Richard Honkanen - Publications

University of South Alabama, Mobile, AL, United States 

39 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Papke CM, Smolen KA, Swingle MR, Cressey L, Heng RA, Toporsian M, Deng L, Hagen J, Shen Y, Chung WK, Kettenbach AN, Honkanen RE. A disorder-related variant (E420K) of a PP2A-regulatory subunit (PPP2R5D) causes constitutively active AKT-mTOR signaling and uncoordinated cell growth. The Journal of Biological Chemistry. 100313. PMID 33482199 DOI: 10.1016/j.jbc.2021.100313  0.88
2020 Haldar B, Hamilton CL, Solodushko V, Abney KA, Alexeyev M, Honkanen RE, Scammell JG, Cioffi DL. S100A6 is a positive regulator of PPP5C-FKBP51-dependent regulation of endothelial calcium signaling. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 31916625 DOI: 10.1096/fj.201901777R  0.52
2019 D'Arcy BM, Prakash A, Honkanen RE. Targeting phosphatases in cancer: suppression of many versus the ablation of one. Oncotarget. 10: 6543-6545. PMID 31762936 DOI: 10.18632/oncotarget.27201  0.52
2019 D'Arcy BM, Swingle MR, Schambeau L, Pannell L, Prakash A, Honkanen RE. Development of a Synthetic 3-ketosteroid Δ-dehydrogenase for the Generation of a Novel Catabolic Pathway Enabling Cholesterol Degradation in Human Cells. Scientific Reports. 9: 5969. PMID 30979909 DOI: 10.1038/s41598-019-42046-8  0.88
2019 D'Arcy BM, Swingle MR, Papke CM, Abney KA, Bouska ES, Prakash A, Honkanen RE. The Antitumor Drug LB-100 is a Catalytic Inhibitor of Protein Phosphatase 2A (PPP2CA) and 5 (PPP5C) Coordinating with the Catalytic Metals in the Active Site of PP5C. Molecular Cancer Therapeutics. PMID 30679389 DOI: 10.1158/1535-7163.MCT-17-1143  0.88
2018 Swingle MR, Honkanen RE. Inhibitors of Serine/Threonine Protein Phosphatases: Biochemical and Structural Studies Provide Insight for Further Development. Current Medicinal Chemistry. PMID 29737249 DOI: 10.2174/0929867325666180508095242  0.88
2017 Hamilton CL, Abney KA, Vasauskas AA, Alexeyev M, Li N, Honkanen RE, Scammell JG, Cioffi DL. EXPRESS: Serine/threonine phosphatase 5 (PP5C/PPP5C) regulates the ISOC channel through a PP5C-FKBP51 axis. Pulmonary Circulation. 2045893217753156. PMID 29283027 DOI: 10.1177/2045893217753156  0.52
2017 Choy MS, Swingle M, D'Arcy B, Abney K, Rusin SF, Kettenbach AN, Page R, Honkanen RE, Peti W. The PP1:tautomycetin complex reveals a path towards the development of PP1-specific inhibitors. Journal of the American Chemical Society. PMID 29156132 DOI: 10.1021/jacs.7b09368  1
2016 Swingle M, Volmar CH, Saldanha SA, Chase P, Eberhart C, Salter EA, D'Arcy B, Schroeder CE, Golden JE, Wierzbicki A, Hodder P, Honkanen RE. An Ultra-High-Throughput Screen for Catalytic Inhibitors of Serine/Threonine Protein Phosphatases Types 1 and 5 (PP1C and PP5C). Journal of Biomolecular Screening. PMID 27628691 DOI: 10.1177/1087057116668852  1
2016 Chattopadhyay D, Swingle MR, Salter EA, Wood E, D'Arcy B, Zivanov C, Abney K, Musiyenko A, Rusin SF, Kettenbach A, Yet L, Schroeder CE, Golden JE, Dunham WH, Gingras AC, ... ... Honkanen RE, et al. Crystal Structures and Mutagenesis of PPP-family ser/thr Protein Phosphatases Elucidate the Selectivity of Cantharidin and Novel Norcantharidin-based Inhibitors of PP5C. Biochemical Pharmacology. PMID 27002182 DOI: 10.1016/j.bcp.2016.03.011  1
2014 Swingle MR, Honkanen RE. Development and validation of a robust and sensitive assay for the discovery of selective inhibitors for serine/threonine protein phosphatases PP1α (PPP1C) and PP5 (PPP5C). Assay and Drug Development Technologies. 12: 481-96. PMID 25383722 DOI: 10.1089/adt.2014.603  1
2014 Mazalouskas MD, Godoy-Ruiz R, Weber DJ, Zimmer DB, Honkanen RE, Wadzinski BE. Small G proteins Rac1 and Ras regulate serine/threonine protein phosphatase 5 (PP5)·extracellular signal-regulated kinase (ERK) complexes involved in the feedback regulation of Raf1. The Journal of Biological Chemistry. 289: 4219-32. PMID 24371145 DOI: 10.1074/jbc.M113.518514  1
2013 Theobald B, Bonness K, Musiyenko A, Andrews JF, Urban G, Huang X, Dean NM, Honkanen RE. Suppression of Ser/Thr phosphatase 4 (PP4C/PPP4C) mimics a novel post-mitotic action of fostriecin, producing mitotic slippage followed by tetraploid cell death. Molecular Cancer Research : McR. 11: 845-55. PMID 23671329 DOI: 10.1158/1541-7786.MCR-13-0032  1
2012 Henesy MB, Britain AL, Zhu B, Amable L, Honkanen RE, Corbin JD, Francis SH, Rich TC. Calcineurin regulates homologous desensitization of natriuretic peptide receptor-A and inhibits ANP-induced testosterone production in MA-10 cells. Plos One. 7: e41711. PMID 22876290 DOI: 10.1371/journal.pone.0041711  0.32
2011 Amable L, Grankvist N, Largen JW, Ortsäter H, Sjöholm Å, Honkanen RE. Disruption of serine/threonine protein phosphatase 5 (PP5:PPP5c) in mice reveals a novel role for PP5 in the regulation of ultraviolet light-induced phosphorylation of serine/threonine protein kinase Chk1 (CHEK1). The Journal of Biological Chemistry. 286: 40413-22. PMID 21921034 DOI: 10.1074/jbc.M111.244053  0.32
2011 Yang X, Liu Y, Yang XM, Hu F, Cui L, Swingle MR, Honkanen RE, Soltani P, Tissier R, Cohen MV, Downey JM. Cardioprotection by mild hypothermia during ischemia involves preservation of ERK activity. Basic Research in Cardiology. 106: 421-30. PMID 21399968 DOI: 10.1007/s00395-011-0165-0  1
2011 Skarra DV, Goudreault M, Choi H, Mullin M, Nesvizhskii AI, Gingras AC, Honkanen RE. Label-free quantitative proteomics and SAINT analysis enable interactome mapping for the human Ser/Thr protein phosphatase 5 Proteomics. 11: 1508-1516. PMID 21360678 DOI: 10.1002/pmic.201000770  1
2010 Burke CP, Swingle MR, Honkanen RE, Boger DL. Total synthesis and evaluation of phostriecin and key structural analogues. The Journal of Organic Chemistry. 75: 7505-13. PMID 20669916 DOI: 10.1021/jo1010203  1
2009 Swingle MR, Amable L, Lawhorn BG, Buck SB, Burke CP, Ratti P, Fischer KL, Boger DL, Honkanen RE. Structure-activity relationship studies of fostriecin, cytostatin, and key analogs, with PP1, PP2A, PP5, and( beta12-beta13)-chimeras (PP1/PP2A and PP5/PP2A), provide further insight into the inhibitory actions of fostriecin family inhibitors. The Journal of Pharmacology and Experimental Therapeutics. 331: 45-53. PMID 19592665 DOI: 10.1124/jpet.109.155630  1
2008 Chen YW, Cleaver JE, Hatahet Z, Honkanen RE, Chang JY, Yen Y, Chou KM. Human DNA polymerase eta activity and translocation is regulated by phosphorylation. Proceedings of the National Academy of Sciences of the United States of America. 105: 16578-83. PMID 18946034 DOI: 10.1073/pnas.0808589105  1
2008 Golden T, Aragon IV, Rutland B, Tucker JA, Shevde LA, Samant RS, Zhou G, Amable L, Skarra D, Honkanen RE. Elevated levels of Ser/Thr protein phosphatase 5 (PP5) in human breast cancer. Biochimica Et Biophysica Acta. 1782: 259-70. PMID 18280813 DOI: 10.1016/j.bbadis.2008.01.004  1
2008 Golden T, Swingle M, Honkanen RE. The role of serine/threonine protein phosphatase type 5 (PP5) in the regulation of stress-induced signaling networks and cancer. Cancer Metastasis Reviews. 27: 169-78. PMID 18253812 DOI: 10.1007/s10555-008-9125-z  1
2007 Ni L, Swingle MS, Bourgeois AC, Honkanen RE. High yield expression of serine/threonine protein phosphatase type 5, and a fluorescent assay suitable for use in the detection of catalytic inhibitors. Assay and Drug Development Technologies. 5: 645-53. PMID 17939754 DOI: 10.1089/adt.2007.079  1
2007 Swingle M, Ni L, Honkanen RE. Small-molecule inhibitors of ser/thr protein phosphatases: specificity, use and common forms of abuse. Methods in Molecular Biology (Clifton, N.J.). 365: 23-38. PMID 17200551 DOI: 10.1385/1-59745-267-X:23  1
2006 Lawhorn BG, Boga SB, Wolkenberg SE, Colby DA, Gauss CM, Swingle MR, Amable L, Honkanen RE, Boger DL. Total synthesis and evaluation of cytostatin, its C10-C11 diastereomers, and additional key analogues: impact on PP2A inhibition. Journal of the American Chemical Society. 128: 16720-32. PMID 17177422 DOI: 10.1021/ja066477d  1
2006 Bonness K, Aragon IV, Rutland B, Ofori-Acquah S, Dean NM, Honkanen RE. Cantharidin-induced mitotic arrest is associated with the formation of aberrant mitotic spindles and lagging chromosomes resulting, in part, from the suppression of PP2Aalpha. Molecular Cancer Therapeutics. 5: 2727-36. PMID 17121919 DOI: 10.1158/1535-7163.MCT-06-0273  0.4
2004 Golden T, Aragon IV, Zhou G, Cooper SR, Dean NM, Honkanen RE. Constitutive over expression of serine/threonine protein phosphatase 5 (PP5) augments estrogen-dependent tumor growth in mice. Cancer Letters. 215: 95-100. PMID 15374638 DOI: 10.1016/j.canlet.2004.03.027  0.56
2004 Zhou G, Golden T, Aragon IV, Honkanen RE. Ser/Thr protein phosphatase 5 inactivates hypoxia-induced activation of an apoptosis signal-regulating kinase 1/MKK-4/JNK signaling cascade. The Journal of Biological Chemistry. 279: 46595-605. PMID 15328343 DOI: 10.1074/jbc.M408320200  0.56
2004 Swingle MR, Honkanen RE, Ciszak EM. Structural basis for the catalytic activity of human serine/threonine protein phosphatase-5. The Journal of Biological Chemistry. 279: 33992-9. PMID 15155720 DOI: 10.1074/jbc.M402855200  1
2003 Buck SB, Hardouin C, Ichikawa S, Soenen DR, Gauss CM, Hwang I, Swingle MR, Bonness KM, Honkanen RE, Boger DL. Fundamental role of the fostriecin unsaturated lactone and implications for selective protein phosphatase inhibition. Journal of the American Chemical Society. 125: 15694-5. PMID 14677930 DOI: 10.1021/ja038672n  1
2003 Urban G, Golden T, Aragon IV, Cowsert L, Cooper SR, Dean NM, Honkanen RE. Identification of a functional link for the p53 tumor suppressor protein in dexamethasone-induced growth suppression. The Journal of Biological Chemistry. 278: 9747-53. PMID 12519780 DOI: 10.1074/jbc.M210993200  0.56
2002 Golden T, Dean NM, Honkanen RE. Use of antisense oligonucleotides: advantages, controls, and cardiovascular tissue. Microcirculation (New York, N.Y. : 1994). 9: 51-64. PMID 11896559 DOI: 10.1038/sj/mn/7800121  0.56
2001 Dean DA, Urban G, Aragon IV, Swingle M, Miller B, Rusconi S, Bueno M, Dean NM, Honkanen RE. Serine/threonine protein phosphatase 5 (PP5) participates in the regulation of glucocorticoid receptor nucleocytoplasmic shuttling. Bmc Cell Biology. 2: 6. PMID 11389770 DOI: 10.1186/1471-2121-2-6  1
2001 Urban G, Golden T, Aragon IV, Scammell JG, Dean NM, Honkanen RE. Identification of an estrogen-inducible phosphatase (PP5) that converts MCF-7 human breast carcinoma cells into an estrogen-independent phenotype when expressed constitutively. The Journal of Biological Chemistry. 276: 27638-46. PMID 11331294 DOI: 10.1074/jbc.M103512200  1
2000 Huang X, Swingle MR, Honkanen RE. Photoreceptor serine/threonine protein phosphatase type 7: cloning, expression, and functional analysis. Methods in Enzymology. 315: 579-93. PMID 10736728  1
1999 Connor JH, Kleeman T, Barik S, Honkanen RE, Shenolikar S. Importance of the beta12-beta13 loop in protein phosphatase-1 catalytic subunit for inhibition by toxins and mammalian protein inhibitors. The Journal of Biological Chemistry. 274: 22366-72. PMID 10428807 DOI: 10.1074/jbc.274.32.22366  1
1999 Zuo Z, Urban G, Scammell JG, Dean NM, McLean TK, Aragon I, Honkanen RE. Ser/Thr protein phosphatase type 5 (PP5) is a negative regulator of glucocorticoid receptor-mediated growth arrest. Biochemistry. 38: 8849-57. PMID 10413457 DOI: 10.1021/bi990842e  1
1995 Honkanen RE, Caplan FR, Baker KK, Baldwin CL, Bobrin SC, Bolis CM, Cabrera GM, Johnson LA, Jung JH, Larsen LK, Levine IA, Moore RE, Nelson CS, Patterson GML, Tschappat KD, et al. Protein phosphatase inhibitory activity in extracts of cultured blue-green algae (cyanophyta) Journal of Phycology. 31: 478-486. DOI: 10.1111/j.0022-3646.1995.00478.x  1
1994 Ämmälä C, Eliasson L, Bokvist K, Berggren PO, Honkanen RE, Sjöholm A, Rorsman P. Activation of protein kinases and inhibition of protein phosphatases play a central role in the regulation of exocytosis in mouse pancreatic β cells Proceedings of the National Academy of Sciences of the United States of America. 91: 4343-4347. PMID 8183910 DOI: 10.1073/pnas.91.10.4343  1
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