Dale L. Boger - Publications

Affiliations: 
Scripps Research Institute, La Jolla, La Jolla, CA, United States 
Area:
synthetic organic chemistry
Website:
http://www.scripps.edu/chem/boger/db.html

247 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Wu ZC, Isley NA, Okano A, Weiss WJ, Boger DL. C1-CBP-vancomycin: Impact of a Vancomycin C-Terminus Trimethylammonium Cation on Pharmacological Properties and Insights into Its Newly Introduced Mechanism of Action. The Journal of Organic Chemistry. PMID 31670958 DOI: 10.1021/acs.joc.9b02314  0.44
2019 Isley NA, Endo Y, Wu ZC, Covington BC, Bushin LB, Seyedsayamdost MR, Boger DL. Total Synthesis and Stereochemical Assignment of Streptide. Journal of the American Chemical Society. PMID 31577142 DOI: 10.1021/jacs.9b09067  0.44
2019 Plewe MB, Whitby LR, Naik S, Brown ER, Sokolova NV, Gantla VR, York J, Nunberg JH, Zhang L, Kalveram B, Freiberg AN, Boger DL, Henkel G, McCormack K. SAR studies of 4-acyl-1,6-dialkylpiperazin-2-one arenavirus cell entry inhibitors. Bioorganic & Medicinal Chemistry Letters. 126620. PMID 31537423 DOI: 10.1016/j.bmcl.2019.08.024  1
2019 Ozog S, Timberlake ND, Hermann K, Garijo O, Haworth KG, Shi G, Glinkerman CM, Schefter LE, D'Souza S, Simpson E, Sghia-Hughes G, Carillo RR, Boger DL, Kiem HP, Slukvin I, et al. Resveratrol trimer enhances gene delivery to hematopoietic stem cells by reducing antiviral restriction at endosomes. Blood. PMID 31416800 DOI: 10.1182/blood.2019000040  0.84
2019 Otrubova K, Chatterjee S, Ghimire S, Cravatt BF, Boger DL. N-Acyl pyrazoles: Effective and tunable inhibitors of serine hydrolases. Bioorganic & Medicinal Chemistry. PMID 30879861 DOI: 10.1016/j.bmc.2019.03.020  0.8
2019 Su L, Wang Y, Wang J, Mifune Y, Morin MD, Jones BT, Moresco EM, Boger DL, Beutler B, Zhang H. Structural basis of TLR2/TLR1 activation by the synthetic agonist Diprovocim. Journal of Medicinal Chemistry. PMID 30829478 DOI: 10.1021/acs.jmedchem.8b01583  0.52
2018 Morin MD, Wang Y, Jones BT, Mifune Y, Su L, Shi H, Moresco EMY, Zhang H, Beutler B, Boger DL. Diprovocims: A New and Exceptionally Potent Class of Toll-like Receptor Agonists. Journal of the American Chemical Society. PMID 30272974 DOI: 10.1021/jacs.8b09223  0.52
2018 Wang Y, Su L, Morin MD, Jones BT, Mifune Y, Shi H, Wang KW, Zhan X, Liu A, Wang J, Li X, Tang M, Ludwig S, Hildebrand S, Zhou K, ... ... Boger DL, et al. Adjuvant effect of the novel TLR1/TLR2 agonist Diprovocim synergizes with anti-PD-L1 to eliminate melanoma in mice. Proceedings of the National Academy of Sciences of the United States of America. PMID 30150374 DOI: 10.1073/pnas.1809232115  0.52
2018 Glinkerman CM, Boger DL. Synthesis, Characterization, and Rapid Cycloadditions of 5-Nitro-1,2,3-triazine. Organic Letters. PMID 29659291 DOI: 10.1021/acs.orglett.8b00825  0.84
2017 Lukesh JC, Carney DW, Dong H, Cross RM, Shukla V, Duncan KK, Yang S, Brody DM, Brütsch MM, Radakovic A, Boger DL. Vinblastine 20' Amides: Synthetic Analogues That Maintain or Improve Potency and Simultaneously Overcome Pgp-Derived Efflux and Resistance. Journal of Medicinal Chemistry. PMID 28857558 DOI: 10.1021/acs.jmedchem.7b00958  0.68
2017 Quiñones RE, Glinkerman CM, Zhu K, Boger DL. Direct Synthesis of β-Aminoenals through Reaction of 1,2,3-Triazine with Secondary Amines. Organic Letters. PMID 28657329 DOI: 10.1021/acs.orglett.7b01543  0.84
2017 Okano A, Isley NA, Boger DL. Peripheral modifications of [Ψ[CH2NH]Tpg(4)]vancomycin with added synergistic mechanisms of action provide durable and potent antibiotics. Proceedings of the National Academy of Sciences of the United States of America. PMID 28559345 DOI: 10.1073/pnas.1704125114  0.44
2017 Allemann O, Cross RM, Brütsch MM, Radakovic A, Boger DL. Key analogs of a uniquely potent synthetic vinblastine that contain modifications of the C20' ethyl substituent. Bioorganic & Medicinal Chemistry Letters. PMID 28551101 DOI: 10.1016/j.bmcl.2017.05.058  0.36
2017 Kornahrens AF, Cognetta AB, Brody DM, Matthews ML, Cravatt BF, Boger DL. Design of Benzoxathiazin-3-one 1,1-Dioxides as a New Class of Irreversible Serine Hydrolase Inhibitors: Discovery of a Uniquely Selective PNPLA4 Inhibitor. Journal of the American Chemical Society. PMID 28498651 DOI: 10.1021/jacs.7b02985  0.8
2017 Okano A, Isley NA, Boger DL. Total Syntheses of Vancomycin-Related Glycopeptide Antibiotics and Key Analogues. Chemical Reviews. PMID 28437097 DOI: 10.1021/acs.chemrev.6b00820  0.44
2017 Yang S, Sankar K, Skepper CK, Barker TJ, Lukesh JC, Brody DM, Brütsch MM, Boger DL. Total synthesis of a key series of vinblastines modified at C4 that define the importance and surprising trends in activity. Chemical Science. 8: 1560-1569. PMID 28194270 DOI: 10.1039/C6SC04146A  0.48
2016 Glinkerman CM, Boger DL. Catalysis of Heterocyclic Azadiene Cycloaddition Reactions by Solvent Hydrogen Bonding: Concise Total Synthesis of Methoxatin. Journal of the American Chemical Society. PMID 27571404 DOI: 10.1021/jacs.6b05438  0.84
2016 Carney DW, Lukesh JC, Brody DM, Brütsch MM, Boger DL. Ultrapotent vinblastines in which added molecular complexity further disrupts the target tubulin dimer-dimer interface. Proceedings of the National Academy of Sciences of the United States of America. PMID 27512044 DOI: 10.1073/pnas.1611405113  0.48
2016 Allemann O, Brutsch M, Lukesh JC, Brody DM, Boger DL. Synthesis of a Potent Vinblastine: Rationally Designed Added Benign Complexity. Journal of the American Chemical Society. PMID 27356080 DOI: 10.1021/jacs.6b04330  0.48
2016 Chanda PB, Boyle KE, Brody DM, Shukla V, Boger DL. Synthesis and evaluation of duocarmycin SA analogs incorporating the methyl 1,2,8,8a-tetrahydrocyclopropa[c]imidazolo[4,5-e]indol-4-one-6-carboxylate (CImI) alkylation subunit. Bioorganic & Medicinal Chemistry. PMID 27221071 DOI: 10.1016/j.bmc.2016.04.050  1
2016 Shankar S, Whitby LR, Casquilho-Gray HE, York J, Boger DL, Nunberg JH. Small-molecule fusion inhibitors bind the pH-sensing SSP-GP2 subunit interface of the Lassa virus envelope glycoprotein. Journal of Virology. PMID 27194767 DOI: 10.1128/JVI.00597-16  0.44
2016 Morin MD, Wang Y, Jones BT, Su L, Surakattula MM, Berger M, Huang H, Beutler EK, Zhang H, Beutler B, Boger DL. Discovery and Structure-Activity Relationships of the Neoseptins: A New Class of Toll-like Receptor-4 (TLR4) Agonists. Journal of Medicinal Chemistry. PMID 27050713 DOI: 10.1021/acs.jmedchem.6b00177  0.52
2016 Wang Y, Su L, Morin MD, Jones BT, Whitby LR, Surakattula MM, Huang H, Shi H, Choi JH, Wang KW, Moresco EM, Berger M, Zhan X, Zhang H, Boger DL, et al. TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS. Proceedings of the National Academy of Sciences of the United States of America. PMID 26831104 DOI: 10.1073/pnas.1525639113  1
2016 Sears JE, Boger DL. Tandem Intramolecular Diels-Alder/1,3-Dipolar Cycloaddition Cascade of 1,3,4-Oxadiazoles: Initial Scope and Applications. Accounts of Chemical Research. PMID 26813287 DOI: 10.1021/acs.accounts.5b00510  1
2015 Janssen FJ, Baggelaar MP, Hummel JJ, Overkleeft HS, Cravatt BF, Boger DL, van der Stelt M. Comprehensive Analysis of Structure Activity Relationships of α-Ketoheterocycles as sn-1-Diacylglycerol Lipase α Inhibitors. Journal of Medicinal Chemistry. PMID 26584396 DOI: 10.1021/acs.jmedchem.5b01627  0.8
2015 Boger DL. ORGANIC SYNTHESIS. When sugar is not so sweet. Science (New York, N.Y.). 350: 275-6. PMID 26472893 DOI: 10.1126/science.aad3298  1
2015 Sears JE, Barker TJ, Boger DL. Total Synthesis of (-)-Vindoline and (+)-4-epi-Vindoline Based on a 1,3,4-Oxadiazole Tandem Intramolecular [4 + 2]/[3 + 2] Cycloaddition Cascade Initiated by an Allene Dienophile. Organic Letters. 17: 5460-3. PMID 26457536 DOI: 10.1021/acs.orglett.5b02818  1
2015 Lee K, Poudel YB, Glinkerman CM, Boger DL. Total synthesis of dihydrolysergic acid and dihydrolysergol: development of a divergent synthetic strategy applicable to rapid assembly of D-ring analogs. Tetrahedron. 71: 5897-5905. PMID 26273113 DOI: 10.1016/j.tet.2015.05.093  1
2015 Glinkerman CM, Boger DL. Cycloadditions of 1,2,3-Triazines Bearing C5-Electron Donating Substituents: Robust Pyrimidine Synthesis. Organic Letters. PMID 26172042 DOI: 10.1021/acs.orglett.5b01870  1
2015 Lee K, Boger DL. Total synthesis of (-)-kopsinine and ent-(+)-kopsinine. Tetrahedron. 71: 3741-3746. PMID 26074629 DOI: 10.1016/j.tet.2014.07.094  1
2015 Uematsu M, Brody DM, Boger DL. A five-membered lactone prodrug of CBI-based analogs of the duocarmycins. Tetrahedron Letters. 56: 3101-3104. PMID 26069351 DOI: 10.1016/j.tetlet.2014.11.038  1
2015 Okano A, Nakayama A, Wu K, Lindsey EA, Schammel AW, Feng Y, Collins KC, Boger DL. Total syntheses and initial evaluation of [Ψ[C(═S)NH]Tpg⁴]vancomycin, [Ψ[C(═NH)NH]Tpg⁴]vancomycin, [Ψ[CH₂NH]Tpg⁴]vancomycin, and their (4-chlorobiphenyl)methyl derivatives: synergistic binding pocket and peripheral modifications for the glycopeptide antibiotics. Journal of the American Chemical Society. 137: 3693-704. PMID 25750995 DOI: 10.1021/jacs.5b01008  1
2015 Sears JE, Boger DL. Total synthesis of vinblastine, related natural products, and key analogues and development of inspired methodology suitable for the systematic study of their structure-function properties. Accounts of Chemical Research. 48: 653-62. PMID 25586069 DOI: 10.1021/ar500400w  1
2015 Zhao N, Darby CM, Small J, Bachovchin DA, Jiang X, Burns-Huang KE, Botella H, Ehrt S, Boger DL, Anderson ED, Cravatt BF, Speers AE, Fernandez-Vega V, Hodder PS, Eberhart C, et al. Target-based screen against a periplasmic serine protease that regulates intrabacterial pH homeostasis in Mycobacterium tuberculosis. Acs Chemical Biology. 10: 364-71. PMID 25457457 DOI: 10.1021/cb500746z  0.8
2015 Lee K, Poudel YB, Glinkerman CM, Boger DL. Total synthesis of dihydrolysergic acid and dihydrolysergol: Development of a divergent synthetic strategy applicable to rapid assembly of D-ring analogs Tetrahedron. DOI: 10.1016/j.tet.2015.05.093  1
2014 Uematsu M, Boger DL. Asymmetric synthesis of a CBI-based cyclic N-acyl O-amino phenol duocarmycin prodrug. The Journal of Organic Chemistry. 79: 9699-703. PMID 25247380 DOI: 10.1021/jo501839x  1
2014 Anderson ED, Duerfeldt AS, Zhu K, Glinkerman CM, Boger DL. Cycloadditions of noncomplementary substituted 1,2,3-triazines. Organic Letters. 16: 5084-7. PMID 25222918 DOI: 10.1021/ol502436n  1
2014 Okano A, Nakayama A, Schammel AW, Boger DL. Total synthesis of [Ψ[C(═NH)NH]Tpg(4)]vancomycin and its (4-chlorobiphenyl)methyl derivative: impact of peripheral modifications on vancomycin analogues redesigned for dual D-Ala-D-Ala and D-Ala-D-Lac binding. Journal of the American Chemical Society. 136: 13522-5. PMID 25211770 DOI: 10.1021/ja507009a  1
2014 Otrubova K, Srinivasan V, Boger DL. Discovery libraries targeting the major enzyme classes: the serine hydrolases. Bioorganic & Medicinal Chemistry Letters. 24: 3807-13. PMID 25037918 DOI: 10.1016/j.bmcl.2014.06.063  1
2014 Nakayama A, Okano A, Feng Y, Collins JC, Collins KC, Walsh CT, Boger DL. Enzymatic glycosylation of vancomycin aglycon: completion of a total synthesis of vancomycin and N- and C-terminus substituent effects of the aglycon substrate. Organic Letters. 16: 3572-5. PMID 24954524 DOI: 10.1021/ol501568t  1
2014 Sanchez-Cespedes J, Moyer CL, Whitby LR, Boger DL, Nemerow GR. Inhibition of adenovirus replication by a trisubstituted piperazin-2-one derivative. Antiviral Research. 108: 65-73. PMID 24907427 DOI: 10.1016/j.antiviral.2014.05.010  1
2014 Duncan KK, Otrubova K, Boger DL. α-Ketoheterocycle inhibitors of fatty acid amide hydrolase: exploration of conformational constraints in the acyl side chain. Bioorganic & Medicinal Chemistry. 22: 2763-70. PMID 24690529 DOI: 10.1016/j.bmc.2014.03.013  1
2014 Lee K, Boger DL. Total syntheses of (-)-kopsifoline D and (-)-deoxoapodine: divergent total synthesis via late-stage key strategic bond formation. Journal of the American Chemical Society. 136: 3312-7. PMID 24499015 DOI: 10.1021/ja500548e  1
2014 Otrubova K, Cravatt BF, Boger DL. Design, synthesis, and characterization of α-ketoheterocycles that additionally target the cytosolic port Cys269 of fatty acid amide hydrolase. Journal of Medicinal Chemistry. 57: 1079-89. PMID 24456116 DOI: 10.1021/jm401820q  1
2014 Dreyton CJ, Anderson ED, Subramanian V, Boger DL, Thompson PR. Insights into the mechanism of streptonigrin-induced protein arginine deiminase inactivation. Bioorganic & Medicinal Chemistry. 22: 1362-9. PMID 24440480 DOI: 10.1016/j.bmc.2013.12.064  1
2014 Duerfeldt AS, Boger DL. Total syntheses of (-)-pyrimidoblamic acid and P-3A. Journal of the American Chemical Society. 136: 2119-25. PMID 24410439 DOI: 10.1021/ja412298c  1
2013 Barker TJ, Duncan KK, Otrubova K, Boger DL. Potent Vinblastine C20' Ureas Displaying Additionally Improved Activity Against a Vinblastine-Resistant Cancer Cell Line. Acs Medicinal Chemistry Letters. 4. PMID 24223237 DOI: 10.1021/ml400281w  1
2013 Campbell EL, Skepper CK, Sankar K, Duncan KK, Boger DL. Transannular Diels-Alder/1,3-dipolar cycloaddition cascade of 1,3,4-oxadiazoles: total synthesis of a unique set of vinblastine analogues. Organic Letters. 15: 5306-9. PMID 24087969 DOI: 10.1021/ol402549n  1
2013 Wolfe AL, Duncan KK, Lajiness JP, Zhu K, Duerfeldt AS, Boger DL. A fundamental relationship between hydrophobic properties and biological activity for the duocarmycin class of DNA-alkylating antitumor drugs: hydrophobic-binding-driven bonding. Journal of Medicinal Chemistry. 56: 6845-57. PMID 23944748 DOI: 10.1021/jm400665c  1
2013 Gochin M, Whitby LR, Phillips AH, Boger DL. NMR-assisted computational studies of peptidomimetic inhibitors bound in the hydrophobic pocket of HIV-1 glycoprotein 41. Journal of Computer-Aided Molecular Design. 27: 569-82. PMID 23893342 DOI: 10.1007/s10822-013-9662-6  1
2013 Pinchman JR, Boger DL. Investigation into the functional impact of the vancomycin C-ring aryl chloride. Bioorganic & Medicinal Chemistry Letters. 23: 4817-9. PMID 23880541 DOI: 10.1016/j.bmcl.2013.06.080  1
2013 Connelly S, DeMartino JK, Boger DL, Wilson IA. Biological and structural evaluation of 10R- and 10S-methylthio-DDACTHF reveals a new role for sulfur in inhibition of glycinamide ribonucleotide transformylase. Biochemistry. 52: 5133-44. PMID 23869564 DOI: 10.1021/bi4005182  1
2013 Vielhauer GA, Swink M, Parelkar NK, Lajiness JP, Wolfe AL, Boger D. Evaluation of a reductively activated duocarmycin prodrug against murine and human solid cancers. Cancer Biology & Therapy. 14: 527-36. PMID 23760495 DOI: 10.4161/cbt.24348  1
2013 Wolfe AL, Duncan KK, Parelkar NK, Brown D, Vielhauer GA, Boger DL. Efficacious cyclic N-acyl O-amino phenol duocarmycin prodrugs. Journal of Medicinal Chemistry. 56: 4104-15. PMID 23627265 DOI: 10.1021/jm400413r  1
2013 Pinchman JR, Boger DL. Probing the role of the vancomycin e-ring aryl chloride: selective divergent synthesis and evaluation of alternatively substituted E-ring analogues. Journal of Medicinal Chemistry. 56: 4116-24. PMID 23617725 DOI: 10.1021/jm4004494  1
2013 Otrubova K, Brown M, McCormick MS, Han GW, O'Neal ST, Cravatt BF, Stevens RC, Lichtman AH, Boger DL. Rational design of fatty acid amide hydrolase inhibitors that act by covalently bonding to two active site residues. Journal of the American Chemical Society. 135: 6289-99. PMID 23581831 DOI: 10.1021/ja4014997  1
2013 Turner TC, Shibayama K, Boger DL. Hypervalent iodine(III)-promoted intermolecular C-C coupling of vindoline with β-ketoesters and related substrates. Organic Letters. 15: 1100-3. PMID 23421318 DOI: 10.1021/ol400135n  1
2013 Xie J, Wolfe AL, Boger DL. Total synthesis of kopsinine. Organic Letters. 15: 868-70. PMID 23391149 DOI: 10.1021/ol303573f  1
2013 Breazzano SP, Poudel YB, Boger DL. A Pd(0)-mediated indole (macro)cyclization reaction. Journal of the American Chemical Society. 135: 1600-6. PMID 23298368 DOI: 10.1021/ja3121394  1
2013 Schleicher KD, Sasaki Y, Tam A, Kato D, Duncan KK, Boger DL. Total synthesis and evaluation of vinblastine analogues containing systematic deep-seated modifications in the vindoline subunit ring system: core redesign. Journal of Medicinal Chemistry. 56: 483-95. PMID 23252481 DOI: 10.1021/jm3014376  1
2013 Leggans EK, Duncan KK, Barker TJ, Schleicher KD, Boger DL. A remarkable series of vinblastine analogues displaying enhanced activity and an unprecedented tubulin binding steric tolerance: C20' urea derivatives. Journal of Medicinal Chemistry. 56: 628-39. PMID 23244701 DOI: 10.1021/jm3015684  1
2012 Barker TJ, Boger DL. Fe(III)/NaBH4-mediated free radical hydrofluorination of unactivated alkenes. Journal of the American Chemical Society. 134: 13588-91. PMID 22860624 DOI: 10.1021/ja3063716  1
2012 Gotoh H, Sears JE, Eschenmoser A, Boger DL. New insights into the mechanism and an expanded scope of the Fe(III)-mediated vinblastine coupling reaction. Journal of the American Chemical Society. 134: 13240-3. PMID 22856867 DOI: 10.1021/ja306229x  1
2012 Whitby LR, Boger DL. Comprehensive peptidomimetic libraries targeting protein-protein interactions. Accounts of Chemical Research. 45: 1698-709. PMID 22799570 DOI: 10.1021/ar300025n  1
2012 Wolfe AL, Duncan KK, Parelkar NK, Weir SJ, Vielhauer GA, Boger DL. A novel, unusually efficacious duocarmycin carbamate prodrug that releases no residual byproduct. Journal of Medicinal Chemistry. 55: 5878-86. PMID 22650244 DOI: 10.1021/jm300330b  1
2012 Otrubova K, Boger DL. α-Ketoheterocycle-based Inhibitors of Fatty Acid Amide Hydrolase (FAAH). Acs Chemical Neuroscience. 3: 340-348. PMID 22639704 DOI: 10.1021/cn2001206  1
2012 Okano A, James RC, Pierce JG, Xie J, Boger DL. Silver(I)-promoted conversion of thioamides to amidines: divergent synthesis of a key series of vancomycin aglycon residue 4 amidines that clarify binding behavior to model ligands. Journal of the American Chemical Society. 134: 8790-3. PMID 22568755 DOI: 10.1021/ja302808p  1
2012 Lajiness JP, Jiang W, Boger DL. Divergent total syntheses of (-)-aspidospermine and (+)-spegazzinine. Organic Letters. 14: 2078-81. PMID 22480368 DOI: 10.1021/ol300599p  1
2012 Whitby LR, Boyle KE, Cai L, Yu X, Gochin M, Boger DL. Discovery of HIV fusion inhibitors targeting gp41 using a comprehensive α-helix mimetic library. Bioorganic & Medicinal Chemistry Letters. 22: 2861-5. PMID 22424973 DOI: 10.1016/j.bmcl.2012.02.062  1
2012 Boger D. Bryostatin analog: Improving on Nature's design Oncotarget. 3: 116-117. PMID 22416072  1
2012 Leggans EK, Barker TJ, Duncan KK, Boger DL. Iron(III)/NaBH4-mediated additions to unactivated alkenes: synthesis of novel 20'-vinblastine analogues. Organic Letters. 14: 1428-31. PMID 22369097 DOI: 10.1021/ol300173v  1
2012 James RC, Pierce JG, Okano A, Xie J, Boger DL. Redesign of glycopeptide antibiotics: back to the future. Acs Chemical Biology. 7: 797-804. PMID 22330049 DOI: 10.1021/cb300007j  1
2012 Xie J, Okano A, Pierce JG, James RC, Stamm S, Crane CM, Boger DL. Total synthesis of [Ψ[C(═S)NH]Tpg4]vancomycin aglycon, [Ψ[C(═NH)NH]Tpg4]vancomycin aglycon, and related key compounds: reengineering vancomycin for dual D-Ala-D-Ala and D-Ala-D-Lac binding. Journal of the American Chemical Society. 134: 1284-97. PMID 22188323 DOI: 10.1021/ja209937s  1
2012 Booker L, Kinsey SG, Abdullah RA, Blankman JL, Long JZ, Ezzili C, Boger DL, Cravatt BF, Lichtman AH. The fatty acid amide hydrolase (FAAH) inhibitor PF-3845 acts in the nervous system to reverse LPS-induced tactile allodynia in mice. British Journal of Pharmacology. 165: 2485-96. PMID 21506952 DOI: 10.1111/j.1476-5381.2011.01445.x  1
2011 Gotoh H, Duncan KK, Robertson WM, Boger DL. 10'-Fluorovinblastine and 10'-Fluorovincristine: Synthesis of a Key Series of Modified Vinca Alkaloids. Acs Medicinal Chemistry Letters. 2: 948-952. PMID 22247789 DOI: 10.1021/ml200236a  1
2011 Breazzano SP, Boger DL. Synthesis and stereochemical determination of complestatin A and B (neuroprotectin A and B). Journal of the American Chemical Society. 133: 18495-502. PMID 21991993 DOI: 10.1021/ja208570q  1
2011 Boger DL. Tetrahedron Young Investigator Award 2011: Carolyn R. Bertozzi. Bioorganic & Medicinal Chemistry Letters. 21: 4944. PMID 21840475 DOI: 10.1016/j.bmcl.2011.08.013  1
2011 Xie J, Pierce JG, James RC, Okano A, Boger DL. A redesigned vancomycin engineered for dual D-Ala-D-ala And D-Ala-D-Lac binding exhibits potent antimicrobial activity against vancomycin-resistant bacteria. Journal of the American Chemical Society. 133: 13946-9. PMID 21823662 DOI: 10.1021/ja207142h  1
2011 Otrubova K, Ezzili C, Boger DL. The discovery and development of inhibitors of fatty acid amide hydrolase (FAAH). Bioorganic & Medicinal Chemistry Letters. 21: 4674-85. PMID 21764305 DOI: 10.1016/j.bmcl.2011.06.096  1
2011 Anderson ED, Boger DL. Inverse electron demand Diels-Alder reactions of 1,2,3-triazines: pronounced substituent effects on reactivity and cycloaddition scope. Journal of the American Chemical Society. 133: 12285-92. PMID 21736324 DOI: 10.1021/ja204856a  1
2011 Whitby LR, Ando Y, Setola V, Vogt PK, Roth BL, Boger DL. Design, synthesis, and validation of a β-turn mimetic library targeting protein-protein and peptide-receptor interactions. Journal of the American Chemical Society. 133: 10184-94. PMID 21609016 DOI: 10.1021/ja201878v  1
2011 Anderson ED, Boger DL. Scope of the inverse electron demand Diels-Alder reactions of 1,2,3-triazine. Organic Letters. 13: 2492-4. PMID 21488676 DOI: 10.1021/ol2007428  1
2011 Ezzili C, Mileni M, McGlinchey N, Long JZ, Kinsey SG, Hochstatter DG, Stevens RC, Lichtman AH, Cravatt BF, Bilsky EJ, Boger DL. Reversible competitive α-ketoheterocycle inhibitors of fatty acid amide hydrolase containing additional conformational constraints in the acyl side chain: orally active, long-acting analgesics. Journal of Medicinal Chemistry. 54: 2805-22. PMID 21428410 DOI: 10.1021/jm101597x  1
2011 Mileni M, Garfunkle J, Ezzili C, Cravatt BF, Stevens RC, Boger DL. Fluoride-mediated capture of a noncovalent bound state of a reversible covalent enzyme inhibitor: X-ray crystallographic analysis of an exceptionally potent α-ketoheterocycle inhibitor of fatty acid amide hydrolase. Journal of the American Chemical Society. 133: 4092-100. PMID 21355555 DOI: 10.1021/ja110877y  1
2011 Lajiness JP, Boger DL. Asymmetric synthesis of 1,2,9,9a-tetrahydrocyclopropa[c]benzo[e]indol-4-one (CBI). The Journal of Organic Chemistry. 76: 583-7. PMID 21192653 DOI: 10.1021/jo102136w  1
2011 Thomas CJ, Casquilho-Gray HE, York J, DeCamp DL, Dai D, Petrilli EB, Boger DL, Slayden RA, Amberg SM, Sprang SR, Nunberg JH. A specific interaction of small molecule entry inhibitors with the envelope glycoprotein complex of the Junín hemorrhagic fever arenavirus. The Journal of Biological Chemistry. 286: 6192-200. PMID 21159779 DOI: 10.1074/jbc.M110.196428  1
2010 Lajiness JP, Robertson WM, Dunwiddie I, Broward MA, Vielhauer GA, Weir SJ, Boger DL. Design, synthesis, and evaluation of duocarmycin O-amino phenol prodrugs subject to tunable reductive activation. Journal of Medicinal Chemistry. 53: 7731-8. PMID 20942408 DOI: 10.1021/jm1010397  1
2010 Tam A, Gotoh H, Robertson WM, Boger DL. Catharanthine C16 substituent effects on the biomimetic coupling with vindoline: preparation and evaluation of a key series of vinblastine analogues. Bioorganic & Medicinal Chemistry Letters. 20: 6408-10. PMID 20932748 DOI: 10.1016/j.bmcl.2010.09.091  1
2010 Ambrus G, Whitby LR, Singer EL, Trott O, Choi E, Olson AJ, Boger DL, Gerace L. Small molecule peptidomimetic inhibitors of importin α/β mediated nuclear transport. Bioorganic & Medicinal Chemistry. 18: 7611-20. PMID 20869252 DOI: 10.1016/j.bmc.2010.08.038  1
2010 Crane CM, Pierce JG, Leung SS, Tirado-Rives J, Jorgensen WL, Boger DL. Synthesis and evaluation of selected key methyl ether derivatives of vancomycin aglycon. Journal of Medicinal Chemistry. 53: 7229-35. PMID 20853900 DOI: 10.1021/jm100946e  1
2010 Lajiness JP, Boger DL. Synthesis and characterization of a cyclobutane duocarmycin derivative incorporating the 1,2,10,11-tetrahydro-9H-cyclobuta[c]benzo[e]indol-4-one (CbBI) alkylation subunit. Journal of the American Chemical Society. 132: 13936-40. PMID 20839806 DOI: 10.1021/ja106986f  1
2010 Ezzili C, Otrubova K, Boger DL. Fatty acid amide signaling molecules. Bioorganic & Medicinal Chemistry Letters. 20: 5959-68. PMID 20817522 DOI: 10.1016/j.bmcl.2010.08.048  1
2010 Sasaki Y, Kato D, Boger DL. Asymmetric total synthesis of vindorosine, vindoline, and key vinblastine analogues. Journal of the American Chemical Society. 132: 13533-44. PMID 20809620 DOI: 10.1021/ja106284s  1
2010 Burke CP, Swingle MR, Honkanen RE, Boger DL. Total synthesis and evaluation of phostriecin and key structural analogues. The Journal of Organic Chemistry. 75: 7505-13. PMID 20669916 DOI: 10.1021/jo1010203  1
2010 Patel PR, Boger DL. Intramolecular Diels-Alder reactions of cyclopropenone ketals. Organic Letters. 12: 3540-3. PMID 20614867 DOI: 10.1021/ol101375a  1
2010 Patel PR, Boger DL. Intramolecular [1 + 2] and [3 + 2] cycloaddition reactions of cyclopropenone ketals. Journal of the American Chemical Society. 132: 8527-9. PMID 20527885 DOI: 10.1021/ja103933n  1
2010 Va P, Campbell EL, Robertson WM, Boger DL. Total synthesis and evaluation of a key series of C5-substituted vinblastine derivatives. Journal of the American Chemical Society. 132: 8489-95. PMID 20518465 DOI: 10.1021/ja1027748  1
2010 Chang MW, Giffin MJ, Muller R, Savage J, Lin YC, Hong S, Jin W, Whitby LR, Elder JH, Boger DL, Torbett BE. Identification of broad-based HIV-1 protease inhibitors from combinatorial libraries. The Biochemical Journal. 429: 527-32. PMID 20507280 DOI: 10.1042/BJ20091645  1
2010 Shimamura H, Breazzano SP, Garfunkle J, Kimball FS, Trzupek JD, Boger DL. Total synthesis of complestatin: development of a Pd(0)-mediated indole annulation for macrocyclization. Journal of the American Chemical Society. 132: 7776-83. PMID 20469945 DOI: 10.1021/ja102304p  1
2010 Robertson WM, Kastrinsky DB, Hwang I, Boger DL. Synthesis and evaluation of a series of C5'-substituted duocarmycin SA analogs. Bioorganic & Medicinal Chemistry Letters. 20: 2722-5. PMID 20381346 DOI: 10.1016/j.bmcl.2010.03.078  1
2010 Kato D, Sasaki Y, Boger DL. Asymmetric total synthesis of vindoline. Journal of the American Chemical Society. 132: 3685-7. PMID 20187641 DOI: 10.1021/ja910695e  1
2010 Boyle KE, MacMillan KS, Ellis DA, Lajiness JP, Robertson WM, Boger DL. Synthesis and evaluation of duocarmycin SA analogs incorporating the methyl 1,2,8,8a-tetrahydrocyclopropa[c]oxazolo[2,3-e]indol-4-one-6-carboxylate (COI) alkylation subunit. Bioorganic & Medicinal Chemistry Letters. 20: 1854-7. PMID 20171886 DOI: 10.1016/j.bmcl.2010.01.145  1
2010 Campbell EL, Zuhl AM, Liu CM, Boger DL. Total synthesis of (+)-fendleridine (aspidoalbidine) and (+)-1-acetylaspidoalbidine. Journal of the American Chemical Society. 132: 3009-12. PMID 20148585 DOI: 10.1021/ja908819q  1
2010 Oakdale JS, Boger DL. Total synthesis of lycogarubin C and lycogalic acid. Organic Letters. 12: 1132-4. PMID 20148525 DOI: 10.1021/ol100146b  1
2010 Burke CP, Haq N, Boger DL. Total synthesis, assignment of the relative and absolute stereochemistry, and structural reassignment of phostriecin (aka Sultriecin). Journal of the American Chemical Society. 132: 2157-9. PMID 20108904 DOI: 10.1021/ja9097252  1
2010 Mileni M, Garfunkle J, Ezzili C, Kimball FS, Cravatt BF, Stevens RC, Boger DL. X-ray crystallographic analysis of alpha-ketoheterocycle inhibitors bound to a humanized variant of fatty acid amide hydrolase. Journal of Medicinal Chemistry. 53: 230-40. PMID 19924997 DOI: 10.1021/jm9012196  1
2009 Clark RC, Lee SY, Hwang I, Searcey M, Boger DL. Evaluation of Chlorofusin, its Seven Chromophore Diastereomers, and Key Analogues. Tetrahedron Letters. 50: 3151-3153. PMID 20161293 DOI: 10.1016/j.tetlet.2009.01.081  1
2009 Gauss CM, Hamasaki A, Parrish JP, Macmillan KS, Rayl TJ, Hwang I, Boger DL. Synthesis and Preliminary Evaluation of Duocarmycin Analogues Incorporating the 1,2,11,11a-Tetrahydrocyclopropa[c]naphtho[2,3-e]indol-4-one (CNI) and 1,2,11,11a-Tetrahydrocyclopropa[c]naphtho[1,2-e]indol-4-one (iso-CNI) Alkylation Subunits. Tetrahedron. 65: 6591-6599. PMID 20161204 DOI: 10.1016/j.tet.2009.02.065  1
2009 Lee SY, Boger DL. Synthesis of the Chlorofusin Cyclic Peptide. Tetrahedron. 65: 3281-3284. PMID 20047009 DOI: 10.1016/j.tet.2008.09.029  1
2009 MacMillan KS, Lajiness JP, Cara CL, Romagnoli R, Robertson WM, Hwang I, Baraldi PG, Boger DL. Synthesis and evaluation of a thio analogue of duocarmycin SA. Bioorganic & Medicinal Chemistry Letters. 19: 6962-5. PMID 19879753 DOI: 10.1016/j.bmcl.2009.10.063  1
2009 Garfunkle J, Kimball FS, Trzupek JD, Takizawa S, Shimamura H, Tomishima M, Boger DL. Total synthesis of chloropeptin II (complestatin) and chloropeptin I. Journal of the American Chemical Society. 131: 16036-8. PMID 19839632 DOI: 10.1021/ja907193b  1
2009 Shi J, Stover JS, Whitby LR, Vogt PK, Boger DL. Small molecule inhibitors of Myc/Max dimerization and Myc-induced cell transformation. Bioorganic & Medicinal Chemistry Letters. 19: 6038-41. PMID 19800226 DOI: 10.1016/j.bmcl.2009.09.044  1
2009 Fang X, Nam J, Shin D, Rew Y, Boger DL, Walker S. Functional and biochemical analysis of a key series of ramoplanin analogues. Bioorganic & Medicinal Chemistry Letters. 19: 6189-91. PMID 19783144 DOI: 10.1016/j.bmcl.2009.09.001  1
2009 Mileni M, Garfunkle J, DeMartino JK, Cravatt BF, Boger DL, Stevens RC. Binding and inactivation mechanism of a humanized fatty acid amide hydrolase by alpha-ketoheterocycle inhibitors revealed from cocrystal structures. Journal of the American Chemical Society. 131: 10497-506. PMID 19722626 DOI: 10.1021/ja902694n  1
2009 Clark RC, Lee SY, Searcey M, Boger DL. The isolation, total synthesis and structure elucidation of chlorofusin, a natural product inhibitor of the p53-mDM2 protein-protein interaction. Natural Product Reports. 26: 465-77. PMID 19642417 DOI: 10.1039/b821676b  1
2009 MacMillan KS, Boger DL. Fundamental relationships between structure, reactivity, and biological activity for the duocarmycins and CC-1065. Journal of Medicinal Chemistry. 52: 5771-80. PMID 19639994 DOI: 10.1021/jm9006214  1
2009 Swingle MR, Amable L, Lawhorn BG, Buck SB, Burke CP, Ratti P, Fischer KL, Boger DL, Honkanen RE. Structure-activity relationship studies of fostriecin, cytostatin, and key analogs, with PP1, PP2A, PP5, and( beta12-beta13)-chimeras (PP1/PP2A and PP5/PP2A), provide further insight into the inhibitory actions of fostriecin family inhibitors. The Journal of Pharmacology and Experimental Therapeutics. 331: 45-53. PMID 19592665 DOI: 10.1124/jpet.109.155630  1
2009 Kinsey SG, Long JZ, O'Neal ST, Abdullah RA, Poklis JL, Boger DL, Cravatt BF, Lichtman AH. Blockade of endocannabinoid-degrading enzymes attenuates neuropathic pain. The Journal of Pharmacology and Experimental Therapeutics. 330: 902-10. PMID 19502530 DOI: 10.1124/jpet.109.155465  1
2009 Hauschild KE, Stover JS, Boger DL, Ansari AZ. CSI-FID: high throughput label-free detection of DNA binding molecules. Bioorganic & Medicinal Chemistry Letters. 19: 3779-82. PMID 19435662 DOI: 10.1016/j.bmcl.2009.04.097  1
2009 Whitby LR, Lee AM, Kunz S, Oldstone MB, Boger DL. Characterization of lassa virus cell entry inhibitors: determination of the active enantiomer by asymmetric synthesis. Bioorganic & Medicinal Chemistry Letters. 19: 3771-4. PMID 19428249 DOI: 10.1016/j.bmcl.2009.04.098  1
2009 Shaginian A, Whitby LR, Hong S, Hwang I, Farooqi B, Searcey M, Chen J, Vogt PK, Boger DL. Design, synthesis, and evaluation of an alpha-helix mimetic library targeting protein-protein interactions. Journal of the American Chemical Society. 131: 5564-72. PMID 19334711 DOI: 10.1021/ja810025g  1
2009 Ishikawa H, Colby DA, Seto S, Va P, Tam A, Kakei H, Rayl TJ, Hwang I, Boger DL. Total synthesis of vinblastine, vincristine, related natural products, and key structural analogues. Journal of the American Chemical Society. 131: 4904-16. PMID 19292450 DOI: 10.1021/ja809842b  1
2009 Stover JS, Shi J, Jin W, Vogt PK, Boger DL. Discovery of inhibitors of aberrant gene transcription from Libraries of DNA binding molecules: inhibition of LEF-1-mediated gene transcription and oncogenic transformation. Journal of the American Chemical Society. 131: 3342-8. PMID 19216569 DOI: 10.1021/ja809083d  1
2009 Crane CM, Boger DL. Synthesis and evaluation of vancomycin aglycon analogues that bear modifications in the N-terminal D-leucyl amino acid. Journal of Medicinal Chemistry. 52: 1471-6. PMID 19209892 DOI: 10.1021/jm801549b  1
2009 Schlosburg JE, Boger DL, Cravatt BF, Lichtman AH. Endocannabinoid modulation of scratching response in an acute allergenic model: a new prospective neural therapeutic target for pruritus. The Journal of Pharmacology and Experimental Therapeutics. 329: 314-23. PMID 19168707 DOI: 10.1124/jpet.108.150136  1
2009 MacMillan KS, Nguyen T, Nguyen T, Hwang I, Boger DL. Total synthesis and evaluation of iso-duocarmycin SA and iso-yatakemycin. Journal of the American Chemical Society. 131: 1187-94. PMID 19154178 DOI: 10.1021/ja808108q  1
2009 Ishikawa H, Boger DL. Total synthesis of vindoline and related alkaloids Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry. 67: 123-133.  1
2008 MacMillan KS, Boger DL. An additional spirocyclization for duocarmycin SA. Journal of the American Chemical Society. 130: 16521-3. PMID 19554689 DOI: 10.1021/ja806593w  1
2008 Clark RC, Lee SY, Boger DL. Total synthesis of chlorofusin, its seven chromophore diastereomers, and key partial structures. Journal of the American Chemical Society. 130: 12355-69. PMID 18712872 DOI: 10.1021/ja8012819  1
2008 DeMartino JK, Hwang I, Connelly S, Wilson IA, Boger DL. Asymmetric synthesis of inhibitors of glycinamide ribonucleotide transformylase. Journal of Medicinal Chemistry. 51: 5441-8. PMID 18686942 DOI: 10.1021/jm800555h  1
2008 Slaymaker IM, Bracey M, Mileni M, Garfunkle J, Cravatt BF, Boger DL, Stevens RC. Correlation of inhibitor effects on enzyme activity and thermal stability for the integral membrane protein fatty acid amide hydrolase. Bioorganic & Medicinal Chemistry Letters. 18: 5847-50. PMID 18644727 DOI: 10.1016/j.bmcl.2008.06.086  1
2008 DeMartino JK, Garfunkle J, Hochstatter DG, Cravatt BF, Boger DL. Exploration of a fundamental substituent effect of alpha-ketoheterocycle enzyme inhibitors: Potent and selective inhibitors of fatty acid amide hydrolase. Bioorganic & Medicinal Chemistry Letters. 18: 5842-6. PMID 18639454 DOI: 10.1016/j.bmcl.2008.06.084  1
2008 Garfunkle J, Ezzili C, Rayl TJ, Hochstatter DG, Hwang I, Boger DL. Optimization of the central heterocycle of alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase. Journal of Medicinal Chemistry. 51: 4392-403. PMID 18630870 DOI: 10.1021/jm800136b  1
2008 Lee AM, Rojek JM, Spiropoulou CF, Gundersen AT, Jin W, Shaginian A, York J, Nunberg JH, Boger DL, Oldstone MB, Kunz S. Unique small molecule entry inhibitors of hemorrhagic fever arenaviruses. The Journal of Biological Chemistry. 283: 18734-42. PMID 18474596 DOI: 10.1074/jbc.M802089200  1
2008 Tichenor MS, Boger DL. Yatakemycin: total synthesis, DNA alkylation, and biological properties. Natural Product Reports. 25: 220-6. PMID 18389136 DOI: 10.1039/b705665f  1
2008 Lu X, Vogt PK, Boger DL, Lunec J. Disruption of the MYC transcriptional function by a small-molecule antagonist of MYC/MAX dimerization. Oncology Reports. 19: 825-30. PMID 18288422  1
2008 Kimball FS, Romero FA, Ezzili C, Garfunkle J, Rayl TJ, Hochstatter DG, Hwang I, Boger DL. Optimization of alpha-ketooxazole inhibitors of fatty acid amide hydrolase. Journal of Medicinal Chemistry. 51: 937-47. PMID 18247553 DOI: 10.1021/jm701210y  1
2008 Ishikawa H, Colby DA, Boger DL. Direct coupling of catharanthine and vindoline to provide vinblastine: total synthesis of (+)- and ent-(-)-vinblastine. Journal of the American Chemical Society. 130: 420-1. PMID 18081297 DOI: 10.1021/ja078192m  1
2008 Jessica K, DeMartino, Boger DL. Glycinamide ribonucleotide transformylase (GAR TFase) as a target for cancer therapy Drugs of the Future. 33: 969-979. DOI: 10.1358/dof.2008.33.11.1247542  1
2008 Di Micco S, Boger DL, Riccio R, Bifulco G. Structural features of the (+)-yatakemycin/d(GACTAATTGAC)-(GTCAATTAGTC) complex - Quantum mechanical calculation of NMR parameters as a tool for the characterization of ligand/DNA interactions European Journal of Organic Chemistry. 2454-2462. DOI: 10.1002/ejoc.200701212  1
2007 Jin W, Trzupek JD, Rayl TJ, Broward MA, Vielhauer GA, Weir SJ, Hwang I, Boger DL. A unique class of duocarmycin and CC-1065 analogues subject to reductive activation. Journal of the American Chemical Society. 129: 15391-7. PMID 18020335 DOI: 10.1021/ja075398e  1
2007 Tichenor MS, MacMillan KS, Stover JS, Wolkenberg SE, Pavani MG, Zanella L, Zaid AN, Spalluto G, Rayl TJ, Hwang I, Baraldi PG, Boger DL. Rational design, synthesis, and evaluation of key analogues of CC-1065 and the duocarmycins. Journal of the American Chemical Society. 129: 14092-9. PMID 17948994 DOI: 10.1021/ja073989z  1
2007 Tichenor MS, MacMillan KS, Trzupek JD, Rayl TJ, Hwang I, Boger DL. Systematic exploration of the structural features of yatakemycin impacting DNA alkylation and biological activity. Journal of the American Chemical Society. 129: 10858-69. PMID 17691783 DOI: 10.1021/ja072777z  1
2007 Lee SY, Clark RC, Boger DL. Total synthesis, stereochemical reassignment, and absolute configuration of chlorofusin. Journal of the American Chemical Society. 129: 9860-1. PMID 17637057 DOI: 10.1021/ja073264v  1
2007 Nam J, Shin D, Rew Y, Boger DL. Alanine scan of [L-Dap(2)]ramoplanin A2 aglycon: assessment of the importance of each residue. Journal of the American Chemical Society. 129: 8747-55. PMID 17592838 DOI: 10.1021/ja068573k  1
2007 Hardouin C, Kelso MJ, Romero FA, Rayl TJ, Leung D, Hwang I, Cravatt BF, Boger DL. Structure-activity relationships of alpha-ketooxazole inhibitors of fatty acid amide hydrolase. Journal of Medicinal Chemistry. 50: 3359-68. PMID 17559203 DOI: 10.1021/jm061414r  1
2007 Xu L, Chong Y, Hwang I, D'Onofrio A, Amore K, Beardsley GP, Li C, Olson AJ, Boger DL, Wilson IA. Structure-based design, synthesis, evaluation, and crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase. The Journal of Biological Chemistry. 282: 13033-46. PMID 17324932 DOI: 10.1074/jbc.M607293200  1
2007 Eubanks LM, Hixon MS, Jin W, Hong S, Clancy CM, Tepp WH, Baldwin MR, Malizio CJ, Goodnough MC, Barbieri JT, Johnson EA, Boger DL, Dickerson TJ, Janda KD. An in vitro and in vivo disconnect uncovered through high-throughput identification of botulinum neurotoxin A antagonists. Proceedings of the National Academy of Sciences of the United States of America. 104: 2602-7. PMID 17293454 DOI: 10.1073/pnas.0611213104  1
2007 Romero FA, Du W, Hwang I, Rayl TJ, Kimball FS, Leung D, Hoover HS, Apodaca RL, Breitenbucher JG, Cravatt BF, Boger DL. Potent and selective alpha-ketoheterocycle-based inhibitors of the anandamide and oleamide catabolizing enzyme, fatty acid amide hydrolase. Journal of Medicinal Chemistry. 50: 1058-68. PMID 17279740 DOI: 10.1021/jm0611509  1
2007 Ishikawa H, Boger DL. Total synthesis of (-)- and ent-(+)-4-desacetoxy-5-desethylvindoline Heterocycles. 72: 95-102.  1
2006 Lawhorn BG, Boga SB, Wolkenberg SE, Colby DA, Gauss CM, Swingle MR, Amable L, Honkanen RE, Boger DL. Total synthesis and evaluation of cytostatin, its C10-C11 diastereomers, and additional key analogues: impact on PP2A inhibition. Journal of the American Chemical Society. 128: 16720-32. PMID 17177422 DOI: 10.1021/ja066477d  1
2006 Tichenor MS, Trzupek JD, Kastrinsky DB, Shiga F, Hwang I, Boger DL. Asymmetric total synthesis of (+)- and ent-(-)-yatakemycin and duocarmycin SA: evaluation of yatakemycin key partial structures and its unnatural enantiomer. Journal of the American Chemical Society. 128: 15683-96. PMID 17147378 DOI: 10.1021/ja064228j  1
2006 Romero FA, Hwang I, Boger DL. Delineation of a fundamental alpha-ketoheterocycle substituent effect for use in the design of enzyme inhibitors. Journal of the American Chemical Society. 128: 14004-5. PMID 17061864 DOI: 10.1021/ja064522b  1
2006 Schnermann MJ, Romero FA, Hwang I, Nakamaru-Ogiso E, Yagi T, Boger DL. Total synthesis of piericidin A1 and B1 and key analogues. Journal of the American Chemical Society. 128: 11799-807. PMID 16953619 DOI: 10.1021/ja0632862  1
2006 Ishikawa H, Elliott GI, Velcicky J, Choi Y, Boger DL. Total synthesis of (-)- and ent-(+)-vindoline and related alkaloids. Journal of the American Chemical Society. 128: 10596-612. PMID 16895428 DOI: 10.1021/ja061256t  1
2006 Elliott GI, Fuchs JR, Blagg BS, Ishikawa H, Tao H, Yuan ZQ, Boger DL. Intramolecular diels-alder/1,3-dipolar cycloaddition cascade of 1,3,4-oxadiazoles. Journal of the American Chemical Society. 128: 10589-95. PMID 16895427 DOI: 10.1021/ja0612549  1
2006 DeMartino JK, Hwang I, Xu L, Wilson IA, Boger DL. Discovery of a potent, nonpolyglutamatable inhibitor of glycinamide ribonucleotide transformylase. Journal of Medicinal Chemistry. 49: 2998-3002. PMID 16686541 DOI: 10.1021/jm0601147  1
2006 Crowley BM, Boger DL. Total synthesis and evaluation of [Psi[CH2NH]Tpg4]vancomycin aglycon: reengineering vancomycin for dual D-Ala-D-Ala and D-Ala-D-Lac binding. Journal of the American Chemical Society. 128: 2885-92. PMID 16506767 DOI: 10.1021/ja0572912  1
2006 Clark RC, Pfeiffer SS, Boger DL. Diastereoselective Diels-Alder reactions of N-sulfonyl-1-aza-1,3-butadienes with optically active enol ethers: an asymmetric variant of the 1-azadiene Diels-Alder reaction. Journal of the American Chemical Society. 128: 2587-93. PMID 16492042 DOI: 10.1021/ja0571646  1
2006 Trzupek JD, Gottesfeld JM, Boger DL. Alkylation of duplex DNA in nucleosome core particles by duocarmycin SA and yatakemycin. Nature Chemical Biology. 2: 79-82. PMID 16415862 DOI: 10.1038/nchembio761  1
2006 Hamasaki A, Ducray R, Boger DL. Two novel 1,2,4,5-tetrazines that participate in inverse electron demand Diels-Alder reactions with an unexpected regioselectivity. The Journal of Organic Chemistry. 71: 185-93. PMID 16388634 DOI: 10.1021/jo051832o  1
2006 Elliott GI, Velcicky J, Ishikawa H, Li Y, Boger DL. Total synthesis of (-)- and ent-(+)-vindorosine: tandem intramolecular Diels-Alder/1,3-dipolar cycloaddition of 1,3,4-oxadiazoles. Angewandte Chemie (International Ed. in English). 45: 620-2. PMID 16355429 DOI: 10.1002/anie.200503024  1
2006 Lawhorn BG, Boga SB, Wolkenberg SE, Boger DL. Total synthesis of cytostatin Heterocycles. 70: 65-70.  1
2005 Tse WC, Boger DL. A fluorescent intercalator displacement assay for establishing DNA binding selectivity and affinity. Current Protocols in Nucleic Acid Chemistry / Edited by Serge L. Beaucage ... [Et Al.]. Unit 8.5. PMID 18428943 DOI: 10.1002/0471142700.nc0805s20  1
2005 Guimarães CR, Boger DL, Jorgensen WL. Elucidation of fatty acid amide hydrolase inhibition by potent alpha-ketoheterocycle derivatives from Monte Carlo simulations. Journal of the American Chemical Society. 127: 17377-84. PMID 16332087 DOI: 10.1021/ja055438j  1
2005 Schnermann MJ, Boger DL. Total synthesis of piericidin A1 and B1. Journal of the American Chemical Society. 127: 15704-5. PMID 16277503 DOI: 10.1021/ja055041f  1
2005 Choi Y, Ishikawa H, Velcicky J, Elliott GI, Miller MM, Boger DL. Total synthesis of (-)- and ent-(+)-vindoline. Organic Letters. 7: 4539-42. PMID 16178578 DOI: 10.1021/ol051975x  1
2005 Hamasaki A, Zimpleman JM, Hwang I, Boger DL. Total synthesis of ningalin D. Journal of the American Chemical Society. 127: 10767-70. PMID 16045367 DOI: 10.1021/ja0526416  1
2005 Capps KJ, Humiston J, Dominique R, Hwang I, Boger DL. Discovery of AICAR Tfase inhibitors that disrupt requisite enzyme dimerization. Bioorganic & Medicinal Chemistry Letters. 15: 2840-4. PMID 15911265 DOI: 10.1016/j.bmcl.2005.03.094  1
2005 Chou TC, Guan Y, Soenen DR, Danishefsky SJ, Boger DL. Potent reversal of multidrug resistance by ningalins and its use in drug combinations against human colon carcinoma xenograft in nude mice. Cancer Chemotherapy and Pharmacology. 56: 379-90. PMID 15875185 DOI: 10.1007/s00280-005-1019-y  1
2005 Cheng H, Hwang I, Chong Y, Tavassoli A, Webb ME, Zhang Y, Wilson IA, Benkovic SJ, Boger DL. Synthesis and biological evaluation of N-[4-[5-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-2-(2,2,2-trifluoroacetyl)pentyl]benzoyl]-L-glutamic acid as a potential inhibitor of GAR Tfase and the de novo purine biosynthetic pathway. Bioorganic & Medicinal Chemistry. 13: 3593-9. PMID 15848772 DOI: 10.1016/j.bmc.2004.11.049  1
2005 Chong Y, Hwang I, Tavassoli A, Zhang Y, Wilson IA, Benkovic SJ, Boger DL. Synthesis and biological evaluation of alpha- and gamma-carboxamide derivatives of 10-CF3CO-DDACTHF. Bioorganic & Medicinal Chemistry. 13: 3587-92. PMID 15848771 DOI: 10.1016/j.bmc.2004.11.050  1
2005 Cheng H, Chong Y, Hwang I, Tavassoli A, Zhang Y, Wilson IA, Benkovic SJ, Boger DL. Design, synthesis, and biological evaluation of 10-methanesulfonyl-DDACTHF, 10-methanesulfonyl-5-DACTHF, and 10-methylthio-DDACTHF as potent inhibitors of GAR Tfase and the de novo purine biosynthetic pathway. Bioorganic & Medicinal Chemistry. 13: 3577-85. PMID 15848770 DOI: 10.1016/j.bmc.2004.12.004  1
2005 Boger DL, Miyauchi H, Du W, Hardouin C, Fecik RA, Cheng H, Hwang I, Hedrick MP, Leung D, Acevedo O, Guimarães CR, Jorgensen WL, Cravatt BF. Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics. Journal of Medicinal Chemistry. 48: 1849-56. PMID 15771430 DOI: 10.1021/jm049614v  1
2005 Leung D, Du W, Hardouin C, Cheng H, Hwang I, Cravatt BF, Boger DL. Discovery of an exceptionally potent and selective class of fatty acid amide hydrolase inhibitors enlisting proteome-wide selectivity screening: concurrent optimization of enzyme inhibitor potency and selectivity. Bioorganic & Medicinal Chemistry Letters. 15: 1423-8. PMID 15713400 DOI: 10.1016/j.bmcl.2004.12.085  1
2005 Yuan ZQ, Ishikawa H, Boger DL. Total synthesis of natural (+)- [corrected] and ent-(-)-4-desacetoxy-6,7-dihydrovindorosine [corrected] and natural and ent-minovine: oxadiazole tandem intramolecular Diels-Alder/1,3-dipolar cycloaddition reaction. Organic Letters. 7: 741-4. PMID 15704939 DOI: 10.1021/ol050017s  1
2005 Walker S, Chen L, Hu Y, Rew Y, Shin D, Boger DL. Chemistry and biology of ramoplanin: a lipoglycodepsipeptide with potent antibiotic activity. Chemical Reviews. 105: 449-76. PMID 15700952 DOI: 10.1021/cr030106n  1
2005 Du W, Hardouin C, Cheng H, Hwang I, Boger DL. Heterocyclic sulfoxide and sulfone inhibitors of fatty acid amide hydrolase. Bioorganic & Medicinal Chemistry Letters. 15: 103-6. PMID 15582420 DOI: 10.1016/j.bmcl.2004.10.025  1
2004 Tse WC, Boger DL. Sequence-selective DNA recognition: natural products and nature's lessons. Chemistry & Biology. 11: 1607-17. PMID 15610844 DOI: 10.1016/j.chembiol.2003.08.012  1
2004 Tao H, Hwang I, Boger DL. Multidrug resistance reversal activity of permethyl ningalin B amide derivatives. Bioorganic & Medicinal Chemistry Letters. 14: 5979-81. PMID 15546712 DOI: 10.1016/j.bmcl.2004.10.002  1
2004 Parrish JP, Trzupek JD, Hughes TV, Hwang I, Boger DL. Synthesis and evaluation of N-aryl and N-alkenyl CBI derivatives. Bioorganic & Medicinal Chemistry. 12: 5845-56. PMID 15498660 DOI: 10.1016/j.bmc.2004.08.032  1
2004 Lee PS, Du W, Boger DL, Jorgensen WL. Energetic preferences for alpha,beta versus beta,gamma unsaturation. The Journal of Organic Chemistry. 69: 5448-53. PMID 15287795 DOI: 10.1021/jo049363y  1
2004 Ham YW, Boger DL. A powerful selection assay for mixture libraries of DNA alkylating agents. Journal of the American Chemical Society. 126: 9194-5. PMID 15281804 DOI: 10.1021/ja0477930  1
2004 Lillo AM, Sun C, Gao C, Ditzel H, Parrish J, Gauss CM, Moss J, Felding-Habermann B, Wirsching P, Boger DL, Janda KD. A human single-chain antibody specific for integrin alpha3beta1 capable of cell internalization and delivery of antitumor agents. Chemistry & Biology. 11: 897-906. PMID 15271348 DOI: 10.1016/j.chembiol.2004.04.018  1
2004 Tichenor MS, Kastrinsky DB, Boger DL. Total synthesis, structure revision, and absolute configuration of (+)-yatakemycin. Journal of the American Chemical Society. 126: 8396-8. PMID 15237994 DOI: 10.1021/ja0472735  1
2004 Lichtman AH, Leung D, Shelton CC, Saghatelian A, Hardouin C, Boger DL, Cravatt BF. Reversible inhibitors of fatty acid amide hydrolase that promote analgesia: evidence for an unprecedented combination of potency and selectivity. The Journal of Pharmacology and Experimental Therapeutics. 311: 441-8. PMID 15229230 DOI: 10.1124/jpet.104.069401  1
2004 Chen L, Yuan Y, Helm JS, Hu Y, Rew Y, Shin D, Boger DL, Walker S. Dissecting ramoplanin: mechanistic analysis of synthetic ramoplanin analogues as a guide to the design of improved antibiotics. Journal of the American Chemical Society. 126: 7462-3. PMID 15198592 DOI: 10.1021/ja047879t  1
2004 Shin D, Rew Y, Boger DL. Total synthesis and structure of the ramoplanin A1 and A3 aglycons: two minor components of the ramoplanin complex. Proceedings of the National Academy of Sciences of the United States of America. 101: 11977-9. PMID 15175429 DOI: 10.1073/pnas.0401419101  1
2004 Crowley BM, Mori Y, McComas CC, Tang D, Boger DL. Total synthesis of the ristocetin aglycon. Journal of the American Chemical Society. 126: 4310-7. PMID 15053621 DOI: 10.1021/ja039795a  1
2004 Kastrinsky DB, Boger DL. Effective asymmetric synthesis of 1,2,9,9a-tetrahydrocyclopropa[c]benzo[e]indol-4-one (CBI). The Journal of Organic Chemistry. 69: 2284-9. PMID 15049620 DOI: 10.1021/jo035465x  1
2004 Rew Y, Shin D, Hwang I, Boger DL. Total synthesis and examination of three key analogues of ramoplanin: a lipoglycodepsipeptide with potent antibiotic activity. Journal of the American Chemical Society. 126: 1041-3. PMID 14746470 DOI: 10.1021/ja039671y  1
2004 Tse WC, Boger DL. A fluorescent intercalator displacement assay for establishing DNA binding selectivity and affinity. Accounts of Chemical Research. 37: 61-9. PMID 14730995 DOI: 10.1021/ar030113y  1
2004 Parrish JP, Hughes TV, Hwang I, Boger DL. Establishing the Parabolic Relationship between Reactivity and Activity for Derivatives and Analogues of the Duocarmycin and CC-1065 Alkylation Subunits Journal of the American Chemical Society. 126: 80-81. PMID 14709069  1
2003 Desai P, Pfeiffer SS, Boger DL. Synthesis of the chlorofusin cyclic peptide: assignment of the asparagine stereochemistry. Organic Letters. 5: 5047-50. PMID 14682761 DOI: 10.1021/ol036083g  1
2003 Buck SB, Hardouin C, Ichikawa S, Soenen DR, Gauss CM, Hwang I, Swingle MR, Bonness KM, Honkanen RE, Boger DL. Fundamental role of the fostriecin unsaturated lactone and implications for selective protein phosphatase inhibition. Journal of the American Chemical Society. 125: 15694-5. PMID 14677930 DOI: 10.1021/ja038672n  1
2003 Bassarello C, Cimino P, Bifulco G, Boger DL, Smith JA, Chazin WJ, Gomez-Paloma L. NMR Structure of the (+)-CPI-indole/d(GACTAATTGAC)-d(GTCAATTAGTC) Covalent Complex Chembiochem. 4: 1188-1193. PMID 14613110 DOI: 10.1002/cbic.200300642  1
2003 McComas CC, Crowley BM, Hwang I, Boger DL. Synthesis and evaluation of methyl ether derivatives of the vancomycin, teicoplanin, and ristocetin aglycon methyl esters. Bioorganic & Medicinal Chemistry Letters. 13: 2933-6. PMID 14611861 DOI: 10.1016/S0960-894X(03)00513-4  1
2003 Parrish JP, Kastrinsky DB, Hwang I, Boger DL. Synthesis and evaluation of duocarmycin and CC-1065 analogues incorporating the 1,2,9,9a-tetrahydrocyclopropa[c]benz[e]-3-azaindol-4-one (CBA) alkylation subunit. The Journal of Organic Chemistry. 68: 8984-90. PMID 14604371 DOI: 10.1021/jo035119f  1
2003 Ham YW, Tse WC, Boger DL. High-resolution assessment of protein DNA binding affinity and selectivity utilizing a fluorescent intercalator displacement (FID) assay. Bioorganic & Medicinal Chemistry Letters. 13: 3805-7. PMID 14552784 DOI: 10.1016/j.bmcl.2003.06.002  1
2003 Yeung BK, Tse WC, Boger DL. Determination of binding affinities of triplex forming oligonucleotides using a fluorescent intercalator displacement (FID) assay. Bioorganic & Medicinal Chemistry Letters. 13: 3801-4. PMID 14552783 DOI: 10.1016/j.bmcl.2003.07.005  1
2003 Boger DL, Desharnais J, Capps K. Solution-phase combinatorial libraries: modulating cellular signaling by targeting protein-protein or protein-DNA interactions. Angewandte Chemie (International Ed. in English). 42: 4138-76. PMID 14502729 DOI: 10.1002/anie.200300574  1
2003 Desharnais J, Hwang I, Zhang Y, Tavassoli A, Baboval J, Benkovic SJ, Wilson IA, Boger DL. Design, synthesis and biological evaluation of 10-CF3CO-DDACTHF analogues and derivatives as inhibitors of GAR Tfase and the de novo purine biosynthetic pathway. Bioorganic & Medicinal Chemistry. 11: 4511-21. PMID 13129587 DOI: 10.1016/S0968-0896(03)00458-9  1
2003 Marsilje TH, Hedrick MP, Desharnais J, Capps K, Tavassoli A, Zhang Y, Wilson IA, Benkovic SJ, Boger DL. 10-(2-benzoxazolcarbonyl)-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid: a potential inhibitor of GAR transformylase and AICAR transformylase. Bioorganic & Medicinal Chemistry. 11: 4503-9. PMID 13129586 DOI: 10.1016/S0968-0896(03)00457-7  1
2003 Marsilje TH, Hedrick MP, Desharnais J, Tavassoli A, Zhang Y, Wilson IA, Benkovic SJ, Boger DL. Design, synthesis, and biological evaluation of simplified alpha-keto heterocycle, trifluoromethyl ketone, and formyl substituted folate analogues as potential inhibitors of GAR transformylase and AICAR transformylase. Bioorganic & Medicinal Chemistry. 11: 4487-501. PMID 13129585 DOI: 10.1016/S0968-0896(03)00456-5  1
2003 Tse WC, Ishii T, Boger DL. Comprehensive high-resolution analysis of hairpin polyamides utilizing a fluorescent intercalator displacement (FID) assay. Bioorganic & Medicinal Chemistry. 11: 4479-86. PMID 13129584 DOI: 10.1016/S0968-0896(03)00455-3  1
2003 Parrish JP, Kastrinsky DB, Wolkenberg SE, Igarashi Y, Boger DL. DNA alkylation properties of yatakemycin. Journal of the American Chemical Society. 125: 10971-6. PMID 12952479 DOI: 10.1021/ja035984h  1
2003 Parrish JP, Kastrinsky DB, Stauffer F, Hedrick MP, Hwang I, Boger DL. Establishment of substituent effects in the DNA binding subunit of CBI analogues of the duocarmycins and CC-1065. Bioorganic & Medicinal Chemistry. 11: 3815-38. PMID 12901927 DOI: 10.1016/S0968-0896(03)00194-9  1
2003 McComas CC, Crowley BM, Boger DL. Partitioning the loss in vancomycin binding affinity for D-Ala-D-Lac into lost H-bond and repulsive lone pair contributions. Journal of the American Chemical Society. 125: 9314-5. PMID 12889959 DOI: 10.1021/ja035901x  1
2003 Parrish JP, Kastrinsky DB, Boger DL. Synthesis and X-ray analysis of an unprecedented and stable 2-aza-4,4-spirocyclopropacyclohexadienone. Organic Letters. 5: 2577-9. PMID 12841785 DOI: 10.1021/ol035000t  1
2003 Yeung BKS, Boger DL. Synthesis of isochrysohermidin - Distamycin hybrids Journal of Organic Chemistry. 68: 5249-5253. PMID 12816485 DOI: 10.1021/jo034326c  1
2003 Zhang Y, Desharnais J, Marsilje TH, Li C, Hedrick MP, Gooljarsingh LT, Tavassoli A, Benkovic SJ, Olson AJ, Boger DL, Wilson IA. Rational design, synthesis, evaluation, and crystal structure of a potent inhibitor of human GAR Tfase: 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid. Biochemistry. 42: 6043-56. PMID 12755606 DOI: 10.1021/bi034219c  1
2003 Leung D, Hardouin C, Boger DL, Cravatt BF. Discovering potent and selective reversible inhibitors of enzymes in complex proteomes. Nature Biotechnology. 21: 687-91. PMID 12740587 DOI: 10.1038/nbt826  1
2003 Soenen DR, Hwang I, Hedrick MP, Boger DL. Multidrug resistance reversal activity of key ningalin analogues. Bioorganic & Medicinal Chemistry Letters. 13: 1777-81. PMID 12729663 DOI: 10.1016/S0960-894X(03)00294-4  1
2003 Soenen DR, Zimpleman JM, Boger DL. Synthesis and inverse electron demand Diels-Alder reactions of 3,6-bis(3,4-dimethoxybenzoyl)-1,2,4,5-tetrazine. The Journal of Organic Chemistry. 68: 3593-8. PMID 12713365 DOI: 10.1021/jo020713v  1
2003 Boger DL. Solution-phase synthesis of combinatorial libraries designed to modulate protein-protein or protein-DNA interactions Bioorganic and Medicinal Chemistry. 11: 1607-1613. PMID 12659745 DOI: 10.1016/S0968-0896(03)00031-2  1
2003 Wanner J, Tang D, McComas CC, Crowley BM, Jiang W, Moss J, Boger DL. A new and improved method for deglycosidation of glycopeptide antibiotics exemplified with vancomycin, ristocetin, and ramoplanin. Bioorganic & Medicinal Chemistry Letters. 13: 1169-73. PMID 12643936 DOI: 10.1016/S0960-894X(03)00051-9  1
2003 Jiang W, Wanner J, Lee RJ, Bounaud PY, Boger DL. Total synthesis of the ramoplanin A2 and ramoplanose aglycon. Journal of the American Chemical Society. 125: 1877-87. PMID 12580615 DOI: 10.1021/ja0212314  1
2003 Krenitsky PJ, Boger DL. Synthesis of the (S,S,S)-diastereomer of the 15-membered biaryl ring system of RP 66453 Tetrahedron Letters. 44: 4019-4022. DOI: 10.1016/S0040-4039(03)00856-6  1
2002 Zhang Y, Desharnais J, Greasley SE, Beardsley GP, Boger DL, Wilson IA. Crystal structures of human GAR Tfase at low and high pH and with substrate beta-GAR. Biochemistry. 41: 14206-15. PMID 12450384 DOI: 10.1021/bi020522m  1
2002 Wolkenberg SE, Boger DL. Total synthesis of anhydrolycorinone utilizing sequential intramolecular Diels-Alder reactions of a 1,3,4-oxadiazole. The Journal of Organic Chemistry. 67: 7361-4. PMID 12375965 DOI: 10.1021/jo020437k  0.68
2002 Lewy DS, Gauss CM, Soenen DR, Boger DL. Fostriecin: chemistry and biology. Current Medicinal Chemistry. 9: 2005-32. PMID 12369868  0.88
2002 Wilkie GD, Elliott GI, Blagg BS, Wolkenberg SE, Soenen DR, Miller MM, Pollack S, Boger DL. Intramolecular Diels-Alder and tandem intramolecular Diels-Alder/1,3-dipolar cycloaddition reactions of 1,3,4-oxadiazoles. Journal of the American Chemical Society. 124: 11292-4. PMID 12236743 DOI: 10.1021/ja027533n  1
2002 Wolkenberg SE, Boger DL. Mechanisms of in situ activation for DNA-targeting antitumor agents. Chemical Reviews. 102: 2477-95. PMID 12105933 DOI: 10.1021/cr010046q  0.68
2002 McAtee JJ, Castle SL, Jin Q, Boger DL. Synthesis and evaluation of vancomycin and vancomycin aglycon analogues that bear modifications in the residue 3 asparagine. Bioorganic & Medicinal Chemistry Letters. 12: 1319-22. PMID 11965380 DOI: 10.1016/S0960-894X(02)00130-0  1
2001 Ellis DA, Wolkenberg SE, Boger DL. Metal cation complexation and activation of reversed CPyI analogues of CC-1065 and duocarmycin SA: partitioning the effects of binding and catalysis. Journal of the American Chemical Society. 123: 9299-306. PMID 11562212 DOI: 10.1021/ja010769r  0.68
2001 Boger DL, Tse WC. Thiazole orange as the fluorescent intercalator in a high resolution fid assay for determining DNA binding affinity and sequence selectivity of small molecules. Bioorganic & Medicinal Chemistry. 9: 2511-8. PMID 11553493 DOI: 10.1016/S0968-0896(01)00243-7  0.96
2001 Boger DL, Hong J. Asymmetric total synthesis of ent-(-)-roseophilin: assignment of absolute configuration. Journal of the American Chemical Society. 123: 8515-9. PMID 11525659  1
2001 Boger DL, Kim SH, Mori Y, Weng JH, Rogel O, Castle SL, McAtee JJ. First and second generation total synthesis of the teicoplanin aglycon. Journal of the American Chemical Society. 123: 1862-71. PMID 11456806 DOI: 10.1021/ja003835i  1
2001 Boger DL, Ichikawa S, Tse WC, Hedrick MP, Jin Q. Total syntheses of thiocoraline and BE-22179 and assessment of their DNA binding and biological properties. Journal of the American Chemical Society. 123: 561-8. PMID 11456568 DOI: 10.1021/ja003602r  0.96
2001 Boger DL, Fink BE, Brunette SR, Tse WC, Hedrick MP. A simple, high-resolution method for establishing DNA binding affinity and sequence selectivity. Journal of the American Chemical Society. 123: 5878-91. PMID 11414820 DOI: 10.1021/ja010041a  0.96
2000 Boger DL, Wolkenberg SE. Total synthesis of Amaryllidaceae alkaloids utilizing sequential intramolecular heterocyclic azadiene Diels-Alder reactions of an unsymmetrical 1,2,4,5-tetrazine. The Journal of Organic Chemistry. 65: 9120-4. PMID 11149859 DOI: 10.1021/jo0012546  0.68
2000 Boger DL, Fecik RA, Patterson JE, Miyauchi H, Patricelli MP, Cravatt BF. Fatty acid amide hydrolase substrate specificity. Bioorganic & Medicinal Chemistry Letters. 10: 2613-6. PMID 11128635 DOI: 10.1016/S0960-894X(00)00528-X  1
2000 Boger DL, Santillán A, Searcey M, Brunette SR, Wolkenberg SE, Hedrick MP, Jin Q. Synthesis and evaluation of 1,2,8, 8a-Tetrahydrocyclopropa[c]pyrrolo[3,2-e]indol-4(5H)-one, the parent alkylation subunit of CC-1065 and the duocarmycins: impact of the alkylation subunit substituents and its implications for DNA alkylation catalysis. The Journal of Organic Chemistry. 65: 4101-11. PMID 10866627 DOI: 10.1021/jo000297j  0.68
2000 Boger DL, Sato H, Lerner AE, Hedrick MP, Fecik RA, Miyauchi H, Wilkie GD, Austin BJ, Patricelli MP, Cravatt BF. Exceptionally potent inhibitors of fatty acid amide hydrolase: the enzyme responsible for degradation of endogenous oleamide and anandamide. Proceedings of the National Academy of Sciences of the United States of America. 97: 5044-9. PMID 10805767 DOI: 10.1073/pnas.97.10.5044  1
2000 Boger DL, Soenen DR, Boyce CW, Hedrick MP, Jin Q. Total synthesis of ningalin B utilizing a heterocyclic azadiene Diels-Alder reaction and discovery of a new class of potent multidrug resistant (MDR) reversal agents. The Journal of Organic Chemistry. 65: 2479-83. PMID 10789460 DOI: 10.1021/jo9916535  0.88
2000 Boger DL, Searcey M, Tse WC, Jin Q. Bifunctional alkylating agents derived from duocarmycin SA: potent antitumor activity with altered sequence selectivity. Bioorganic & Medicinal Chemistry Letters. 10: 495-8. PMID 10743956 DOI: 10.1016/S0960-894X(00)00042-1  0.96
1999 Boger DL, Castle SL, Miyazaki S, Wu JH, Beresis RT, Loiseleur O. Vancomycin CD and DE Macrocyclization and Atropisomerism Studies. The Journal of Organic Chemistry. 64: 70-80. PMID 11674087 DOI: 10.1021/jo980880o  1
1999 Boger DL, Sato H, Lerner AE, Austin BJ, Patterson JE, Patricelli MP, Cravatt BF. Trifluoromethyl ketone inhibitors of fatty acid amide hydrolase: a probe of structural and conformational features contributing to inhibition. Bioorganic & Medicinal Chemistry Letters. 9: 265-70. PMID 10021942 DOI: 10.1016/S0960-894X(98)00734-3  1
1998 Boger DL, Henriksen SJ, Cravatt BF. Oleamide: an endogenous sleep-inducing lipid and prototypical member of a new class of biological signaling molecules. Current Pharmaceutical Design. 4: 303-14. PMID 10197045  1
1998 Patricelli MP, Patterson JE, Boger DL, Cravatt BF. An endogenous sleep-inducing compound is a novel competitive inhibitor of fatty acid amide hydrolase. Bioorganic & Medicinal Chemistry Letters. 8: 613-8. PMID 9871570 DOI: 10.1016/S0960-894X(98)00073-0  1
1998 Boger DL, Beresis RT, Loiseleur O, Wu JH, Castle SL. Synthesis of the vancomycin CDE ring system. Bioorganic & Medicinal Chemistry Letters. 8: 721-4. PMID 9871529 DOI: 10.1016/S0960-894X(98)00110-3  1
1998 Boger DL, Patterson JE, Guan X, Cravatt BF, Lerner RA, Gilula NB. Chemical requirements for inhibition of gap junction communication by the biologically active lipid oleamide. Proceedings of the National Academy of Sciences of the United States of America. 95: 4810-5. PMID 9560184 DOI: 10.1073/pnas.95.9.4810  1
1997 Boger DL, Zhou J, Borzilleri RM, Nukui S, Castle SL. Synthesis of (9R,12S)- and (9S,12S)-Cycloisodityrosine and Their N-Methyl Derivatives. The Journal of Organic Chemistry. 62: 2054-2069. PMID 11671510 DOI: 10.1021/jo961346o  1
1997 Guan X, Cravatt BF, Ehring GR, Hall JE, Boger DL, Lerner RA, Gilula NB. The sleep-inducing lipid oleamide deconvolutes gap junction communication and calcium wave transmission in glial cells. The Journal of Cell Biology. 139: 1785-92. PMID 9412472 DOI: 10.1083/jcb.139.7.1785  1
1996 Cravatt BF, Giang DK, Mayfield SP, Boger DL, Lerner RA, Gilula NB. Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides. Nature. 384: 83-7. PMID 8900284 DOI: 10.1038/384083a0  1
1995 Cravatt BF, Prospero-Garcia O, Siuzdak G, Gilula NB, Henriksen SJ, Boger DL, Lerner RA. Chemical characterization of a family of brain lipids that induce sleep. Science (New York, N.Y.). 268: 1506-9. PMID 7770779  1
1994 Lerner RA, Siuzdak G, Prospero-Garcia O, Henriksen SJ, Boger DL, Cravatt BF. Cerebrodiene: a brain lipid isolated from sleep-deprived cats. Proceedings of the National Academy of Sciences of the United States of America. 91: 9505-8. PMID 7937797  1
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