David A. Colby - Publications

Chemistry Purdue University, West Lafayette, IN, United States 
natural product synthesis

40 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Alshammari MD, Kucheryavy PV, Ashpole NM, Colby DA. Synthesis, biological evaluation, and NMR studies of 3-fluorinated derivatives of 3',4',5'-trihydroxyflavone and 3',4',5'-trimethoxyflavone. Bioorganic & Medicinal Chemistry Letters. 32: 127720. PMID 33259925 DOI: 10.1016/j.bmcl.2020.127720  0.48
2020 Adam AT, Fronczek FR, Colby DA. Synthesis of β-Fluoro-α,β-Unsaturated Amides from the Fragmentation of Morpholine 3,3,3-Trifluoropropanamide by Grignard Reagents. Organic Letters. PMID 32181669 DOI: 10.1021/acs.orglett.0c00599  0.48
2019 Khatri HR, Han C, Luong E, Pan X, Adam AT, Alshammari MD, Shao Y, Colby DA. Controlling the Cleavage of Carbon-Carbon Bonds to Generate α,α-Difluorobenzyl Carbanions for the Construction of Difluoromethylbenzenes. The Journal of Organic Chemistry. PMID 31449418 DOI: 10.1021/acs.joc.9b01595  0.96
2018 Sowaileh MF, Salyer AE, Roy KK, John JP, Woods JR, Doerksen RJ, Hockerman GH, Colby DA. Agonists of the γ-aminobutyric acid type B (GABA) receptor derived from β-hydroxy and β-amino difluoromethyl ketones. Bioorganic & Medicinal Chemistry Letters. PMID 29657102 DOI: 10.1016/j.bmcl.2018.04.003  0.84
2018 Nguyen AL, Khatri HR, Woods JR, Baldwin CS, Fronczek FR, Colby DA. Magnesium-promoted Additions of Difluoroenolates to Unactivated Imines. The Journal of Organic Chemistry. PMID 29446944 DOI: 10.1021/acs.joc.7b03014  0.48
2017 Sowaileh MF, Han C, Hazlitt RA, Kim EH, John JP, Colby DA. Conversion of Methyl Ketones and Methyl Sulfones into α-Deutero-α,α-Difluoromethyl Ketones and α-Deutero-α,α-Difluoromethyl Sulfones in Three Synthetic Steps. Tetrahedron Letters. 58: 396-400. PMID 28943667 DOI: 10.1016/j.tetlet.2016.12.018  0.96
2017 Sowaileh MF, Hazlitt RA, Colby DA. Application of the Pentafluorosulfanyl Group as a Bioisosteric Replacement. Chemmedchem. PMID 28782186 DOI: 10.1002/cmdc.201700356  0.84
2017 Hazlitt RA, Tran QL, Sowaileh MF, Colby DA. Generation of Magnesium Pentafluoropropen-2-olate from Hexafluoroisopropanol and Synthesis of 2,2,4,4,4-Pentafluoro-3,3-dihydroxyketones. The Journal of Organic Chemistry. PMID 28107014 DOI: 10.1021/acs.joc.6b02863  0.84
2016 Gunasekara DC, Zheng MM, Mojtahed T, Woods JR, Fandy TE, Riofski MV, Glackin CA, Hassan HE, Kirshner J, Colby DA. 15-Methylene-Eburnamonine Kills Leukemic Stem Cells and Reduces Engraftment in a Humanized Bone Marrow Xenograft Mouse Model of Leukemia. Chemmedchem. PMID 27677525 DOI: 10.1002/cmdc.201600334  0.96
2016 Hazlitt RA, John JP, Tran QL, Colby DA. Optimized Synthesis of a Pentafluoro-gem-diol and Conversion to a CF2Br-Glucopyranose through Trifluoroacetate-Release and Halogenation. Tetrahedron Letters. 57: 1906-1908. PMID 27182091 DOI: 10.1016/j.tetlet.2016.03.064  0.84
2015 Barrios FJ, Springer BC, Hazlitt RA, Colby DA. Effect of Substituents and Stability of Transient Aluminum-Aminals in the Presence of Nucleophiles. Synthesis. 47: 175-180. PMID 28250502 DOI: 10.1055/s-0034-1379635  0.96
2015 Fandy TE, Abdallah I, Khayat M, Colby DA, Hassan HE. In vitro characterization of transport and metabolism of the alkaloids: vincamine, vinpocetine and eburnamonine. Cancer Chemotherapy and Pharmacology. PMID 26666648 DOI: 10.1007/s00280-015-2924-3  0.96
2015 Glauber KM, Dana CE, Park SS, Colby DA, Noro Y, Fujisawa T, Chamberlin AR, Steele RE. A small molecule screen identifies a novel compound that induces a homeotic transformation in Hydra. Development (Cambridge, England). 142: 2081. PMID 26015540 DOI: 10.1242/dev.126235  0.96
2015 Brown KM, Roy KK, Hockerman GH, Doerksen RJ, Colby DA. Activation of the γ-Aminobutyric Acid Type B (GABAB) Receptor by Agonists and Positive Allosteric Modulators. Journal of Medicinal Chemistry. PMID 25856547 DOI: 10.1021/jm5018913  0.96
2015 Barrios FJ, Springer BC, Hazlitt RA, Colby DA. Effect of Substituents and Stability of Transient Aluminum-Aminals in the Presence of Nucleophiles Synthesis (Germany). 47: 175-180. DOI: 10.1055/s-0034-1379635  0.96
2014 Thorlton J, Colby DA, Devine P. Proposed actions for the US Food and Drug Administration to implement to minimize adverse effects associated with energy drink consumption. American Journal of Public Health. 104: 1175-80. PMID 24832439 DOI: 10.2105/AJPH.2014.301967  0.96
2013 Glauber KM, Dana CE, Park SS, Colby DA, Noro Y, Fujisawa T, Chamberlin AR, Steele RE. A small molecule screen identifies a novel compound that induces a homeotic transformation in Hydra. Development (Cambridge, England). 140: 4788-96. PMID 24255098 DOI: 10.1242/dev.094490  0.96
2013 Woods JR, Riofski MV, Zheng MM, O'Banion MA, Mo H, Kirshner J, Colby DA. Synthesis of 15-methylene-eburnamonine from (+)-vincamine, evaluation of anticancer activity, and investigation of mechanism of action by quantitative NMR. Bioorganic & Medicinal Chemistry Letters. 23: 5865-9. PMID 24055047 DOI: 10.1016/j.bmcl.2013.08.095  0.96
2013 Barrios FJ, Springer BC, Colby DA. Control of transient aluminum-aminals for masking and unmasking reactive carbonyl groups. Organic Letters. 15: 3082-5. PMID 23730896 DOI: 10.1021/ol401265a  0.96
2013 Han C, Salyer AE, Kim EH, Jiang X, Jarrard RE, Powers MS, Kirchhoff AM, Salvador TK, Chester JA, Hockerman GH, Colby DA. Evaluation of difluoromethyl ketones as agonists of the γ-aminobutyric acid type B (GABAB) receptor. Journal of Medicinal Chemistry. 56: 2456-65. PMID 23428109 DOI: 10.1021/jm301805e  0.96
2013 Riofski MV, Hart AD, Colby DA. Amidinate salt of hexafluoroacetone hydrate for the preparation of fluorinated compounds by the release of trifluoroacetate. Organic Letters. 15: 208-11. PMID 23240844 DOI: 10.1021/ol303291x  0.96
2013 Woods JR, Mo H, Bieberich AA, Alavanja T, Colby DA. Amino-derivatives of the sesquiterpene lactone class of natural products as prodrugs Medchemcomm. 4: 27-33. DOI: 10.1039/c2md20172k  0.96
2012 Han C, Kim EH, Colby DA. Cleaving carbon-carbon bonds by the release of trifluoroacetate to remodel molecules and assemble fluorinated structures Synlett. 23: 1559-1563. DOI: 10.1055/s-0031-1291156  0.96
2011 Woods JR, Mo H, Bieberich AA, Alavanja T, Colby DA. Fluorinated amino-derivatives of the sesquiterpene lactone, parthenolide, as (19)f NMR probes in deuterium-free environments. Journal of Medicinal Chemistry. 54: 7934-41. PMID 22029741 DOI: 10.1021/jm201114t  0.96
2011 John JP, Colby DA. Synthesis of α-halo-α,α-difluoromethyl ketones by a trifluoroacetate release/halogenation protocol. The Journal of Organic Chemistry. 76: 9163-8. PMID 21995668 DOI: 10.1021/jo2017179  0.96
2011 Riofski MV, John JP, Zheng MM, Kirshner J, Colby DA. Exploiting the facile release of trifluoroacetate for the α-methylenation of the sterically hindered carbonyl groups on (+)-sclareolide and (-)-eburnamonine. The Journal of Organic Chemistry. 76: 3676-83. PMID 21491928 DOI: 10.1021/jo102114f  0.96
2011 Han C, Kim EH, Colby DA. Cleavage of carbon-carbon bonds through the mild release of trifluoroacetate: generation of α,α-difluoroenolates for aldol reactions. Journal of the American Chemical Society. 133: 5802-5. PMID 21443226 DOI: 10.1021/ja202213f  0.96
2011 Gunn EJ, Williams JT, Huynh DT, Iannotti MJ, Han C, Barrios FJ, Kendall S, Glackin CA, Colby DA, Kirshner J. The natural products parthenolide and andrographolide exhibit anti-cancer stem cell activity in multiple myeloma. Leukemia & Lymphoma. 52: 1085-97. PMID 21417826 DOI: 10.3109/10428194.2011.555891  0.96
2010 Barrios FJ, Zhang X, Colby DA. Dialkylaluminum N,O-dimethylhydroxylamine complex as a reagent to mask reactive carbonyl groups in situ from nucleophiles. Organic Letters. 12: 5588-91. PMID 21038923 DOI: 10.1021/ol102495v  0.96
2010 Mo H, Balko KM, Colby DA. A practical deuterium-free NMR method for the rapid determination of 1-octanol/water partition coefficients of pharmaceutical agents. Bioorganic & Medicinal Chemistry Letters. 20: 6712-5. PMID 20864340 DOI: 10.1016/j.bmcl.2010.08.145  0.96
2009 Han C, Barrios FJ, Riofski MV, Colby DA. Semisynthetic derivatives of sesquiterpene lactones by palladium-catalyzed arylation of the alpha-methylene-gamma-lactone substructure. The Journal of Organic Chemistry. 74: 7176-9. PMID 19697954 DOI: 10.1021/jo901533e  0.96
2009 Ishikawa H, Colby DA, Seto S, Va P, Tam A, Kakei H, Rayl TJ, Hwang I, Boger DL. Total synthesis of vinblastine, vincristine, related natural products, and key structural analogues. Journal of the American Chemical Society. 131: 4904-16. PMID 19292450 DOI: 10.1021/ja809842b  0.96
2008 Ishikawa H, Colby DA, Boger DL. Direct coupling of catharanthine and vindoline to provide vinblastine: total synthesis of (+)- and ent-(-)-vinblastine. Journal of the American Chemical Society. 130: 420-1. PMID 18081297 DOI: 10.1021/ja078192m  0.96
2007 Mohrig JR, Hammond CN, Colby DA. On the successful use of inquiry-driven experiments in the organic chemistry laboratory Journal of Chemical Education. 84: 992-998.  0.96
2006 Lawhorn BG, Boga SB, Wolkenberg SE, Colby DA, Gauss CM, Swingle MR, Amable L, Honkanen RE, Boger DL. Total synthesis and evaluation of cytostatin, its C10-C11 diastereomers, and additional key analogues: impact on PP2A inhibition. Journal of the American Chemical Society. 128: 16720-32. PMID 17177422 DOI: 10.1021/ja066477d  0.96
2006 Colby DA, Chamberlin AR. Pharmacophore identification: the case of the ser/thr protein phosphatase inhibitors. Mini Reviews in Medicinal Chemistry. 6: 657-65. PMID 16787376 DOI: 10.2174/138955706777435715  0.96
2003 Colby DA, Liu W, Sheppeck JE, Huang HB, Nairn AC, Chamberlin AR. A new model of the tautomycin-PP1 complex that is not analogous to the corresponding okadaic acid structure. Bioorganic & Medicinal Chemistry Letters. 13: 1601-5. PMID 12699764 DOI: 10.1016/S0960-894X(03)00106-9  0.96
2003 Liu W, Sheppeck JE, Colby DA, Huang HB, Nairn AC, Chamberlin AR. The selective inhibition of phosphatases by natural toxins: the anhydride domain of tautomycin is not a primary factor in controlling PP1/PP2A selectivity. Bioorganic & Medicinal Chemistry Letters. 13: 1597-600. PMID 12699763 DOI: 10.1016/S0960-894X(03)00105-7  0.96
2002 Romero-Ortega M, Colby DA, Olivo HF. Synthesis of the C10-C17 fragment of aurisides and callipeltosides Tetrahedron Letters. 43: 6439-6441. DOI: 10.1016/S0040-4039(02)01340-0  0.96
1999 Olivo HF, Colby DA, Hemenway MS. Syntheses of New Open-Ring and homo-Epibatidine Analogues from Tropinone. The Journal of Organic Chemistry. 64: 4966-4968. PMID 11674583 DOI: 10.1021/jo990097b  0.96
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