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Jeremiah S. Helm, Ph.D. - Publications

Affiliations: 
2004 Princeton University, Princeton, NJ 
Area:
Chemical biology, enzymology, antibiotics, glycosyltransferases, inhibitors
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7 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2004 Chen L, Yuan Y, Helm JS, Hu Y, Rew Y, Shin D, Boger DL, Walker S. Dissecting ramoplanin: mechanistic analysis of synthetic ramoplanin analogues as a guide to the design of improved antibiotics. Journal of the American Chemical Society. 126: 7462-3. PMID 15198592 DOI: 10.1021/ja047879t  0.72
2004 Hu Y, Helm JS, Chen L, Ginsberg C, Gross B, Kraybill B, Tiyanont K, Fang X, Wu T, Walker S. Identification of selective inhibitors for the glycosyltransferase MurG via high-throughput screening. Chemistry & Biology. 11: 703-11. PMID 15157881 DOI: 10.1016/j.chembiol.2004.02.024  0.72
2003 Helm JS, Hu Y, Chen L, Gross B, Walker S. Identification of active-site inhibitors of MurG using a generalizable, high-throughput glycosyltransferase screen. Journal of the American Chemical Society. 125: 11168-9. PMID 16220917 DOI: 10.1021/ja036494s  0.72
2003 Hu Y, Helm JS, Chen L, Ye XY, Walker S. Ramoplanin inhibits bacterial transglycosylases by binding as a dimer to lipid II. Journal of the American Chemical Society. 125: 8736-7. PMID 12862463 DOI: 10.1021/ja035217i  0.72
2002 Helm JS, Chen L, Walker S. Rethinking ramoplanin: the role of substrate binding in inhibition of peptidoglycan biosynthesis. Journal of the American Chemical Society. 124: 13970-1. PMID 12440876 DOI: 10.1021/ja021097n  0.72
2001 Lo MC, Helm JS, Sarngadharan G, Pelczer I, Walker S. A new structure for the substrate-binding antibiotic ramoplanin. Journal of the American Chemical Society. 123: 8640-1. PMID 11525690 DOI: 10.1021/ja011080p  0.72
2000 Lo MC, Men H, Branstrom A, Helm J, Yao N, Goldman R, Walker S. A new mechanism of action proposed for ramoplanin [10] Journal of the American Chemical Society. 122: 3540-3541. DOI: 10.1021/ja000182x  0.72
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