inhibitor of AICAR Tfase. Bioorganic & Medicinal Chemistry. 5: 1839-46. PMID 9354239 DOI: 10.1016/S0968-0896(97)00122-3  0.333
1997 Boger DL, Haynes NE, Warren MS, Gooljarsingh LT, Ramcharan J, Kitos PA, Benkovic SJ. Functionalized analogues of 5,8,10-trideazafolate as potential inhibitors of GAR Tfase or AICAR Tfase. Bioorganic & Medicinal Chemistry. 5: 1831-8. PMID 9354238 DOI: 10.1016/S0968-0896(97)00121-1  0.305
1997 Boger DL, Haynes NE, Kitos PA, Warren MS, Ramcharan J, Marolewski AE, Benkovic SJ. 10-Formyl-5,8,10-trideazafolic acid (10-formyl-TDAF): a potent inhibitor of glycinamide ribonucleotide transformylase. Bioorganic & Medicinal Chemistry. 5: 1817-30. PMID 9354237 DOI: 10.1016/S0968-0896(97)00120-X  0.374
1997 Boger DL, Teramoto S, Cai H. N-methyl threonine analogues of deglycobleomycin A2: synthesis and evaluation. Bioorganic & Medicinal Chemistry. 5: 1577-89. PMID 9313863 DOI: 10.1016/S0968-0896(97)00107-7  0.332
1997 Boger DL, Garbaccio RM. Catalysis of the CC-1065 and duocarmycin DNA alkylation reaction: DNA binding induced conformational change in the agent results in activation. Bioorganic & Medicinal Chemistry. 5: 263-76. PMID 9061191 DOI: 10.1016/S0968-0896(96)00238-6  0.34
1997 Boger DL, Han N. CC-1065/duocarmycin and bleomycin A2 hybrid agents: Lack of enhancement of DNA alkylation by attachment to noncomplementary DNA binding subunits Bioorganic and Medicinal Chemistry. 5: 233-243. PMID 9061188 DOI: 10.1016/S0968-0896(96)00237-4  0.334
1997 Boger DL, Zhou J, Cai H. Demonstration and definition of the noncovalent binding selectivity of agents related to CC-1065 by an affinity cleavage agent: noncovalent binding coincidental with alkylation. Bioorganic & Medicinal Chemistry. 4: 859-67. PMID 8818235 DOI: 10.1016/0968-0896(96)00073-9  0.324
1997 Boger D, McKie J, Boyce C. Asymmetric Synthesis of the CBI Alkylation Subunit of the CC-1065 and Duocarmycin Analogs Synlett. 1997: 515-517. DOI: 10.1055/S-1997-6110  0.386
1997 Boger DL, Garbaccio RM, Jin Q. Synthesis and Evaluation of CC-1065 and Duocarmycin Analogues Incorporating the Iso-CI and Iso-CBI Alkylation Subunits:  Impact of Relocation of the C-4 Carbonyl The Journal of Organic Chemistry. 62: 8875-8891. DOI: 10.1021/Jo971686P  0.415
1997 Boger DL, Turnbull P. Synthesis and Evaluation of CC-1065 and Duocarmycin Analogs Incorporating the 1,2,3,4,11,11a-Hexahydrocyclopropa[c]naphtho[2,1-b]azepin-6-one (CNA) Alkylation Subunit:  Structural Features that Govern Reactivity and Reaction Regioselectivity The Journal of Organic Chemistry. 62: 5849-5863. DOI: 10.1021/Jo9707085  0.416
1997 Boger DL, Borzilleri RM, Nukui S, Beresis RT. Synthesis of the Vancomycin CD and DE Ring Systems The Journal of Organic Chemistry. 62: 4721-4736. DOI: 10.1021/Jo970560P  0.306
1997 Boger DL, Bollinger B, Hertzog DL, Johnson DS, Cai H, Mésini P, Garbaccio RM, Jin Q, Kitos PA. Reversed and Sandwiched Analogs of Duocarmycin SA:  Establishment of the Origin of the Sequence-Selective Alkylation of DNA and New Insights into the Source of Catalysis Journal of the American Chemical Society. 119: 4987-4998. DOI: 10.1021/Ja9637210  0.375
1997 Boger DL, Hertzog DL, Bollinger B, Johnson DS, Cai H, Goldberg J, Turnbull P. Duocarmycin SA Shortened, Simplified, and Extended Agents:  A Systematic Examination of the Role of the DNA Binding Subunit Journal of the American Chemical Society. 119: 4977-4986. DOI: 10.1021/Ja9637208  0.345
1997 Boger DL, McKie JA, Nishi T, Ogiku T. Total Synthesis of (+)-Duocarmycin A,epi-(+)-Duocarmycin A and Their Unnatural Enantiomers:  Assessment of Chemical and Biological Properties Journal of the American Chemical Society. 119: 311-325. DOI: 10.1021/Ja962431G  0.394
1997 Boger DL, Loiseleur O, Castle SL, Beresis RT, Wu JH. Thermal atropisomerism of fully functinalized vancomycin CD, DE, and CDE ring systems Bioorganic and Medicinal Chemistry Letters. 7: 3199-3202. DOI: 10.1016/S0960-894X(97)10182-2  0.603
1997 Boger DL, Ozer RS, Andersson CM. Generation of targeted C2-symmetrical compound libraries by solution-phase combinatorial chemistry Bioorganic and Medicinal Chemistry Letters. 7: 1903-1908. DOI: 10.1016/S0960-894X(97)00330-2  0.318
1997 Boger DL, Chai W, Ozer RS, Andersson CM. Solution-phase combinatorial synthesis via the olefin metathesis reaction Bioorganic and Medicinal Chemistry Letters. 7: 463-468. DOI: 10.1016/S0960-894X(97)00043-7  0.328
1997 Sakya SM, Groskopf KK, Boger DL. Preparation and inverse electron demand Diels-Alder reactions of 3-methoxy-6-methylthio-1,2,4,5-tetrazine Tetrahedron Letters. 38: 3805-3808. DOI: 10.1016/S0040-4039(97)00751-X  0.349
1997 Boger DL. Applications of Free Radicals in Organic Synthesis Israel Journal of Chemistry. 37: 119-129. DOI: 10.1002/Ijch.199700014  0.36
1996 Cravatt BF, Giang DK, Mayfield SP, Boger DL, Lerner RA, Gilula NB. Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides. Nature. 384: 83-7. PMID 8900284 DOI: 10.1038/384083A0  0.574
1996 Boger DL, Teramoto S, Cai H. Synthesis and evaluation of deglycobleomycin A2 analogues containing a tertiary N-methyl amide and simple ester replacement for the L-histidine secondary amide: direct functional characterization of the requirement for secondary amide metal complexation. Bioorganic & Medicinal Chemistry. 4: 179-93. PMID 8814877 DOI: 10.1016/0968-0896(95)00183-2  0.328
1996 Cheng S, Tarby CM, Comer DD, Williams JP, Caporale LH, Myers PL, Boger DL. A solution-phase strategy for the synthesis of chemical libraries containing small organic molecules: a universal and dipeptide mimetic template. Bioorganic & Medicinal Chemistry. 4: 727-37. PMID 8804539 DOI: 10.1016/0968-0896(96)00069-7  0.341
1996 Boger DL, Zhou J, Winter B, Kitos PA. Key analogs of the tetrapeptide subunit of RA-VII and deoxybouvardin. Bioorganic & Medicinal Chemistry. 3: 1579-93. PMID 8770383 DOI: 10.1016/0968-0896(95)00141-7  0.32
1996 Boger DL, Colletti SL, Teramoto S, Ramsey TM, Zhou J. Synthesis of key analogs of bleomycin A2 that permit a systematic evaluation of the linker region: identification of an exceptionally prominent role for the L-threonine substituent. Bioorganic & Medicinal Chemistry. 3: 1281-95. PMID 8564421 DOI: 10.1016/0968-0896(95)00113-U  0.345
1996 Boger DL, Han N, Tarby CM, Boyce CW, Cai H, Jin Q, Kitos PA. Synthesis, Chemical Properties, and Preliminary Evaluation of Substituted CBI Analogs of CC-1065 and the Duocarmycins Incorporating the 7-Cyano-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one Alkylation Subunit:  Hammett Quantitation of the Magnitude of Electronic Effects on Functional Reactivity The Journal of Organic Chemistry. 61: 4894-4912. DOI: 10.1021/Jo9605298  0.413
1996 Boger DL, Borzilleri RM, Nukui S. Synthesis of (R)-(4-Methoxy-3,5-dihydroxyphenyl)glycine Derivatives:  The Central Amino Acid of Vancomycin and Related Agents The Journal of Organic Chemistry. 61: 3561-3565. DOI: 10.1021/Jo960085F  0.31
1996 Boger DL, Jenkins TJ. Synthesis, X-ray Structure, and Properties of Fluorocyclopropane Analogs of the Duocarmycins Incorporating the 9,9-Difluoro-1,2,9,9a-tetrahydrocyclopropa[c]benzo[e]indol-4-one (F2CBI) Alkylation Subunit Journal of the American Chemical Society. 118: 8860-8870. DOI: 10.1021/Ja961888N  0.371
1996 Patterson JE, Ollmann IR, Cravatt BF, Boger DL, Wong CH, Lerner RA. Inhibition of oleamide hydrolase catalyzed hydrolysis of the endogenous sleep-inducing lipid cis-9-octadecenamide Journal of the American Chemical Society. 118: 5938-5945. DOI: 10.1021/Ja954064Z  0.594
1996 Boger DL, McKie JA, Nishi T, Ogiku T. Enantioselective Total Synthesis of (+)-Duocarmycin A,epi-(+)-Duocarmycin A, and Their Unnatural Enantiomers Journal of the American Chemical Society. 118: 2301-2302. DOI: 10.1021/Ja953777E  0.376
1996 Cravatt BF, Lerner RA, Boger DL. Structure determination of an endogenous sleep-inducing lipid, cis-9-octadecenamide (oleamide): A synthetic approach to the chemical analysis of trace quantities of a natural product Journal of the American Chemical Society. 118: 580-590. DOI: 10.1021/Ja9532345  0.55
1996 Cheng S, Comer DD, Williams JP, Myers PL, Boger DL. Novel Solution Phase Strategy for the Synthesis of Chemical Libraries Containing Small Organic Molecules Journal of the American Chemical Society. 118: 2567-2573. DOI: 10.1021/Ja9530681  0.305
1996 Boger DL, Chen J, Saionz KW. (−)-Sandramycin:  Total Synthesis and Characterization of DNA Binding Properties Journal of the American Chemical Society. 118: 1629-1644. DOI: 10.1021/Ja952799Y  0.41
1996 Boger DL, Bollinger B, Johnson DS. Examination of the role of the duocarmycin SA methoxy substituents: Identification of the minimum, fully potent DNA binding subunit Bioorganic & Medicinal Chemistry Letters. 6: 2207-2210. DOI: 10.1016/0960-894X(96)00401-5  0.349
1996 Boger DL, Goldberg J, McKie JA. A comparative study of the solvolysis reactivity, regioselectivity, and stereochemistry of the duocarmycin a and sa alkylation subunits Bioorganic & Medicinal Chemistry Letters. 6: 1955-1960. DOI: 10.1016/0960-894X(96)00346-0  0.353
1996 Boger DL, Zhou J, Borzilleri RM, Nukui S. Synthesis of (9S,12S)-cycloisodityrosine and its unnatural (9R,12S)-diastereomer Bioorganic & Medicinal Chemistry Letters. 6: 1089-1092. DOI: 10.1016/0960-894X(96)00179-5  0.347
1996 Boger DL, McKie JA, Han N, Tarby CM, Riggs HW, Kitos PA. A Hammett correlation for CC-1065 and duocarmycin analogs: Magnitude of substituent electronic effects on functional reactivity Bioorganic & Medicinal Chemistry Letters. 6: 659-664. DOI: 10.1016/0960-894X(96)00093-5  0.364
1996 Boger DL. Azadiene diels-alder reactions: Scope and applications. Total synthesis of natural andEnt-fredericamycin A Journal of Heterocyclic Chemistry. 33: 1519-1531. DOI: 10.1002/Jhet.5570330508  0.369
1996 Boger DL, Johnson DS. CC-1065 and the Duocarmycins: Understanding their Biological Function through Mechanistic Studies Angewandte Chemie International Edition in English. 35: 1438-1474. DOI: 10.1002/Anie.199614381  0.36
1995 Boger DL, Yun W, Han N. 1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (CBI) analogs of CC-1065 and the duocarmycins: synthesis and evaluation Bioorganic and Medicinal Chemistry. 3: 1429-1453. PMID 8634824 DOI: 10.1016/0968-0896(95)00130-9  0.403
1995 Boger DL, Nishi T. Diastereoselective Dieckmann condensation suitable for introduction of the duocarmycin A C6 center: Development of a divergent strategy for the total synthesis of duocarmycins A and SA Bioorganic and Medicinal Chemistry. 3: 67-77. PMID 8612048 DOI: 10.1016/0968-0896(94)00147-U  0.349
1995 Cravatt BF, Prospero-Garcia O, Siuzdak G, Gilula NB, Henriksen SJ, Boger DL, Lerner RA. Chemical characterization of a family of brain lipids that induce sleep. Science (New York, N.Y.). 268: 1506-9. PMID 7770779 DOI: 10.1126/Science.7770779  0.559
1995 Boger DL, Johnson DS. CC-1065 and the duocarmycins: unraveling the keys to a new class of naturally derived DNA alkylating agents. Proceedings of the National Academy of Sciences of the United States of America. 92: 3642-9. PMID 7731958 DOI: 10.1073/Pnas.92.9.3642  0.372
1995 Boger DL, Yun W, Cai H, Han N. CBI-CDPBO1 and CBI-CDPBI1: CC-1065 analogs containing deep-seated modifications in the DNA binding subunit. Bioorganic & Medicinal Chemistry. 3: 761-7. PMID 7582954 DOI: 10.1016/0968-0896(95)00066-P  0.396
1995 Boger DL, Yun W, Han N, Johnson DS. CC-1065 CBI analogs: an example of enhancement of DNA alkylation efficiency through introduction of stabilizing electrostatic interactions. Bioorganic & Medicinal Chemistry. 3: 611-21. PMID 7582940 DOI: 10.1016/0968-0896(95)00048-L  0.308
1995 Boger DL, Chen J. A Modified Friedlander Condensation for the Synthesis of 3-Hydroxyquinoline-2-carboxylates The Journal of Organic Chemistry. 60: 7369-7371. DOI: 10.1021/Jo00127A055  0.39
1995 Boger DL, McKie JA. An Efficient Synthesis of 1,2,9,9a-Tetrahydrocyclopropa[c]benz[e]indol-4-one CBI: An Enhanced and Simplified Analog of the CC-1065 and Duocarmycin Alkylation Subunits The Journal of Organic Chemistry. 60: 1271-1275. DOI: 10.1021/Jo00110A034  0.337
1995 Boger DL, Takahashi K. Total Synthesis of Granditropone, Grandirubrine, Imerubrine, and Isoimerubrine Journal of the American Chemical Society. 117: 12452-12459. DOI: 10.1021/Ja00155A009  0.365
1995 Boger DL, Hueter O, Mbiya K, Zhang M. Total Synthesis of Natural and ent-Fredericamycin A Journal of the American Chemical Society. 117: 11839-11849. DOI: 10.1021/Ja00153A004  0.365
1995 Boger DL, Mesini P. DNA Alkylation Properties of CC-1065 and Duocarmycin Analogs Incorporating the 2,3,10,10a-Tetrahydrocyclopropa[d]benzo[f]quinol-5-one Alkylation Subunit: Identification of Subtle Structural Features That Contribute to the Regioselectivity of the Adenine N3 Alkylation Reaction Journal of the American Chemical Society. 117: 11647-11655. DOI: 10.1021/Ja00152A004  0.348
1995 Boger DL. The Duocarmycins: Synthetic and Mechanistic Studies Accounts of Chemical Research. 28: 20-29. DOI: 10.1021/Ar00049A004  0.336
1995 Boger DL, Borzilleri RM. An unusually facile SnAr 14-membered biaryl ether macrocyclization reaction suitable for preparation of the cycloisodityrosine subunit of bouvardin, deoxybouvardin and related agents Bioorganic & Medicinal Chemistry Letters. 5: 1187-1190. DOI: 10.1016/0960-894X(95)00192-V  0.4
1994 Mohamadi F, Spees MM, Staten GS, Marder P, Kipka JK, Johnson DA, Boger DL, Zarrinmayeh H. Total synthesis and biological properties of novel antineoplastic (chloromethyl)furanoindolines: an asymmetric hydroboration mediated synthesis of the alkylation subunits. Journal of Medicinal Chemistry. 37: 232-9. PMID 8295210 DOI: 10.1021/Jm00028A005  0.413
1994 Boger DL, Johnson DS, Palanki MS, Kitos PA, Chang J, Dowell P. Evaluation of functional analogs of CC-1065 and the duocarmycins incorporating the cross-linking 9a-chloromethyl-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-on e (C2BI) alkylation subunit. Bioorganic & Medicinal Chemistry. 1: 27-38. PMID 8081835 DOI: 10.1016/S0968-0896(00)82100-8  0.365
1994 Lerner RA, Siuzdak G, Prospero-Garcia O, Henriksen SJ, Boger DL, Cravatt BF. Cerebrodiene: a brain lipid isolated from sleep-deprived cats. Proceedings of the National Academy of Sciences of the United States of America. 91: 9505-8. PMID 7937797 DOI: 10.1073/Pnas.91.20.9505  0.547
1994 Boger DL, Patane MA, Jin Q, Kitos PA. Design, synthesis and evaluation of bouvardin, deoxybouvardin and RA-I-XIV pharmacophore analogs. Bioorganic & Medicinal Chemistry. 2: 85-100. PMID 7922127 DOI: 10.1016/S0968-0896(00)82005-2  0.341
1994 Boger DL, Johnson DS, Yun W, Tarby CM. Molecular basis for sequence selective DNA alkylation by (+)- and ent-(-)-CC-1065 and related agents: alkylation site models that accommodate the offset AT-rich adenine N3 alkylation selectivity. Bioorganic & Medicinal Chemistry. 2: 115-35. PMID 7922122 DOI: 10.1016/S0968-0896(00)82007-6  0.321
1994 Boger DL. Design, synthesis, and evaluation of DNA minor groove binding agents: the duocarmycins Pure and Applied Chemistry. 66: 837-844. DOI: 10.1351/Pac199466040837  0.333
1994 Boger DL, Lerner RA, Cravatt BF. Synthesis of a Functionalized Rigid Bicyclo[2.2.1]heptane: A Useful Hapten for Eliciting Catalytic Antibodies The Journal of Organic Chemistry. 59: 5078-5079. DOI: 10.1021/Jo00096A064  0.583
1994 Boger DL, Kochanny MJ. Inverse Electron Demand Diels-Alder Reactions of Heterocyclic Azadienes: [4 + 2] Cycloaddition Reaction of Amidines with 1,3,5-Triazines The Journal of Organic Chemistry. 59: 4950-4955. DOI: 10.1021/Jo00096A044  0.341
1994 Boger DL, Zhu Y. Diels-Alder Reactions of Cyclopropenone Ketals: A Concise Tropolone Annulation Applicable to Rubrolone C Ring Introduction The Journal of Organic Chemistry. 59: 3453-3458. DOI: 10.1021/Jo00091A040  0.323
1994 Boger DL, Mesini P. Design, Synthesis, and Evaluation of CC-1065 and Duocarmycin Analogs Incorporating the 2,3,10,10a-Tetrahydro-1H-cyclopropa[d]benzo[f]quinol-5-one (CBQ) Alkylation Subunit: Identification and Structural Origin of Subtle Stereoelectronic Features That Govern Reactivity and Regioselectivity Journal of the American Chemical Society. 116: 11335-11348. DOI: 10.1021/Ja00104A013  0.31
1994 Boger DL, Yun W. CBI-TMI: Synthesis and evaluation of a key analog of the duocarmycins. Validation of a direct relationship between chemical solvolytic stability and cytotoxic potency and confirmation of the structural features responsible for the distinguishing behavior of enantiomeric pairs of agents Journal of the American Chemical Society. 116: 7996-8006. DOI: 10.1021/Ja00097A006  0.373
1994 Cravatt BF, Ashley JA, Janda KD, Boger DL, Lerner RA. Crossing Extreme Mechanistic Barriers by Antibody Catalysis: Syn Elimination to a Cis Olefin Journal of the American Chemical Society. 116: 6013-6014. DOI: 10.1021/Ja00092A080  0.543
1994 Boger DL, Honda T. Total Synthesis of Bleomycin A2 and Related Agents. 4. Synthesis of the Disaccharide Subunit 2-O-(3-O-Carbamoyl-.alpha.-D-mannopyranosyl)-L-gulopyranose and Completion of the Total Synthesis of Bleomycin A2 Journal of the American Chemical Society. 116: 5647-5656. DOI: 10.1021/Ja00092A014  0.304
1994 Boger DL, Honda T, Dang Q. Total Synthesis of Bleomycin A2 and Related Agents. 2. Synthesis of (-)-Pyrimidoblamic Acid, epi-(+)-Pyrimidoblamic Acid, (+)-Desacetamidopyrimidoblamic Acid, and (-)-Descarboxamidopyrimidoblamic Acid Journal of the American Chemical Society. 116: 5619-5630. DOI: 10.1021/Ja00092A012  0.301
1994 Boger DL, Colletti SL, Honda T, Menezes RF. Total Synthesis of Bleomycin A2 and Related Agents. 1. Synthesis and DNA Binding Properties of the Extended C-Terminus: Tripeptide S, Tetrapeptide S, Pentapeptide S, and Related Agents Journal of the American Chemical Society. 116: 5607-5618. DOI: 10.1021/Ja00092A011  0.335
1994 Boger DL, Johnson DS, Yun W. (+)- and ent-(-)-duocarmycin SA and (+)- and ent-(-)-N-BOC-DSA DNA alkylation properties. Alkylation site models that accomodate the offset AT-rich adenine N3 alkylation selectivity of the enantiomeric agents Journal of the American Chemical Society. 116: 1635-1656. DOI: 10.1021/Ja00084A004  0.318
1994 Boger DL, Honda T, Menezes RF, Colletti SL, Dang Q, Yang W. Total syntheses of (+)-P-3A, epi-(-)-P-3A, and (-)-desacetamido P-3A Journal of the American Chemical Society. 116: 82-92. DOI: 10.1021/Ja00080A010  0.304
1993 Boger DL. Design, synthesis, and evaluation of DNA minor groove binding agents Pure and Applied Chemistry. 65: 1123-1132. DOI: 10.1351/Pac199365061123  0.349
1993 Boger DL, Zhou J. CDPI3-enediyne and CDPI3-EDTA conjugates: a new class of DNA cleaving agents The Journal of Organic Chemistry. 58: 3018-3024. DOI: 10.1021/Jo00063A019  0.329
1993 Boger DL, Corbett WL. 4.pi. Participation of 1-aza-1,3-butadienes in [4 + 2] cycloaddition reactions: intramolecular Diels-Alder reactions of .alpha.,.beta.-unsaturated N-sulfonylimines The Journal of Organic Chemistry. 58: 2068-2074. DOI: 10.1021/Jo00060A022  0.351
1993 Boger DL, Nomoto Y, Teegarden BR. Vancomycin and ristocetin models: synthesis via the Ullmann macrocyclization reaction The Journal of Organic Chemistry. 58: 1425-1433. DOI: 10.1021/Jo00058A024  0.402
1993 Boger DL, Chen JH. (-)-Sandramycin: total synthesis and preliminary DNA binding properties Journal of the American Chemical Society. 115: 11624-11625. DOI: 10.1021/Ja00077A082  0.327
1993 Boger DL, Zhou J. Total synthesis of (+)-Piperazinomycin Journal of the American Chemical Society. 115: 11426-11433. DOI: 10.1021/Ja00077A047  0.412
1993 Boger DL, Baldino CM. d,l- and meso-Isochrysohermidin: total synthesis and interstrand DNA crosslinking Journal of the American Chemical Society. 115: 11418-11425. DOI: 10.1021/Ja00077A046  0.399
1993 Boger DL, Cassidy KC, Nakahara S. Total synthesis of streptonigrone Journal of the American Chemical Society. 115: 10733-10741. DOI: 10.1021/Ja00076A035  0.409
1993 Boger DL, Yun W. Reversibility of the duocarmycin A and SA DNA alkylation reaction Journal of the American Chemical Society. 115: 9872-9873. DOI: 10.1021/Ja00074A093  0.324
1993 Boger DL, Machiya K, Hertzog DL, Kitos PA, Holmes D. Total synthesis and preliminary evaluation of (+)- and ent-(-)-duocarmycin SA Journal of the American Chemical Society. 115: 9025-9036. DOI: 10.1021/Ja00073A019  0.406
1993 Boger DL, Yohannes D, Zhou J, Patane MA. Total synthesis of cycloisodityrosine, RA-VII, deoxybouvardin, and N29-desmethyl-RA-VII: Identification of the pharmacophore and reversal of the subunit functional roles Journal of the American Chemical Society. 115: 3420-3430. DOI: 10.1021/Ja00062A004  0.664
1993 Boger DL, Yohannes D. K-13 and of4949: Evaluation of key partial structures and pharmacophore delineation Bioorganic & Medicinal Chemistry Letters. 3: 245-250. DOI: 10.1016/S0960-894X(01)80885-4  0.624
1993 Boger DL, Honda T. Studies on the synthesis of bleomycin A2: Observations on a diastereoselective imine addition reaction for C2-acetamido side chain introduction Tetrahedron Letters. 34: 1567-1570. DOI: 10.1016/0040-4039(93)85008-K  0.368
1993 Boger DL, Menezes RF, Honda T. Total Synthesis of(−)-Pyrimidoblamic Acid and Deglycobleomycin A2 Angewandte Chemie International Edition in English. 32: 273-275. DOI: 10.1002/Anie.199302731  0.304
1992 Boger DL, Menezes RF, Dang Q. Synthesis of desacetamidopyrimidoblamic acid and deglyco desacetamidobleomycin A2 The Journal of Organic Chemistry. 57: 4333-4336. DOI: 10.1021/Jo00042A004  0.392
1992 Boger DL, Menezes RF. Synthesis of tri- and tetrapeptide S: the extended C-terminus of bleomycin A2 The Journal of Organic Chemistry. 57: 4331-4333. DOI: 10.1021/Jo00042A003  0.326
1992 Boger DL, Zhang M. A concise synthesis of the fredericamycin A DEF ring system: [4 + 2] cycloaddition reactions of 1-aza-1,3-butadienes The Journal of Organic Chemistry. 57: 3974-3977. DOI: 10.1021/Jo00040A044  0.39
1992 Boger DL, Yun W, Teegarden BR. An improved synthesis of 1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (CBI): a simplified analog of the CC-1065 alkylation subunit The Journal of Organic Chemistry. 57: 2873-2876. DOI: 10.1021/Jo00036A023  0.37
1992 Boger DL, Curran TT. Synthesis of the lower subunit of rhizoxin Journal of Organic Chemistry. 57: 2235-2244. DOI: 10.1021/Jo00034A010  0.34
1992 Boger DL, Dang Q. Synthesis of desacetamido P-3A: 1,3,5-triazine .fwdarw. pyrimidine heteroaromatic azadiene Diels-Alder reaction The Journal of Organic Chemistry. 57: 1631-1633. DOI: 10.1021/Jo00032A001  0.365
1992 Boger DL, Mathvink RJ. Acyl radicals: intermolecular and intramolecular alkene addition reactions The Journal of Organic Chemistry. 57: 1429-1443. DOI: 10.1021/Jo00031A021  0.347
1992 Boger DL, Yohannes D, Myers JB. Synthesis of N29-desmethyl RA-VII. Identification of the pharmacophore of RA-I-VII and deoxybouvardin and reassignment of the subunit functional roles The Journal of Organic Chemistry. 57: 1319-1321. DOI: 10.1021/Jo00031A001  0.621
1992 Boger DL, Machiya K. Total synthesis of (+)-duocarmycin SA Journal of the American Chemical Society. 114: 10056-10058. DOI: 10.1021/Ja00051A045  0.363
1992 Boger DL, Palanki MSS. Functional analogs of CC-1065 and the duocarmycins incorporating the 9a-(chloromethyl)-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (C2BI) alkylation subunit: synthesis and preliminary DNA alkylation studies Journal of the American Chemical Society. 114: 9318-9327. DOI: 10.1021/Ja00050A012  0.372
1992 Boger DL, Munk SA. DNA alkylation properties of enhanced functional analogs of CC-1065 incorporating the 1,2,9,9a-tetrahydrocyclopropa[1,2-c]benz[1,2-e]indol-4-one (CBI) alkylation subunit Journal of the American Chemical Society. 114: 5487-5496. DOI: 10.1021/Ja00040A001  0.353
1992 Boger DL, Yun W, Terashima S, Fukuda Y, Nakatani K, Kitos PA, Jin Q. DNA alkylation properties of the duocarmycins: (+)-duocarmycin A, epi-(+)-duocarmycin A, ent-(−)-duocarmycin A and epi,ent-(−)-duocarmycin A Bioorganic & Medicinal Chemistry Letters. 2: 759-765. DOI: 10.1016/S0960-894X(00)80407-2  0.301
1991 Boger DL, Zarrinmayeh H, Munk SA, Kitos PA, Suntornwat O. Demonstration of a pronounced effect of noncovalent binding selectivity on the (+)-CC-1065 DNA alkylation and identification of the pharmacophore of the alkylation subunit. Proceedings of the National Academy of Sciences of the United States of America. 88: 1431-5. PMID 1847523 DOI: 10.1073/Pnas.88.4.1431  0.799
1991 Boger DL, Myers JB. Design and synthesis of a conformational analog of deoxybouvardin The Journal of Organic Chemistry. 56: 5385-5390. DOI: 10.1021/Jo00018A035  0.321
1991 Boger DL, Sakya SM, Yohannes D. Total synthesis of combretastatin D-2: intramolecular Ullmann macrocyclization reaction The Journal of Organic Chemistry. 56: 4204-4207. DOI: 10.1021/Jo00013A024  0.679
1991 Boger DL, Jacobson IC. Synthesis and preliminary evaluation of the fredericamycin A ABCDE ring system The Journal of Organic Chemistry. 56: 2115-2122. DOI: 10.1021/Jo00006A029  0.377
1991 Boger DL, Yohannes D. Intramolecular Ullmann condensation reaction: an effective approach to macrocyclic diaryl ethers The Journal of Organic Chemistry. 56: 1763-1767. DOI: 10.1021/Jo00005A020  0.666
1991 Boger DL, Nakahara S. Diels-Alder reactions of N-sulfonyl-1-aza-1,3-butadienes: development of a synthetic approach to the streptonigrone C ring The Journal of Organic Chemistry. 56: 880-884. DOI: 10.1021/Jo00002A077  0.361
1991 Boger DL, Zhang M. Total synthesis of (.+-.)-cis and (.+-.)-trans-Trikentrin A: Diels-Alder reactions of heteroaromatic azadienes Journal of the American Chemical Society. 113: 4230-4234. DOI: 10.1021/Ja00011A026  0.369
1991 Boger DL, Munk SA, Zarrinmayeh H. (+)-CC-1065 DNA alkylation: key studies demonstrating a noncovalent binding selectivity contribution to the alkylation selectivity Journal of the American Chemical Society. 113: 3980-3983. DOI: 10.1021/Ja00010A046  0.323
1991 Boger DL, Corbett WL, Curran TT, Kasper AM. Inverse electron-demand Diels-Alder reactions of N-sulfonyl .alpha.,.beta.-unsaturated imines: a general approach to implementation of the 4.pi. participation of 1-aza-1,3-butadienes in Diels-Alder reactions Journal of the American Chemical Society. 113: 1713-1729. DOI: 10.1021/Ja00005A040  0.345
1991 Boger DL, Yohannes D. Total synthesis of deoxybouvardin and RA-VII: macrocyclization via an intramolecular Ullmann reaction Journal of the American Chemical Society. 113: 1427-1429. DOI: 10.1021/Ja00004A062  0.666
1991 Boger DL, Ishizaki T, Zarrinmayeh H, Kitos PA, Suntornwat O. A potent, simple derivative of an analog of the CC-1065 alkylation subunit Bioorganic & Medicinal Chemistry Letters. 1: 55-58. DOI: 10.1016/S0960-894X(01)81090-8  0.349
1991 Boger DL, Myers JB, Yohannes D, Kitos PA, Suntomwat O, Kitos JC. Evaluation of bouvardin, deoxybouvardin, and RA-I - RA-VII partial structures: reassignment of the pharmacophore Bioorganic & Medicinal Chemistry Letters. 1: 313-316. DOI: 10.1016/S0960-894X(01)80815-5  0.598
1991 Boger DL, Ishizaki T, Sakya SM, Munk SA, Kitos PA, Jin Q, Besterman JM. Synthesis and preliminary evaluation of (+)-CBI-indole2: an enhanced functional analog of (+)-CC-1065 Bioorganic & Medicinal Chemistry Letters. 1: 115-120. DOI: 10.1016/S0960-894X(00)80243-7  0.384
1991 Boger DL, Munk SA, Zarrinmayeh H, Ishizaki T, Haught J, Bina M. An alternative and convenient strategy for generation of substantial quantities of singly 5′-32p-end-labeled double-stranded DNA for binding studies: Development of a protocol for examination of functional features of (+)-CC-1065 and the duocarmycins that contribute to their sequence-selective DNA alkylation properties Tetrahedron. 47: 2661-2682. DOI: 10.1016/S0040-4020(01)81798-1  0.366
1991 Boger DL, Zhu Y. Studies on the synthesis of rubrolone: 4π participation of O-alkyl α,β-unsaturated oximes in intramolecular [4 + 2] cycloaddition reactions Tetrahedron Letters. 32: 7643-7646. DOI: 10.1016/0040-4039(91)80554-J  0.334
1990 Boger DL, Invergo BJ, Coleman RS, Zarrinmayeh H, Kitos PA, Thompson SC, Leong T, McLaughlin LW. A demonstration of the intrinsic importance of stabilizing hydrophobic binding and non-covalent van der Waals contacts dominant in the non-covalent CC-1065/B-DNA binding. Chemico-Biological Interactions. 73: 29-52. PMID 2406033 DOI: 10.1016/0009-2797(90)90107-X  0.52
1990 Boger DL, Yohannes D. Design and Total Synthesis of a Conformational Analog of Bouvardin/Deoxybouvardin Synlett. 1990: 33-36. DOI: 10.1055/S-1990-20976  0.652
1990 Boger DL, Yohannes D. Total synthesis of L,L-isodityrosine and isodityrosine-derived agents: K-13, OF4949-III, and OF4949-IV The Journal of Organic Chemistry. 55: 6000-6017. DOI: 10.1021/Jo00311A019  0.674
1990 Boger DL, Ishizaki T, Kitos PA, Suntornwat O. Synthesis of N-(tert-butyloxycarbonyl)-CBI, CBI, CBI-CDPI1, and CBI-CDPI2: enhanced functional analogs of CC-1065 incorporating the 1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (CBI) left-hand subunit The Journal of Organic Chemistry. 55: 5823-5832. DOI: 10.1021/Jo00310A013  0.347
1990 Boger DL, Curran TT. Diels-Alder reactions of 1-aza-1,3-butadienes: room temperature, endo-selective LUMOdiene-controlled [4 + 2] cycloaddition reactions of N-sulfonyl-4-(ethoxycarbonyl)-1-aza-1,3-butadienes The Journal of Organic Chemistry. 55: 5439-5442. DOI: 10.1021/Jo00307A009  0.308
1990 Boger DL, Ishizaki T, Zarrinmayeh H, Kitos PA, Suntornwat O. Synthesis and preliminary evaluation of agents incorporating the pharmacophore of the duocarmycin/pyrindamycin alkylation subunit: identification of the CC-1065/duocarmycin common pharmacophore The Journal of Organic Chemistry. 55: 4499-4502. DOI: 10.1021/Jo00302A002  0.363
1990 Boger DL, Corbett WL, Wiggins JM. Room-temperature, endo-specific 1-aza-1,3-butadiene Diels-Alder reactions: acceleration of the LUMOdiene-controlled [4 + 2] cycloaddition reactions through noncomplementary aza diene substitution The Journal of Organic Chemistry. 55: 2999-3000. DOI: 10.1021/Jo00297A006  0.319
1990 Boger DL, Jacobson IC. Studies of the total synthesis of fredericamycin A. Preparation of key partial structures and development of an intermolecular alkyne-chromium carbene complex benzannulation cyclization approach to the ABCD(E) ring system The Journal of Organic Chemistry. 55: 1919-1928. DOI: 10.1021/Jo00293A043  0.374
1990 Boger DL, Zarrinmayeh H. Regiocontrolled nucleophilic addition to selectively activated p-quinone diimines: alternative preparation of a key intermediate employed in the preparation of the CC-1065 left-hand subunit The Journal of Organic Chemistry. 55: 1379-1390. DOI: 10.1021/Jo00291A059  0.326
1990 Boger DL, Ishizaki T, Zarrinmayeh H, Munk SA, Kitos PA, Suntornwat O. Duocarmycin-pyrindamycin DNA alkylation properties and identification, synthesis, and evaluation of agents incorporating the pharmacophore of the duocarmycin-pyrindamycin alkylation subunit. Identification of the CC-1065 duocarmycin common pharmacophore Journal of the American Chemical Society. 112: 8961-8971. DOI: 10.1021/Ja00180A048  0.362
1990 Boger DL, Coleman RS, Invergo BJ, Sakya SM, Ishizaki T, Munk SA, Zarrinmayeh H, Kitos PA, Thompson SC. Synthesis and evaluation of aborted and extended CC-1065 functional analogs: (+)- and (-)-CPI-PDE-I1, (+)- and (-)-CPI-CDPI1, and (.+-.)-, (+)-, and (-)-CPI-CDPI3. Preparation of key partial structures and definition of an additional functional role of the CC-1065 central and right-hand subunits Journal of the American Chemical Society. 112: 4623-4632. DOI: 10.1021/Ja00168A002  0.539
1990 Boger DL, Mathvink RJ. Intramolecular acyl radical-alkene addition reactions: macrocyclization reactions Journal of the American Chemical Society. 112: 4008-4011. DOI: 10.1021/Ja00166A044  0.316
1990 Boger DL, Ishizaki T. Resolution of a CBI precursor and incorporation into the synthesis of (+)-cbi, (+)-CBI-CDPI1, (+)-CBI-CDPI2: enhanced functional analogs of (+)-CC-1065. A critical appraisal of a proposed relationship between electrophile reactivity, DNA binding properties, and cytotoxic potency. Tetrahedron Letters. 31: 793-796. DOI: 10.1016/S0040-4039(00)94629-X  0.333
1990 BOGER DL, COLEMAN RS, INVERGO BJ, SAKYA SM, ISHIZAKI T, MUNK SA, ZARRINMAYEH H, KITOS PA, THOMPSON SC. ChemInform Abstract: Synthesis and Evaluation of Aborted and Extended CC-1065 Functional Analogues: (+)- and (-)-CPI-PDE-I1, (+)- and (-)-CPI-CDPI1, and (.+-.)-, (+)-, and (-)-CPI-CDPI3. Preparation of Key Partial Structures and Definition of an Additiona Cheminform. 21. DOI: 10.1002/chin.199040325  0.514
1990 BOGER DL, YOHANNES D. ChemInform Abstract: Design and Total Synthesis of a Conformational Analog (I) of Bouvardin/ Deoxybouvardin. Cheminform. 21. DOI: 10.1002/chin.199022267  0.625
1990 COLEMAN RS, BOGER DL. ChemInform Abstract: Natural and Synthetic Antitumor Agents: Synthetic Studies on CC-1065 and Functionally Related Agents Cheminform. 21. DOI: 10.1002/chin.199004341  0.448
1989 Boger DL, Yohannes D. Total synthesis of K-13 The Journal of Organic Chemistry. 54: 2498-2502. DOI: 10.1021/Jo00272A003  0.622
1989 Boger DL, Mathvink RJ. Phenyl selenoesters as effective precursors of acyl radicals for use in intermolecular alkene addition reactions The Journal of Organic Chemistry. 54: 1777-1779. DOI: 10.1021/Jo00269A001  0.324
1989 Boger DL, Wysocki RJ. A study of the scope of the [4 + 2] cycloaddition reactions of unactivated 1,3-oxazin-6-ones The Journal of Organic Chemistry. 54: 714-718. DOI: 10.1021/Jo00264A041  0.315
1989 Boger DL, Ishizaki T, Wysocki RJ, Munk SA, Kitos PA, Suntornwat O. Total synthesis and evaluation of (.+-.)-N-(tert-butoxycarbonyl)-CBI, (.+-.)-CBI-CDPI1, and (.+-.)-CBI-CDPI2: CC-1065 functional agents incorporating the equivalent 1,2,9,9a-tetrahydrocyclopropa[1,2-c]benz[1,2-e]indol-4-one (CBI) left-hand subunit Journal of the American Chemical Society. 111: 6461-6463. DOI: 10.1021/Ja00198A089  0.324
1989 Boger DL, Yohannes D. Synthesis of l,l-isodityrosine Tetrahedron Letters. 30: 2053-2056. DOI: 10.1016/S0040-4039(01)93709-8  0.654
1989 Boger DL, Jacobson IC. Studies on the total synthesis of fredericamycin A: Development of an intermolecular alkyne-chromium carbene complex cyclization approach to the ABCDE ring system Tetrahedron Letters. 30: 2037-2040. DOI: 10.1016/S0040-4039(01)93705-0  0.354
1989 Boger DL, Yohannes D. Total synthesis of OF4949-III and OF4949-IV: Unusual effects of remote substituents on the rate of macrocyclization reactions Tetrahedron Letters. 30: 5061-5064. DOI: 10.1016/S0040-4039(01)93447-1  0.682
1989 Boger DL. Diels–Alder Reactions of Heterocyclic Azadienes: Development of a Strategy for the Total Synthesis of Streptonigrin, Lavendamycin, and Synthetic Quinoline-5, 8-Quinones Strategies and Tactics in Organic Synthesis. 2: 1-56. DOI: 10.1016/B978-0-08-092429-8.50006-4  0.389
1989 BOGER DL, YOHANNES D. ChemInform Abstract: Synthesis of L,L-Isodityrosine (I). Cheminform. 20. DOI: 10.1002/chin.198948292  0.578
1989 BOGER DL, CERBONE LR, YOHANNES D. ChemInform Abstract: Oxidative Coupling of Methyl 6-Hydroxyindole-2-carboxylate with Primary Amines: Preparation of 2-Substituted Methyl Pyrrolo(2,3-e)benzoxazole-5-carboxylates. Cheminform. 20. DOI: 10.1002/chin.198915189  0.608
1988 Boger DL, Robarge KD. Divergent de novo synthesis of carbohydrates based on an accelerated inverse electron demand Diels-Alder reaction of 1-oxa-1,3-butadienes The Journal of Organic Chemistry. 53: 5793-5796. DOI: 10.1021/Jo00259A040  0.352
1988 Boger DL, Cerbone LR, Yohannes D. Oxidative coupling of methyl 6-hydroxyindole-2-carboxylate with primary amines. Preparation of 2-substituted methyl pyrrolo[2,3-e]benzoxazole-5-carboxylates The Journal of Organic Chemistry. 53: 5163-5166. DOI: 10.1021/Jo00256A053  0.639
1988 Boger DL, Sakya SM. Inverse electron demand Diels-Alder reactions of 3,6-bis(methylthio)-1,2,4,5-tetrazine. 1,2-Diazine introduction and direct implementation of a divergent 1,2,4,5-tetrazine .fwdarw. 1,2-diazine .fwdarw. benzene (indoline/indole) Diels-Alder strategy The Journal of Organic Chemistry. 53: 1415-1423. DOI: 10.1021/Jo00242A014  0.333
1988 Boger DL, Patel M. Total synthesis of prodigiosin, prodigiosene, and desmethoxyprodigiosin: Diels-Alder reactions of heterocyclic azadienes and development of an effective palladium(II)-promoted 2,2'-bipyrrole coupling procedure The Journal of Organic Chemistry. 53: 1405-1415. DOI: 10.1021/Jo00242A013  0.346
1988 Boger DL, Coleman RS. Total synthesis of (+)- and (-)-CPI-CDPI2: (+)-(3bR,4aS)- and (-)-(3bS,4aR)-deoxy-CC-1065 The Journal of Organic Chemistry. 53: 695-698. DOI: 10.1021/Jo00238A042  0.517
1988 Boger DL, Yohannes D. Studies on the total synthesis of bouvardin and deoxybouvardin: cyclic hexapeptide cyclization studies and preparation of key partial structures The Journal of Organic Chemistry. 53: 487-499. DOI: 10.1021/Jo00238A005  0.684
1988 Boger DL, Coleman RS. Total synthesis of (.+-.)-N2-(phenylsulfonyl)-CPI, (.+-.)-CC-1065, (+)-CC-1065, ent-(-)-CC-1065, and the precise, functional agents (.+-.)-CPI-CDPI2, (+)-CPI-CDPI2, and (-)-CPI-CDPI2 [(.+-.)-(3bR*,4aS*)-, (+)-(3bR,4aS)-, and (-)-(3bS,4aR)-deoxy-CC-1065] Journal of the American Chemical Society. 110: 4796-4807. DOI: 10.1021/Ja00222A043  0.533
1988 Boger DL, Coleman RS. Total synthesis of (+)-CC-1065 and ent-(-)-CC-1065 Journal of the American Chemical Society. 110: 1321-1323. DOI: 10.1021/Ja00212A067  0.558
1988 Boger DL, Dang Q. Inverse Electron Demand Diels-Alder Reactions of 2,4,6-Tris(ethoxycarbonyl)-l,3,5-triazine and 2,4,6-Tris(methylthio)-1,3,5-triazine: Pyrimidine Introduction Tetrahedron. 44: 3379-3390. DOI: 10.1016/S0040-4020(01)85973-1  0.338
1988 BOGER DL, COLEMAN RS. ChemInform Abstract: Total Synthesis of (.+-.)-N2-(Phenylsulfonyl)-CPI, (.+-.)-CC-1065, (+)-CC-1065, ent-(-)-CC-1065, and the Precise, Functional Agents (.+-.)-CPI-CDPI2, (+)-CPI-CDPI2, and (-)-CPI-CDPI2 ((.+-.)-(3bR*,4aS*)-, (+)-(3bR,4aS)-, and (-)-(3bS, Cheminform. 19. DOI: 10.1002/chin.198845327  0.458
1988 BOGER DL, COLEMAN RS. ChemInform Abstract: Total Synthesis of (+)- and (-)-CPI-CDPI2: (+)-(3bR,4aS)- and (-)-(3bS,4aR)-Deoxy-CC-1065. Cheminform. 19. DOI: 10.1002/chin.198825369  0.464
1988 BOGER DL, YOHANNES D. ChemInform Abstract: Studies on the Total Synthesis of Bouvardin and Deoxybouvardin: Cyclic Hexapeptide Cyclization Studies and Preparation of Key Partial Structures. Cheminform. 19. DOI: 10.1002/chin.198825336  0.656
1988 BOGER DL, COLEMAN RS. ChemInform Abstract: Total Synthesis of (+)-CC-1065 and ent-(-)-CC-1065. Cheminform. 19. DOI: 10.1002/chin.198823341  0.506
1988 BOGER DL, YOHANNES D. ChemInform Abstract: Selectively Protected L-Dopa Derivatives: Application of the Benzylic Hydroperoxide Rearrangement. Cheminform. 19. DOI: 10.1002/chin.198817324  0.594
1987 Boger DL, Yasuda M, Mitscher LA, Drake SD, Kitos PA, Thompson SC. Streptonigrin and lavendamycin partial structures. Probes for the minimum, potent pharmacophore of streptonigrin, lavendamycin, and synthetic quinoline-5,8-diones. Journal of Medicinal Chemistry. 30: 1918-28. PMID 3656364 DOI: 10.1021/Jm00393A040  0.349
1987 Boger DL, Patel M. Activation and coupling of pyrrole-1-carboxylic acid in the formation of pyrrole N-carbonyl compounds: pyrrole-1-carboxylic acid anhydride The Journal of Organic Chemistry. 52: 2319-2323. DOI: 10.1021/Jo00387A046  0.317
1987 Boger DL, Coleman RS, Invergo BJ. Studies on the total synthesis of CC-1065: preparation of a synthetic simplified 3-carbamoyl-1,2-dihydro-3H-pyrrolo[3,2-e]indole dimer/trimer/tetramer (CDPI dimer/trimer/tetramer) and development of methodology for PDE-I dimer methyl ester formation The Journal of Organic Chemistry. 52: 1521-1530. DOI: 10.1021/Jo00384A026  0.567
1987 Boger DL, Yohannes D. Selectively protected L-dopa derivatives: application of the benzylic hydroperoxide rearrangement The Journal of Organic Chemistry. 52: 5283-5286. DOI: 10.1021/Jo00232A044  0.622
1987 Boger DL, Patel M. Indole N-carbonyl compounds: preparation and coupling of indole-1-carboxylic acid anhydride The Journal of Organic Chemistry. 52: 3934-3936. DOI: 10.1021/Jo00226A044  0.323
1987 Boger DL, Coleman RS. Diels-Alder reactions of heterocyclic azadienes: total synthesis of PDE I, PDE II, and PDE I dimer methyl ester Journal of the American Chemical Society. 109: 2717-2727. DOI: 10.1021/Ja00243A027  0.578
1987 Boger DL, S. Coleman R. Further observations on the Lewis acid-catalyzed benzylic hydroperoxide rearrangement: use of a boron-trifluoride/ hydrogen peroxide preformed, aged reagent Tetrahedron Letters. 28: 1027-1030. DOI: 10.1016/S0040-4039(00)95902-1  0.335
1987 Boger DL, Patel M. Total synthesis of prodigiosin Tetrahedron Letters. 28: 2499-2502. DOI: 10.1016/S0040-4039(00)95451-0  0.401
1987 Yasuda M, Boger DL. Streptonigrin and lavendamycin partial structures. Preparation of 7-amino-2-(2′-pyridyl)quinoline-5,8-quinone-6′-carboxylic acid: A probe for the minimum, potent pharmacophore of the naturally occurring antitumor-antibiotics Journal of Heterocyclic Chemistry. 24: 1253-1260. DOI: 10.1002/Jhet.5570240504  0.357
1987 BOGER DL, COLEMAN RS, INVERGO BJ. ChemInform Abstract: Studies on the Total Synthesis of CC-1065: Preparation of a Synthetic, Simplified 3-Carbamoyl-1,2-dihydro-3H-pyrrolo(3,2-e)indole Dimer/Trimer/Tetramer (CDPI Dimer/Trimer/Tetramer), and Development of Methodology for PDE-I Dimer Methy Cheminform. 18. DOI: 10.1002/chin.198739337  0.499
1987 BOGER DL, COLEMAN RS. ChemInform Abstract: Diels-Alder Reactions of Heterocyclic Azadienes: Total Synthesis of PDE I (XVIIIa), PDE II (XVIIIb), and PDE I Dimer Methyl Ester (XX). Cheminform. 18. DOI: 10.1002/chin.198736345  0.528
1987 BOGER DL, COLEMAN RS. ChemInform Abstract: Further Observations on the Lewis Acid-Catalyzed Benzylic Hydroperoxide Rearrangement: Use of a Boron Trifluoride/Hydrogen Peroxide, Preformed, Aged Reagent. Cheminform. 18. DOI: 10.1002/chin.198734190  0.447
1987 BOGER DL, COLEMAN RS. ChemInform Abstract: Benzylic Hydroperoxide Rearrangement: Observations on a Viable and Convenient Alternative to the Baeyer-Villiger Rearrangement. Cheminform. 18. DOI: 10.1002/chin.198730108  0.479
1987 BOGER DL, COLEMAN RS. ChemInform Abstract: Diels-Alder Reactions of Heterocyclic Azadienes: Total Synthesis of PDE-II Methyl Ester. Cheminform. 18. DOI: 10.1002/chin.198705207  0.524
1986 Boger DL, Coleman RS. Benzylic hydroperoxide rearrangement: observations on a viable and convenient alternative to the Baeyer-Villiger rearrangement The Journal of Organic Chemistry. 51: 5436-5439. DOI: 10.1021/Jo00376A079  0.534
1986 Boger DL, Coleman RS. Diels-Alder reactions of heterocyclic azadienes: total synthesis of PDE-II methyl ester The Journal of Organic Chemistry. 51: 3250-3252. DOI: 10.1021/Jo00366A048  0.541
1986 Boger DL, Brotherton CE. Thermal reactions of cyclopropenone ketals. Application of the cycloaddition reactions of delocalized singlet vinylcarbenes: three-carbon 1,1-/1,3-dipoles. An alternative synthesis of deacetamidocolchiceine: formal total synthesis of colchicine Journal of the American Chemical Society. 108: 6713-6719. DOI: 10.1021/Ja00281A042  0.36
1986 Boger DL. Diels-Alder reactions of heterocyclic aza dienes. Scope and applications Chemical Reviews. 86: 781-793. DOI: 10.1021/Cr00075A004  0.32
1986 Boger DL, Patel M. Diels-Alder cycloadditions of rigid dienophiles: A probe for allylic axial substituent control of the pi-facial selectivity in the Diels-Alder reaction Tetrahedron Letters. 27: 683-686. DOI: 10.1016/S0040-4039(00)84072-1  0.351
1986 Boger DL, Brotherton CE. Diels-alder cycloaddition reactions of cyclopropenone ketals Tetrahedron. 42: 2777-2785. DOI: 10.1016/S0040-4020(01)90567-8  0.313
1986 BOGER DL, DUFF SR, PANEK JS, YASUDA M. ChemInform Abstract: Inverse Electron Demand Diels-Alder Reactions of Heterocyclic Aza Dienes. Chemischer Informationsdienst. 17. DOI: 10.1002/Chin.198629197  0.669
1986 BOGER DL, COLEMAN RS, PANEK JS, HUBER FX, SAUER J. ChemInform Abstract: A Detailed, Convenient Preparation of Dimethyl l,2,4,5-Tetrazine-3,6- dicarboxylate. Chemischer Informationsdienst. 17. DOI: 10.1002/chin.198622222  0.437
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